PE20020157A1 - Compuestos derivados de piridona como inhibidores de proteasas de picornaviral 3c, composiciones, sus usos farmaceuticos y materiales para su sintesis - Google Patents

Compuestos derivados de piridona como inhibidores de proteasas de picornaviral 3c, composiciones, sus usos farmaceuticos y materiales para su sintesis

Info

Publication number
PE20020157A1
PE20020157A1 PE2000001276A PE0012762000A PE20020157A1 PE 20020157 A1 PE20020157 A1 PE 20020157A1 PE 2000001276 A PE2000001276 A PE 2000001276A PE 0012762000 A PE0012762000 A PE 0012762000A PE 20020157 A1 PE20020157 A1 PE 20020157A1
Authority
PE
Peru
Prior art keywords
picornaviral
alkyl
synthesis
compositions
materials
Prior art date
Application number
PE2000001276A
Other languages
English (en)
Inventor
Peter S Dragovich
Thomas J Prins
Ru Zhou
Theodore O Johnson
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of PE20020157A1 publication Critical patent/PE20020157A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A CARBONILAMINO PIRIDIN 2-OXO DE FORMULA I DONDE Ra ES HETEROCICLOALQUILO, HETEROCICLOALQUILALQUILO; Rb ES UN GRUPO a; Ri, Rg SON H, ALQUILO; m ES 0-1; p ES 0-5; A1 ES CH, N; A2 Y A3 SON C(Rh)(Ri), NRj, SO, SO2; Rh, Ri, Rj SON H, ALQUILO; CUANDO p ES 1-5; A4 ES N(Rk)(Rl), C(Rh)(Ri)(Rj), ORi; Rk Y Rl SON H, ALQUILO, ARILO, ACILO; Rc ES H, HALOGENO, ALQUILO; Rd ES H, HALOGENO, HIDROXILO, ENTRE OTROS; Re ES H, ALQUILO; Z Y Z1 SON H, F, ALQUILO, ENTRE OTROS; Z Y Rd O Z Y Z1 JUNTOS FORMAN CICLOALQUILO, HETEROCICLOALQUILO; SON COMPUESTOS PREFERIDOS DE FORMULA II, ENTRE OTROS, EL COMPUESTO I ES UN INHIBIDOR DE PICORNAVIRAL 3C PROTEASA (RINOVIRUS 3C PROTEASA) Y PUEDE SER UTIL PARA EL TRATAMIENTO DE INFECCIONES RINOVIRALES
PE2000001276A 1999-12-03 2000-11-30 Compuestos derivados de piridona como inhibidores de proteasas de picornaviral 3c, composiciones, sus usos farmaceuticos y materiales para su sintesis PE20020157A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16898699P 1999-12-03 1999-12-03
US19205200P 2000-03-24 2000-03-24

Publications (1)

Publication Number Publication Date
PE20020157A1 true PE20020157A1 (es) 2002-02-22

Family

ID=26864652

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001276A PE20020157A1 (es) 1999-12-03 2000-11-30 Compuestos derivados de piridona como inhibidores de proteasas de picornaviral 3c, composiciones, sus usos farmaceuticos y materiales para su sintesis

Country Status (31)

Country Link
US (1) US6514997B2 (es)
EP (1) EP1252145A1 (es)
JP (1) JP2003515591A (es)
KR (1) KR20020058076A (es)
CN (1) CN1402710A (es)
AP (1) AP2002002510A0 (es)
AR (1) AR030540A1 (es)
AU (1) AU777943B2 (es)
BG (1) BG106754A (es)
BR (1) BR0016742A (es)
CA (1) CA2392504A1 (es)
CO (1) CO5261566A1 (es)
CZ (1) CZ20021906A3 (es)
DO (1) DOP2000000108A (es)
EA (1) EA200200625A1 (es)
EE (1) EE200200281A (es)
HK (1) HK1052933A1 (es)
HU (1) HUP0204006A3 (es)
IL (1) IL149427A0 (es)
IS (1) IS6378A (es)
MX (1) MXPA02005124A (es)
NO (1) NO20022589L (es)
NZ (1) NZ518934A (es)
OA (1) OA12101A (es)
PA (1) PA8507801A1 (es)
PE (1) PE20020157A1 (es)
PL (1) PL356062A1 (es)
SK (1) SK7602002A3 (es)
UY (1) UY26465A1 (es)
WO (1) WO2001040189A1 (es)
YU (1) YU40002A (es)

