BR0008566B1 - processo para cristalização de n-(4-trifluormetilfenil)-5-metil-isoxazol-4-carboxami da. - Google Patents

processo para cristalização de n-(4-trifluormetilfenil)-5-metil-isoxazol-4-carboxami da.

Info

Publication number
BR0008566B1
BR0008566B1 BRPI0008566-9A BR0008566A BR0008566B1 BR 0008566 B1 BR0008566 B1 BR 0008566B1 BR 0008566 A BR0008566 A BR 0008566A BR 0008566 B1 BR0008566 B1 BR 0008566B1
Authority
BR
Brazil
Prior art keywords
isoxazol
trifluoromethylphenyl
carboxamide
crystallization
methyl
Prior art date
Application number
BRPI0008566-9A
Other languages
English (en)
Other versions
BR0008566A (pt
Inventor
Hans-Hermann Lau
Udo Hedtmann
Holger Faasch
Andreas Gappisch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BR0008566A publication Critical patent/BR0008566A/pt
Publication of BR0008566B1 publication Critical patent/BR0008566B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI0008566-9A 1999-02-26 2000-02-12 processo para cristalização de n-(4-trifluormetilfenil)-5-metil-isoxazol-4-carboxami da. BR0008566B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19908527A DE19908527C2 (de) 1999-02-26 1999-02-26 Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid
PCT/EP2000/001151 WO2000050411A1 (de) 1999-02-26 2000-02-12 Verfahren zur kristallisation von n- (4-trifluormethylphenyl) -5-methyl- isoxazol- 4-carboxamid

Publications (2)

Publication Number Publication Date
BR0008566A BR0008566A (pt) 2002-01-22
BR0008566B1 true BR0008566B1 (pt) 2011-03-22

Family

ID=7899073

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0008566-9A BR0008566B1 (pt) 1999-02-26 2000-02-12 processo para cristalização de n-(4-trifluormetilfenil)-5-metil-isoxazol-4-carboxami da.

Country Status (22)

Country Link
US (1) US6303792B1 (pt)
EP (1) EP1155004B1 (pt)
JP (1) JP4625187B2 (pt)
KR (1) KR100626110B1 (pt)
CN (1) CN1127491C (pt)
AR (1) AR022737A1 (pt)
AT (1) ATE257828T1 (pt)
AU (1) AU762394B2 (pt)
BR (1) BR0008566B1 (pt)
CA (1) CA2363875C (pt)
DE (2) DE19908527C2 (pt)
DK (1) DK1155004T3 (pt)
ES (1) ES2214259T3 (pt)
HK (1) HK1043787B (pt)
HU (1) HU228918B1 (pt)
IL (2) IL144867A0 (pt)
NO (1) NO319830B1 (pt)
NZ (1) NZ513777A (pt)
PL (1) PL199365B1 (pt)
PT (1) PT1155004E (pt)
WO (1) WO2000050411A1 (pt)
ZA (1) ZA200106973B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19610955A1 (de) * 1996-03-20 1997-09-25 Hoechst Ag Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid
PT987256E (pt) * 1997-08-08 2002-03-28 Aventis Pharma Gmbh Forma cristalina da n-(4-trifluorometilfenil)-5-metil-isoxazol-4-carboxamida
IL149792A0 (en) * 1999-12-16 2002-11-10 Teva Pharma Novel processes for making and a new crystalline form of leflunomide
ES2237553T3 (es) * 2000-02-15 2005-08-01 Teva Pharmaceutical Industries Ltd. Procedimiento para la sintesis de leflunomida.
CN107311954B (zh) * 2017-05-17 2020-04-07 力赛生物医药科技（厦门）有限公司 来氟米特晶型化合物、制备方法及其应用
CN114436894A (zh) * 2020-11-04 2022-05-06 欣凯医药化工中间体（上海）有限公司 泰瑞米特钠晶型及制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2854439A1 (de) 1978-12-16 1980-07-03 Hoechst Ag Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung
DE3534440A1 (de) * 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
US5494911A (en) * 1990-05-18 1996-02-27 Hoechst Aktiengesellschaft Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use
DE4127737A1 (de) * 1991-08-22 1993-02-25 Hoechst Ag Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen
US5519042A (en) * 1994-01-13 1996-05-21 Hoechst Aktiengesellschaft Method of treating hyperproliferative vascular disease
PT987256E (pt) 1997-08-08 2002-03-28 Aventis Pharma Gmbh Forma cristalina da n-(4-trifluorometilfenil)-5-metil-isoxazol-4-carboxamida
DE19734438A1 (de) * 1997-08-08 1999-02-11 Hoechst Marion Roussel De Gmbh Kristallform von N-(4-Trifluormethylphenyl)-5-methyl-isoxazole-4-carboxamid

Also Published As

Publication number Publication date
WO2000050411A1 (de) 2000-08-31
CA2363875A1 (en) 2000-08-31
CA2363875C (en) 2008-04-29
JP2002537388A (ja) 2002-11-05
BR0008566A (pt) 2002-01-22
HUP0200058A2 (hu) 2002-05-29
AU3803800A (en) 2000-09-14
HU228918B1 (en) 2013-06-28
AR022737A1 (es) 2002-09-04
KR20010103774A (ko) 2001-11-23
NO20014077L (no) 2001-10-24
NO20014077D0 (no) 2001-08-22
HK1043787A1 (en) 2002-09-27
DE19908527A1 (de) 2000-08-31
ES2214259T3 (es) 2004-09-16
IL144867A0 (en) 2002-06-30
HK1043787B (zh) 2004-03-05
PL350422A1 (en) 2002-12-16
EP1155004A1 (de) 2001-11-21
DE19908527C2 (de) 2001-08-30
DK1155004T3 (da) 2004-04-13
PL199365B1 (pl) 2008-09-30
HUP0200058A3 (en) 2004-07-28
AU762394B2 (en) 2003-06-26
CN1341106A (zh) 2002-03-20
CN1127491C (zh) 2003-11-12
NO319830B1 (no) 2005-09-19
PT1155004E (pt) 2004-05-31
IL144867A (en) 2006-12-31
ZA200106973B (en) 2002-08-22
KR100626110B1 (ko) 2006-09-20
ATE257828T1 (de) 2004-01-15
EP1155004B1 (de) 2004-01-14
DE50005025D1 (de) 2004-02-19
NZ513777A (en) 2004-01-30
US6303792B1 (en) 2001-10-16
JP4625187B2 (ja) 2011-02-02

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE)

Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/03/2011, OBSERVADAS AS CONDICOES LEGAIS.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 22.03.2021