TR199801594A2 - CCR-3 reseptör antagonistleri. - Google Patents
CCR-3 reseptör antagonistleri.Info
- Publication number
- TR199801594A2 TR199801594A2 TR1998/01594A TR9801594A TR199801594A2 TR 199801594 A2 TR199801594 A2 TR 199801594A2 TR 1998/01594 A TR1998/01594 A TR 1998/01594A TR 9801594 A TR9801594 A TR 9801594A TR 199801594 A2 TR199801594 A2 TR 199801594A2
- Authority
- TR
- Turkey
- Prior art keywords
- ccr
- receptor antagonists
- methods
- relates
- cyclic amine
- Prior art date
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Hydrogenated Pyridines (AREA)
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- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Bu bulus, Formül (1)'in belirli siklik amin türevleri ile ilgilidir.Bu bulus siklik amin türevleri CCR-3 reseptör antagonistleri, onlari içeren farmasötik kompozisyonlar, onlarin kullanim yöntemleri ve bu bilesimleri hazirlama yöntemleri ile ilgilidir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5600197P | 1997-08-18 | 1997-08-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
TR199801594A2 true TR199801594A2 (tr) | 1999-03-22 |
TR199801594A3 TR199801594A3 (tr) | 1999-03-22 |
Family
ID=22001512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR1998/01594A TR199801594A3 (tr) | 1997-08-18 | 1998-08-18 | CCR-3 reseptör antagonistleri. |
Country Status (31)
Country | Link |
---|---|
US (3) | US6323223B1 (tr) |
EP (1) | EP0903349B1 (tr) |
JP (1) | JP3014367B2 (tr) |
KR (1) | KR100339460B1 (tr) |
CN (1) | CN1107061C (tr) |
AR (1) | AR016822A1 (tr) |
AT (1) | ATE315035T1 (tr) |
AU (1) | AU744059B2 (tr) |
BR (1) | BR9803179A (tr) |
CA (1) | CA2245043A1 (tr) |
CO (1) | CO4980871A1 (tr) |
CZ (1) | CZ256698A3 (tr) |
DE (2) | DE69833073T2 (tr) |
ES (2) | ES2255119T3 (tr) |
FR (1) | FR2767826A1 (tr) |
GB (1) | GB2330580A (tr) |
HR (1) | HRP980450A2 (tr) |
HU (2) | HU9801861D0 (tr) |
ID (1) | ID21679A (tr) |
IL (1) | IL125658A0 (tr) |
IT (1) | IT1304150B1 (tr) |
MA (1) | MA26532A1 (tr) |
NO (1) | NO983749L (tr) |
NZ (1) | NZ331319A (tr) |
PE (1) | PE106499A1 (tr) |
PL (1) | PL328049A1 (tr) |
SG (1) | SG70110A1 (tr) |
TR (1) | TR199801594A3 (tr) |
UY (1) | UY25142A1 (tr) |
YU (1) | YU34898A (tr) |
ZA (1) | ZA987448B (tr) |
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IL125658A0 (en) | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
JP2002501052A (ja) | 1998-01-21 | 2002-01-15 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | ケモカイン受容体アンタゴニストおよびその使用方法 |
AU763960B2 (en) | 1998-11-20 | 2003-08-07 | F. Hoffmann-La Roche Ag | Pyrrolidine derivatives-CCR-3 receptor antagonists |
AU2482100A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
CA2366111C (en) | 1999-03-12 | 2004-05-25 | Bombardier Transportation Gmbh | Power rail and guidebeam assembly for a vehicle transportation system |
-
1998
- 1998-08-05 IL IL12565898A patent/IL125658A0/xx unknown
- 1998-08-10 DE DE69833073T patent/DE69833073T2/de not_active Expired - Fee Related
- 1998-08-10 EP EP98114971A patent/EP0903349B1/en not_active Expired - Lifetime
- 1998-08-10 AT AT98114971T patent/ATE315035T1/de not_active IP Right Cessation
- 1998-08-10 ES ES98114971T patent/ES2255119T3/es not_active Expired - Lifetime
- 1998-08-11 NZ NZ331319A patent/NZ331319A/xx unknown
- 1998-08-12 HU HU9801861A patent/HU9801861D0/hu unknown
- 1998-08-13 CZ CZ982566A patent/CZ256698A3/cs unknown
- 1998-08-14 CA CA002245043A patent/CA2245043A1/en not_active Abandoned
- 1998-08-14 CO CO98046764A patent/CO4980871A1/es unknown
- 1998-08-14 ES ES009801760A patent/ES2154167B1/es not_active Expired - Lifetime
- 1998-08-14 US US09/134,013 patent/US6323223B1/en not_active Expired - Fee Related
- 1998-08-14 KR KR1019980033037A patent/KR100339460B1/ko not_active IP Right Cessation
- 1998-08-17 UY UY25142A patent/UY25142A1/es not_active Application Discontinuation
- 1998-08-17 NO NO983749A patent/NO983749L/no not_active Application Discontinuation
- 1998-08-17 HU HU9801887A patent/HUP9801887A3/hu unknown
- 1998-08-17 GB GB9817910A patent/GB2330580A/en not_active Withdrawn
- 1998-08-17 MA MA25214A patent/MA26532A1/fr unknown
- 1998-08-18 HR HR60/056,001A patent/HRP980450A2/hr not_active Application Discontinuation
- 1998-08-18 AR ARP980104061A patent/AR016822A1/es unknown
- 1998-08-18 PL PL98328049A patent/PL328049A1/xx unknown
- 1998-08-18 ZA ZA987448A patent/ZA987448B/xx unknown
- 1998-08-18 ID IDP981141A patent/ID21679A/id unknown
- 1998-08-18 AU AU80800/98A patent/AU744059B2/en not_active Ceased
- 1998-08-18 DE DE19837386A patent/DE19837386A1/de not_active Withdrawn
- 1998-08-18 CN CN98117990A patent/CN1107061C/zh not_active Expired - Fee Related
- 1998-08-18 TR TR1998/01594A patent/TR199801594A3/tr unknown
- 1998-08-18 YU YU34898A patent/YU34898A/sh unknown
- 1998-08-18 FR FR9810504A patent/FR2767826A1/fr not_active Withdrawn
- 1998-08-18 SG SG1998003133A patent/SG70110A1/en unknown
- 1998-08-18 PE PE1998000744A patent/PE106499A1/es not_active Application Discontinuation
- 1998-08-18 IT IT1998MI001902A patent/IT1304150B1/it active
- 1998-08-18 BR BR9803179-1A patent/BR9803179A/pt not_active Application Discontinuation
- 1998-08-18 JP JP10231918A patent/JP3014367B2/ja not_active Expired - Fee Related
-
2001
- 2001-09-26 US US09/965,068 patent/US6683074B1/en not_active Expired - Fee Related
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2003
- 2003-11-21 US US10/719,204 patent/US6984637B2/en not_active Expired - Fee Related
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