WO2002030876A3 - Cyclic carboxylic acids as integrin antagonists - Google Patents

Cyclic carboxylic acids as integrin antagonists Download PDF

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Publication number
WO2002030876A3
WO2002030876A3 PCT/EP2001/011585 EP0111585W WO0230876A3 WO 2002030876 A3 WO2002030876 A3 WO 2002030876A3 EP 0111585 W EP0111585 W EP 0111585W WO 0230876 A3 WO0230876 A3 WO 0230876A3
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WIPO (PCT)
Prior art keywords
carboxylic acids
cyclic carboxylic
integrin antagonists
pharmaceutical compositions
integrin
Prior art date
Application number
PCT/EP2001/011585
Other languages
French (fr)
Other versions
WO2002030876A2 (en
Inventor
Thomas Lehmann
Thomas Roelle
Markus Albers
Gerhard Mueller
Gerhard Hessler
Ruediger Fischer
Masaomi Tajimi
Karl Ziegelbauer
Kevin Bacon
Haruki Hasegawa
Hiromi Okigami
Original Assignee
Bayer Ag
Thomas Lehmann
Thomas Roelle
Markus Albers
Gerhard Mueller
Gerhard Hessler
Ruediger Fischer
Masaomi Tajimi
Karl Ziegelbauer
Kevin Bacon
Haruki Hasegawa
Hiromi Okigami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Thomas Lehmann, Thomas Roelle, Markus Albers, Gerhard Mueller, Gerhard Hessler, Ruediger Fischer, Masaomi Tajimi, Karl Ziegelbauer, Kevin Bacon, Haruki Hasegawa, Hiromi Okigami filed Critical Bayer Ag
Priority to AU2002218214A priority Critical patent/AU2002218214A1/en
Publication of WO2002030876A2 publication Critical patent/WO2002030876A2/en
Publication of WO2002030876A3 publication Critical patent/WO2002030876A3/en

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    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

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  • Medicinal Chemistry (AREA)
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  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Diabetes (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
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  • Hematology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)

Abstract

The present invention relates to compounds of the general formula (I), process for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory diseases.
PCT/EP2001/011585 2000-10-09 2001-10-08 Cyclic carboxylic acids as integrin antagonists WO2002030876A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002218214A AU2002218214A1 (en) 2000-10-09 2001-10-08 Cyclic carboxylic acids as integrin antagonists

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0024695A GB2367817A (en) 2000-10-09 2000-10-09 Cyclic carboxylic acids as integrin antagonists
GB0024695.9 2000-10-09

Publications (2)

Publication Number Publication Date
WO2002030876A2 WO2002030876A2 (en) 2002-04-18
WO2002030876A3 true WO2002030876A3 (en) 2002-09-19

Family

ID=9900925

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/011585 WO2002030876A2 (en) 2000-10-09 2001-10-08 Cyclic carboxylic acids as integrin antagonists

Country Status (3)

Country Link
AU (1) AU2002218214A1 (en)
GB (1) GB2367817A (en)
WO (1) WO2002030876A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2377933A (en) 2001-07-06 2003-01-29 Bayer Ag Succinic acid derivatives useful as integrin antagonists

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999005148A1 (en) * 1997-07-24 1999-02-04 University Of Kentucky Research Foundation Phosphonated agents and their antiangiogenic and antitumorigenic use
WO2000035864A1 (en) * 1998-12-16 2000-06-22 Bayer Aktiengesellschaft New biphenyl and biphenyl-analogous compounds as integrin antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03192348A (en) * 1989-12-22 1991-08-22 Fuji Photo Film Co Ltd Silver halide color photographic sensitive material
EP1140840B1 (en) * 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999005148A1 (en) * 1997-07-24 1999-02-04 University Of Kentucky Research Foundation Phosphonated agents and their antiangiogenic and antitumorigenic use
WO2000035864A1 (en) * 1998-12-16 2000-06-22 Bayer Aktiengesellschaft New biphenyl and biphenyl-analogous compounds as integrin antagonists

Also Published As

Publication number Publication date
AU2002218214A1 (en) 2002-04-22
GB2367817A (en) 2002-04-17
WO2002030876A2 (en) 2002-04-18
GB0024695D0 (en) 2000-11-22

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