HK1034517A1 - Thermodynamically stable form of (r)-3-((4-fluoro phenyl) sulphonyl)amino)-1,2,3,4-tetrahydro-9h-carbazole-9-propanoic acid (ramatroban). - Google Patents

Thermodynamically stable form of (r)-3-((4-fluoro phenyl) sulphonyl)amino)-1,2,3,4-tetrahydro-9h-carbazole-9-propanoic acid (ramatroban).

Info

Publication number
HK1034517A1
HK1034517A1 HK01105260A HK01105260A HK1034517A1 HK 1034517 A1 HK1034517 A1 HK 1034517A1 HK 01105260 A HK01105260 A HK 01105260A HK 01105260 A HK01105260 A HK 01105260A HK 1034517 A1 HK1034517 A1 HK 1034517A1
Authority
HK
Hong Kong
Prior art keywords
ramatroban
sulphonyl
carbazole
tetrahydro
amino
Prior art date
Application number
HK01105260A
Other languages
English (en)
Inventor
Alfons Grunenberg
Karl-Heinz Wahl
Klaus-Peter Voges
Original Assignee
Bayer Yakuhin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Yakuhin Ltd filed Critical Bayer Yakuhin Ltd
Publication of HK1034517A1 publication Critical patent/HK1034517A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
HK01105260A 1997-12-24 2001-07-27 Thermodynamically stable form of (r)-3-((4-fluoro phenyl) sulphonyl)amino)-1,2,3,4-tetrahydro-9h-carbazole-9-propanoic acid (ramatroban). HK1034517A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19757983A DE19757983A1 (de) 1997-12-24 1997-12-24 Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban)
PCT/JP1998/005844 WO1999033803A1 (en) 1997-12-24 1998-12-24 Thermodynamically stable form of (r)-3-[ [(4-fluorophenyl) sulphonyl]amino] -1,2,3,4- tetrahydro -9h-carbazole -9-propanoic acid (ramatroban)

Publications (1)

Publication Number Publication Date
HK1034517A1 true HK1034517A1 (en) 2001-10-26

Family

ID=7853457

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01105260A HK1034517A1 (en) 1997-12-24 2001-07-27 Thermodynamically stable form of (r)-3-((4-fluoro phenyl) sulphonyl)amino)-1,2,3,4-tetrahydro-9h-carbazole-9-propanoic acid (ramatroban).

Country Status (37)

Country Link
US (1) US6362214B1 (es)
EP (1) EP1051398B1 (es)
JP (2) JP3817668B2 (es)
KR (1) KR100586350B1 (es)
CN (1) CN1140510C (es)
AR (1) AR013803A1 (es)
AT (1) ATE263152T1 (es)
AU (1) AU744242B2 (es)
BG (1) BG65024B1 (es)
BR (1) BR9814496A (es)
CA (1) CA2313230A1 (es)
CO (1) CO4970800A1 (es)
DE (2) DE19757983A1 (es)
DK (1) DK1051398T3 (es)
ES (1) ES2218874T3 (es)
GT (1) GT199800198A (es)
HK (1) HK1034517A1 (es)
HN (1) HN1998000186A (es)
HU (1) HUP0004432A3 (es)
ID (1) ID25446A (es)
IL (1) IL136278A (es)
IN (1) IN192932B (es)
MY (1) MY116312A (es)
NO (1) NO316618B1 (es)
NZ (1) NZ504741A (es)
PE (1) PE20000115A1 (es)
PL (1) PL341359A1 (es)
PT (1) PT1051398E (es)
RU (1) RU2220137C2 (es)
SI (1) SI1051398T1 (es)
SK (1) SK285109B6 (es)
TR (1) TR200001936T2 (es)
TW (1) TW552258B (es)
UA (1) UA66832C2 (es)
UY (2) UY25324A1 (es)
WO (1) WO1999033803A1 (es)
ZA (1) ZA9811817B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2395120T3 (es) * 2006-12-20 2013-02-08 Cardoz Ab Combinación de pemirolast y ramotrobán para su uso en el tratamiento de transtornos inflamatorios
CA2675520A1 (en) * 2007-01-16 2008-07-24 Cardoz Ab New combination for use in the treatment of inflammatory disorders
WO2009007674A2 (en) * 2007-07-11 2009-01-15 Cardoz Ab Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast
CN101434571B (zh) * 2007-11-13 2012-05-30 杭州容立医药科技有限公司 环烷并[1,2-b]吲哚磺酰胺、其异构体或其盐的合成方法
WO2011115069A1 (ja) * 2010-03-19 2011-09-22 第一三共株式会社 結晶の網羅的探索
CN103054857A (zh) * 2012-12-30 2013-04-24 北京阜康仁生物制药科技有限公司 一种以雷马曲班为活性成分的固体制剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1015711B (zh) 1986-02-21 1992-03-04 拜尔公司 制备环烷并[1，2-b]吲哚-磺酰胺类化合物的方法
DE3631824A1 (de) 1986-02-21 1988-03-31 Bayer Ag Cycloalkano(1.2-b)indol-sulfonamide
DE19506739A1 (de) 1995-02-27 1996-08-29 Bayer Ag [3-Amino]-tetrahydrocarbazol-propansäureester

