HK1043787B - N-(4-三氟甲基苯基)-5-甲基-異噁唑-4-酰胺的結晶方法 - Google Patents

N-(4-三氟甲基苯基)-5-甲基-異噁唑-4-酰胺的結晶方法

Info

Publication number
HK1043787B
HK1043787B HK02104056.1A HK02104056A HK1043787B HK 1043787 B HK1043787 B HK 1043787B HK 02104056 A HK02104056 A HK 02104056A HK 1043787 B HK1043787 B HK 1043787B
Authority
HK
Hong Kong
Prior art keywords
crystallising
trifluoromethylphenyl
isoxazole
carboxamide
methyl
Prior art date
Application number
HK02104056.1A
Other languages
English (en)
Other versions
HK1043787A1 (en
Inventor
H-H‧勞
U‧海德曼
H‧法施
A‧伽匹施
Original Assignee
薩諾費-阿文蒂斯德國有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 薩諾費-阿文蒂斯德國有限公司 filed Critical 薩諾費-阿文蒂斯德國有限公司
Publication of HK1043787A1 publication Critical patent/HK1043787A1/xx
Publication of HK1043787B publication Critical patent/HK1043787B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK02104056.1A 1999-02-26 2002-05-31 N-(4-三氟甲基苯基)-5-甲基-異噁唑-4-酰胺的結晶方法 HK1043787B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19908527A DE19908527C2 (de) 1999-02-26 1999-02-26 Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid
PCT/EP2000/001151 WO2000050411A1 (de) 1999-02-26 2000-02-12 Verfahren zur kristallisation von n- (4-trifluormethylphenyl) -5-methyl- isoxazol- 4-carboxamid

Publications (2)

Publication Number Publication Date
HK1043787A1 HK1043787A1 (en) 2002-09-27
HK1043787B true HK1043787B (zh) 2004-03-05

Family

ID=7899073

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02104056.1A HK1043787B (zh) 1999-02-26 2002-05-31 N-(4-三氟甲基苯基)-5-甲基-異噁唑-4-酰胺的結晶方法

Country Status (22)

Country Link
US (1) US6303792B1 (zh)
EP (1) EP1155004B1 (zh)
JP (1) JP4625187B2 (zh)
KR (1) KR100626110B1 (zh)
CN (1) CN1127491C (zh)
AR (1) AR022737A1 (zh)
AT (1) ATE257828T1 (zh)
AU (1) AU762394B2 (zh)
BR (1) BR0008566B1 (zh)
CA (1) CA2363875C (zh)
DE (2) DE19908527C2 (zh)
DK (1) DK1155004T3 (zh)
ES (1) ES2214259T3 (zh)
HK (1) HK1043787B (zh)
HU (1) HU228918B1 (zh)
IL (2) IL144867A0 (zh)
NO (1) NO319830B1 (zh)
NZ (1) NZ513777A (zh)
PL (1) PL199365B1 (zh)
PT (1) PT1155004E (zh)
WO (1) WO2000050411A1 (zh)
ZA (1) ZA200106973B (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19610955A1 (de) * 1996-03-20 1997-09-25 Hoechst Ag Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid
PT987256E (pt) * 1997-08-08 2002-03-28 Aventis Pharma Gmbh Forma cristalina da n-(4-trifluorometilfenil)-5-metil-isoxazol-4-carboxamida
IL149792A0 (en) * 1999-12-16 2002-11-10 Teva Pharma Novel processes for making and a new crystalline form of leflunomide
ES2237553T3 (es) * 2000-02-15 2005-08-01 Teva Pharmaceutical Industries Ltd. Procedimiento para la sintesis de leflunomida.
CN107311954B (zh) * 2017-05-17 2020-04-07 力赛生物医药科技（厦门）有限公司 来氟米特晶型化合物、制备方法及其应用
CN114436894A (zh) * 2020-11-04 2022-05-06 欣凯医药化工中间体（上海）有限公司 泰瑞米特钠晶型及制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2854439A1 (de) 1978-12-16 1980-07-03 Hoechst Ag Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung
DE3534440A1 (de) * 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
US5494911A (en) * 1990-05-18 1996-02-27 Hoechst Aktiengesellschaft Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use
DE4127737A1 (de) * 1991-08-22 1993-02-25 Hoechst Ag Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen
US5519042A (en) * 1994-01-13 1996-05-21 Hoechst Aktiengesellschaft Method of treating hyperproliferative vascular disease
PT987256E (pt) 1997-08-08 2002-03-28 Aventis Pharma Gmbh Forma cristalina da n-(4-trifluorometilfenil)-5-metil-isoxazol-4-carboxamida
DE19734438A1 (de) * 1997-08-08 1999-02-11 Hoechst Marion Roussel De Gmbh Kristallform von N-(4-Trifluormethylphenyl)-5-methyl-isoxazole-4-carboxamid

Also Published As

Publication number Publication date
WO2000050411A1 (de) 2000-08-31
CA2363875A1 (en) 2000-08-31
CA2363875C (en) 2008-04-29
BR0008566B1 (pt) 2011-03-22
JP2002537388A (ja) 2002-11-05
BR0008566A (pt) 2002-01-22
HUP0200058A2 (hu) 2002-05-29
AU3803800A (en) 2000-09-14
HU228918B1 (en) 2013-06-28
AR022737A1 (es) 2002-09-04
KR20010103774A (ko) 2001-11-23
NO20014077L (no) 2001-10-24
NO20014077D0 (no) 2001-08-22
HK1043787A1 (en) 2002-09-27
DE19908527A1 (de) 2000-08-31
ES2214259T3 (es) 2004-09-16
IL144867A0 (en) 2002-06-30
PL350422A1 (en) 2002-12-16
EP1155004A1 (de) 2001-11-21
DE19908527C2 (de) 2001-08-30
DK1155004T3 (da) 2004-04-13
PL199365B1 (pl) 2008-09-30
HUP0200058A3 (en) 2004-07-28
AU762394B2 (en) 2003-06-26
CN1341106A (zh) 2002-03-20
CN1127491C (zh) 2003-11-12
NO319830B1 (no) 2005-09-19
PT1155004E (pt) 2004-05-31
IL144867A (en) 2006-12-31
ZA200106973B (en) 2002-08-22
KR100626110B1 (ko) 2006-09-20
ATE257828T1 (de) 2004-01-15
EP1155004B1 (de) 2004-01-14
DE50005025D1 (de) 2004-02-19
NZ513777A (en) 2004-01-30
US6303792B1 (en) 2001-10-16
JP4625187B2 (ja) 2011-02-02

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PE Patent expired

Effective date: 20200211