YU40002A - Antipikornavirusna jedinjenja i kompozicije, njihove farmaceutske upotrebe, i materijali za njihove sinteze - Google Patents

Antipikornavirusna jedinjenja i kompozicije, njihove farmaceutske upotrebe, i materijali za njihove sinteze

Info

Publication number
YU40002A
YU40002A YU40002A YUP40002A YU40002A YU 40002 A YU40002 A YU 40002A YU 40002 A YU40002 A YU 40002A YU P40002 A YUP40002 A YU P40002A YU 40002 A YU40002 A YU 40002A
Authority
YU
Yugoslavia
Prior art keywords
compounds
synthesis
compositions
formula
materials
Prior art date
Application number
YU40002A
Other languages
English (en)
Inventor
Peter S. Dragovich
Thomas J. Prins
Ru Zhou
Theodore O. Johnson
Original Assignee
Agouron Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharmaceuticals Inc. filed Critical Agouron Pharmaceuticals Inc.
Publication of YU40002A publication Critical patent/YU40002A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Jedinjenja formule: u kojoj su promenljive vrednosti formule kao što je prethodno definisano, otkriveno je da poboljšano inhibiraju ili blokiraju biološku aktivnost pikornavirusne 3C proteaze. Takodje su otkrivena jedinjenja formule: u kojoj su promenljive vrednosti formule kao što je prethodno definisano, a koje poboljšano inhibiraju ili blokiraju biološku aktivnost pikornavirusne 3C proteaze. Ova jedinjenja, kao i farmaceutske smese koje sadrže ova jedinjenja, korisna su za lečenje pacijenata ili domaćina zaraženih sa jednim ili više pikornavirusa, kao što su rinovirus 3C proteaze. Intermedijari i sintetički postupci za dobijanje takvih jedinjenja takodje su opisani.[Compounds of formula (I), where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the picornaviral 3C protease. Also disclosed are compounds of formula (II) where the formula variables are as defined herein that advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as rhinovirus 3C proteases. Intermediates and synthetic methods for preparing such compounds are also described.
YU40002A 1999-12-03 2000-12-01 Antipikornavirusna jedinjenja i kompozicije, njihove farmaceutske upotrebe, i materijali za njihove sinteze YU40002A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16898699P 1999-12-03 1999-12-03
US19205200P 2000-03-24 2000-03-24

Publications (1)

Publication Number Publication Date
YU40002A true YU40002A (sh) 2006-01-16

Family

ID=26864652

Family Applications (1)

Application Number Title Priority Date Filing Date
YU40002A YU40002A (sh) 1999-12-03 2000-12-01 Antipikornavirusna jedinjenja i kompozicije, njihove farmaceutske upotrebe, i materijali za njihove sinteze

Country Status (31)

Country Link
US (1) US6514997B2 (sh)
EP (1) EP1252145A1 (sh)
JP (1) JP2003515591A (sh)
KR (1) KR20020058076A (sh)
CN (1) CN1402710A (sh)
AP (1) AP2002002510A0 (sh)
AR (1) AR030540A1 (sh)
AU (1) AU777943B2 (sh)
BG (1) BG106754A (sh)
BR (1) BR0016742A (sh)
CA (1) CA2392504A1 (sh)
CO (1) CO5261566A1 (sh)
CZ (1) CZ20021906A3 (sh)
DO (1) DOP2000000108A (sh)
EA (1) EA200200625A1 (sh)
EE (1) EE200200281A (sh)
HK (1) HK1052933A1 (sh)
HU (1) HUP0204006A3 (sh)
IL (1) IL149427A0 (sh)
IS (1) IS6378A (sh)
MX (1) MXPA02005124A (sh)
NO (1) NO20022589L (sh)
NZ (1) NZ518934A (sh)
OA (1) OA12101A (sh)
PA (1) PA8507801A1 (sh)
PE (1) PE20020157A1 (sh)
PL (1) PL356062A1 (sh)
SK (1) SK7602002A3 (sh)
UY (1) UY26465A1 (sh)
WO (1) WO2001040189A1 (sh)
YU (1) YU40002A (sh)

