UY25575A1 - Procedimiento para preparar forma termodinamicamente estable del acido (r)-3-[[(4-fluorofenil)sulfonil]amino]-1,2,3,4-tetrahidro-9h-carbazol-9-propanoico (ramatroban) - Google Patents
Procedimiento para preparar forma termodinamicamente estable del acido (r)-3-[[(4-fluorofenil)sulfonil]amino]-1,2,3,4-tetrahidro-9h-carbazol-9-propanoico (ramatroban)Info
- Publication number
- UY25575A1 UY25575A1 UY25575A UY25575A UY25575A1 UY 25575 A1 UY25575 A1 UY 25575A1 UY 25575 A UY25575 A UY 25575A UY 25575 A UY25575 A UY 25575A UY 25575 A1 UY25575 A1 UY 25575A1
- Authority
- UY
- Uruguay
- Prior art keywords
- thermodynamically stable
- ramatroban
- propanoico
- sulfonil
- carbazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Procedimiento para la preparación de una modificación termodinamicamente estable del compuesto activo ramatroban, mediante la fusión de la forma metaestable y subsiguiente recristalización o sembrando una solución del compuesto activo metaestable con un cristal para sembrar de la forma termodinamicamente estable. El compuesto activo termodinamicamente estable puede ser empleado como un agente para el asma. Una modificación de ramatrobán ha sido descubierta , siendo estable termodinámicamente y estable en su almacenamiento despues del procesamiento por medio de suspensiones y, por lo tanto, es especialmente adecuada para formulaciones farmacéuticas como suspensiones o cremas o granulacion acuosa o trituración en húmedo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19757983A DE19757983A1 (de) | 1997-12-24 | 1997-12-24 | Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban) |
UY25324A UY25324A1 (es) | 1997-12-24 | 1998-12-23 | Forma termodinamicamente estable del ácido (r)-3-(((4-fluoro fenil)sulfonil)amino)-1,2,3,4-tetrahidro-9h-carbazol-9-propanoico (ramatroban) |
Publications (1)
Publication Number | Publication Date |
---|---|
UY25575A1 true UY25575A1 (es) | 1999-11-17 |
Family
ID=7853457
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY25324A UY25324A1 (es) | 1997-12-24 | 1998-12-23 | Forma termodinamicamente estable del ácido (r)-3-(((4-fluoro fenil)sulfonil)amino)-1,2,3,4-tetrahidro-9h-carbazol-9-propanoico (ramatroban) |
UY25575A UY25575A1 (es) | 1997-12-24 | 1999-06-18 | Procedimiento para preparar forma termodinamicamente estable del acido (r)-3-[[(4-fluorofenil)sulfonil]amino]-1,2,3,4-tetrahidro-9h-carbazol-9-propanoico (ramatroban) |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY25324A UY25324A1 (es) | 1997-12-24 | 1998-12-23 | Forma termodinamicamente estable del ácido (r)-3-(((4-fluoro fenil)sulfonil)amino)-1,2,3,4-tetrahidro-9h-carbazol-9-propanoico (ramatroban) |
Country Status (37)
Country | Link |
---|---|
US (1) | US6362214B1 (es) |
EP (1) | EP1051398B1 (es) |
JP (2) | JP3817668B2 (es) |
KR (1) | KR100586350B1 (es) |
CN (1) | CN1140510C (es) |
AR (1) | AR013803A1 (es) |
AT (1) | ATE263152T1 (es) |
AU (1) | AU744242B2 (es) |
BG (1) | BG65024B1 (es) |
BR (1) | BR9814496A (es) |
CA (1) | CA2313230A1 (es) |
CO (1) | CO4970800A1 (es) |
DE (2) | DE19757983A1 (es) |
DK (1) | DK1051398T3 (es) |
ES (1) | ES2218874T3 (es) |
GT (1) | GT199800198A (es) |
HK (1) | HK1034517A1 (es) |
HN (1) | HN1998000186A (es) |
HU (1) | HUP0004432A3 (es) |
ID (1) | ID25446A (es) |
IL (1) | IL136278A (es) |
IN (1) | IN192932B (es) |
MY (1) | MY116312A (es) |
NO (1) | NO316618B1 (es) |
NZ (1) | NZ504741A (es) |
PE (1) | PE20000115A1 (es) |
PL (1) | PL341359A1 (es) |
PT (1) | PT1051398E (es) |
RU (1) | RU2220137C2 (es) |
SI (1) | SI1051398T1 (es) |
SK (1) | SK285109B6 (es) |
TR (1) | TR200001936T2 (es) |
TW (1) | TW552258B (es) |
UA (1) | UA66832C2 (es) |
UY (2) | UY25324A1 (es) |
WO (1) | WO1999033803A1 (es) |
ZA (1) | ZA9811817B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2007336077A1 (en) * | 2006-12-20 | 2008-06-26 | Cardoz Ab | New combination for use in the treatment of inflammatory disorders |
EP2104534A1 (en) * | 2007-01-16 | 2009-09-30 | Cardoz AB | New combination for use in the treatment of inflammatory disorders |
WO2009007674A2 (en) * | 2007-07-11 | 2009-01-15 | Cardoz Ab | Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast |
CN101434571B (zh) * | 2007-11-13 | 2012-05-30 | 杭州容立医药科技有限公司 | 环烷并[1,2-b]吲哚磺酰胺、其异构体或其盐的合成方法 |
WO2011115069A1 (ja) * | 2010-03-19 | 2011-09-22 | 第一三共株式会社 | 結晶の網羅的探索 |
CN103054857A (zh) * | 2012-12-30 | 2013-04-24 | 北京阜康仁生物制药科技有限公司 | 一种以雷马曲班为活性成分的固体制剂 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3631824A1 (de) | 1986-02-21 | 1988-03-31 | Bayer Ag | Cycloalkano(1.2-b)indol-sulfonamide |
CN1015711B (zh) * | 1986-02-21 | 1992-03-04 | 拜尔公司 | 制备环烷并[1,2-b]吲哚-磺酰胺类化合物的方法 |
DE19506739A1 (de) | 1995-02-27 | 1996-08-29 | Bayer Ag | [3-Amino]-tetrahydrocarbazol-propansäureester |
-
1997
- 1997-12-24 DE DE19757983A patent/DE19757983A1/de not_active Withdrawn
-
1998
- 1998-12-09 HN HN1998000186A patent/HN1998000186A/es unknown
- 1998-12-11 AR ARP980106318A patent/AR013803A1/es unknown
- 1998-12-15 GT GT199800198A patent/GT199800198A/es unknown
- 1998-12-22 PE PE1998001272A patent/PE20000115A1/es not_active Application Discontinuation
- 1998-12-22 MY MYPI98005837A patent/MY116312A/en unknown
- 1998-12-23 TW TW087121479A patent/TW552258B/zh not_active IP Right Cessation
- 1998-12-23 UY UY25324A patent/UY25324A1/es not_active IP Right Cessation
- 1998-12-23 CO CO98076459A patent/CO4970800A1/es unknown
- 1998-12-23 ZA ZA9811817A patent/ZA9811817B/xx unknown
- 1998-12-24 TR TR2000/01936T patent/TR200001936T2/xx unknown
- 1998-12-24 UA UA2000074335A patent/UA66832C2/uk unknown
- 1998-12-24 WO PCT/JP1998/005844 patent/WO1999033803A1/en not_active Application Discontinuation
- 1998-12-24 SI SI9830656T patent/SI1051398T1/xx unknown
- 1998-12-24 KR KR1020007007031A patent/KR100586350B1/ko not_active IP Right Cessation
- 1998-12-24 IL IL13627898A patent/IL136278A/xx not_active IP Right Cessation
- 1998-12-24 EP EP98961506A patent/EP1051398B1/en not_active Expired - Lifetime
- 1998-12-24 PL PL98341359A patent/PL341359A1/xx not_active Application Discontinuation
- 1998-12-24 DK DK98961506T patent/DK1051398T3/da active
- 1998-12-24 ES ES98961506T patent/ES2218874T3/es not_active Expired - Lifetime
- 1998-12-24 US US09/582,250 patent/US6362214B1/en not_active Expired - Fee Related
- 1998-12-24 NZ NZ504741A patent/NZ504741A/xx unknown
- 1998-12-24 AU AU16874/99A patent/AU744242B2/en not_active Ceased
- 1998-12-24 SK SK975-2000A patent/SK285109B6/sk unknown
- 1998-12-24 HU HU0004432A patent/HUP0004432A3/hu unknown
- 1998-12-24 RU RU2000119741/04A patent/RU2220137C2/ru not_active IP Right Cessation
- 1998-12-24 CA CA002313230A patent/CA2313230A1/en not_active Abandoned
- 1998-12-24 CN CNB98812405XA patent/CN1140510C/zh not_active Expired - Fee Related
- 1998-12-24 PT PT98961506T patent/PT1051398E/pt unknown
- 1998-12-24 JP JP2000526487A patent/JP3817668B2/ja not_active Expired - Lifetime
- 1998-12-24 BR BR9814496-0A patent/BR9814496A/pt not_active Application Discontinuation
- 1998-12-24 IN IN43MU2000 patent/IN192932B/en unknown
- 1998-12-24 AT AT98961506T patent/ATE263152T1/de not_active IP Right Cessation
- 1998-12-24 ID IDW20001226A patent/ID25446A/id unknown
- 1998-12-24 DE DE69822882T patent/DE69822882T2/de not_active Expired - Fee Related
-
1999
- 1999-06-18 UY UY25575A patent/UY25575A1/es unknown
-
2000
- 2000-06-21 NO NO20003217A patent/NO316618B1/no unknown
- 2000-06-23 BG BG104554A patent/BG65024B1/bg unknown
-
2001
- 2001-07-27 HK HK01105260A patent/HK1034517A1/xx not_active IP Right Cessation
-
2005
- 2005-11-25 JP JP2005340586A patent/JP4411269B2/ja not_active Expired - Lifetime
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