AR012157A1 - Derivados de piridina, composiciones farmaceuticas que los contienen y procedimiento para la preparacion de dichos derivados. - Google Patents
Derivados de piridina, composiciones farmaceuticas que los contienen y procedimiento para la preparacion de dichos derivados.Info
- Publication number
- AR012157A1 AR012157A1 ARP980101343A ARP980101343A AR012157A1 AR 012157 A1 AR012157 A1 AR 012157A1 AR P980101343 A ARP980101343 A AR P980101343A AR P980101343 A ARP980101343 A AR P980101343A AR 012157 A1 AR012157 A1 AR 012157A1
- Authority
- AR
- Argentina
- Prior art keywords
- nr7r8
- optionally substituted
- derivatives
- 6alkyl
- alkyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- -1 nitro, cyano, pyridyl Chemical group 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000005037 alkyl phenyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 239000012453 solvate Chemical group 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Derivados de piridina caracterizado porque comprenden la formula I: en el cual X es O o S; R1 y R2 son independientemente hidrogeno, alquilo C1-6 ocicloalquilo C3-6 o R1 y R2 conjuntamente con el átomo de carbono al cual están unidos forman ungrup o cicloalquilo C3-6, R3 es hidrogeno, y R4 es alquilo C1-6o cicloalquilo C3-6 o R3 y R4 conjuntamente con el átomo de carbono al cual están unidos forman un grupo cicloalquilo C3-6; Ar1 es indanilo,tetrahidronaftilo, naftilo, fenilo,alquilfenilo C7-9 o bifenilo, cuyos ultimos cuatro grupos pueden estar opcionalmente substituídos con uno o más gruposseleccionados de halo, nitro, ciano, piridilo, tiacinilo, alquilo C1-10 (opcionalmente substituído con uno o más átomos defluor, -Y-OR5 ,-Y-NR6C(O)NR7-R8, -O-Z-C(O)NR7R8, -O-Y-C(S)NR7R8, -Y-C(O)NR7R8, -Y-SO2NR7R8, -Y-NR7R8, -Y-OC(O)NR7R8, -Y-C(S)NR7R8, -Y-C(O)R9, -Y-OC(O)R9, -Y-CO2R9,-Y-NR10C(O)NR11-Z-R12, SO2NR10C(O)NR7-R8-, -Y-SO2NHNR7-R8, -Y-C(O)NR11-Z-R12, -Y-C(S)NR11-Z-R12, -Y-N(R10)SO2R11, -Y-N(R10)C(O)R11 o -Y-N(R10)CO2R11; donde:Y es un enlace, alquileno C1-6 o alquenileno C2-6; R7 y R8, son independientemente hidrogeno o alquilo C1-6 o conjuntamente con el átomo denitrogeno al cualestán unidos form an un anillo heterocíclico de 5 o 7 miembros opcionalmente substituido que contiene opcionalmente otro heteroátomoseleccionado de nitrogeno, axígeno, o azufre; R5, R6, R9, R10 y R11, son independientemente hidrogeno oalquilo C1-10 (opcionalme ntesubstituído con unoo más átomos de fluor); Z es alquileno C1-6; y R12 es un grupo NR10C(O)R11, NR10CO2R11, OR5, NR7R8, o CO2R13 donde R5, R7, R10 y R11 son tal como se hadefinido más arriba y R13 es alquilo C1-6;alquilarilo C1-6; o arilo opcionalmente substituído con hidroxi, o una sal o solvato de los mismos,
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9701100A SE9701100D0 (sv) | 1997-03-25 | 1997-03-25 | Novel compounds |
| SE9702199A SE9702199D0 (sv) | 1997-06-09 | 1997-06-09 | Novel compounds |
| SE9704403A SE9704403D0 (sv) | 1997-11-28 | 1997-11-28 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012157A1 true AR012157A1 (es) | 2000-09-27 |
Family
ID=27355863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101343A AR012157A1 (es) | 1997-03-25 | 1998-03-24 | Derivados de piridina, composiciones farmaceuticas que los contienen y procedimiento para la preparacion de dichos derivados. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6300352B1 (es) |
| EP (1) | EP0971892A1 (es) |
| JP (1) | JP2001518115A (es) |
| KR (1) | KR20010005646A (es) |
| CN (1) | CN1257481A (es) |
| AR (1) | AR012157A1 (es) |
| AU (1) | AU6530998A (es) |
| BR (1) | BR9808042A (es) |
| CA (1) | CA2284200A1 (es) |
| EE (1) | EE9900426A (es) |
| ID (1) | ID22660A (es) |
| IL (1) | IL131846A0 (es) |
| NO (1) | NO994659L (es) |
| PL (1) | PL335905A1 (es) |
| SK (1) | SK130599A3 (es) |
| TR (1) | TR199902350T2 (es) |
| WO (1) | WO1998042670A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6521618B2 (en) | 2000-03-28 | 2003-02-18 | Wyeth | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors |
| US6376524B1 (en) | 2000-06-21 | 2002-04-23 | Sunesis Pharmaceuticals, Inc. | Triphenyl compounds as interleukin-4 antagonists |
| US7335779B2 (en) * | 2002-03-08 | 2008-02-26 | Quonova, Llc | Modulation of pathogenicity |
| US7338969B2 (en) * | 2002-03-08 | 2008-03-04 | Quonova, Llc | Modulation of pathogenicity |
| JP4820094B2 (ja) * | 2002-11-12 | 2011-11-24 | アボット・ラボラトリーズ | ヒスタミン−３受容体リガンドとしての２環式置換アミン |
| US7153889B2 (en) * | 2002-11-12 | 2006-12-26 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
| US20040092521A1 (en) * | 2002-11-12 | 2004-05-13 | Altenbach Robert J. | Bicyclic-substituted amines as histamine-3 receptor ligands |
| US20070196340A1 (en) * | 2003-05-06 | 2007-08-23 | Aldo Ammendola | Modulation of Pathogenicity |
| EP1778214A4 (en) * | 2004-07-27 | 2010-04-14 | Glaxosmithkline Llc | NEW BIPHENYL COMPOUNDS AND THEIR USE |
| US7498049B1 (en) * | 2007-01-03 | 2009-03-03 | Shmuel Gonen | Topical treatment of acne with combined herbal extracts and minerals |
| ES2879826T3 (es) | 2015-06-15 | 2021-11-23 | Nmd Pharma As | Compuestos para su uso en el tratamiento de trastornos neuromusculares |
| US11147788B2 (en) | 2017-12-14 | 2021-10-19 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| US11730714B2 (en) | 2017-12-14 | 2023-08-22 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| CN114989114A (zh) * | 2022-06-02 | 2022-09-02 | 杭州福斯特电子材料有限公司 | 一种n-丙烯酰吗啉的合成方法及光固化组合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0267439A3 (en) | 1986-10-14 | 1988-08-31 | G.D. Searle & Co. | Alpha-(phenylalkyl) pyridinealkanol derivatives |
| AU7975887A (en) | 1986-10-16 | 1988-04-21 | G.D. Searle & Co. | Alpha-((phenylmethoxy)methyl)pyridine alkanols |
| CN1208403A (zh) * | 1995-12-06 | 1999-02-17 | 英国阿斯特拉药品有限公司 | 化合物 |
-
1998
- 1998-03-20 KR KR1019997008714A patent/KR20010005646A/ko not_active Application Discontinuation
- 1998-03-20 JP JP54555898A patent/JP2001518115A/ja active Pending
- 1998-03-20 BR BR9808042-3A patent/BR9808042A/pt not_active IP Right Cessation
- 1998-03-20 CN CN98805262A patent/CN1257481A/zh active Pending
- 1998-03-20 PL PL98335905A patent/PL335905A1/xx unknown
- 1998-03-20 ID IDW991080A patent/ID22660A/id unknown
- 1998-03-20 EP EP98911337A patent/EP0971892A1/en not_active Ceased
- 1998-03-20 EE EEP199900426A patent/EE9900426A/xx unknown
- 1998-03-20 CA CA002284200A patent/CA2284200A1/en not_active Abandoned
- 1998-03-20 AU AU65309/98A patent/AU6530998A/en not_active Abandoned
- 1998-03-20 IL IL13184698A patent/IL131846A0/xx unknown
- 1998-03-20 SK SK1305-99A patent/SK130599A3/sk unknown
- 1998-03-20 WO PCT/SE1998/000505 patent/WO1998042670A1/en not_active Application Discontinuation
- 1998-03-20 US US09/068,522 patent/US6300352B1/en not_active Expired - Fee Related
- 1998-03-20 TR TR1999/02350T patent/TR199902350T2/xx unknown
- 1998-03-24 AR ARP980101343A patent/AR012157A1/es unknown
-
1999
- 1999-09-24 NO NO994659A patent/NO994659L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EE9900426A (et) | 2000-04-17 |
| WO1998042670A1 (en) | 1998-10-01 |
| EP0971892A1 (en) | 2000-01-19 |
| CN1257481A (zh) | 2000-06-21 |
| BR9808042A (pt) | 2000-03-08 |
| TR199902350T2 (xx) | 2000-04-21 |
| AU6530998A (en) | 1998-10-20 |
| NO994659D0 (no) | 1999-09-24 |
| ID22660A (id) | 1999-12-02 |
| PL335905A1 (en) | 2000-05-22 |
| JP2001518115A (ja) | 2001-10-09 |
| US6300352B1 (en) | 2001-10-09 |
| KR20010005646A (ko) | 2001-01-15 |
| SK130599A3 (en) | 2000-05-16 |
| CA2284200A1 (en) | 1998-10-01 |
| IL131846A0 (en) | 2001-03-19 |
| NO994659L (no) | 1999-11-25 |
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