Also Published As

Publication number Publication date
BR9814496A (pt) 2000-10-10
WO1999033803A1 (en) 1999-07-08
RU2220137C2 (ru) 2003-12-27
DE69822882D1 (en) 2004-05-06
ID25446A (id) 2000-10-05
SI1051398T1 (en) 2004-08-31
US6362214B1 (en) 2002-03-26
PT1051398E (pt) 2004-07-30
AR013803A1 (es) 2001-01-10
NZ504741A (en) 2002-10-25
AU1687499A (en) 1999-07-19
NO316618B1 (no) 2004-03-08
KR100586350B1 (ko) 2006-06-07
DE19757983A1 (de) 1999-07-01
CA2313230A1 (en) 1999-07-08
IL136278A0 (en) 2001-05-20
HUP0004432A2 (hu) 2001-06-28
JP4411269B2 (ja) 2010-02-10
BG65024B1 (bg) 2006-12-29
JP2001527067A (ja) 2001-12-25
CO4970800A1 (es) 2000-11-07
TW552258B (en) 2003-09-11
AU744242B2 (en) 2002-02-21
ATE263152T1 (de) 2004-04-15
SK9752000A3 (en) 2001-02-12
KR20010033529A (ko) 2001-04-25
ES2218874T3 (es) 2004-11-16
DK1051398T3 (da) 2004-07-19
MY116312A (en) 2003-12-31
IN192932B (es) 2004-06-12
JP3817668B2 (ja) 2006-09-06
SK285109B6 (sk) 2006-06-01
CN1282320A (zh) 2001-01-31
DE69822882T2 (de) 2005-02-03
TR200001936T2 (tr) 2001-01-22
HUP0004432A3 (en) 2002-10-28
NO20003217L (no) 2000-06-21
IL136278A (en) 2005-03-20
JP2006151977A (ja) 2006-06-15
PE20000115A1 (es) 2000-03-26
UY25324A1 (es) 2000-12-29
NO20003217D0 (no) 2000-06-21
UA66832C2 (uk) 2004-06-15
EP1051398B1 (en) 2004-03-31
CN1140510C (zh) 2004-03-03
UY25575A1 (es) 1999-11-17
ZA9811817B (en) 1999-06-29
BG104554A (en) 2001-05-31
GT199800198A (es) 1998-12-15
PL341359A1 (en) 2001-04-09
HN1998000186A (es) 1999-11-03
EP1051398A1 (en) 2000-11-15

Similar Documents

Publication Publication Date Title
PL331985A1 (en) Substituted n-[(amino-imino methy- or amino-methyl-)phenyl]-propylamides
PT946100E (pt) Composicoes herbicidas contendo n-¬(4,6-dimetoxipirimidin-2-il)aminocarbonil|-5-metilsulfonamidometil-2-alcoxicarbonilbenzenossulfonamidas
DE69812633D1 (de) Von nitrone- oder nitroso-verbindungen abgeleitete alkoxyaminverbindungen-enthaltende polymerisierbare zusammensetzungen
ZA987126B (en) Aryloxyarylsulfonylamino hydroxamic acid derivatives.
CA2296769A1 (en) Modified dorsal tissue affecting factor and compositions
GR3017455T3 (en) 1-((O-(cyclopropylcarbonyl)phenyl)sulfamoyl)-3-(4,6-dimethoxy-2-pyrimidinyl)urea and method for the preparation thereof.
AU1692399A (en) Aromatic compounds having cyclic amino or salts thereof
AP2002002472A0 (en) Hexahydrofuro [2,3-b] furan-3- YN-N-[3-[(1,3-benzodioxol-5- ylsufonyl) (isobutyl) amino]-1-benzyl-2-hydroxypropyl] carbamate as retroviral protease inhibitor.
DE69823394D1 (de) Verfahren zur Herstellung von 1-(9'H-Carbazol-4'-yloxy)-3-(2''-(2'''-methoxy-phenoxy)-ethylamino)-propan-2-ol ( Carvediol)
HK1034517A1 (en) Thermodynamically stable form of (r)-3-((4-fluoro phenyl) sulphonyl)amino)-1,2,3,4-tetrahydro-9h-carbazole-9-propanoic acid (ramatroban).
TR199801903A3 (tr) Sulfonamid ikameli ve bunlari içeren farmakolojik bilesimler.
AU5703796A (en) Improved retroviral vectors, especially suitable for gene th erapy
DE69905162D1 (de) 3-[2-oxo-(1,3')bipyrrolidinyl-3-yliden-methyl]-cephemderivate
ZA986752B (en) Basimino-substituted phenyl compounds.
AU7717800A (en) Novel polynucleotides encoding proteins containing thrombospondin type 1 repeats
DE59907340D1 (de) Wasserdispergierbare Polyether-modifizierte Polyisocyanatgemische
ZA981168B (en) Compounds and processes for making herbicidal sulfonamides.
AUPP003297A0 (en) 4,5-diaryloxazole compounds
AU6904698A (en) Herbicidal 3,5-difluoropyridines
DE69002478T2 (de) N-Substituierte 3-[(2,3-Dimethylmaleimido)-amino)-benzolsulfonamid-Derivate, Verfahren zu ihrer Herstellung und herbicid wirkende Zusammensetzungen.
ZA982862B (en) N-acyl oxaziridines as bleach agents.
Sparks Eucalyptus.
EP1052982A4 (en) AMINOTETRALINS AS AGONISTS OF 5-HT 1D $ g (a)?
GB9929545D0 (en) Retroviral vectors
AU8463098A (en) Process for preparing (2r,3s)-3-(substituted or unsubstituted phenyl)glycidamidecompounds by asymmetric amidation

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20081224