DE69533589D1 - Tetra-substituierte phenyl-derivate verwendbar als pde iv hemmer - Google Patents
Tetra-substituierte phenyl-derivate verwendbar als pde iv hemmerInfo
- Publication number
- DE69533589D1 DE69533589D1 DE69533589T DE69533589T DE69533589D1 DE 69533589 D1 DE69533589 D1 DE 69533589D1 DE 69533589 T DE69533589 T DE 69533589T DE 69533589 T DE69533589 T DE 69533589T DE 69533589 D1 DE69533589 D1 DE 69533589D1
- Authority
- DE
- Germany
- Prior art keywords
- pde
- tetra
- inhibitors
- substituted phenyl
- derivatives used
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9412571 | 1994-06-22 | ||
GB9412571A GB9412571D0 (en) | 1994-06-22 | 1994-06-22 | Chemical compounds |
PCT/GB1995/001467 WO1995035285A1 (en) | 1994-06-22 | 1995-06-22 | Tetra-substituted phenyl derivatives useful as pde iv inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69533589D1 true DE69533589D1 (de) | 2004-11-04 |
DE69533589T2 DE69533589T2 (de) | 2005-02-10 |
Family
ID=10757176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69533589T Expired - Fee Related DE69533589T2 (de) | 1994-06-22 | 1995-06-22 | Tetra-substituierte phenyl-derivate verwendbar als pde iv hemmer |
Country Status (6)
Country | Link |
---|---|
US (3) | US5780478A (de) |
EP (1) | EP0766671B1 (de) |
AU (1) | AU2746895A (de) |
DE (1) | DE69533589T2 (de) |
GB (1) | GB9412571D0 (de) |
WO (1) | WO1995035285A1 (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9304919D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
US6245774B1 (en) | 1994-06-21 | 2001-06-12 | Celltech Therapeutics Limited | Tri-substituted phenyl or pyridine derivatives |
US5786354A (en) * | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
GB9412571D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
GB9412573D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
GB9622363D0 (en) | 1996-10-28 | 1997-01-08 | Celltech Therapeutics Ltd | Chemical compounds |
AU5330698A (en) | 1996-12-23 | 1998-07-17 | Celltech Therapeutics Limited | Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors |
WO1998030718A1 (en) * | 1997-01-09 | 1998-07-16 | Merck Frosst Canada Co. | System for stably expressing a high-affinity camp phosphodiesterase and use thereof |
US5922557A (en) * | 1997-01-09 | 1999-07-13 | Merck & Co., Inc. | System for stably expressing a high-affinity camp phosphodiesterase and use thereof |
GB9705361D0 (en) | 1997-03-14 | 1997-04-30 | Celltech Therapeutics Ltd | Chemical compounds |
GB9713087D0 (en) * | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
DE19728301A1 (de) * | 1997-07-03 | 1999-01-07 | Dresden Arzneimittel | Verwendung von Inhibitoren der Phosphodiesterase 4 für die Behandlung der allergischen Rhinitis |
US20040220103A1 (en) | 1999-04-19 | 2004-11-04 | Immunex Corporation | Soluble tumor necrosis factor receptor treatment of medical disorders |
GB9914258D0 (en) * | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
EP2289549A3 (de) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunokonjugate für Krebsbehandlung |
GB9924862D0 (en) * | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
US6410563B1 (en) | 1999-12-22 | 2002-06-25 | Merck Frosst Canada & Co. | Substituted 8-arylquinoline phosphodiesterase-4 inhibitors |
MY123585A (en) | 2000-03-23 | 2006-05-31 | Merck Canada Inc | Tri-aryl-substituted-ethane pde4 inhibitors. |
US6639077B2 (en) | 2000-03-23 | 2003-10-28 | Merck Frosst Canada & Co. | Tri-aryl-substituted-ethane PDE4 inhibitors |
AU2001261962B2 (en) | 2000-05-25 | 2005-04-21 | Merck Frosst Canada Ltd | Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor |
US6740666B2 (en) | 2000-12-20 | 2004-05-25 | Merck & Co., Inc. | Substituted 8-arylquinoline phosphodiesterase-4 inhibitors |
US6699890B2 (en) | 2000-12-22 | 2004-03-02 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
US7205320B2 (en) * | 2001-01-22 | 2007-04-17 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
US7153871B2 (en) * | 2001-01-22 | 2006-12-26 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs |
ES2320204T3 (es) * | 2001-05-29 | 2009-05-20 | Bayer Schering Pharma Aktiengesellschaft | Pirimidinas inhibidoras de cdk, su preparacion y su utilizacion como medicamentos. |
JO2311B1 (en) | 2001-08-29 | 2005-09-12 | ميرك فروست كندا ليمتد | Alkyl inhibitors Ariel phosphodiesterase-4 |
DE60325984D1 (de) * | 2002-07-19 | 2009-03-12 | Memory Pharmaceutical Corp | 4-aminobenzofuranverbindungen als phosphodiesterase-4-inhibitoren |
CA2492907A1 (en) | 2002-07-19 | 2004-01-29 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs |
EP1569908B1 (de) | 2002-11-19 | 2010-09-15 | Memory Pharmaceuticals Corporation | Pyridin-n-oxidverbindungen alsphosphodiesterase-4-inhibitoren |
MY141255A (en) * | 2003-12-11 | 2010-03-31 | Memory Pharm Corp | Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs |
WO2007025177A2 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP2258358A3 (de) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
EP1940389A2 (de) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation von neurogenese durch pde-hemmung |
JP2009513672A (ja) | 2005-10-31 | 2009-04-02 | ブレインセルス,インコーポレイティド | 神経発生のgaba受容体媒介調節 |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2377531A2 (de) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenese mittels Angiotensin-Modulation |
CA2651862A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
WO2008030651A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
US20100029689A1 (en) * | 2008-07-02 | 2010-02-04 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
AR091507A1 (es) | 2012-06-21 | 2015-02-11 | Intra Cellular Therapies Inc | SALES DE (6aR,9aS)-5,6a,7,8,9,9a-HEXAHIDRO-5-METIL-3-(FENILAMINO)-2-((4-(6-FLUOROPIRIDIN-2-IL)FENIL)METIL)-CICLOPENT[4,5]IMIDAZO[1,2-a]PIRAZOLO[4,3-e]PIRIMIDIN-4(2H)-ONA |
RU2675851C2 (ru) * | 2013-06-21 | 2018-12-25 | Интра-Селлулар Терапиз, Инк. | Кристаллические формы свободного основания |
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GB9412571D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
GB9412672D0 (en) | 1994-06-23 | 1994-08-10 | Celltech Ltd | Chemical compounds |
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GB9526245D0 (en) | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
GB9526246D0 (en) | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
GB9608435D0 (en) | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
GB9619284D0 (en) | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
GB9625184D0 (en) | 1996-12-04 | 1997-01-22 | Celltech Therapeutics Ltd | Chemical compounds |
-
1994
- 1994-06-22 GB GB9412571A patent/GB9412571D0/en active Pending
-
1995
- 1995-06-21 US US08/493,264 patent/US5780478A/en not_active Expired - Fee Related
- 1995-06-22 WO PCT/GB1995/001467 patent/WO1995035285A1/en active IP Right Grant
- 1995-06-22 EP EP95922641A patent/EP0766671B1/de not_active Expired - Lifetime
- 1995-06-22 DE DE69533589T patent/DE69533589T2/de not_active Expired - Fee Related
- 1995-06-22 AU AU27468/95A patent/AU2746895A/en not_active Abandoned
-
1998
- 1998-03-26 US US09/048,608 patent/US6197792B1/en not_active Expired - Fee Related
-
2001
- 2001-03-05 US US09/800,023 patent/US20010034450A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
GB9412571D0 (en) | 1994-08-10 |
DE69533589T2 (de) | 2005-02-10 |
EP0766671B1 (de) | 2004-09-29 |
US6197792B1 (en) | 2001-03-06 |
EP0766671A1 (de) | 1997-04-09 |
AU2746895A (en) | 1996-01-15 |
US5780478A (en) | 1998-07-14 |
WO1995035285A1 (en) | 1995-12-28 |
US20010034450A1 (en) | 2001-10-25 |
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