DE69711020D1 - Thiazole derivate als protein kinase c inhibitoren - Google Patents
Thiazole derivate als protein kinase c inhibitorenInfo
- Publication number
- DE69711020D1 DE69711020D1 DE69711020T DE69711020T DE69711020D1 DE 69711020 D1 DE69711020 D1 DE 69711020D1 DE 69711020 T DE69711020 T DE 69711020T DE 69711020 T DE69711020 T DE 69711020T DE 69711020 D1 DE69711020 D1 DE 69711020D1
- Authority
- DE
- Germany
- Prior art keywords
- inhibitors
- protein kinase
- thiazole derivatives
- thiazole
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20089896 | 1996-07-31 | ||
PCT/JP1997/002609 WO1998004536A1 (en) | 1996-07-31 | 1997-07-29 | Thiazole derivative as protein kinase c inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69711020D1 true DE69711020D1 (de) | 2002-04-18 |
DE69711020T2 DE69711020T2 (de) | 2002-11-21 |
Family
ID=16432095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69711020T Expired - Fee Related DE69711020T2 (de) | 1996-07-31 | 1997-07-29 | Thiazole derivate als protein kinase c inhibitoren |
Country Status (17)
Country | Link |
---|---|
US (1) | US6140330A (de) |
EP (1) | EP0858452B1 (de) |
KR (1) | KR19990063910A (de) |
CN (1) | CN1070856C (de) |
AR (1) | AR008111A1 (de) |
AT (1) | ATE214381T1 (de) |
AU (1) | AU695817B2 (de) |
BR (1) | BR9706792A (de) |
CA (1) | CA2233611A1 (de) |
DE (1) | DE69711020T2 (de) |
DK (1) | DK0858452T3 (de) |
ES (1) | ES2179355T3 (de) |
HK (1) | HK1016586A1 (de) |
ID (1) | ID19474A (de) |
PT (1) | PT858452E (de) |
TW (1) | TW513418B (de) |
WO (1) | WO1998004536A1 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5849769A (en) * | 1994-08-24 | 1998-12-15 | Medivir Ab | N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection |
IL135574A0 (en) | 1997-10-27 | 2001-05-20 | Agouron Pharma | Substituted 4-amino-thiazol-2-yl compounds as cdk inhibitors |
IL135176A0 (en) | 1997-11-10 | 2001-05-20 | Bristol Myers Squibb Co | Benzothiazole derivatives and pharmaceutical compositions containing the same |
CA2330558A1 (en) * | 1998-05-12 | 1999-11-18 | Wyeth | (2-acylaminothiazole-4-yl)acetic acid derivatives |
JP2002518380A (ja) * | 1998-06-18 | 2002-06-25 | ブリストル−マイヤーズ スクイブ カンパニー | サイクリン依存キナーゼの炭素置換アミノチアゾール抑制剤 |
US6407124B1 (en) | 1998-06-18 | 2002-06-18 | Bristol-Myers Squibb Company | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases |
GB9823871D0 (en) | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
US6114365A (en) * | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
TWI284639B (en) * | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
AU2001230026A1 (en) * | 2000-02-04 | 2001-08-14 | Novo-Nordisk A/S | 2,4-diaminothiazole derivatives |
MXPA02007632A (es) * | 2000-02-07 | 2004-08-23 | Abbott Gmbh & Co Kg | Derivados de 2-benzotiazolil urea y su uso como inhibidores de proteina cinasa. |
EP1721609A3 (de) * | 2001-05-16 | 2007-01-31 | GPC Biotech AG | Pyridylpyrimidinderivate als effektive Verbindungen gegen Prioninfektionen und prion Erkrankungen |
HN2002000156A (es) | 2001-07-06 | 2003-11-27 | Inc Agouron Pharmaceuticals | Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización. |
EP1724270A3 (de) | 2001-07-19 | 2007-01-03 | Pfizer Italia S.r.l. | Phenylacetamido-thiazole Verbindungen, Verfahren zu ihren Herstellung und ihre Anwendung als antitumor Mittel |
MXPA04007213A (es) * | 2002-01-25 | 2005-02-25 | Pharmacia Corp | Terapia de bloqueo de la aldosterona para prevenir o tratar trastornos relacionados con la inflamacion. |
