BR9814496A - Composto, processos para a preparação de cristais de sementes da modificação termodinamicamente estável i de ramatroban, para a preparação de uma forma termodinamicamente estável de ramatroban, medicamento, e, uso de uma modificação termodinamicamente estável de ramatroban - Google Patents

Composto, processos para a preparação de cristais de sementes da modificação termodinamicamente estável i de ramatroban, para a preparação de uma forma termodinamicamente estável de ramatroban, medicamento, e, uso de uma modificação termodinamicamente estável de ramatroban

Info

Publication number
BR9814496A
BR9814496A BR9814496-0A BR9814496A BR9814496A BR 9814496 A BR9814496 A BR 9814496A BR 9814496 A BR9814496 A BR 9814496A BR 9814496 A BR9814496 A BR 9814496A
Authority
BR
Brazil
Prior art keywords
ramatroban
thermodynamically stable
preparation
modification
compound
Prior art date
Application number
BR9814496-0A
Other languages
English (en)
Inventor
Alfons Grunenberg
Karl-Heinz Wahl
Klaus-Peter Voges
Original Assignee
Bayer Yakuhin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Yakuhin Ltd filed Critical Bayer Yakuhin Ltd
Publication of BR9814496A publication Critical patent/BR9814496A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

"COMPOSTO, PROCESSOS PARA A PREPARAçãO DE CRISTAIS DE SEMENTES DA MODIFICAçãO TERMODINAMICAMENTE ESTáVEL I DE RAMATROBAN, PARA A PREPARAçãO DE UMA FORMA TERMODINAMICAMENTE ESTáVEL DE RAMATROBAN, MEDICAMENTO, E, USO DE UMA MODIFICAçãO TERMODINAMICAMENTE ESTáVEL DE RAMATROBAN" A presente invenção diz respeito a uma modificação termodinamicamente estável do composto ativo de ramatroban da fórmula (I) A forma termodinamicamente estável é preparada pela fusão da forma metaestável e recristalização subsequente ou pela semeadura de uma solução do composto ativo metaestável com um cristal de semente da forma termodinamicamente estável. O composto ativo termodinamicamente estável pode ser utilizado como um agente de asma.
BR9814496-0A 1997-12-24 1998-12-24 Composto, processos para a preparação de cristais de sementes da modificação termodinamicamente estável i de ramatroban, para a preparação de uma forma termodinamicamente estável de ramatroban, medicamento, e, uso de uma modificação termodinamicamente estável de ramatroban BR9814496A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19757983A DE19757983A1 (de) 1997-12-24 1997-12-24 Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban)
PCT/JP1998/005844 WO1999033803A1 (en) 1997-12-24 1998-12-24 Thermodynamically stable form of (r)-3-[ [(4-fluorophenyl) sulphonyl]amino] -1,2,3,4- tetrahydro -9h-carbazole -9-propanoic acid (ramatroban)

Publications (1)

Publication Number Publication Date
BR9814496A true BR9814496A (pt) 2000-10-10

Family

ID=7853457

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814496-0A BR9814496A (pt) 1997-12-24 1998-12-24 Composto, processos para a preparação de cristais de sementes da modificação termodinamicamente estável i de ramatroban, para a preparação de uma forma termodinamicamente estável de ramatroban, medicamento, e, uso de uma modificação termodinamicamente estável de ramatroban

Country Status (37)