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ES2205760T3 (es) 1998-04-30 2004-05-01 Agouron Pharmaceuticals, Inc. Compuestos antipicornavirales, su preparacion y su utilizacion.
PE20011277A1 (es) 2000-04-14 2002-01-07 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
JP2004503533A (ja) * 2000-06-14 2004-02-05 アグロン・ファーマシュウティカルズ・インコーポレーテッド 抗ピコルナウイルス化合物及び組成物、その医薬的使用、並びにその合成のための物質
US6977266B2 (en) * 2000-12-28 2005-12-20 Shionogi & Co., Ltd. Pyridone derivatives having affinity for cannabinoid 2-type receptor
EP1523483A4 (en) 2002-06-26 2006-03-08 Bristol Myers Squibb Co AMINO-BICYCLIC PYRAZINONE AND PYRIDINONE FOR INHIBITING THE COOKING OF SERIN PROTEASE
US20060172019A1 (en) * 2003-03-07 2006-08-03 Ralston Stuart H Cannabinoid receptor inverse agonists and neutral antagonists as therapeutic agents for the treatment of bone disorders
WO2004093860A1 (en) * 2003-04-21 2004-11-04 Pfizer Inc. Inhibitors of sars related coronavirus proteinase
US20040235952A1 (en) * 2003-05-05 2004-11-25 Agouron Pharmaceuticals, Inc. Inhibitors of severe acute respiratory syndrome (SARS) 3C-like proteinase
CN1922137A (zh) * 2003-12-31 2007-02-28 太景生物科技股份有限公司 蛋白酶抑制剂
US7462594B2 (en) * 2003-12-31 2008-12-09 Taigen Biotechnology Co., Ltd. Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases
WO2005110988A1 (en) * 2004-05-07 2005-11-24 Janssen Pharmaceutica, N.V. Pyridone compounds as inhibitors of bacterial type iii protein secretion systems
GB0702862D0 (en) * 2007-02-14 2007-03-28 Univ Aberdeen Therapeutic compounds
KR100891699B1 (ko) 2007-04-10 2009-04-03 광주과학기술원 7-아미노-4-((ｓ)-3-(4-플루오로페닐)-2-((r)-3-메틸-2-(5-메틸이소옥사졸-3-카복사미도)부탄아미도)프로판아미도)-7-옥소-2-헵테노에이트 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 바이러스성 질환의 예방 및 치료용 약학적 조성물
NZ591824A (en) * 2008-08-29 2013-07-26 Treventis Corp Butyrylcholinesterase ligands as diagnostic tools and treatment for deseases of the nervous system
KR101385855B1 (ko) * 2012-10-16 2014-04-22 이동익 카뎁신 검출용 다이아로마틱 아미노산 기질
WO2017197377A1 (en) * 2016-05-13 2017-11-16 Emory University Peptidomimetics for the treatment of norovirus infection
US11124497B1 (en) 2020-04-17 2021-09-21 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
US11174231B1 (en) 2020-06-09 2021-11-16 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds

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BR0012970A (pt) 1999-08-04 2002-04-30 Agouron Pharma Compostos e composições antipicornavirais, seus usos farmacêuticos e materiais para a sua sìntese
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CN1157391C (zh) 1999-08-24 2004-07-14 阿古龙制药有限公司 制备异噁唑甲酰胺及其类似物的方法和中间体

Also Published As

Publication number Publication date
JP2003515591A (ja) 2003-05-07
HUP0204006A3 (en) 2004-11-29
CZ20021906A3 (cs) 2003-02-12
BR0016742A (pt) 2002-09-03
CN1402710A (zh) 2003-03-12
AP2002002510A0 (en) 2002-06-30
UY26465A1 (es) 2001-06-29
HUP0204006A2 (hu) 2003-03-28
KR20020058076A (ko) 2002-07-12
CA2392504A1 (en) 2001-06-07
BG106754A (bg) 2003-07-31
NO20022589L (no) 2002-07-31
EP1252145A1 (en) 2002-10-30
WO2001040189A1 (en) 2001-06-07
AR030540A1 (es) 2003-08-27
NO20022589D0 (no) 2002-05-31
PA8507801A1 (es) 2002-08-26
AU1809401A (en) 2001-06-12
IL149427A0 (en) 2002-11-10
MXPA02005124A (es) 2003-01-28
DOP2000000108A (es) 2003-03-15
US20010047006A1 (en) 2001-11-29
US6514997B2 (en) 2003-02-04
EA200200625A1 (ru) 2002-12-26
AU777943B2 (en) 2004-11-04
YU40002A (sh) 2006-01-16
CO5261566A1 (es) 2003-03-31
EE200200281A (et) 2003-06-16
IS6378A (is) 2002-05-10
NZ518934A (en) 2003-11-28
HK1052933A1 (zh) 2003-10-03
PL356062A1 (en) 2004-06-14
SK7602002A3 (en) 2003-02-04
OA12101A (en) 2006-05-04

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