US7101898B2 (en) * | 2002-02-01 | 2006-09-05 | Novo Nordisk A/S | Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes |
CN103130739B (zh) * | 2003-08-12 | 2015-09-16 | 盐野义制药株式会社 | 具有血小板生成素受体激动作用的化合物 |
WO2006032273A1 (en) * | 2004-09-22 | 2006-03-30 | H. Lundbeck A/S | 2-acylaminothiazole derivatives |
US7674912B2 (en) * | 2005-04-25 | 2010-03-09 | H. Lundbeck A/S | Pro-drugs of N-thiazol-2-yl-benzamide derivatives |
BRPI0714463A2 (pt) * | 2006-07-19 | 2013-04-02 | Astrazeneca Ab | compostos de espiropiperidina tricÍclicos, sua sÍntese e seus usos como moduladores de atividade receptora de quimiocina |
WO2009011653A1 (en) * | 2007-07-17 | 2009-01-22 | Astrazeneca Ab | A process for the preparation of intermediates and their us in the synthesis of spiropiperidine compounds |
WO2009120826A1 (en) * | 2008-03-27 | 2009-10-01 | Wyeth | 2-aryl- and 2-heteroarylthiazolyl compounds, methods for their preparation and use thereof |
EP2470539A1 (de) * | 2009-08-28 | 2012-07-04 | Array Biopharma, Inc. | Raf-hemmende verbindungen und anwendungsverfahren dafür |
PL2588475T3 (pl) * | 2010-07-02 | 2015-10-30 | Gilead Sciences Inc | Inhibitory kinazy regulującej sygnał apoptozy |
WO2012104857A1 (en) * | 2011-02-04 | 2012-08-09 | Council Of Scientific & Industrial Research | Amidobenzothiazoles and process for the preparation thereof |
ES2489297B1 (es) * | 2013-01-22 | 2015-06-10 | Consejo Superior De Investigaciones Científicas (Csic) | Benzotiazoles sustituidos y sus aplicaciones terapeuticas para el tratamiento de enfermedades humanas |
GB201401886D0 (en) | 2014-02-04 | 2014-03-19 | Lytix Biopharma As | Neurodegenerative therapies |
CN110317230B (zh) * | 2018-03-30 | 2023-11-07 | 上海昇悦医药科技有限公司 | 磷酸盐类衍生物及其用途 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1982001517A1 (en) * | 1980-11-04 | 1982-05-13 | Martin C Anderson | Basic color media set for providing tonally matched palettes |
US4957932A (en) * | 1987-11-25 | 1990-09-18 | Merck Frosst Canada, Inc. | Benzoheterazoles |
IL90337A0 (en) * | 1988-05-24 | 1989-12-15 | Pfizer | Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents |
JP2869561B2 (ja) * | 1989-05-22 | 1999-03-10 | 大塚製薬株式会社 | 血小板粘着抑制剤 |
TW205041B (de) * | 1989-08-07 | 1993-05-01 | Fujisawa Pharmaceutical Co | |
CA2132724A1 (en) * | 1992-04-10 | 1993-10-28 | Robert Zamboni | Thiazole-substituted benzyl alcohols as leukotriene antagonists |
WO1993021169A1 (en) * | 1992-04-10 | 1993-10-28 | Merck Frosst Canada Inc. | Benzothiazole-substituted benzyl alcohols as leukotriene antagonists |
WO1994019336A1 (en) * | 1993-02-19 | 1994-09-01 | Asahi Kasei Kogyo Kabushiki Kaisha | Benzothiazolesulfonamide derivative, process for producing the same, and use thereof |
-
1997
- 1997-07-28 TW TW086110703A patent/TW513418B/zh not_active IP Right Cessation
- 1997-07-29 CA CA002233611A patent/CA2233611A1/en not_active Abandoned
- 1997-07-29 BR BR9706792-0A patent/BR9706792A/pt not_active Application Discontinuation
- 1997-07-29 US US09/043,642 patent/US6140330A/en not_active Expired - Fee Related
- 1997-07-29 AU AU36354/97A patent/AU695817B2/en not_active Ceased
- 1997-07-29 DK DK97933046T patent/DK0858452T3/da active
- 1997-07-29 AT AT97933046T patent/ATE214381T1/de not_active IP Right Cessation
- 1997-07-29 EP EP97933046A patent/EP0858452B1/de not_active Expired - Lifetime