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HUP0400624A2 (hu) 1998-04-30 2004-06-28 Agouron Pharmaceuticals, Inc. Picornavírus-ellenes vegyületek, előállításuk és alkalmazásuk
PE20011277A1 (es) 2000-04-14 2002-01-07 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
MXPA02012456A (es) * 2000-06-14 2004-01-26 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y materiales para su sintesis.
KR20030070082A (ko) * 2000-12-28 2003-08-27 시오노기세이야쿠가부시키가이샤 칸나비노이드 2형 수용체 친화 작용을 갖는 피리돈 유도체
AU2003243657A1 (en) * 2002-06-26 2004-01-19 Bristol-Myers Squibb Company Amino-bicyclic pyrazinones and pyridinones
EP1606019A1 (en) * 2003-03-07 2005-12-21 The University Court of The University of Aberdeen Cannabinoid receptor inverse agonists and neutral antagonists as therapeutic agents for the treatment of bone disorders
WO2004093860A1 (en) * 2003-04-21 2004-11-04 Pfizer Inc. Inhibitors of sars related coronavirus proteinase
US20040235952A1 (en) * 2003-05-05 2004-11-25 Agouron Pharmaceuticals, Inc. Inhibitors of severe acute respiratory syndrome (SARS) 3C-like proteinase
US7462594B2 (en) * 2003-12-31 2008-12-09 Taigen Biotechnology Co., Ltd. Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases
AU2004312547A1 (en) * 2003-12-31 2005-07-21 Taigen Biotechnology Protease inhibitors
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GB0702862D0 (en) * 2007-02-14 2007-03-28 Univ Aberdeen Therapeutic compounds
KR100891699B1 (ko) 2007-04-10 2009-04-03 광주과학기술원 7-아미노-4-((ｓ)-3-(4-플루오로페닐)-2-((r)-3-메틸-2-(5-메틸이소옥사졸-3-카복사미도)부탄아미도)프로판아미도)-7-옥소-2-헵테노에이트 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 바이러스성 질환의 예방 및 치료용 약학적 조성물
US8795630B2 (en) * 2008-08-29 2014-08-05 Treventis Corporation Butyrylcholinesterase ligands as diagnostic tools and treatment for diseases of the nervous system
KR101385855B1 (ko) * 2012-10-16 2014-04-22 이동익 카뎁신 검출용 다이아로마틱 아미노산 기질
WO2017197377A1 (en) * 2016-05-13 2017-11-16 Emory University Peptidomimetics for the treatment of norovirus infection
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US11174231B1 (en) 2020-06-09 2021-11-16 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds

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Also Published As

Publication number Publication date
HUP0204006A2 (hu) 2003-03-28
PA8507801A1 (es) 2002-08-26
AU1809401A (en) 2001-06-12
BG106754A (bg) 2003-07-31
KR20020058076A (ko) 2002-07-12
BR0016742A (pt) 2002-09-03
WO2001040189A1 (en) 2001-06-07
NO20022589L (no) 2002-07-31
HUP0204006A3 (en) 2004-11-29
HK1052933A1 (zh) 2003-10-03
CA2392504A1 (en) 2001-06-07
US20010047006A1 (en) 2001-11-29
MXPA02005124A (es) 2003-01-28
NZ518934A (en) 2003-11-28
AP2002002510A0 (en) 2002-06-30
EA200200625A1 (ru) 2002-12-26
EP1252145A1 (en) 2002-10-30
CO5261566A1 (es) 2003-03-31
EE200200281A (et) 2003-06-16
CN1402710A (zh) 2003-03-12
CZ20021906A3 (cs) 2003-02-12
SK7602002A3 (en) 2003-02-04
PL356062A1 (en) 2004-06-14
IS6378A (is) 2002-05-10
JP2003515591A (ja) 2003-05-07
IL149427A0 (en) 2002-11-10
UY26465A1 (es) 2001-06-29
PE20020157A1 (es) 2002-02-22
US6514997B2 (en) 2003-02-04
NO20022589D0 (no) 2002-05-31
AU777943B2 (en) 2004-11-04
DOP2000000108A (es) 2003-03-15
AR030540A1 (es) 2003-08-27
OA12101A (en) 2006-05-04

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