YU88601A - Antifungalna oralna kompozicija koja sadrži itrakonazol i postupak za dobijanje iste - Google Patents
Antifungalna oralna kompozicija koja sadrži itrakonazol i postupak za dobijanje isteInfo
- Publication number
- YU88601A YU88601A YU88601A YUP88601A YU88601A YU 88601 A YU88601 A YU 88601A YU 88601 A YU88601 A YU 88601A YU P88601 A YUP88601 A YU P88601A YU 88601 A YU88601 A YU 88601A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- oral composition
- composition containing
- preparing same
- containing itraconazole
- itraconazole
- Prior art date
Links
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 title abstract 3
- 229960004130 itraconazole Drugs 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000000843 anti-fungal effect Effects 0.000 title abstract 2
- 229940121375 antifungal agent Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Antifungalna oralna kompozicija koja obuhvata stopljenu smešu itrakonazola i fosforne kiseline i obezbedjuje visoku in vivo biodostupnost itrakonazola.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019990022472A KR100331529B1 (ko) | 1999-06-16 | 1999-06-16 | 난용성 항진균제의 경구투여용 조성물 및 그의 제조 방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
YU88601A true YU88601A (sh) | 2004-07-15 |
RS50008B RS50008B (sr) | 2008-09-29 |
Family
ID=36441999
Country Status (18)
Country | Link |
---|---|
US (1) | US6039981A (sh) |
EP (1) | EP1185273B1 (sh) |
JP (1) | JP3717849B2 (sh) |
KR (1) | KR100331529B1 (sh) |
CN (1) | CN1170539C (sh) |
AT (1) | ATE324893T1 (sh) |
AU (1) | AU754300B2 (sh) |
CA (1) | CA2376706C (sh) |
CZ (1) | CZ292146B6 (sh) |
DE (1) | DE60027717T2 (sh) |
ES (1) | ES2262517T3 (sh) |
HU (1) | HUP0201533A3 (sh) |
MX (1) | MXPA01012739A (sh) |
RS (1) | RS50008B (sh) |
RU (1) | RU2216323C2 (sh) |
SI (1) | SI20677A (sh) |
TR (1) | TR200103681T2 (sh) |
WO (1) | WO2000076520A1 (sh) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3310299B2 (ja) | 1995-11-23 | 2002-08-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 溶融−押し出しにより調製されるシクロデキストリンの固体混合物 |
GB9720061D0 (en) | 1997-09-19 | 1997-11-19 | Crosfield Joseph & Sons | Metal compounds as phosphate binders |
KR100331529B1 (ko) * | 1999-06-16 | 2002-04-06 | 민경윤 | 난용성 항진균제의 경구투여용 조성물 및 그의 제조 방법 |
CA2291346A1 (en) * | 1999-11-26 | 2001-05-26 | Bernard Charles Sherman | Antifungal solutions |
GB0015239D0 (en) * | 2000-06-21 | 2000-08-16 | Biochemie Gmbh | Organic compounds |
US6977085B2 (en) * | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
US6951656B2 (en) * | 2000-12-22 | 2005-10-04 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
US20040256749A1 (en) * | 2000-12-22 | 2004-12-23 | Mahesh Chaubal | Process for production of essentially solvent-free small particles |
US9700866B2 (en) * | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
MXPA03005496A (es) * | 2000-12-22 | 2004-05-14 | Baxter Int | Metodo para preparar suspensiones de submicroparticulas. |
US6869617B2 (en) * | 2000-12-22 | 2005-03-22 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
US7193084B2 (en) * | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
US20050048126A1 (en) * | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
US6884436B2 (en) * | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
KR100435141B1 (ko) * | 2000-12-28 | 2004-06-09 | 한미약품 주식회사 | 난용성 항진균제의 경구투여용 조성물 및 그의 제조 방법 |
US6673373B2 (en) | 2001-02-01 | 2004-01-06 | Carlsbad Technology Inc. | Antifungal formulation and the methods for manufacturing and using the same |
US6663897B2 (en) * | 2001-02-06 | 2003-12-16 | Dsm Ip Assets B.V. | Oral itraconazole formulations and methods of making the same |
EP1842532A3 (en) * | 2001-02-06 | 2009-04-22 | Stiefel Laboratories, Inc. | Oral sparingly water-soluble antifungal formulations and methods of making the same |
KR100455216B1 (ko) * | 2001-06-27 | 2004-11-09 | 한미약품 주식회사 | 난용성 항진균제의 경구투여용 조성물 및 이의 제조 방법 |
US8071133B2 (en) * | 2001-08-20 | 2011-12-06 | Stiefel Laboratories, Inc. | Oral dosage forms of water insoluble drugs and methods of making the same |
KR100425755B1 (ko) * | 2001-08-27 | 2004-04-03 | 주식회사 원진신약 | 이트라코나졸을 함유하는 조성물 및 그 제조방법 |
US20060003012A9 (en) * | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
JP2005504090A (ja) * | 2001-09-26 | 2005-02-10 | バクスター・インターナショナル・インコーポレイテッド | 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製 |
US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
CA2363376A1 (en) * | 2001-11-16 | 2003-05-16 | Bernard Charles Sherman | Solid pharmaceutical compositions for oral administration comprising itraconazole |
KR100441745B1 (ko) * | 2001-11-30 | 2004-07-27 | 환인제약 주식회사 | 이트라코나졸의 경구투여용 조성물과 그 제조방법 |
US20040115266A1 (en) * | 2002-02-01 | 2004-06-17 | Namburi Ranga Raju | Oral itraconazole formulations and methods of making the same |
US20040266776A1 (en) | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
AU2003256089A1 (en) * | 2002-07-22 | 2004-02-09 | Nanohybrid Co., Ltd. | Hybrid of itraconazole, cyclosporine or carvedilol with a layered silicate and a process for preparing the same |
US20050058670A1 (en) * | 2003-09-09 | 2005-03-17 | Jong-Soo Woo | Oral itraconazole composition which is not affected by ingested food and process for preparing same |
US20060068015A1 (en) * | 2003-10-10 | 2006-03-30 | Per Holm | Solid dosage form comprising a fibrate and a statin |
KR20060085686A (ko) * | 2003-10-10 | 2006-07-27 | 라이프사이클 파마 에이/에스 | 피브레이트를 포함하는 고형 제제 |
US9173847B2 (en) * | 2003-10-10 | 2015-11-03 | Veloxis Pharmaceuticals A/S | Tablet comprising a fibrate |
US20050118265A1 (en) * | 2003-11-28 | 2005-06-02 | Anandi Krishnan | Antifungal oral dosage forms and the methods for preparation |
JP2005239696A (ja) * | 2004-01-30 | 2005-09-08 | Daiichi Suntory Pharma Co Ltd | 無機物質を配合した医薬硬質カプセル剤 |
EP1711163A2 (en) * | 2004-02-05 | 2006-10-18 | Baxter International Inc. | Dispersions prepared by use of self-stabilizing agents |
CN1294912C (zh) * | 2004-03-01 | 2007-01-17 | 上海医药工业研究院 | 伊曲康唑盐酸盐组合物及其冻干粉针 |
KR20050119397A (ko) * | 2004-06-16 | 2005-12-21 | 보람제약주식회사 | 고상용해를 이용한 난용성 약물의 가용화 방법과 이를이용한 가용화 조성물 |
US9492446B2 (en) * | 2004-06-24 | 2016-11-15 | Ctc Bio, Inc. | Manufacturing method of solid dispersion containing itraconazole |
US20060280787A1 (en) * | 2005-06-14 | 2006-12-14 | Baxter International Inc. | Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof |
US20070134341A1 (en) * | 2005-11-15 | 2007-06-14 | Kipp James E | Compositions of lipoxygenase inhibitors |
MY157620A (en) | 2006-01-31 | 2016-06-30 | Cytochroma Dev Inc | A granular material of a solid water-soluble mixed metal compound capable of binding phosphate |
GB0612809D0 (en) * | 2006-06-28 | 2006-08-09 | Univ Sunderland | Formulation |
US20090152176A1 (en) * | 2006-12-23 | 2009-06-18 | Baxter International Inc. | Magnetic separation of fine particles from compositions |
US8426467B2 (en) * | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
US8722736B2 (en) * | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
US20080293814A1 (en) * | 2007-05-22 | 2008-11-27 | Deepak Tiwari | Concentrate esmolol |
GB0714670D0 (en) * | 2007-07-27 | 2007-09-05 | Ineos Healthcare Ltd | Use |
GB0720220D0 (en) * | 2007-10-16 | 2007-11-28 | Ineos Healthcare Ltd | Compound |
GB0720716D0 (en) * | 2007-10-23 | 2007-12-05 | York Pharma Plc | Novel formulation |
GB0913525D0 (en) | 2009-08-03 | 2009-09-16 | Ineos Healthcare Ltd | Method |
GB201001779D0 (en) | 2010-02-04 | 2010-03-24 | Ineos Healthcare Ltd | Composition |
US10736891B2 (en) * | 2016-01-07 | 2020-08-11 | Roy MADIGAN | Composition and method for treating chagas disease |
CN110755369A (zh) * | 2019-10-30 | 2020-02-07 | 天津市保灵动物保健品有限公司 | 一种伊曲康唑软膏及其制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU661754B2 (en) * | 1992-02-12 | 1995-08-03 | Janssen - Cilag - S.p.a. | Liposomal itraconazole formulations |
WO1994016700A1 (en) * | 1993-01-27 | 1994-08-04 | Sepracor, Inc. | Method and composition employing (2r,4s) itraconazole |
WO1994016701A1 (en) * | 1993-01-27 | 1994-08-04 | Sepracor, Inc. | Methods and compositions of (2s,4r) itraconazole for treating fungal yeast and dermatophyte infections |
US5750147A (en) * | 1995-06-07 | 1998-05-12 | Emisphere Technologies, Inc. | Method of solubilizing and encapsulating itraconazole |
CA2240161C (en) * | 1996-05-20 | 2005-05-24 | Janssen Pharmaceutica N.V. | Antifungal compositions with improved bioavailability |
KR100321617B1 (ko) * | 1997-06-16 | 2002-07-27 | 동아제약 주식회사 | 항진균제와 유기산류의 공융혼합물 및 이를 함유하는 약학적 제제 |
KR100367483B1 (ko) * | 1997-12-19 | 2003-03-26 | 동아제약 주식회사 | 당류를이용하여용해도및용해속도를증가시킨이트라코나졸경구용조성물및그제조방법 |
US6383471B1 (en) * | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
KR100331529B1 (ko) * | 1999-06-16 | 2002-04-06 | 민경윤 | 난용성 항진균제의 경구투여용 조성물 및 그의 제조 방법 |
-
1999
- 1999-06-16 KR KR1019990022472A patent/KR100331529B1/ko not_active IP Right Cessation
- 1999-10-04 US US09/411,510 patent/US6039981A/en not_active Expired - Fee Related
-
2000
- 2000-06-16 EP EP00935726A patent/EP1185273B1/en not_active Expired - Lifetime
- 2000-06-16 JP JP2001502853A patent/JP3717849B2/ja not_active Expired - Fee Related
- 2000-06-16 RS YUP-886/01A patent/RS50008B/sr unknown
- 2000-06-16 MX MXPA01012739A patent/MXPA01012739A/es active IP Right Grant
- 2000-06-16 CN CNB008089485A patent/CN1170539C/zh not_active Expired - Fee Related
- 2000-06-16 CZ CZ20014508A patent/CZ292146B6/cs not_active IP Right Cessation
- 2000-06-16 AT AT00935726T patent/ATE324893T1/de not_active IP Right Cessation
- 2000-06-16 RU RU2002100645/14A patent/RU2216323C2/ru not_active IP Right Cessation
- 2000-06-16 TR TR2001/03681T patent/TR200103681T2/xx unknown
- 2000-06-16 AU AU51144/00A patent/AU754300B2/en not_active Ceased
- 2000-06-16 DE DE60027717T patent/DE60027717T2/de not_active Expired - Lifetime
- 2000-06-16 HU HU0201533A patent/HUP0201533A3/hu unknown
- 2000-06-16 SI SI200020024A patent/SI20677A/sl not_active IP Right Cessation
- 2000-06-16 CA CA002376706A patent/CA2376706C/en not_active Expired - Fee Related
- 2000-06-16 WO PCT/KR2000/000637 patent/WO2000076520A1/en active IP Right Grant
- 2000-06-16 ES ES00935726T patent/ES2262517T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2262517T3 (es) | 2006-12-01 |
CN1390127A (zh) | 2003-01-08 |
HUP0201533A2 (en) | 2002-09-28 |
EP1185273B1 (en) | 2006-05-03 |
CZ20014508A3 (cs) | 2003-03-12 |
ATE324893T1 (de) | 2006-06-15 |
KR20010002590A (ko) | 2001-01-15 |
RS50008B (sr) | 2008-09-29 |
WO2000076520A1 (en) | 2000-12-21 |
AU5114400A (en) | 2001-01-02 |
RU2216323C2 (ru) | 2003-11-20 |
CA2376706A1 (en) | 2000-12-21 |
CA2376706C (en) | 2006-06-06 |
EP1185273A4 (en) | 2004-03-10 |
DE60027717T2 (de) | 2007-05-10 |
TR200103681T2 (tr) | 2002-05-21 |
MXPA01012739A (es) | 2002-07-02 |
US6039981A (en) | 2000-03-21 |
AU754300B2 (en) | 2002-11-14 |
CN1170539C (zh) | 2004-10-13 |
EP1185273A1 (en) | 2002-03-13 |
HUP0201533A3 (en) | 2006-07-28 |
JP2003501475A (ja) | 2003-01-14 |
KR100331529B1 (ko) | 2002-04-06 |
CZ292146B6 (cs) | 2003-08-13 |
SI20677A (sl) | 2002-04-30 |
JP3717849B2 (ja) | 2005-11-16 |
DE60027717D1 (de) | 2006-06-08 |
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