- 1997-07-29 CN CN97190997A patent/CN1070856C/zh not_active Expired - Fee Related
- 1997-07-29 PT PT97933046T patent/PT858452E/pt unknown
- 1997-07-29 KR KR1019980702383A patent/KR19990063910A/ko not_active Application Discontinuation
- 1997-07-29 WO PCT/JP1997/002609 patent/WO1998004536A1/en not_active Application Discontinuation
- 1997-07-29 DE DE69711020T patent/DE69711020T2/de not_active Expired - Fee Related
- 1997-07-29 ES ES97933046T patent/ES2179355T3/es not_active Expired - Lifetime
- 1997-07-30 AR ARP970103439A patent/AR008111A1/es not_active Application Discontinuation
- 1997-07-31 ID IDP972653A patent/ID19474A/id unknown
-
1999
- 1999-04-12 HK HK99101470A patent/HK1016586A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN1070856C (zh) | 2001-09-12 |
ATE214381T1 (de) | 2002-03-15 |
AU3635497A (en) | 1998-02-20 |
DE69711020T2 (de) | 2002-11-21 |
ID19474A (id) | 1998-07-16 |
KR19990063910A (ko) | 1999-07-26 |
US6140330A (en) | 2000-10-31 |
BR9706792A (pt) | 2001-11-27 |
EP0858452B1 (de) | 2002-03-13 |
CN1198160A (zh) | 1998-11-04 |
PT858452E (pt) | 2002-07-31 |
ES2179355T3 (es) | 2003-01-16 |
EP0858452A1 (de) | 1998-08-19 |
CA2233611A1 (en) | 1998-02-05 |
HK1016586A1 (en) | 1999-11-05 |
DK0858452T3 (da) | 2002-05-21 |
TW513418B (en) | 2002-12-11 |
AU695817B2 (en) | 1998-08-20 |
AR008111A1 (es) | 1999-12-09 |
WO1998004536A1 (en) | 1998-02-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69711020T2 (de) | Thiazole derivate als protein kinase c inhibitoren | |
ATE430149T1 (de) | Heterocyclen substituierte imidazopyrazine als protein- tyrosin-kinase-inhibitoren | |
LTPA2014028I1 (lt) | Pakeistieji 3-cianochinolinai kaip proteintirozinkinazės inhibitoriai | |
DE69627179D1 (de) | Substituierte 2-anilino-pyrimidines verwendbar als protein kinase inhibitoren | |
ATE315394T1 (de) | Benzothiazole als protein tyrosin-kinase inhibitoren | |
ATE251612T1 (de) | 6-phenylpyridyl-2-amin-derivate verwendbar als nos-inhibitoren | |
ATE255575T1 (de) | Substituierte 3-cyanochinoline als protein tyrosine kinase inhibitoren | |
CY2008015I2 (el) | Δικυκλικες ετepοαρωματικες ενωσεις σαν αναστολεις πρωτεϊνης κινασης τυροσινης | |
DK0912559T3 (da) | Kondenserede heterocykliske forbindelser som proteintyrosinkinaseinhibitorer | |
DE69716615D1 (de) | Heterozyklische metalloproteaseinhibitoren | |
DE69706292T2 (de) | Chinazoline derivate | |
DE69720522T2 (de) | Substituierte stickstoff enthaltende heterocyclen als p38 protein kinase inhibitoren | |
NO974453D0 (no) | Proteinkinase C-hemmere | |
DE69511253D1 (de) | Wasserlösliche 3-arylidene-2-oxindole derivate als tyrosine kinase inhibitoren | |
DE69906311D1 (de) | Diarylbenzopyranderivate als cyclooxygenase-2-inhibitoren | |
DE69706823T2 (de) | Bicyclische 4-aralkylaminopyrimidin-derivate als tyrosinkinase-inhibitoren | |
DE69811844D1 (de) | Thiazole Derivate | |
DE69730962D1 (de) | Alkylaminobenzothiazole und -benzoxazole derivate | |
ATE387448T1 (de) | 4,5-pyrazinoxindole als proteinkinasehemmer | |
DE69814894T2 (de) | Isochinolin derivate als urokinase inhibitoren | |
ATE273307T1 (de) | Benzo(5,6)cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren | |
DE69917058D1 (de) | Thiazole derivate | |
DE69805974D1 (de) | 5-aroylnaphthalin derivate | |
ATE372989T1 (de) | Azolinderivate | |
DE69838303D1 (de) | Hydroxyprolin derivate |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |