ES2145014T3 - Derivados de piperazina como inhibidores de la colagenasa. - Google Patents

Derivados de piperazina como inhibidores de la colagenasa.

Info

Publication number
ES2145014T3
ES2145014T3 ES92922404T ES92922404T ES2145014T3 ES 2145014 T3 ES2145014 T3 ES 2145014T3 ES 92922404 T ES92922404 T ES 92922404T ES 92922404 T ES92922404 T ES 92922404T ES 2145014 T3 ES2145014 T3 ES 2145014T3
Authority
ES
Spain
Prior art keywords
piperazine derivatives
collagenase inhibitors
alkilo
alkyl
collagenase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92922404T
Other languages
English (en)
Inventor
Yukio Sugimura
Kazuhiko Tamaki
Tomowo Kobayashi
Kazuhiko Tanzawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2145014T3 publication Critical patent/ES2145014T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

CONSTITUCION: UN NUEVO COMPUESTO REPRESENTADO POR LA FORMULA GENERAL (I), EN LA QUE R1 REPRESENTA -OR3 (SIENDO R3 H O ALKILO), NR4R5 (SIENDO R5 Y R5 CADA UNO H, ALKILO O ALCOXI), -NHCH(R6)CONR9R10 (SIENDO R9 Y R10 CADA UNO H, ALKILO O ALTERNATIVAMENTE NR9R10 SIENDO UN GRUPO HETEROCICLICO COMO UN TODO); Y R2 REPRESENTA H, ALKILO O ARILAKILO. EFECTO: YA QUE EL COMPUESTO TIENE UNA COLAGENASA DE TIPO IV DE ACTIVIDAD INHIBITORIA, ES UTIL COMO INHIBIDOR CONTRA LA INFILTRACION DE CANCER, VASCULARIZACION O METASTASIS DE CANCER.
ES92922404T 1991-11-08 1992-11-02 Derivados de piperazina como inhibidores de la colagenasa. Expired - Lifetime ES2145014T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29288491 1991-11-08

Publications (1)

Publication Number Publication Date
ES2145014T3 true ES2145014T3 (es) 2000-07-01

Family

ID=17787629

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92922404T Expired - Lifetime ES2145014T3 (es) 1991-11-08 1992-11-02 Derivados de piperazina como inhibidores de la colagenasa.

Country Status (17)

Country Link
US (1) US5643908A (es)
EP (1) EP0621270B1 (es)
JP (2) JPH05194414A (es)
KR (1) KR100255203B1 (es)
AT (1) ATE191713T1 (es)
AU (1) AU661058B2 (es)
CA (1) CA2123104A1 (es)
CZ (1) CZ112694A3 (es)
DE (1) DE69230916T2 (es)
DK (1) DK0621270T3 (es)
ES (1) ES2145014T3 (es)
FI (1) FI942094A7 (es)
GR (1) GR3033368T3 (es)
HU (1) HUT67374A (es)
NO (1) NO306507B1 (es)
RU (1) RU2091373C1 (es)
WO (1) WO1993009097A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
DK0822186T3 (da) * 1994-01-20 2000-06-26 British Biotech Pharm L-tert-leucin-2-pyridylamid
WO1995029892A1 (en) * 1994-04-28 1995-11-09 The Du Pont Merck Pharmaceutical Company Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents
GB9411598D0 (en) * 1994-06-09 1994-08-03 Hoffmann La Roche Hydroxamic acid derivatives
GB9423914D0 (en) * 1994-11-26 1995-01-11 British Biotech Pharm Polyether derivatives as metalloproteinase inhibitors
US5919940A (en) * 1995-01-20 1999-07-06 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
US5917090A (en) * 1995-06-30 1999-06-29 British Biotech Pharmaceuticals Ltd. Matrix metalloproteinase inhibitors
JP2000500761A (ja) 1995-11-23 2000-01-25 ブリティッシュ バイオテック ファーマシューティカルズ リミテッド 金属タンパク質分解酵素阻害剤
AU2090897A (en) * 1996-02-29 1997-09-16 Mikael Bols Hydroxyhexahydropyridazines
US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
GB9803005D0 (en) 1998-02-12 1998-04-08 British Biotech Pharm Anti-inflammatory agents
US7253169B2 (en) * 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
US6797820B2 (en) 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
ATE360014T1 (de) * 2001-06-15 2007-05-15 Vicuron Pharm Inc Bicyclische pyrrolidinverbindungen
US20030068655A1 (en) * 2001-09-12 2003-04-10 Protiveris, Inc. Microcantilever apparatus and methods for detection of enzymes
FR2835835B1 (fr) * 2002-02-11 2004-04-16 Aventis Pharma Sa Nouveaux derives de la pyridazine, leur utilisation comme medicaments, compositions pharmaceutiques et leur procede de preparation
US7807177B2 (en) 2004-01-27 2010-10-05 Toshikazu Nakamura Segment of glycosylation-deficient HGFalpha-chain
EP2249828A1 (en) * 2008-01-07 2010-11-17 Janssen Pharmaceutica, N.V. Preparation of sulfamide derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659711A (en) * 1983-01-31 1987-04-21 Usv Pharmaceutical Corporation 1,2,3,4-Tetrahydrophthalazine and hexahydropyridazine compounds for treating hypertension
US4604407A (en) * 1985-04-04 1986-08-05 E. R. Squibb & Sons, Inc. Hydroxamates
JPH0670019B2 (ja) * 1989-07-21 1994-09-07 明治製菓株式会社 新抗生物質ｓｆ２１９７ｃ物質およびその製造法
JPH03157372A (ja) * 1989-11-13 1991-07-05 Yamanouchi Pharmaceut Co Ltd Ｙｌ―０１８６９ｐ物質及びその製造法
WO1991017982A1 (fr) * 1990-05-21 1991-11-28 Sankyo Company, Limited Nouveau compose de matristatine
AU2228292A (en) * 1991-06-14 1993-01-12 Research Corporation Technologies, Inc. Peptide derivatives of collagenase inhibitor

Also Published As

Publication number Publication date
FI942094A0 (fi) 1994-05-06
ATE191713T1 (de) 2000-04-15
RU2091373C1 (ru) 1997-09-27
US5643908A (en) 1997-07-01
CZ112694A3 (en) 1994-12-15
KR100255203B1 (ko) 2000-05-01
DE69230916T2 (de) 2000-12-14
CA2123104A1 (en) 1993-05-13
AU661058B2 (en) 1995-07-13
GR3033368T3 (en) 2000-09-29
JPH05194414A (ja) 1993-08-03
NO941698D0 (no) 1994-05-06
FI942094A7 (fi) 1994-07-01
NO941698L (no) 1994-07-07
DE69230916D1 (de) 2000-05-18
EP0621270A1 (en) 1994-10-26
WO1993009097A1 (fr) 1993-05-13
DK0621270T3 (da) 2000-07-17
HUT67374A (en) 1995-03-28
EP0621270A4 (en) 1995-01-18
NO306507B1 (no) 1999-11-15
AU2799392A (en) 1993-06-07
HU9401420D0 (en) 1994-08-29
JPH05194415A (ja) 1993-08-03
EP0621270B1 (en) 2000-04-12

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