DE69230916D1 - Piperazin Derivate als Collagenase Inhibitoren - Google Patents

Piperazin Derivate als Collagenase Inhibitoren

Info

Publication number
DE69230916D1
DE69230916D1 DE69230916T DE69230916T DE69230916D1 DE 69230916 D1 DE69230916 D1 DE 69230916D1 DE 69230916 T DE69230916 T DE 69230916T DE 69230916 T DE69230916 T DE 69230916T DE 69230916 D1 DE69230916 D1 DE 69230916D1
Authority
DE
Germany
Prior art keywords
alkyl
nhch
piperazine derivatives
collagenase inhibitors
collagenase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69230916T
Other languages
English (en)
Other versions
DE69230916T2 (de
Inventor
Yukio Sugimura
Kazuhiko Tamaki
Tomowo Kobayashi
Kazuhiko Tanzawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of DE69230916D1 publication Critical patent/DE69230916D1/de
Application granted granted Critical
Publication of DE69230916T2 publication Critical patent/DE69230916T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69230916T 1991-11-08 1992-11-02 Piperazin Derivate als Collagenase Inhibitoren Expired - Fee Related DE69230916T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP29288491 1991-11-08
PCT/JP1992/001420 WO1993009097A1 (en) 1991-11-08 1992-11-02 Collagenase inhibitor

Publications (2)

Publication Number Publication Date
DE69230916D1 true DE69230916D1 (de) 2000-05-18
DE69230916T2 DE69230916T2 (de) 2000-12-14

Family

ID=17787629

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69230916T Expired - Fee Related DE69230916T2 (de) 1991-11-08 1992-11-02 Piperazin Derivate als Collagenase Inhibitoren

Country Status (17)

Country Link
US (1) US5643908A (de)
EP (1) EP0621270B1 (de)
JP (2) JPH05194414A (de)
KR (1) KR100255203B1 (de)
AT (1) ATE191713T1 (de)
AU (1) AU661058B2 (de)
CA (1) CA2123104A1 (de)
CZ (1) CZ112694A3 (de)
DE (1) DE69230916T2 (de)
DK (1) DK0621270T3 (de)
ES (1) ES2145014T3 (de)
FI (1) FI942094A (de)
GR (1) GR3033368T3 (de)
HU (1) HUT67374A (de)
NO (1) NO306507B1 (de)
RU (1) RU2091373C1 (de)
WO (1) WO1993009097A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
EP0740652B1 (de) * 1994-01-20 1998-05-06 British Biotech Pharmaceuticals Limited Metalloproteinaseinhibitoren
AU2394795A (en) * 1994-04-28 1995-11-29 Du Pont Merck Pharmaceutical Company, The Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents
GB9411598D0 (en) * 1994-06-09 1994-08-03 Hoffmann La Roche Hydroxamic acid derivatives
GB9423914D0 (en) * 1994-11-26 1995-01-11 British Biotech Pharm Polyether derivatives as metalloproteinase inhibitors
US5919940A (en) * 1995-01-20 1999-07-06 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
US5917090A (en) * 1995-06-30 1999-06-29 British Biotech Pharmaceuticals Ltd. Matrix metalloproteinase inhibitors
HUP9903863A3 (en) 1995-11-23 2000-11-28 British Biotech Pharm Metalloproteinase inhibitors
WO1997031901A1 (en) * 1996-02-29 1997-09-04 Mikael Bols Hydroxyhexahydropyridazines
US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
GB9803005D0 (en) 1998-02-12 1998-04-08 British Biotech Pharm Anti-inflammatory agents
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
US7253169B2 (en) * 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
US6797820B2 (en) 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
US6987104B2 (en) 2001-06-15 2006-01-17 Vicuron Pharmaceuticals Inc. Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use
US20030068655A1 (en) * 2001-09-12 2003-04-10 Protiveris, Inc. Microcantilever apparatus and methods for detection of enzymes
FR2835835B1 (fr) * 2002-02-11 2004-04-16 Aventis Pharma Sa Nouveaux derives de la pyridazine, leur utilisation comme medicaments, compositions pharmaceutiques et leur procede de preparation
US7807177B2 (en) 2004-01-27 2010-10-05 Toshikazu Nakamura Segment of glycosylation-deficient HGFalpha-chain
US20090176996A1 (en) * 2008-01-07 2009-07-09 Ahmed Abdel-Magid Process for the preparation of sulfamide derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659711A (en) * 1983-01-31 1987-04-21 Usv Pharmaceutical Corporation 1,2,3,4-Tetrahydrophthalazine and hexahydropyridazine compounds for treating hypertension
US4604407A (en) * 1985-04-04 1986-08-05 E. R. Squibb & Sons, Inc. Hydroxamates
JPH0670019B2 (ja) * 1989-07-21 1994-09-07 明治製菓株式会社 新抗生物質ｓｆ２１９７ｃ物質およびその製造法
JPH03157372A (ja) * 1989-11-13 1991-07-05 Yamanouchi Pharmaceut Co Ltd Ｙｌ―０１８６９ｐ物質及びその製造法
WO1991017982A1 (en) * 1990-05-21 1991-11-28 Sankyo Company, Limited Novel compound matristatin
AU2228292A (en) * 1991-06-14 1993-01-12 Research Corporation Technologies, Inc. Peptide derivatives of collagenase inhibitor

Also Published As

Publication number Publication date
WO1993009097A1 (en) 1993-05-13
HU9401420D0 (en) 1994-08-29
NO941698D0 (no) 1994-05-06
US5643908A (en) 1997-07-01
FI942094A (fi) 1994-07-01
EP0621270B1 (de) 2000-04-12
ATE191713T1 (de) 2000-04-15
HUT67374A (en) 1995-03-28
JPH05194415A (ja) 1993-08-03
NO941698L (no) 1994-07-07
FI942094A0 (fi) 1994-05-06
RU2091373C1 (ru) 1997-09-27
CZ112694A3 (en) 1994-12-15
DK0621270T3 (da) 2000-07-17
JPH05194414A (ja) 1993-08-03
ES2145014T3 (es) 2000-07-01
KR100255203B1 (ko) 2000-05-01
DE69230916T2 (de) 2000-12-14
AU2799392A (en) 1993-06-07
EP0621270A4 (de) 1995-01-18
NO306507B1 (no) 1999-11-15
CA2123104A1 (en) 1993-05-13
GR3033368T3 (en) 2000-09-29
EP0621270A1 (de) 1994-10-26
AU661058B2 (en) 1995-07-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee