ATE283838T1 - Wirksame derivate der valproinsäure zur behandlung von neurologischen und psychotischen störungen, und ein verfahren zu ihrer herstellung - Google Patents

Wirksame derivate der valproinsäure zur behandlung von neurologischen und psychotischen störungen, und ein verfahren zu ihrer herstellung

Info

Publication number
ATE283838T1
ATE283838T1 AT01117213T AT01117213T ATE283838T1 AT E283838 T1 ATE283838 T1 AT E283838T1 AT 01117213 T AT01117213 T AT 01117213T AT 01117213 T AT01117213 T AT 01117213T AT E283838 T1 ATE283838 T1 AT E283838T1
Authority
AT
Austria
Prior art keywords
treatment
neurological
production
psychotic disorders
valproic acid
Prior art date
Application number
AT01117213T
Other languages
English (en)
Inventor
Meir Bialer
Niv Papo
Boris Yagen
Original Assignee
Yissum Res Dev Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co filed Critical Yissum Res Dev Co
Application granted granted Critical
Publication of ATE283838T1 publication Critical patent/ATE283838T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT01117213T 2000-07-28 2001-07-16 Wirksame derivate der valproinsäure zur behandlung von neurologischen und psychotischen störungen, und ein verfahren zu ihrer herstellung ATE283838T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/628,016 US6323365B1 (en) 2000-07-28 2000-07-28 Active derivative of valproic acid for the treatment of neurological and psychotic disorders and a method for their preparation

Publications (1)

Publication Number Publication Date
ATE283838T1 true ATE283838T1 (de) 2004-12-15

Family

ID=24517062

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01117213T ATE283838T1 (de) 2000-07-28 2001-07-16 Wirksame derivate der valproinsäure zur behandlung von neurologischen und psychotischen störungen, und ein verfahren zu ihrer herstellung

Country Status (5)

Country Link
US (1) US6323365B1 (de)
EP (1) EP1176138B1 (de)
AT (1) ATE283838T1 (de)
DE (1) DE60107505T2 (de)
ES (1) ES2233529T3 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL157751A0 (en) * 2003-02-28 2004-03-28 Yissum Res Dev Co New amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid, a method for their synthesis and pharmaceutical compositions containing them
US20060025477A1 (en) * 2004-07-22 2006-02-02 Artman Linda D Analogs of isovaleramide, a pharmaceutical composition including the same, and a method of treating central nervous system conditions or diseases
WO2006102521A2 (en) * 2005-03-24 2006-09-28 Davis, John M. Methods of determining compounds useful in the treatment of bipolar disorder and methods of treating such disorders
US20080234213A1 (en) * 2005-09-02 2008-09-25 Matthias Wabl Oncogenic regulatory RNAs for diagnostics and therapeutics
US7459280B2 (en) * 2006-02-27 2008-12-02 Picobella, Llc Methods for diagnosing and treating kidney cancer
US20080267977A1 (en) * 2007-04-26 2008-10-30 Friedrich-Alexander University Of Erlangen-Nuremberg Combined immunological agent and sensitizing agent for the treatment of cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1421743A (en) * 1972-04-18 1976-01-21 Wilkinson Sword Ltd Ingestible topical and other compositions
US5585358A (en) * 1993-07-06 1996-12-17 Yissum Research Development Corporation Of The Hebrew University Of Jerusalem Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents

Also Published As

Publication number Publication date
US6323365B1 (en) 2001-11-27
DE60107505T2 (de) 2005-10-20
ES2233529T3 (es) 2005-06-16
DE60107505D1 (de) 2005-01-05
EP1176138B1 (de) 2004-12-01
EP1176138A1 (de) 2002-01-30

Similar Documents

Publication Publication Date Title
ATE411280T1 (de) Phenoxyessigsäure-derivate zur behandlung von störungen der atemwege
MY142029A (en) Phenoxyacetic acid derivatives
EA200600294A1 (ru) [1,8] нафтиридин-2-оны и родственные соединения для лечения шизофрении
UA49011C2 (uk) Похідні циклічної амінокислоти, фармацевтична композиція та спосіб лікування
NO20080765L (no) Prodrug av eksitasjonsaminosyrer
IL176546A0 (en) Imidazoline derivatives having cb1-antagonistic activity
DOP2002000512A (es) Sales de acido succinato de 5,7,14-triazatetraciclo [10.3.1.0² ¹¹.04,9] hexadeca-2 (11),3,5,7,9-pentaeno y composiciones farmaceuticas de las mismas
DE60112766D1 (de) Verwendung von derivaten der valproinsäureamide und 2-valproinsäureamid zur behandlung und prävention von schmerzen und/oder kopfschmerzen
CA2415354A1 (en) Phospholipid derivatives of valproic acid and mixtures thereof
ATE367387T1 (de) Verwendung von oxindolderivaten zur behandlung von mit demenz in zusammenhang stehenden krankheiten, alzheimer-krankheit und mit glycogensynthasekinase-3 assoziierten leiden
DE50113943D1 (de) 4-alkoxy-cyclohexan-1-amino-carbonsäureester und verfahren zu ihrer herstellung
ATE206926T1 (de) Verwendung eines phosphorsäurediesters zur herstellung eines arzneimittels zur behandlung von akne
HK1046902A1 (zh) 新型哌嗪基烷基硫代嘧啶衍生物，包含該衍生物的藥物組合物以及製備該活性物質的方法
ATE283838T1 (de) Wirksame derivate der valproinsäure zur behandlung von neurologischen und psychotischen störungen, und ein verfahren zu ihrer herstellung
WO2002042256A3 (en) N-alkylated gaba compounds, processes for their preparation and their use as medicaments
ATE242200T1 (de) Valnoctamid-stereoisomere, eine methode zu ihrer herstellung und abtrennung und ihre anwendungen
DE60041137D1 (de) Ceramid ähnliche verbindungen, verfahren zu deren herstellung und deren verwendung als antitumormittel
DE69917668D1 (de) Substanz gm-95, verfahren zu ihrer herstellung und ihre verwendung
WO2002055481A8 (en) Prodrugs of excitatory amino acids
MX9704704A (es) Amidas de acido 4-amino-2-ureido-pirimidin-5-carboxilico, procedimientos para su obtencion, medicamentos que contienen estos compuestos, y su utilizacion.
NO20031137D0 (no) Fremgangsmåte for fremstilling av kirale forbindelser
WO2002030874A3 (en) Aliphatic, cyclic amino carboxylic acids as integrin antagonists
WO2002030876A3 (en) Cyclic carboxylic acids as integrin antagonists
UA84737C2 (ru) Производные имидазолина с антагонистической активностью относительно cb1
EA200300782A1 (ru) Пролекарства возбуждающих аминокислот

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties