DE602004019548D1 - Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri) - Google Patents

Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri)

Info

Publication number
DE602004019548D1
DE602004019548D1 DE602004019548T DE602004019548T DE602004019548D1 DE 602004019548 D1 DE602004019548 D1 DE 602004019548D1 DE 602004019548 T DE602004019548 T DE 602004019548T DE 602004019548 T DE602004019548 T DE 602004019548T DE 602004019548 D1 DE602004019548 D1 DE 602004019548D1
Authority
DE
Germany
Prior art keywords
glutamatracemase
muri
inhibitors
condensed heterocycles
heterocycles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602004019548T
Other languages
English (en)
Inventor
Gregory S Basarab
Charles J Eyermann
Madhusudhan R Gowravaram
Oluyinka Green
Andrew Kiely
Lawrence J Macpherson
Marshall L Morningstar
Nguyen Metabasis Th Thanh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE602004019548D1 publication Critical patent/DE602004019548D1/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE602004019548T 2003-08-15 2004-08-12 Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri) Expired - Fee Related DE602004019548D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49561503P 2003-08-15 2003-08-15
PCT/GB2004/003464 WO2005016929A1 (en) 2003-08-15 2004-08-12 Fused heterocylcles as inhibitors of glutamate racemase (muri)

Publications (1)

Publication Number Publication Date
DE602004019548D1 true DE602004019548D1 (de) 2009-04-02

Family

ID=34193331

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004019548T Expired - Fee Related DE602004019548D1 (de) 2003-08-15 2004-08-12 Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri)

Country Status (6)

Country Link
US (1) US7371757B2 (de)
EP (1) EP1664052B1 (de)
JP (1) JP2007502307A (de)
AT (1) ATE423122T1 (de)
DE (1) DE602004019548D1 (de)
WO (1) WO2005016929A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1664052B1 (de) 2003-08-15 2009-02-18 AstraZeneca AB Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri)
US8008327B2 (en) * 2008-04-29 2011-08-30 Boehringer Ingelheim International Gmbh Indazole compounds as CCR1 receptor antagonists
WO2009137338A1 (en) * 2008-05-06 2009-11-12 Boehringer Ingelheim International Gmbh Pyrazole compounds as ccr1 antagonists
CN102227425A (zh) 2008-09-26 2011-10-26 贝林格尔·英格海姆国际有限公司 作为ccr1受体拮抗剂的氮杂吲唑化合物
UY32174A (es) * 2008-10-14 2010-05-31 Astrazeneca Ab Nuevos heterociclos sustituidos, composiciones farmaceuticas conteniendolos, procedimientos de preparacion y aplicaciones
US9040528B2 (en) 2008-10-14 2015-05-26 Astrazeneca Ab Chemical compounds 542
SI2491028T1 (sl) 2009-10-21 2014-03-31 Boehringer Ingelheim International Gmbh Indazolne in pirazolopiridinske spojine kot antagonisti receptorja CCR1
US8927550B2 (en) 2009-10-27 2015-01-06 Boehringer Ingelheim International Gmbh Heterocyclic compounds as CCR1 receptor antagonists
CN102596908A (zh) * 2009-12-08 2012-07-18 贝林格尔.英格海姆国际有限公司 用于制备取代的吲唑和氮杂吲唑化合物的中间体的合成方法
EP2563787B1 (de) 2010-04-30 2014-11-26 Boehringer Ingelheim International GmbH Azaindazolamidverbindungen als ccr1-rezeptor-antagonisten
JP5684406B2 (ja) 2010-12-23 2015-03-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体アンタゴニストとしてのピラゾロピペリジン化合物
AU2013270036B2 (en) 2012-05-31 2016-12-01 Phenex Pharmaceuticals Ag Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR(gamma)
JO3215B1 (ar) 2012-08-09 2018-03-08 Phenex Pharmaceuticals Ag حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy
US8889671B2 (en) 2013-01-23 2014-11-18 Astrazeneca Ab Compounds and methods for treating bacterial infections
US20160115136A1 (en) * 2013-03-13 2016-04-28 University Of Iowa Research Foundation Compounds, compositions comprsing same, and methods related thereto
MX365261B (es) 2014-05-29 2019-05-27 Entasis Therapeutics Ltd Compuestos heteroaromaticos espirociclicos, fusionados para el tratamiento de infecciones bacterianas.
ME03733B (de) 2015-05-20 2021-01-20 Amgen Inc Triazolagonisten des apj-rezeptors
CN108699024B (zh) 2015-12-09 2022-03-11 伊利诺伊大学评议会 苯并噻吩基选择性雌激素受体下调剂化合物
WO2017192485A1 (en) 2016-05-03 2017-11-09 Amgen Inc. Heterocyclic triazole compounds as agonists of the apj receptor
WO2018081168A2 (en) 2016-10-24 2018-05-03 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective mixed estrogen receptor downregulators
EP3541805B1 (de) 2016-11-16 2020-10-14 Amgen Inc. Heteroaryl-substituierte triazole als apj-rezeptoragonisten
EP3541792B1 (de) 2016-11-16 2020-12-23 Amgen Inc. Triazol-furan-verbindungen als agonisten des apj-rezeptors
US10689367B2 (en) 2016-11-16 2020-06-23 Amgen Inc. Triazole pyridyl compounds as agonists of the APJ receptor
MA46827A (fr) 2016-11-16 2019-09-25 Amgen Inc Composés de triazole à substitution cycloalkyle en tant qu'agonistes du récepteur apj
US10906890B2 (en) 2016-11-16 2021-02-02 Amgen Inc. Triazole phenyl compounds as agonists of the APJ receptor
WO2018093576A1 (en) 2016-11-16 2018-05-24 Amgen Inc. Alkyl substituted triazole compounds as agonists of the apj receptor
KR102576011B1 (ko) 2017-01-06 2023-09-06 쥐원 쎄라퓨틱스, 인크. 암의 치료를 위한 조합 요법
WO2018148576A1 (en) 2017-02-10 2018-08-16 G1 Therapeutics, Inc. Benzothiophene estrogen receptor modulators
US11149040B2 (en) 2017-11-03 2021-10-19 Amgen Inc. Fused triazole agonists of the APJ receptor
MA52487A (fr) 2018-05-01 2021-03-10 Amgen Inc Pyrimidinones substituées en tant qu'agonistes du récepteur apj

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102315D0 (sv) * 2001-06-28 2001-06-28 Astrazeneca Ab Compounds
EP1664052B1 (de) 2003-08-15 2009-02-18 AstraZeneca AB Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri)

Also Published As

Publication number Publication date
EP1664052B1 (de) 2009-02-18
US20060252781A1 (en) 2006-11-09
EP1664052A1 (de) 2006-06-07
US7371757B2 (en) 2008-05-13
JP2007502307A (ja) 2007-02-08
WO2005016929A1 (en) 2005-02-24
ATE423122T1 (de) 2009-03-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee