PL341359A1 - Thermodynamically stable form of (r)-3-{[(4-fluorophenyl)sulphonyl]amino}-1,2,3,4-tetrahydro-9h-cabazol-9-propanic acid (ramatrobane) - Google Patents

Thermodynamically stable form of (r)-3-{[(4-fluorophenyl)sulphonyl]amino}-1,2,3,4-tetrahydro-9h-cabazol-9-propanic acid (ramatrobane)

Info

Publication number
PL341359A1
PL341359A1 PL98341359A PL34135998A PL341359A1 PL 341359 A1 PL341359 A1 PL 341359A1 PL 98341359 A PL98341359 A PL 98341359A PL 34135998 A PL34135998 A PL 34135998A PL 341359 A1 PL341359 A1 PL 341359A1
Authority
PL
Poland
Prior art keywords
ramatrobane
cabazol
sulphonyl
fluorophenyl
tetrahydro
Prior art date
Application number
PL98341359A
Inventor
Alfons Grunenberg
Karl-Heinz Wahl
Klaus-Peter Voges
Original Assignee
Bayer Yakuhin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Yakuhin filed Critical Bayer Yakuhin
Publication of PL341359A1 publication Critical patent/PL341359A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
PL98341359A 1997-12-24 1998-12-24 Thermodynamically stable form of (r)-3-{[(4-fluorophenyl)sulphonyl]amino}-1,2,3,4-tetrahydro-9h-cabazol-9-propanic acid (ramatrobane) PL341359A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19757983A DE19757983A1 (en) 1997-12-24 1997-12-24 Thermodynamically stable form of (r) -3 [[(4-fluorophenyl) sulfonyl] amino] -1,2,3,4-tetrahydro-9H-carbazole-0-propanoic acid (Ramatroban)

Publications (1)

Publication Number Publication Date
PL341359A1 true PL341359A1 (en) 2001-04-09

Family

ID=7853457

Family Applications (1)

Application Number Title Priority Date Filing Date
PL98341359A PL341359A1 (en) 1997-12-24 1998-12-24 Thermodynamically stable form of (r)-3-{[(4-fluorophenyl)sulphonyl]amino}-1,2,3,4-tetrahydro-9h-cabazol-9-propanic acid (ramatrobane)

Country Status (37)

Country Link
US (1) US6362214B1 (en)
EP (1) EP1051398B1 (en)
JP (2) JP3817668B2 (en)
KR (1) KR100586350B1 (en)
CN (1) CN1140510C (en)
AR (1) AR013803A1 (en)
AT (1) ATE263152T1 (en)
AU (1) AU744242B2 (en)
BG (1) BG65024B1 (en)
BR (1) BR9814496A (en)
CA (1) CA2313230A1 (en)
CO (1) CO4970800A1 (en)
DE (2) DE19757983A1 (en)
DK (1) DK1051398T3 (en)
ES (1) ES2218874T3 (en)
GT (1) GT199800198A (en)
HK (1) HK1034517A1 (en)
HN (1) HN1998000186A (en)
HU (1) HUP0004432A3 (en)
ID (1) ID25446A (en)
IL (1) IL136278A (en)
IN (1) IN192932B (en)
MY (1) MY116312A (en)
NO (1) NO316618B1 (en)
NZ (1) NZ504741A (en)
PE (1) PE20000115A1 (en)
PL (1) PL341359A1 (en)
PT (1) PT1051398E (en)
RU (1) RU2220137C2 (en)
SI (1) SI1051398T1 (en)
SK (1) SK285109B6 (en)
TR (1) TR200001936T2 (en)
TW (1) TW552258B (en)
UA (1) UA66832C2 (en)
UY (2) UY25324A1 (en)
WO (1) WO1999033803A1 (en)
ZA (1) ZA9811817B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE543501T1 (en) * 2006-12-20 2012-02-15 Cardoz Ab COMBINATION OF PEMIROLAST AND RAMATROBAN FOR USE IN THE TREATMENT OF INFLAMMATORY DISEASES
AU2007344274A1 (en) * 2007-01-16 2008-07-24 Cardoz Ab New combination for use in the treatment of inflammatory disorders
WO2009007674A2 (en) * 2007-07-11 2009-01-15 Cardoz Ab Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast
CN101434571B (en) * 2007-11-13 2012-05-30 杭州容立医药科技有限公司 Cycloalkano [1,2-b] indole sulfonic acid amide, and method for synthesizing isomer or salt thereof
WO2011115069A1 (en) * 2010-03-19 2011-09-22 第一三共株式会社 Exhaustive searching for crystals
CN103054857A (en) * 2012-12-30 2013-04-24 北京阜康仁生物制药科技有限公司 Solid preparation taking ramatroban as active ingredient
US20180021302A1 (en) 2015-02-13 2018-01-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1015711B (en) * 1986-02-21 1992-03-04 拜尔公司 Cycloalkaho [1,2-b] indole-sulphonamides
DE3631824A1 (en) 1986-02-21 1988-03-31 Bayer Ag CYCLOALKANO (1.2-B) INDOL-SULFONAMIDE
DE19506739A1 (en) 1995-02-27 1996-08-29 Bayer Ag [3-Amino] tetrahydrocarbazole propanoic acid ester

Also Published As

Publication number Publication date
CN1282320A (en) 2001-01-31
BR9814496A (en) 2000-10-10
CO4970800A1 (en) 2000-11-07
NZ504741A (en) 2002-10-25
NO20003217D0 (en) 2000-06-21
AU744242B2 (en) 2002-02-21
HUP0004432A3 (en) 2002-10-28
IN192932B (en) 2004-06-12
HK1034517A1 (en) 2001-10-26
UY25575A1 (en) 1999-11-17
US6362214B1 (en) 2002-03-26
DE69822882D1 (en) 2004-05-06
JP2001527067A (en) 2001-12-25
KR100586350B1 (en) 2006-06-07
SK285109B6 (en) 2006-06-01
ZA9811817B (en) 1999-06-29
IL136278A (en) 2005-03-20
DE19757983A1 (en) 1999-07-01
HUP0004432A2 (en) 2001-06-28
DK1051398T3 (en) 2004-07-19
WO1999033803A1 (en) 1999-07-08
JP3817668B2 (en) 2006-09-06
NO20003217L (en) 2000-06-21
JP2006151977A (en) 2006-06-15
MY116312A (en) 2003-12-31
CA2313230A1 (en) 1999-07-08
HN1998000186A (en) 1999-11-03
NO316618B1 (en) 2004-03-08
PE20000115A1 (en) 2000-03-26
EP1051398B1 (en) 2004-03-31
SI1051398T1 (en) 2004-08-31
GT199800198A (en) 1998-12-15
BG104554A (en) 2001-05-31
RU2220137C2 (en) 2003-12-27
ID25446A (en) 2000-10-05
UA66832C2 (en) 2004-06-15
AR013803A1 (en) 2001-01-10
IL136278A0 (en) 2001-05-20
CN1140510C (en) 2004-03-03
AU1687499A (en) 1999-07-19
ES2218874T3 (en) 2004-11-16
JP4411269B2 (en) 2010-02-10
PT1051398E (en) 2004-07-30
EP1051398A1 (en) 2000-11-15
TR200001936T2 (en) 2001-01-22
ATE263152T1 (en) 2004-04-15
KR20010033529A (en) 2001-04-25
SK9752000A3 (en) 2001-02-12
UY25324A1 (en) 2000-12-29
BG65024B1 (en) 2006-12-29
DE69822882T2 (en) 2005-02-03
TW552258B (en) 2003-09-11

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Legal Events

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REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)