Country Link
US (1) US6362214B1 (pt)
EP (1) EP1051398B1 (pt)
JP (2) JP3817668B2 (pt)
KR (1) KR100586350B1 (pt)
CN (1) CN1140510C (pt)
AR (1) AR013803A1 (pt)
AT (1) ATE263152T1 (pt)
AU (1) AU744242B2 (pt)
BG (1) BG65024B1 (pt)
BR (1) BR9814496A (pt)
CA (1) CA2313230A1 (pt)
CO (1) CO4970800A1 (pt)
DE (2) DE19757983A1 (pt)
DK (1) DK1051398T3 (pt)
ES (1) ES2218874T3 (pt)
GT (1) GT199800198A (pt)
HK (1) HK1034517A1 (pt)
HN (1) HN1998000186A (pt)
HU (1) HUP0004432A3 (pt)
ID (1) ID25446A (pt)
IL (1) IL136278A (pt)
IN (1) IN192932B (pt)
MY (1) MY116312A (pt)
NO (1) NO316618B1 (pt)
NZ (1) NZ504741A (pt)
PE (1) PE20000115A1 (pt)
PL (1) PL341359A1 (pt)
PT (1) PT1051398E (pt)
RU (1) RU2220137C2 (pt)
SI (1) SI1051398T1 (pt)
SK (1) SK285109B6 (pt)
TR (1) TR200001936T2 (pt)
TW (1) TW552258B (pt)
UA (1) UA66832C2 (pt)
UY (2) UY25324A1 (pt)
WO (1) WO1999033803A1 (pt)
ZA (1) ZA9811817B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007336077A1 (en) * 2006-12-20 2008-06-26 Cardoz Ab New combination for use in the treatment of inflammatory disorders
EP2104534A1 (en) * 2007-01-16 2009-09-30 Cardoz AB New combination for use in the treatment of inflammatory disorders
WO2009007674A2 (en) * 2007-07-11 2009-01-15 Cardoz Ab Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast
CN101434571B (zh) * 2007-11-13 2012-05-30 杭州容立医药科技有限公司 环烷并[1,2-b]吲哚磺酰胺、其异构体或其盐的合成方法
WO2011115069A1 (ja) * 2010-03-19 2011-09-22 第一三共株式会社 結晶の網羅的探索
CN103054857A (zh) * 2012-12-30 2013-04-24 北京阜康仁生物制药科技有限公司 一种以雷马曲班为活性成分的固体制剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3631824A1 (de) 1986-02-21 1988-03-31 Bayer Ag Cycloalkano(1.2-b)indol-sulfonamide
CN1015711B (zh) * 1986-02-21 1992-03-04 拜尔公司 制备环烷并[1，2-b]吲哚-磺酰胺类化合物的方法
DE19506739A1 (de) 1995-02-27 1996-08-29 Bayer Ag [3-Amino]-tetrahydrocarbazol-propansäureester

Also Published As

Publication number Publication date
AU744242B2 (en) 2002-02-21
DK1051398T3 (da) 2004-07-19
PT1051398E (pt) 2004-07-30
HUP0004432A3 (en) 2002-10-28
PE20000115A1 (es) 2000-03-26
IN192932B (pt) 2004-06-12
BG104554A (en) 2001-05-31
CN1282320A (zh) 2001-01-31
UA66832C2 (uk) 2004-06-15
US6362214B1 (en) 2002-03-26
DE19757983A1 (de) 1999-07-01
JP2001527067A (ja) 2001-12-25
BG65024B1 (bg) 2006-12-29
ATE263152T1 (de) 2004-04-15
MY116312A (en) 2003-12-31
JP4411269B2 (ja) 2010-02-10
TR200001936T2 (tr) 2001-01-22
NZ504741A (en) 2002-10-25
AR013803A1 (es) 2001-01-10
CN1140510C (zh) 2004-03-03
KR20010033529A (ko) 2001-04-25
DE69822882D1 (en) 2004-05-06
NO20003217L (no) 2000-06-21
AU1687499A (en) 1999-07-19
JP3817668B2 (ja) 2006-09-06
EP1051398A1 (en) 2000-11-15
IL136278A (en) 2005-03-20
ZA9811817B (en) 1999-06-29
KR100586350B1 (ko) 2006-06-07
SK285109B6 (sk) 2006-06-01
IL136278A0 (en) 2001-05-20
TW552258B (en) 2003-09-11
RU2220137C2 (ru) 2003-12-27
NO316618B1 (no) 2004-03-08
WO1999033803A1 (en) 1999-07-08
HUP0004432A2 (hu) 2001-06-28
NO20003217D0 (no) 2000-06-21
GT199800198A (es) 1998-12-15
UY25575A1 (es) 1999-11-17
DE69822882T2 (de) 2005-02-03
CO4970800A1 (es) 2000-11-07
ID25446A (id) 2000-10-05
PL341359A1 (en) 2001-04-09
SI1051398T1 (en) 2004-08-31
JP2006151977A (ja) 2006-06-15
EP1051398B1 (en) 2004-03-31
SK9752000A3 (en) 2001-02-12
HK1034517A1 (en) 2001-10-26
CA2313230A1 (en) 1999-07-08
ES2218874T3 (es) 2004-11-16
UY25324A1 (es) 2000-12-29
HN1998000186A (es) 1999-11-03

