BR0013323A - Processos úteis para a preparação de agentes antipicornavirais, processos úteis para a preparação de um composto, compostos, processos para preparação de um composto e processos para a execução de uma reação catalisada por um grande catalisador - Google Patents
Processos úteis para a preparação de agentes antipicornavirais, processos úteis para a preparação de um composto, compostos, processos para preparação de um composto e processos para a execução de uma reação catalisada por um grande catalisadorInfo
- Publication number
- BR0013323A BR0013323A BR0013323-0A BR0013323A BR0013323A BR 0013323 A BR0013323 A BR 0013323A BR 0013323 A BR0013323 A BR 0013323A BR 0013323 A BR0013323 A BR 0013323A
- Authority
- BR
- Brazil
- Prior art keywords
- processes
- preparation
- useful
- compound
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/2415—Tubular reactors
- B01J19/2435—Loop-type reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/2475—Membrane reactors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00002—Chemical plants
- B01J2219/00027—Process aspects
- B01J2219/00033—Continuous processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
- B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
- B01J2219/00099—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor the reactor being immersed in the heat exchange medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
- B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
- B01J2219/00103—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor in a heat exchanger separate from the reactor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00159—Controlling the temperature controlling multiple zones along the direction of flow, e.g. pre-heating and after-cooling
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00162—Controlling or regulating processes controlling the pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00177—Controlling or regulating processes controlling the pH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pyridine Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
"PROCESSOS úTEIS PARA A PREPARAçãO DE AGENTES ANTIPICORNAVIRAIS, PROCESSOS úTEIS PARA A PREPARAçãO DE UM COMPOSTO, COMPOSTOS, PROCESSOS PARA PREPARAçãO DE UM COMPOSTO E PROCESSOS PARA A EXECUçãO DE UMA REAçãO CATALISADA POR UM GRANDE CATALISADOR". As vias sintéticas eficientes para a preparação de inibidores de protease do rinovírus de Fórmula (1), intermediários-chaves úteis nessas vias sintéticas, bem como um reator de membrana continua útil para essas vias sintéticas. Esses compostos de Fórmula (1), bem como as composições farmacêuticas que contêm esses compostos, são adequados para o tratamento de pacientes ou hospedeiros infectados com um ou mais picornavírus.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15036599P | 1999-08-24 | 1999-08-24 | |
PCT/US2000/023032 WO2001014576A2 (en) | 1999-08-24 | 2000-08-23 | Process and intermediates for the preparation of isoxazolecaroxamides and analogues |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0013323A true BR0013323A (pt) | 2002-04-02 |
Family
ID=22534191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0013323-0A BR0013323A (pt) | 1999-08-24 | 2000-08-23 | Processos úteis para a preparação de agentes antipicornavirais, processos úteis para a preparação de um composto, compostos, processos para preparação de um composto e processos para a execução de uma reação catalisada por um grande catalisador |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP1206470A2 (pt) |
JP (1) | JP2003511350A (pt) |
KR (1) | KR20020030795A (pt) |
CN (2) | CN1157391C (pt) |
AU (1) | AU778062B2 (pt) |
BR (1) | BR0013323A (pt) |
CA (1) | CA2376509A1 (pt) |
CZ (1) | CZ2002634A3 (pt) |
HK (1) | HK1051363A1 (pt) |
HU (1) | HUP0203315A3 (pt) |
IL (1) | IL147862A0 (pt) |
MX (1) | MXPA02001947A (pt) |
PL (1) | PL357162A1 (pt) |
WO (1) | WO2001014576A2 (pt) |
ZA (1) | ZA200200506B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2205760T3 (es) | 1998-04-30 | 2004-05-01 | Agouron Pharmaceuticals, Inc. | Compuestos antipicornavirales, su preparacion y su utilizacion. |
