FR2447904A1 - Nouveau derive d'alcool benzylique, son procede de production et composition pharmaceutique le contenant - Google Patents
Nouveau derive d'alcool benzylique, son procede de production et composition pharmaceutique le contenantInfo
- Publication number
- FR2447904A1 FR2447904A1 FR8002013A FR8002013A FR2447904A1 FR 2447904 A1 FR2447904 A1 FR 2447904A1 FR 8002013 A FR8002013 A FR 8002013A FR 8002013 A FR8002013 A FR 8002013A FR 2447904 A1 FR2447904 A1 FR 2447904A1
- Authority
- FR
- France
- Prior art keywords
- same
- alcohol derivative
- producing
- pharmaceutical composition
- composition containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical class OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 HYDROXY, BENZYLOXY Chemical group 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- 229940125708 antidiabetic agent Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/32—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups bound to acyclic carbon atoms and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
L'INVENTION A TRAIT AU DOMAINE DE LA CHIMIE PHARMACEUTIQUE. ELLE CONCERNE UN NOUVEAU DERIVE D'ALCOOL BENZYLIQUE DE FORMULE: (CF DESSIN DANS BOPI) (DANS LAQUELLE R EST UN GROUPE HYDROXY, BENZYLOXY OU ALKOXY AYANT 1 A 4ATOMES DE CARBONE OU UN HALOGENE ET LE NOYAU A EST UN NOYAU MONOMETHOXYPHENYLE, DIMETHOXYPHENYLE, TRIMETHOXYPHENYLE OU 3-4-METHYLENEDIOXYPHENYLE), LES SELS D'ADDITION D'ACIDES ACCEPTABLES DU POINT DE VUE PHARMACEUTIQUE DE CE COMPOSE, ET UN PROCEDE PERMETTANT DE LES OBTENIR. LE COMPOSE DE L'INVENTION ET SES SELS D'ADDITION D'ACIDES ACCEPTABLES DU POINT DE VUE PHARMACEUTIQUE SONT UTILES COMME AGENTS ANTIDIABETIQUES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP54010562A JPS6010021B2 (ja) | 1979-01-31 | 1979-01-31 | 新規ベンジルアルコ−ル誘導体及びその製法 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2447904A1 true FR2447904A1 (fr) | 1980-08-29 |
FR2447904B1 FR2447904B1 (fr) | 1986-03-28 |
Family
ID=11753672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8002013A Expired FR2447904B1 (fr) | 1979-01-31 | 1980-01-30 | Nouveau derive d'alcool benzylique, son procede de production et composition pharmaceutique le contenant |
Country Status (9)
Country | Link |
---|---|
US (1) | US4276304A (fr) |
JP (1) | JPS6010021B2 (fr) |
BE (1) | BE881419A (fr) |
CH (1) | CH646136A5 (fr) |
DE (1) | DE3003505A1 (fr) |
FR (1) | FR2447904B1 (fr) |
GB (1) | GB2042525B (fr) |
IT (1) | IT1133054B (fr) |
NL (1) | NL8000589A (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002006276A1 (fr) * | 2000-07-13 | 2002-01-24 | Eli Lilly And Company | Agonistes adrenergiques beta3 |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2555574B2 (fr) * | 1979-07-13 | 1986-11-14 | Lafon Labor | Derives de 2-amino-1-(methoxyphenyl)-1-ethanol utiles en tant que medicaments |
US4404222A (en) * | 1980-08-25 | 1983-09-13 | American Cyanamid Company | Phenylethanolamine derivatives and acid addition salts thereof for enhancing the growth rate of meat-producing animals and improving the efficiency of feed utilization thereby |
US4407819A (en) * | 1980-08-25 | 1983-10-04 | American Cyanamid Company | Phenylethanolamine derivatives and acid addition salts thereof for the depression of fat deposition in warm blooded animals |
US4432995A (en) * | 1980-12-22 | 1984-02-21 | American Cyanamid Company | 5-[2-(Ethylamino)-1-hydroxylethyl] anthranilonitrile and the use thereof in meat producing animals |
DE3267406D1 (en) * | 1981-07-11 | 1985-12-19 | Beecham Group Plc | Secondary phenyl ethanol amines and their pharmaceutical use |
CH653322A5 (de) * | 1982-12-01 | 1985-12-31 | Siegfried Ag | Verfahren zur herstellung von phenylethanolaminen. |
US5530029A (en) * | 1987-09-15 | 1996-06-25 | The Rowett Research Institute | Therapeutic applications of clenbuterol |
US5552442A (en) * | 1987-09-15 | 1996-09-03 | The Rowett Research Institute | Therapeutic applications of clenbuterol |
US4871873A (en) * | 1988-03-18 | 1989-10-03 | Merck & Company Incorporated | Process for synthesis of arylglyoxal arylimines |
US5061727A (en) * | 1990-05-04 | 1991-10-29 | American Cyanamid Company | Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles |
US5245053A (en) * | 1990-05-04 | 1993-09-14 | American Cyanamid Company | Substituted 5-(2-(2-aryl-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxoles |
US5106867A (en) * | 1990-05-04 | 1992-04-21 | American Cyanamid Company | Method of increasing lean meat in edible animals |
US5151439A (en) * | 1990-05-04 | 1992-09-29 | American Cyanamid Company | Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles |
US5482971A (en) * | 1993-10-01 | 1996-01-09 | American Cyanamid Company | Beta3 -adrenergic agents and their use in pharmaceutical compositions |
JP2004513164A (ja) | 2000-11-10 | 2004-04-30 | イーライ・リリー・アンド・カンパニー | 3−置換オキシインドールβ3アゴニスト |
EP1444224B1 (fr) * | 2001-08-14 | 2006-05-03 | Eli Lilly And Company | Agonistes de beta-3 a base d'oxyndole 3-substitue |
EP1421078B1 (fr) * | 2001-08-14 | 2006-09-27 | Eli Lilly And Company | Derives d'indole en tantqu'agonistes du recepteur beta-3 adrenergique pour le traitement du diabete type 2 |
DE60204718T2 (de) * | 2001-11-20 | 2006-05-18 | Eli Lilly And Co., Indianapolis | 3-substituierte oxindol beta 3 agonisten |
AU2002353844A1 (en) * | 2001-11-20 | 2003-06-10 | Eli Lilly And Company | Beta 3 adrenergic agonists |
US7009060B2 (en) * | 2002-01-11 | 2006-03-07 | Eli Lilly And Company | 2-oxo-benzimidazolyl substituted ethanolamine derivatives and their use as β3 agonists |
CN110172028A (zh) * | 2019-05-27 | 2019-08-27 | 安徽恒星制药有限公司 | 一种工业化生产妥洛特罗的方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1541394A (fr) * | 1966-10-18 | 1968-10-04 | Boehringer Sohn Ingelheim | Procédé de fabrication de nouvelles 3, 4-dihydroxyphénylalcanolamines |
US3700692A (en) * | 1971-06-04 | 1972-10-24 | Colgate Palmolive Co | 1-(4{40 -hydroxy-3{40 -(hydroxy methyl)-phenyl)-1-hydroxy-2-aralkylaminoethanes |
FR2326182A1 (fr) * | 1974-06-10 | 1977-04-29 | Tanabe Seiyaku Co | Nouveau derive de l'alcool benzylique et son procede de preparation |
FR2334345A1 (fr) * | 1975-12-11 | 1977-07-08 | Tanabe Seiyaku Co | Nouveau derive d'alcool benzylique, son procede de preparation et medicament le contenant |
FR2392957A1 (fr) * | 1977-06-02 | 1978-12-29 | Tanabe Seiyaku Co | Alcool a-(2,3,4-trimethoxyphenethylaminomethyl)-2-hydroxybenzylique, son procede de fabrication et ses applications comme medicament |
EP0004835A1 (fr) * | 1978-04-10 | 1979-10-17 | Aktiebolaget DRACO | Composés ethanolamine, procédés pour leur préparation, préparations pharmaceutiques les contenant et leur utilisation médicale |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS516657B1 (fr) * | 1970-08-07 | 1976-03-01 | ||
JPS5271428A (en) * | 1975-12-11 | 1977-06-14 | Tanabe Seiyaku Co Ltd | Preparation of benzylalcohol derivatives |
-
1979
- 1979-01-31 JP JP54010562A patent/JPS6010021B2/ja not_active Expired
-
1980
- 1980-01-18 US US06/113,218 patent/US4276304A/en not_active Expired - Lifetime
- 1980-01-28 GB GB8002802A patent/GB2042525B/en not_active Expired
- 1980-01-29 BE BE6/47068A patent/BE881419A/fr not_active IP Right Cessation
- 1980-01-30 CH CH74180A patent/CH646136A5/de not_active IP Right Cessation
- 1980-01-30 IT IT67134/80A patent/IT1133054B/it active
- 1980-01-30 NL NL8000589A patent/NL8000589A/nl not_active Application Discontinuation
- 1980-01-30 FR FR8002013A patent/FR2447904B1/fr not_active Expired
- 1980-01-31 DE DE19803003505 patent/DE3003505A1/de not_active Withdrawn
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1541394A (fr) * | 1966-10-18 | 1968-10-04 | Boehringer Sohn Ingelheim | Procédé de fabrication de nouvelles 3, 4-dihydroxyphénylalcanolamines |
US3700692A (en) * | 1971-06-04 | 1972-10-24 | Colgate Palmolive Co | 1-(4{40 -hydroxy-3{40 -(hydroxy methyl)-phenyl)-1-hydroxy-2-aralkylaminoethanes |
FR2326182A1 (fr) * | 1974-06-10 | 1977-04-29 | Tanabe Seiyaku Co | Nouveau derive de l'alcool benzylique et son procede de preparation |
FR2334345A1 (fr) * | 1975-12-11 | 1977-07-08 | Tanabe Seiyaku Co | Nouveau derive d'alcool benzylique, son procede de preparation et medicament le contenant |
US4131686A (en) * | 1975-12-11 | 1978-12-26 | Tanabe Seiyaku Co., Ltd. | Novel benzylalcohol derivatives and processes for preparing the same |
FR2392957A1 (fr) * | 1977-06-02 | 1978-12-29 | Tanabe Seiyaku Co | Alcool a-(2,3,4-trimethoxyphenethylaminomethyl)-2-hydroxybenzylique, son procede de fabrication et ses applications comme medicament |
EP0004835A1 (fr) * | 1978-04-10 | 1979-10-17 | Aktiebolaget DRACO | Composés ethanolamine, procédés pour leur préparation, préparations pharmaceutiques les contenant et leur utilisation médicale |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002006276A1 (fr) * | 2000-07-13 | 2002-01-24 | Eli Lilly And Company | Agonistes adrenergiques beta3 |
Also Published As
Publication number | Publication date |
---|---|
IT1133054B (it) | 1986-07-09 |
FR2447904B1 (fr) | 1986-03-28 |
JPS55102546A (en) | 1980-08-05 |
NL8000589A (nl) | 1980-08-04 |
GB2042525A (en) | 1980-09-24 |
BE881419A (fr) | 1980-05-16 |
IT8067134A0 (it) | 1980-01-30 |
GB2042525B (en) | 1982-12-08 |
CH646136A5 (de) | 1984-11-15 |
JPS6010021B2 (ja) | 1985-03-14 |
US4276304A (en) | 1981-06-30 |
DE3003505A1 (de) | 1980-08-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FR2447904A1 (fr) | Nouveau derive d'alcool benzylique, son procede de production et composition pharmaceutique le contenant | |
SU1535377A3 (ru) | Способ получени производных ароматических аминоспиртов или их фармакологически приемлемых солей | |
RU95117719A (ru) | Производные ароил-пиперидина | |
FR2438028A1 (fr) | Nouveaux derives polysubstitues de pentene, leur procede de production et leur application en parfumerie | |
BR112021006710A2 (pt) | composto análogos de iludina, usos dos mesmos e métodos para sintetizar os mesmos | |
JPS6092287A (ja) | 9−デスオキソ−9−ハイドロオキシ−フエオホ−バイド誘導体およびそれらのアルカリ塩類 | |
FR2543140A1 (fr) | Nouveaux acides flavone-carboxyliques-4', leur methode de preparation et leur application en therapeutique | |
Hill et al. | Transfer of Asymmetry from Nitrogen to Carbon in the Stevens Rearrangement | |
EP0515540B1 (fr) | Derive de la beta-phenylisoserine, sa preparation et son emploi | |
EP0023959B1 (fr) | Méthode de préparation de 4-hydroxy-3-méthyl-2-(2-propynyl)-2-cyclopenténolone optiquement active et de ses produits intermédiaires, et les composés ainsi préparés | |
FR2450837A1 (fr) | Acides penicillaniques 6-b-substitues inhibiteurs de b-lactamase, leur procede de production et composition pharmaceutique les contenant | |
US3344188A (en) | d (-)-n-tert.butyl- and -n-isopropyl-1-phenyl-2-amino-ethanols | |
EP0002978A2 (fr) | Dérivés de thiazolidinedione-2,4, leur préparation et leur application en thérapeutique | |
US4965064A (en) | Pheophorbide derivatives | |
CA1228354A (fr) | Procede de preparation de derives de 4-alkyl 2-hydroxy 3-methyl 2-phenyl morpholine et les derives ainsi obtenus | |
FR2623811A1 (fr) | Procede de preparation d'acides phosphiniques utilises pour preparer des inhibiteurs de l'enzyme de conversion de l'angiotensine, et intermediaires ainsi obtenus | |
CH636076A5 (de) | Benzylalkoholderivate und verfahren zu deren herstellung. | |
US3637804A (en) | Phenylalanine derivatives and preparation thereof | |
Bunce et al. | Phototoxicity of chlorpromazine | |
US3551491A (en) | 4 - halothymyl - (n - ethyl - n - beta - chloroethyl - 1- and-2 - amino propyl(2) and (1)) ether and salts thereof | |
CA2247675C (fr) | Antifongiques | |
DE69303333T2 (de) | Substituierte Benzoate-Derivate | |
CA1052271A (fr) | 1,2 - et 2,3 - epoxyalkanes | |
FR2439191A1 (fr) | Derives 2-amino ou 2-thio substitues de 4,5-diphenyloxazole et procede pour leur preparation | |
CH615171A5 (fr) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |