ES2187030T3 - Una nueva sal. - Google Patents

Una nueva sal.

Info

Publication number
ES2187030T3
ES2187030T3 ES98925993T ES98925993T ES2187030T3 ES 2187030 T3 ES2187030 T3 ES 2187030T3 ES 98925993 T ES98925993 T ES 98925993T ES 98925993 T ES98925993 T ES 98925993T ES 2187030 T3 ES2187030 T3 ES 2187030T3
Authority
ES
Spain
Prior art keywords
tartrate
salt
new salt
dicyclobutylamino
benzopyran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98925993T
Other languages
English (en)
Inventor
Hakan Nyqvist
Daniel D Sohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of ES2187030T3 publication Critical patent/ES2187030T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere a un nuevo hidrógeno-tartrato de (R)-3-N,N-diciclobutilamino-8-fluoro.3,4-dihidro-2H-1-benzopiran-5-carboxamido, particularmente a su tartrato-(2R,3R), y más particularmente al monohidrato de tartrato (R)-3-N,N-diciclobutilamino-8-fluoro-3,3-dihidro-2H-1-benzopiran-5-carbonamido. La invención también se refiere a un proceso para la fabricación de la sal de tartrato, a la utilización de la sal en la medicina, a la utilización de la sal del tartrato en la fabricación de formulaciones farmacéuticas y a un procedimiento para el tratamiento de las enfermedades del SNC mediante la administración de la sal del tartrato a un sujeto que necesite el tratamiento.
ES98925993T 1997-05-30 1998-05-15 Una nueva sal. Expired - Lifetime ES2187030T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9702066A SE510305C2 (sv) 1997-05-30 1997-05-30 Nytt salt

Publications (1)

Publication Number Publication Date
ES2187030T3 true ES2187030T3 (es) 2003-05-16

Family

ID=20407187

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98925993T Expired - Lifetime ES2187030T3 (es) 1997-05-30 1998-05-15 Una nueva sal.

Country Status (34)

Country Link
US (2) US6858645B2 (es)
EP (1) EP0984952B1 (es)
JP (1) JP3554338B2 (es)
KR (1) KR20010013127A (es)
CN (1) CN1198814C (es)
AR (1) AR012751A1 (es)
AT (1) ATE228121T1 (es)
AU (1) AU729301B2 (es)
BG (1) BG64051B1 (es)
BR (1) BR9809519A (es)
CA (1) CA2291732C (es)
DE (1) DE69809547T2 (es)
DK (1) DK0984952T3 (es)
EE (1) EE03874B1 (es)
ES (1) ES2187030T3 (es)
HK (1) HK1025575A1 (es)
HU (1) HUP0001878A3 (es)
ID (1) ID23794A (es)
IL (1) IL133234A (es)
IS (1) IS1943B (es)
MY (1) MY117960A (es)
NO (1) NO995853L (es)
NZ (1) NZ501075A (es)
PL (1) PL337181A1 (es)
PT (1) PT984952E (es)
RU (1) RU2193560C2 (es)
SE (1) SE510305C2 (es)
SK (1) SK282755B6 (es)
TR (1) TR199902926T2 (es)
TW (1) TW510899B (es)
UA (1) UA53720C2 (es)
WO (1) WO1998054166A1 (es)
YU (1) YU62499A (es)
ZA (1) ZA984486B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102888D0 (sv) * 2001-08-29 2001-08-29 Astrazeneca Ab New formulation
SE0102887D0 (sv) * 2001-08-29 2001-08-29 Astrazeneca Ab New formulation
SE0102886D0 (sv) * 2001-08-29 2001-08-29 Astrazeneca Ab New formulation
SE0301796D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use II
SE0301795D0 (sv) * 2003-06-19 2003-06-19 Astrazeneca Ab New use I
EP2022110B1 (en) * 2006-05-11 2011-10-12 Johnson Controls Saft Advanced Power Solutions LLC Modular battery system
JP5163931B2 (ja) * 2007-03-08 2013-03-13 株式会社リコー 定着装置及び画像形成装置
EP2065385A1 (en) * 2007-11-28 2009-06-03 Laboratorios SALVAT, S.A. Stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabiciyclo [2.2.2]oct-3-yl ester
CN101747305B (zh) * 2008-11-28 2014-06-18 中国医学科学院药物研究所 硝克柳胺化合物晶v型、其制法和其药物组合物与用途
LT2989095T (lt) * 2013-04-26 2019-03-12 Sanofi 5-chlortiofen-2-karboksirūgšties [(s)-2-[metil-3-(2-okso-pirolidin-1-il)-benzensulfonilamino]-3-(4-metilpiperazin-1 -il)-3-oksopropil]amido tartrato druska

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
US5616610A (en) * 1989-12-22 1997-04-01 Astra Aktiebolag (R)-5-carbamoyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzopyrans
US5990114A (en) * 1996-02-28 1999-11-23 Recordati, S.A., Chemical And Pharmaceutical Company Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence
IT1282705B1 (it) 1996-02-28 1998-03-31 Recordati Chem Pharm Uso di antagonisti del recettore serotoninergico 5-ht|a per il trattamento dell'incontinenza urinaria

Also Published As

Publication number Publication date
AU7792398A (en) 1998-12-30
SE510305C2 (sv) 1999-05-10
BR9809519A (pt) 2000-06-20
ID23794A (id) 2000-05-11
BG103949A (en) 2000-07-31
SK282755B6 (sk) 2002-12-03
AU729301B2 (en) 2001-02-01
CA2291732C (en) 2003-12-30
SE9702066L (sv) 1998-12-01
US6858645B2 (en) 2005-02-22
EP0984952A1 (en) 2000-03-15
SE9702066D0 (sv) 1997-05-30
EP0984952B1 (en) 2002-11-20
WO1998054166A1 (en) 1998-12-03
SK159499A3 (en) 2000-10-09
KR20010013127A (ko) 2001-02-26
US20030109576A1 (en) 2003-06-12
AR012751A1 (es) 2000-11-08
IS5270A (is) 1999-11-24
IS1943B (is) 2004-08-13
IL133234A0 (en) 2001-03-19
JP2002501527A (ja) 2002-01-15
CA2291732A1 (en) 1998-12-03
IL133234A (en) 2004-05-12
US20050085532A1 (en) 2005-04-21
NO995853L (no) 2000-01-31
PT984952E (pt) 2003-03-31
HK1025575A1 (en) 2000-11-17
DE69809547T2 (de) 2003-08-21
ATE228121T1 (de) 2002-12-15
CN1258290A (zh) 2000-06-28
EE9900549A (et) 2000-06-15
DE69809547D1 (de) 2003-01-02
TW510899B (en) 2002-11-21
MY117960A (en) 2004-08-30
BG64051B1 (bg) 2003-11-28
JP3554338B2 (ja) 2004-08-18
NO995853D0 (no) 1999-11-29
UA53720C2 (uk) 2003-02-17
YU62499A (sh) 2002-06-19
DK0984952T3 (da) 2003-02-24
HUP0001878A2 (hu) 2001-05-28
PL337181A1 (en) 2000-08-14
TR199902926T2 (xx) 2000-03-21
ZA984486B (en) 1998-11-30
RU2193560C2 (ru) 2002-11-27
NZ501075A (en) 2001-08-31
CN1198814C (zh) 2005-04-27
HUP0001878A3 (en) 2002-04-29
EE03874B1 (et) 2002-10-15

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