BR0012970A (pt) | 1999-08-04 | 2002-04-30 | Agouron Pharma | Compostos e composições antipicornavirais, seus usos farmacêuticos e materiais para a sua sìntese |
US6774243B2 (en) | 1999-08-24 | 2004-08-10 | Agouron Pharmaceuticals, Inc. | Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates |
PE20020157A1 (es) | 1999-12-03 | 2002-02-22 | Agouron Pharma | Compuestos derivados de piridona como inhibidores de proteasas de picornaviral 3c, composiciones, sus usos farmaceuticos y materiales para su sintesis |
PE20011277A1 (es) | 2000-04-14 | 2002-01-07 | Agouron Pharma | Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis |
JP2004503533A (ja) | 2000-06-14 | 2004-02-05 | アグロン・ファーマシュウティカルズ・インコーポレーテッド | 抗ピコルナウイルス化合物及び組成物、その医薬的使用、並びにその合成のための物質 |
DE10208007A1 (de) * | 2002-02-26 | 2003-09-18 | Forschungszentrum Juelich Gmbh | Verfahren zur Herstellung von Alkoholen aus Substraten mittels Oxidoreduktasen, Zweiphasensystem umfassend eine wässrige Phase und eine organische Phase sowie Vorrichtung zur Durchführung des Verfahrens |
CN106831657B (zh) * | 2017-02-23 | 2019-07-16 | 江苏工程职业技术学院 | 一种环氧丙酸钾的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2426651C3 (de) * | 1974-06-01 | 1982-04-08 | Bayer Ag, 5090 Leverkusen | (-)-Antipode des 3-(p-Chlorphenyl)-2-chlorpropionsäuremethylesters, Verfahren zu dessen Herstellung sowie dessen Verwendung als Herbizid |
DE2930087A1 (de) * | 1979-07-25 | 1981-02-26 | Biotechnolog Forschung Gmbh | Verfahren zur kontinuierlichen enzymatischen umwandlung von wasserloeslichen alpha -ketocarbonsaeuren in die entsprechenden alpha -hydroxycarbonsaeuren |
JPH0623131B2 (ja) * | 1984-08-07 | 1994-03-30 | 三井東圧化学株式会社 | α−ケト酸のアルカリ金属塩の製造法 |
JPH066539B2 (ja) * | 1986-03-14 | 1994-01-26 | 三共株式会社 | α−ハイドロキシカルボン酸誘導体の製法 |
FR2686897B1 (fr) * | 1992-02-05 | 1995-07-13 | Sonertec | Procede en continu de fabrication d'acides organiques. |
US5360927A (en) * | 1994-01-24 | 1994-11-01 | Development Center For Biotechnology | Process for the preparation of monohydrated sodium phenylpyruvate |
US5869697A (en) * | 1994-05-02 | 1999-02-09 | Council Of Scientific & Industrial Research | Process for preparing diltiazem |
-
2000
- 2000-08-23 CN CNB008120110A patent/CN1157391C/zh not_active Expired - Fee Related
- 2000-08-23 PL PL00357162A patent/PL357162A1/xx not_active Application Discontinuation
- 2000-08-23 CN CNA2004100054455A patent/CN1524960A/zh active Pending
- 2000-08-23 AU AU67970/00A patent/AU778062B2/en not_active Ceased
- 2000-08-23 HU HU0203315A patent/HUP0203315A3/hu unknown
- 2000-08-23 KR KR1020027002323A patent/KR20020030795A/ko not_active Application Discontinuation
- 2000-08-23 CA CA002376509A patent/CA2376509A1/en not_active Abandoned
- 2000-08-23 WO PCT/US2000/023032 patent/WO2001014576A2/en not_active Application Discontinuation
- 2000-08-23 BR BR0013323-0A patent/BR0013323A/pt not_active IP Right Cessation
- 2000-08-23 CZ CZ2002634A patent/CZ2002634A3/cs unknown
- 2000-08-23 JP JP2001518887A patent/JP2003511350A/ja active Pending
- 2000-08-23 MX MXPA02001947A patent/MXPA02001947A/es unknown
- 2000-08-23 EP EP00955830A patent/EP1206470A2/en not_active Withdrawn
- 2000-08-23 IL IL14786200A patent/IL147862A0/xx unknown
-
2002
- 2002-01-21 ZA ZA200200506A patent/ZA200200506B/en unknown
-
2003
- 2003-05-15 HK HK03103445A patent/HK1051363A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU778062B2 (en) | 2004-11-11 |
CZ2002634A3 (cs) | 2002-09-11 |
CN1524960A (zh) | 2004-09-01 |
IL147862A0 (en) | 2002-08-14 |
HK1051363A1 (en) | 2003-08-01 |
KR20020030795A (ko) | 2002-04-25 |
CA2376509A1 (en) | 2001-03-01 |
HUP0203315A3 (en) | 2003-12-29 |
JP2003511350A (ja) | 2003-03-25 |
WO2001014576A3 (en) | 2001-08-30 |
CN1157391C (zh) | 2004-07-14 |
PL357162A1 (en) | 2004-07-26 |
HUP0203315A2 (hu) | 2003-02-28 |
EP1206470A2 (en) | 2002-05-22 |
WO2001014576B1 (en) | 2001-09-27 |
CN1382139A (zh) | 2002-11-27 |
WO2001014576A8 (en) | 2002-06-20 |
MXPA02001947A (es) | 2002-10-31 |
ZA200200506B (en) | 2003-06-25 |
AU6797000A (en) | 2001-03-19 |
WO2001014576A2 (en) | 2001-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009. |