PE25698A1 - PROCEDURES AND INTERMEDIATES TO PREPARE 1-BENCIL-4 - ((5,6-DIMETOXI-1-INDANON) -2-IL) METHYLPIPERIDINE - Google Patents
PROCEDURES AND INTERMEDIATES TO PREPARE 1-BENCIL-4 - ((5,6-DIMETOXI-1-INDANON) -2-IL) METHYLPIPERIDINEInfo
- Publication number
- PE25698A1 PE25698A1 PE1996000883A PE00088396A PE25698A1 PE 25698 A1 PE25698 A1 PE 25698A1 PE 1996000883 A PE1996000883 A PE 1996000883A PE 00088396 A PE00088396 A PE 00088396A PE 25698 A1 PE25698 A1 PE 25698A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- react
- iii
- alkyl
- bencil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIEREN A LOS COMPUESTOS INTERMEDIOS DE FORMULAS (I), (II) Y (III), EN DONDE: R1 ES R2O(CO) o R3(CO); R2 ES ALQUILO C1-C4; R3 ES ALQUILO C1-C4 O FENILO CON OPCIONALMENTE 1; 2 o 3 SUSTITUYENTES ALQUILO C1-C4, ALCOXI C1-C4, HALO o CF3. TAMBIEN SE REFIEREN A LOS PROCEDIMIENTOS DE PREPARACION QUE COMPRENDE: 1) HACER REACCIONAR UN COMPUESTO (IV) CON (V) EN PRESENCIA DE AlCl3 Y CLORURO DE METILENO, PARA FORMAR (III); 2) HACER REACCIONAR (III) CON UN AGENTE DE METENILACION, PARA FORMAR (II); 3) HACER REACCIONAR (II) CON H2SO4; 3) AISLAR MEDIANTE LA ADICION DE SOLUCION FUERTEMENTE ACIDA A HIELO/AGUA, SEGUIDA POR EXTRACCION CON UN DISOLVENTE ORGANICO Y ELIMINACION DEL DISOLVENTE ORGANICO ANTES DE QUE SE TRATE CON UNA BASE; 4) HACER REACCIONAR (I) CON HIDROXIDO, PARA FORMAR (VI) EN DONDE: (VI) ES EL COMPUESTO (I) EN EL QUE R1 ES H, Y HACER REACCIONAR DICHO COMPUESTO CON UN HALURO DE BENCILO, PARA FORMAR UN COMPUESTO FINAL ANTICOLINESTERASA DE FORMULA (VII), EN DONDE: (VII) ES (I) EN EL QUE R1 ES BENCILO. EL COMPUESTO OBTENIDO ES USADO PARA EL TRATAMIENTO DE LA DEMENCIA SENIL, PARTICULARMENTE DEL TIPO ALZHEIMER Y DE LA ENFERMEDAD CEREBROVASCULAR QUE ACOMPANA A LA APOPLEJIA CEREBRALTHEY REFER TO THE INTERMEDIATE COMPOUNDS OF FORMULAS (I), (II) AND (III), WHERE: R1 IS R2O (CO) or R3 (CO); R2 IS C1-C4 ALKYL; R3 IS C1-C4 ALKYL OR PHENYL WITH OPTIONALLY 1; 2 or 3 ALKYL SUBSTITUTES C1-C4, ALCOXI C1-C4, HALO or CF3. THEY ALSO REFER TO THE PREPARATION PROCEDURES THAT INCLUDE: 1) REACTING A COMPOUND (IV) WITH (V) IN THE PRESENCE OF AlCl3 AND METHYLENE CHLORIDE, TO FORM (III); 2) MAKE REACT (III) WITH A METHENILATION AGENT, TO FORM (II); 3) REACT (II) WITH H2SO4; 3) ISOLATE THROUGH ADDITION OF SOLUTION STRONGLY ACIDED TO ICE / WATER, FOLLOWED BY EXTRACTION WITH AN ORGANIC SOLVENT AND DISPOSAL OF THE ORGANIC SOLVENT BEFORE IT IS TREATED WITH A BASE; 4) REACT (I) WITH HYDROXIDE, TO FORM (VI) WHERE: (VI) IS THE COMPOUND (I) IN WHICH R1 IS H, AND REACT THIS COMPOUND WITH A BENZYL HALIDE, TO FORM A FINAL COMPOUND ANTICHOLINESTERASE OF FORMULA (VII), WHERE: (VII) IS (I) IN WHICH R1 IS BENCIL. THE COMPOUND OBTAINED IS USED FOR THE TREATMENT OF SENILE DEMENTIA, PARTICULARLY OF THE ALZHEIMER TYPE AND CEREBROVASCULAR DISEASE ACCOMPANYING BRAIN APOPLEJIA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US875395P | 1995-12-15 | 1995-12-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE25698A1 true PE25698A1 (en) | 1998-05-21 |
Family
ID=21733469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1996000883A PE25698A1 (en) | 1995-12-15 | 1996-12-09 | PROCEDURES AND INTERMEDIATES TO PREPARE 1-BENCIL-4 - ((5,6-DIMETOXI-1-INDANON) -2-IL) METHYLPIPERIDINE |
Country Status (33)
Country | Link |
---|---|
EP (1) | EP0883607A1 (en) |
JP (1) | JP3066083B2 (en) |
KR (1) | KR20000064387A (en) |
AP (1) | AP708A (en) |
AR (1) | AR004368A1 (en) |
AU (1) | AU716462B2 (en) |
BG (1) | BG102525A (en) |
BR (1) | BR9612018A (en) |
CA (1) | CA2237647A1 (en) |
CO (1) | CO4750831A1 (en) |
CZ (1) | CZ180898A3 (en) |
DZ (1) | DZ2141A1 (en) |
GT (1) | GT199600092A (en) |
HN (1) | HN1996000065A (en) |
HR (1) | HRP960592A2 (en) |
HU (1) | HUP9904275A3 (en) |
IL (3) | IL136421A0 (en) |
IS (1) | IS4752A (en) |
MA (1) | MA24032A1 (en) |
NO (1) | NO982712L (en) |
NZ (1) | NZ318843A (en) |
OA (1) | OA10694A (en) |
PE (1) | PE25698A1 (en) |
PL (1) | PL197306B1 (en) |
RO (1) | RO121382B1 (en) |
RU (1) | RU2160731C2 (en) |
SK (1) | SK75498A3 (en) |
TN (1) | TNSN96153A1 (en) |
TW (1) | TW414787B (en) |
UY (1) | UY24401A1 (en) |
WO (1) | WO1997022584A1 (en) |
YU (1) | YU49486B (en) |
ZA (1) | ZA9610533B (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1047674B1 (en) | 1998-01-16 | 2005-03-30 | Eisai Co., Ltd. | Process for production of donepezil derivatives |
IL125809A (en) | 1998-08-17 | 2005-08-31 | Finetech Lab Ltd | Process and intermediates for production of donepezil and related compounds |
US7148354B2 (en) * | 2002-07-24 | 2006-12-12 | Dr. Reddy's Laboratories Limited | Process for preparation of donepezil |
IL150982A (en) | 2002-07-30 | 2007-02-11 | Ori Lerman | Process for the preparation of donepezil |
IL151253A0 (en) * | 2002-08-14 | 2003-04-10 | Finetech Lab Ltd | Process for production of highly pure donepezil hydrochloride |
US6953856B2 (en) | 2003-02-12 | 2005-10-11 | Usv, Limited | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) |
US6649765B1 (en) | 2003-02-12 | 2003-11-18 | Usv Limited, Bsd Marg. | Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL) |
WO2004082685A1 (en) * | 2003-03-21 | 2004-09-30 | Ranbaxy Laboratories Limited | Process for the preparation of donepezil and derivatives thereof |
WO2004099142A1 (en) * | 2003-05-05 | 2004-11-18 | Ranbaxy Laboratories Limited | Hydrobromide salt of benzyl-piperidylmethyl-indanone and its polymorphs |
AU2003247158A1 (en) | 2003-07-01 | 2005-01-21 | Hetero Drugs Limited | Preparation of intermediates for acetyl cholinesterase inhibitors |
CN1280273C (en) * | 2003-11-05 | 2006-10-18 | 天津和美生物技术有限公司 | Synthesis of donepizin and its derivative |
CA2581926A1 (en) | 2004-09-29 | 2006-04-06 | Chemagis Ltd. | Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride |
CN100436416C (en) * | 2005-07-29 | 2008-11-26 | 西南合成制药股份有限公司 | Novel donepezil synthesis process |
GB0515803D0 (en) * | 2005-07-30 | 2005-09-07 | Pliva Hrvatska D O O | Intermediate compounds |
AR057910A1 (en) | 2005-11-18 | 2007-12-26 | Synthon Bv | PROCESS TO PREPARE DONEPEZILO |
EP1973878B1 (en) | 2006-01-04 | 2010-11-24 | Cipla Limited | Process and intermediate for preparation of donepezil |
CN101626688A (en) * | 2006-12-11 | 2010-01-13 | 雷维瓦药品公司 | Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors |
WO2013078608A1 (en) | 2011-11-29 | 2013-06-06 | Ziqiang Gu | Donepezil pamoate and methods of making and using the same |
EP3033082B1 (en) | 2013-08-16 | 2021-06-16 | Universiteit Maastricht | Treatment of cognitive impairment with pde4 inhibitor |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI95572C (en) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Process for the preparation of a medicament useful as a piperidine derivative or its pharmaceutical salt |
FR2642069B1 (en) * | 1989-01-20 | 1991-04-12 | Rhone Poulenc Sante | NOVEL BENZOPYRAN DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
DE4439822A1 (en) * | 1994-11-08 | 1996-08-29 | Bayer Ag | Process for the preparation of benzyl-piperidylmethyl-indanones |
-
1996
- 1996-10-11 NZ NZ318843A patent/NZ318843A/en unknown
- 1996-10-11 EP EP96931937A patent/EP0883607A1/en not_active Withdrawn
- 1996-10-11 CZ CZ981808A patent/CZ180898A3/en unknown
- 1996-10-11 HU HU9904275A patent/HUP9904275A3/en unknown
- 1996-10-11 IL IL13642196A patent/IL136421A0/en unknown
- 1996-10-11 RU RU98111204/04A patent/RU2160731C2/en not_active IP Right Cessation
- 1996-10-11 IL IL12445296A patent/IL124452A0/en unknown
- 1996-10-11 KR KR1019980704423A patent/KR20000064387A/en not_active Application Discontinuation
- 1996-10-11 RO RO98-01070A patent/RO121382B1/en unknown
- 1996-10-11 CA CA002237647A patent/CA2237647A1/en not_active Abandoned
- 1996-10-11 BR BR9612018A patent/BR9612018A/en not_active Application Discontinuation
- 1996-10-11 SK SK754-98A patent/SK75498A3/en unknown
- 1996-10-11 WO PCT/IB1996/001076 patent/WO1997022584A1/en not_active Application Discontinuation
- 1996-10-11 IL IL13642096A patent/IL136420A0/en unknown
- 1996-10-11 JP JP9522607A patent/JP3066083B2/en not_active Expired - Lifetime
- 1996-10-11 PL PL327512A patent/PL197306B1/en not_active IP Right Cessation
- 1996-10-11 AU AU70925/96A patent/AU716462B2/en not_active Ceased
- 1996-10-14 TW TW085112515A patent/TW414787B/en not_active IP Right Cessation
- 1996-10-15 HN HN1996000065A patent/HN1996000065A/en unknown
- 1996-11-18 GT GT199600092A patent/GT199600092A/en unknown
- 1996-12-09 PE PE1996000883A patent/PE25698A1/en not_active Application Discontinuation
- 1996-12-10 AR ARP960105577A patent/AR004368A1/en unknown
- 1996-12-11 TN TNTNSN96153A patent/TNSN96153A1/en unknown
- 1996-12-11 DZ DZ960186A patent/DZ2141A1/en active
- 1996-12-11 MA MA24424A patent/MA24032A1/en unknown
- 1996-12-11 YU YU66096A patent/YU49486B/en unknown
- 1996-12-12 AP APAP/P/1996/000892A patent/AP708A/en active
- 1996-12-12 CO CO96065334A patent/CO4750831A1/en unknown
- 1996-12-12 UY UY24401A patent/UY24401A1/en not_active IP Right Cessation
- 1996-12-13 ZA ZA9610533A patent/ZA9610533B/en unknown
- 1996-12-13 HR HR60/008,753A patent/HRP960592A2/en not_active Application Discontinuation
-
1998
- 1998-05-22 IS IS4752A patent/IS4752A/en unknown
- 1998-06-05 OA OA9800076A patent/OA10694A/en unknown
- 1998-06-09 BG BG102525A patent/BG102525A/en unknown
- 1998-06-12 NO NO982712A patent/NO982712L/en not_active Application Discontinuation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE25698A1 (en) | PROCEDURES AND INTERMEDIATES TO PREPARE 1-BENCIL-4 - ((5,6-DIMETOXI-1-INDANON) -2-IL) METHYLPIPERIDINE | |