Similar Documents

Publication Publication Date Title
PT97689A (pt) Processo para a preparacao de composicoes farmaceuticas incorporando como ingrediente activo isoxazol-4-carboxilamida e hidroxialquilideno-cianoacetamida
AR025959A1 (es) DERIVADOS DE TER.-BUTIL-(7-METIL-IMIDAZO[1,2,a]PIRIDIN-3-IL)-AMINA, PROCEDIMIENTO PARA SU PREPARACION, MEDICAMENTOS QUE LOS CONTIENEN, SU USO PARA LAPREPARACION DE UN MEDICAMENTO PARA LA INHIBICION DE NO-SINTASA Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN
HUP0200714A2 (hu) Gyógyhatású vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
IS1564B (is) Aðferð við framleiðslu á N1-súbstitúeruðum bensimidasólafleiðum til að nota við lækningar
EP1362846A4 (en) AMINOETHANOLDERIVATE
AR012294A1 (es) Derivados de sulfonamida, un procedimiento para su preparacion, composiciones farmaceuticas que los contienen, uso de dichos derivados para lapreparacion de un medicamento.
NO883229L (no) Nye benzimidazolderivater, fremgangsmaate for deres fremstilling og farmasoeytisk preparat inneholdende slike derivater.
NO894616L (no) Fremgangsmaate for fremstilling av anti-aterosklerotisk aktive diarylforbindelser.
NO304113B1 (no) Krystallinsk tiagabinhydrokloridmonohydrat, farmas°ytisk preparat som omfatter det, og anvendelse derav for fremstilling av et medikament
AR035889A1 (es) Citrato de 5,7,14-triazatetraciclo[10.3.1.02,11.04,9]hexadeca-2(11),3,5,7,9- pentaeno y composiciones farmaceuticas que la contienen y su uso para la elaboracion de medicamentos
BR9814496A (pt) Composto, processos para a preparação de cristais de sementes da modificação termodinamicamente estável i de ramatroban, para a preparação de uma forma termodinamicamente estável de ramatroban, medicamento, e, uso de uma modificação termodinamicamente estável de ramatroban
AU2896197A (en) Adenosine derivatives
BR0210123A (pt) Composto, formulação farmacêutica, e, uso de um composto
MX9405111A (es) Nuevos derivados de (1-fenil-1-heterociclil)metanol y(1-fenil-1-heterociclil-metilamina).
CA2470066A1 (en) 3-phenyl-2-arylalkylthiopropionic acid derivatives as selective agonists of ppar-alpha
ES2175419T3 (es) Preparacion farmaceutica que contiene nimesulida para uso topico.
HRP20060040A2 (en) PURE D-(17α)-13-ETHYL-17-HYDROXY-18,19-DINORPREGN-4-ENE-20-YNE-3-ONE-3E- AND -3Z-OXIME ISOMERS, AS WELL AS PROCESS FOR THE SYNTHESIS OF THE MIXTURE OF ISOMERS AND THE PURE ISOMERS
HUP0103077A2 (hu) Új benzotiadiazinvegyületek, eljárás ezek előállítására, és ezeket tartalmazó gyógyászati készítmények
DE69318715D1 (de) Pharmakologisch aktive alpha-(tertiär-aminoethyl)-phenylmethanol-derivate
CA2165836A1 (fr) Utilisation des derives du rosmanol pour la fabrication des medicaments anti-radicalaires et/ou antilipoperoxydantes et/ou hepatotropes
ES2036539T3 (es) Un procedimiento para preparar derivados de ergolina.
ECSP982809A (es) Forma termodinamicamente estable del acido (r)-3-[[(4- fluorofenil) sulfonil] amino]- 1,2,3,4,-tetrahidro-9h- carbazol-9-propanoico (ramatroban)
SE0301698D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
ATE21908T1 (de) Derivate von 1,4-diaminocyclitol, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
BR9812862A (pt) Composto, formulação farmacêutica, e, processo para a preparação de um composto

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL.8: C07D 209/88, A61K 31/403, A61P 7/02

Ipc: C07D 209/88 (2008.01), A61K 31/403 (2008.01), A61P

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DE ACORDO COM ART. 8O DA LPI.