AR030540A1 - Compuestos antipicornavirales y composiciones, su uso farmaceutico, y materiales para su sintesis - Google Patents

Compuestos antipicornavirales y composiciones, su uso farmaceutico, y materiales para su sintesis

Info

Publication number
AR030540A1
AR030540A1 ARP000106412A ARP000106412A AR030540A1 AR 030540 A1 AR030540 A1 AR 030540A1 AR P000106412 A ARP000106412 A AR P000106412A AR P000106412 A ARP000106412 A AR P000106412A AR 030540 A1 AR030540 A1 AR 030540A1
Authority
AR
Argentina
Prior art keywords
compounds
formula
synthesis
compositions
materials
Prior art date
Application number
ARP000106412A
Other languages
English (en)
Inventor
Dragovich Peter S I
Thomas J Prins
Ru Zhou
Theodore O Johnson Jr
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of AR030540A1 publication Critical patent/AR030540A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se divulgan los compuestos de la formula 1 donde las variables de la formula son como se las define en la presente, y que de manera conveniente, inhiben o bloquean la actividad biologica de la proteasa picornaviral 3c. Asimismo se divulgan los compuestos de la formula 2 donde las variables de la formula son tal como se las define en la presente y que, de manera conveniente, inhiben o bloquean la actividad biologica de la proteasa picornavirus 3c. Estos compuestos, así como las composiciones farmacéuticas que contienen estos compuestos, son utiles para el tratamiento de pacientes o huéspedes infectados con uno o más picornacirus tales como las proteasas del rinovirus 3c. También se describen métodos intermediarios y sintéticos para preparar tales compuestos.
ARP000106412A 1999-12-03 2000-12-04 Compuestos antipicornavirales y composiciones, su uso farmaceutico, y materiales para su sintesis AR030540A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16898699P 1999-12-03 1999-12-03
US19205200P 2000-03-24 2000-03-24

Publications (1)

Publication Number Publication Date
AR030540A1 true AR030540A1 (es) 2003-08-27

Family

ID=26864652

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000106412A AR030540A1 (es) 1999-12-03 2000-12-04 Compuestos antipicornavirales y composiciones, su uso farmaceutico, y materiales para su sintesis

Country Status (31)

Country Link
US (1) US6514997B2 (es)
EP (1) EP1252145A1 (es)
JP (1) JP2003515591A (es)
KR (1) KR20020058076A (es)
CN (1) CN1402710A (es)
AP (1) AP2002002510A0 (es)
AR (1) AR030540A1 (es)
AU (1) AU777943B2 (es)
BG (1) BG106754A (es)
BR (1) BR0016742A (es)
CA (1) CA2392504A1 (es)
CO (1) CO5261566A1 (es)
CZ (1) CZ20021906A3 (es)
DO (1) DOP2000000108A (es)
EA (1) EA200200625A1 (es)
EE (1) EE200200281A (es)
HK (1) HK1052933A1 (es)
HU (1) HUP0204006A3 (es)
IL (1) IL149427A0 (es)
IS (1) IS6378A (es)
MX (1) MXPA02005124A (es)
NO (1) NO20022589L (es)
NZ (1) NZ518934A (es)
OA (1) OA12101A (es)
PA (1) PA8507801A1 (es)
PE (1) PE20020157A1 (es)
PL (1) PL356062A1 (es)
SK (1) SK7602002A3 (es)
UY (1) UY26465A1 (es)
WO (1) WO2001040189A1 (es)
YU (1) YU40002A (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1198838C (zh) 1998-04-30 2005-04-27 阿格罗尼制药公司 抗小rna病毒化合物及其制备方法和用途
PE20011277A1 (es) 2000-04-14 2002-01-07 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
PL365470A1 (en) * 2000-06-14 2005-01-10 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
ATE438624T1 (de) * 2000-12-28 2009-08-15 Shionogi & Co 2-pyridonderivate mit affinität für den cannabinoid-typ-2-rezeptor
WO2004002405A2 (en) * 2002-06-26 2004-01-08 Bristol-Myers Squibb Company Amino-bicyclic pyrazinones and pyridinones
EP1606019A1 (en) * 2003-03-07 2005-12-21 The University Court of The University of Aberdeen Cannabinoid receptor inverse agonists and neutral antagonists as therapeutic agents for the treatment of bone disorders
WO2004093860A1 (en) * 2003-04-21 2004-11-04 Pfizer Inc. Inhibitors of sars related coronavirus proteinase
US20040235952A1 (en) * 2003-05-05 2004-11-25 Agouron Pharmaceuticals, Inc. Inhibitors of severe acute respiratory syndrome (SARS) 3C-like proteinase
CA2550515A1 (en) * 2003-12-31 2005-07-21 Taigen Biotechnology Protease inhibitors
US7462594B2 (en) * 2003-12-31 2008-12-09 Taigen Biotechnology Co., Ltd. Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases
WO2005110988A1 (en) * 2004-05-07 2005-11-24 Janssen Pharmaceutica, N.V. Pyridone compounds as inhibitors of bacterial type iii protein secretion systems
GB0702862D0 (en) * 2007-02-14 2007-03-28 Univ Aberdeen Therapeutic compounds
KR100891699B1 (ko) 2007-04-10 2009-04-03 광주과학기술원 7-아미노-4-((ｓ)-3-(4-플루오로페닐)-2-((r)-3-메틸-2-(5-메틸이소옥사졸-3-카복사미도)부탄아미도)프로판아미도)-7-옥소-2-헵테노에이트 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 바이러스성 질환의 예방 및 치료용 약학적 조성물
JP5734853B2 (ja) * 2008-08-29 2015-06-17 トレヴェンティス コーポレイションＴｒｅｖｅｎｔｉｓ Ｃｏｒｐｏｒａｔｉｏｎ 神経系疾患用の診断ツール及び治療としてのブチリルコリンエステラーゼリガンド
KR101385855B1 (ko) * 2012-10-16 2014-04-22 이동익 카뎁신 검출용 다이아로마틱 아미노산 기질
CA3024120A1 (en) * 2016-05-13 2017-11-16 Emory University Peptidomimetics for the treatment of norovirus infection
US11124497B1 (en) 2020-04-17 2021-09-21 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
US11174231B1 (en) 2020-06-09 2021-11-16 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds

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CN1198838C (zh) 1998-04-30 2005-04-27 阿格罗尼制药公司 抗小rna病毒化合物及其制备方法和用途
US6369226B1 (en) 1999-06-21 2002-04-09 Agouron Pharmaceuticals, Inc. Substituted benzamide inhibitors of rhinovirus 3C protease
ES2230135T3 (es) 1999-08-04 2005-05-01 Agouron Pharmaceuticals, Inc. Compuestos y composiciones anti-picornavirales; utilizaciones farmaceuticas y materiales utilizados para su sintesis.
IL147862A0 (en) 1999-08-24 2002-08-14 Agouron Pharma Process and intermediates for the preparation os isoxazolecaroxamides and analogues
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Also Published As

Publication number Publication date
IL149427A0 (en) 2002-11-10
DOP2000000108A (es) 2003-03-15
JP2003515591A (ja) 2003-05-07
NZ518934A (en) 2003-11-28
IS6378A (is) 2002-05-10
KR20020058076A (ko) 2002-07-12
HUP0204006A2 (hu) 2003-03-28
EA200200625A1 (ru) 2002-12-26
US6514997B2 (en) 2003-02-04
WO2001040189A1 (en) 2001-06-07
UY26465A1 (es) 2001-06-29
AU1809401A (en) 2001-06-12
CA2392504A1 (en) 2001-06-07
BR0016742A (pt) 2002-09-03
NO20022589D0 (no) 2002-05-31
BG106754A (bg) 2003-07-31
EE200200281A (et) 2003-06-16
PL356062A1 (en) 2004-06-14
CZ20021906A3 (cs) 2003-02-12
CN1402710A (zh) 2003-03-12
US20010047006A1 (en) 2001-11-29
HUP0204006A3 (en) 2004-11-29
AU777943B2 (en) 2004-11-04
EP1252145A1 (en) 2002-10-30
YU40002A (sh) 2006-01-16
MXPA02005124A (es) 2003-01-28
HK1052933A1 (zh) 2003-10-03
NO20022589L (no) 2002-07-31
AP2002002510A0 (en) 2002-06-30
SK7602002A3 (en) 2003-02-04
OA12101A (en) 2006-05-04
PE20020157A1 (es) 2002-02-22
CO5261566A1 (es) 2003-03-31
PA8507801A1 (es) 2002-08-26

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