CO5570667A2 (en) | SUBSTITUTED SUBSTITUTE SUBSTITUTED SUBSTITUTE COMPOUNDS WITH HETEROARILO FOR THE TREATMENT OF DISEASES | |
CU22939A3 (en) | PROCESS FOR THE SYNTHESIS OF 1,3 DIOLES | |
CO4950563A1 (en) | NEW COMPOUNDS | |
Fort et al. | Synthesis of fluorinated tricyclic scaffolds by intramolecular [2+ 2] photocycloaddition reactions | |
FR2447904A1 (en) | NOVEL BENZYL ALCOHOL DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | |
DK0707851T3 (en) | Benzopyran-phenol derivatives for use as antibacterial, antiviral and wound healing agents | |
MX173360B (en) | PROCEDURE FOR THE PRODUCTION OF PHENYL-4,5,6,7-TETRAHYDRO-2H-ISOINDOL-1,3-DIONAS 2-SUBSTITUTED | |
ATE59943T1 (en) | PROCESS FOR THE MANUFACTURE OF Effervescent GRANULATE, THEN PRODUCED Effervescent GRANULATE AND THEIR USE. | |
PT88301A (en) | PROCESS FOR THE PREPARATION OF OXIMA DERIVATIVES OF 1,2,5,6-TETRAIDROPYRIDINE AND OF PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
BR0315254A (en) | Process for manufacturing a compound, and, compound | |
ATE1625T1 (en) | ISOXAZOLYLCARBONIC ACID ANILIDES, THEIR PRODUCTION, FUNCIDAL AGENTS CONTAINING THEM AND METHODS FOR COMBATING FUNGI. | |
KR910004563A (en) | 4,4-disubstituted piperidine derivatives and pharmaceutical compositions containing the compounds and methods for their preparation | |
DE59104965D1 (en) | Process for the preparation of 9,9-bis (4-hydroxyphenyl) fluorene. | |
MX12707A (en) | PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF THE OXIME OF 1, 2, 5, 6-TETRAHIDROPIRIDIN-3-CARBOXALDEHIDO. | |
ES2108364T3 (en) | AZEOTROPIC COMPOSITIONS INCLUDING WATER AND A HYDROFLUOROCARBIDE, PROCEDURE FOR THE ELIMINATION OF WATER FROM A SOLUTION BY AZEOTROPIC DISTILLATION AND A PRODUCTION PROCEDURE FOR A HYDROFLUOROALCAN. | |
BR0008566A (en) | Process for crystallization of n- (4-trifluormethylphenyl) -5-methyl-isoxazol-4-carboxamide | |
ES2085923T3 (en) | PROCEDURE FOR THE PREPARATION OF AROMATIC POLYAMIDES WITH HIGH STABILITY AGAINST HYDROLYSIS. | |
AR002510A1 (en) | A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 1- (3-TRIALQUILSILIL- FENIL) -2,2,2-TRIFLUOROMETILETANONA THAT ARE USEFUL IN THE TREATMENT OF ALZHEIMER DISEASE AND SENILE DEMENTIA AND PROCEDURE FOR THE PURIFICATION OF SUCH DERIVATIVE WITH SUCH PROCEDURE PREPARATION. | |
AR016818A1 (en) | PROCESS TO PREPARE A STABLE POLYMORPH COMPOUND OF 10,10-BIS ((2-FLUOR 4-PIRIDINIL) METHYL) -9 (10H) -TRANTRYCENE CRYSTALINE, AND THE INITIAL COMPOSITE MIXTURE OF STAGE (1) AND THE STAGE COMPOSITE (two); SUCH POLYMORPH COMPOSITE OF FORM 2, PHARMACEUTICAL COMPOSITION CONTAINING IT AND METHOD BEHIND | |
RU94037761A (en) | Method of synthesis of 3-acylestratrienes and acylbenzenes | |
ATE233234T1 (en) | METHOD FOR PRODUCING 4,4'-DIHALOGEN-O-HYDROXYDIPHENYL COMPOUNDS | |
IT1092224B (en) | PROCEDURE FOR THE PRODUCTION OF BENZYL AND BENZOIC DERIVATIVES BY TREATMENT OF A TAR CONTAINING BENZYLBENZOATE | |
DE60136085D1 (en) | LITTLE-COLORED TRANS-1,3-DICHLORPROPENE AND PROCESS FOR THE PRODUCTION THEREOF | |
TNSN86135A1 (en) | PROCESS FOR THE PREPARATION OF NEW BICYCLIC DERIVATIVES OF CATECHOL |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |