ATE423122T1 - Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri) - Google Patents

Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri)

Info

Publication number
ATE423122T1
ATE423122T1 AT04743692T AT04743692T ATE423122T1 AT E423122 T1 ATE423122 T1 AT E423122T1 AT 04743692 T AT04743692 T AT 04743692T AT 04743692 T AT04743692 T AT 04743692T AT E423122 T1 ATE423122 T1 AT E423122T1
Authority
AT
Austria
Prior art keywords
glutamatracemase
muri
inhibitors
condensed heterocycles
heterocycles
Prior art date
Application number
AT04743692T
Other languages
English (en)
Inventor
Gregory Basarab
Charles Eyermann
Madhusudhan Gowravaram
Oluyinka Green
Andrew Kiely
Lawrence Macpherson
Marshall Morningstar
Nguyen Thanh
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE423122T1 publication Critical patent/ATE423122T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT04743692T 2003-08-15 2004-08-12 Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri) ATE423122T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49561503P 2003-08-15 2003-08-15

Publications (1)

Publication Number Publication Date
ATE423122T1 true ATE423122T1 (de) 2009-03-15

Family

ID=34193331

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04743692T ATE423122T1 (de) 2003-08-15 2004-08-12 Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri)

Country Status (6)

Country Link
US (1) US7371757B2 (de)
EP (1) EP1664052B1 (de)
JP (1) JP2007502307A (de)
AT (1) ATE423122T1 (de)
DE (1) DE602004019548D1 (de)
WO (1) WO2005016929A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7371757B2 (en) 2003-08-15 2008-05-13 Astrazeneca Ab Fused heterocycles as inhibitors of glutamate racemase(MURI)
WO2009134666A1 (en) 2008-04-29 2009-11-05 Boehringer Ingelheim International Gmbh Indazole compounds as ccr1 receptor antagonists
WO2009137338A1 (en) * 2008-05-06 2009-11-12 Boehringer Ingelheim International Gmbh Pyrazole compounds as ccr1 antagonists
JP5507567B2 (ja) 2008-09-26 2014-05-28 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体拮抗薬としてのアザインダゾール化合物
US9040528B2 (en) 2008-10-14 2015-05-26 Astrazeneca Ab Chemical compounds 542
ES2565611T3 (es) * 2008-10-14 2016-04-05 Entasis Therapeutics Limited Compuestos heteroaromáticos espirocíclicos y condensados para el tratamiento de infecciones bacterianas
KR20120087923A (ko) 2009-10-21 2012-08-07 베링거 인겔하임 인터내셔날 게엠베하 Ｃｃｒ１ 수용체 길항제로서의 인다졸 및 피라졸로피리딘 화합물
US8927550B2 (en) 2009-10-27 2015-01-06 Boehringer Ingelheim International Gmbh Heterocyclic compounds as CCR1 receptor antagonists
BR112012013582A2 (pt) * 2009-12-08 2016-07-05 Boehringer Ingelheim Int processo para síntese de intermediários úteis para a produção de compostos de indazol e azaindazol substituídos
US8871786B2 (en) 2010-04-30 2014-10-28 Boehringer Ingelheim International Gmbh Azaindazole amide compounds as CCR1 receptor antagonists
JP5684406B2 (ja) 2010-12-23 2015-03-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体アンタゴニストとしてのピラゾロピペリジン化合物
PE20150229A1 (es) 2012-05-31 2015-03-02 Phenex Pharmaceuticals Ag Tiazoles sustituidos por carboxamida o sulfonamida y derivados relacionados como moduladores para el receptor nuclear huerfano rory
JO3215B1 (ar) 2012-08-09 2018-03-08 Phenex Pharmaceuticals Ag حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy
US8889671B2 (en) 2013-01-23 2014-11-18 Astrazeneca Ab Compounds and methods for treating bacterial infections
WO2014160405A1 (en) * 2013-03-13 2014-10-02 University Of Iowa Research Foundation Compounds, compositions comprising same, and methods related thereto
MX365261B (es) 2014-05-29 2019-05-27 Entasis Therapeutics Ltd Compuestos heteroaromaticos espirociclicos, fusionados para el tratamiento de infecciones bacterianas.
TN2017000483A1 (en) 2015-05-20 2019-04-12 Amgen Inc Triazole agonists of the apj receptor.
US10118910B2 (en) 2015-12-09 2018-11-06 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective estrogen receptor downregulators
WO2017192485A1 (en) 2016-05-03 2017-11-09 Amgen Inc. Heterocyclic triazole compounds as agonists of the apj receptor
WO2018081168A2 (en) 2016-10-24 2018-05-03 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective mixed estrogen receptor downregulators
MA46824A (fr) 2016-11-16 2019-09-25 Amgen Inc Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj
US11020395B2 (en) 2016-11-16 2021-06-01 Amgen Inc. Cycloalkyl substituted triazole compounds as agonists of the APJ receptor
US10689367B2 (en) 2016-11-16 2020-06-23 Amgen Inc. Triazole pyridyl compounds as agonists of the APJ receptor
WO2018097945A1 (en) 2016-11-16 2018-05-31 Amgen Inc. Heteroaryl-substituted triazoles as apj receptor agonists
EP3541792B1 (de) 2016-11-16 2020-12-23 Amgen Inc. Triazol-furan-verbindungen als agonisten des apj-rezeptors
WO2018093579A1 (en) 2016-11-16 2018-05-24 Amgen Inc. Triazole phenyl compounds as agonists of the apj receptor
CN110177554B (zh) 2017-01-06 2023-06-02 G1治疗公司 用于治疗癌症的组合疗法
CN110461853A (zh) 2017-02-10 2019-11-15 G1治疗公司 苯并噻吩雌激素受体调节剂
MA50509A (fr) 2017-11-03 2021-06-02 Amgen Inc Agonistes de triazole fusionnés du récepteur apj
WO2019213006A1 (en) 2018-05-01 2019-11-07 Amgen Inc. Substituted pyrimidinones as agonists of the apj receptor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102315D0 (sv) 2001-06-28 2001-06-28 Astrazeneca Ab Compounds
US7371757B2 (en) 2003-08-15 2008-05-13 Astrazeneca Ab Fused heterocycles as inhibitors of glutamate racemase(MURI)

Also Published As

Publication number Publication date
US7371757B2 (en) 2008-05-13
US20060252781A1 (en) 2006-11-09
EP1664052A1 (de) 2006-06-07
EP1664052B1 (de) 2009-02-18
JP2007502307A (ja) 2007-02-08
WO2005016929A1 (en) 2005-02-24
DE602004019548D1 (de) 2009-04-02

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