AR008111A1 - Compuesto de tiazol, inhibidor de proteina quinasa c que lo comprende y procedimiento para preparar dicho compuesto. - Google Patents

Compuesto de tiazol, inhibidor de proteina quinasa c que lo comprende y procedimiento para preparar dicho compuesto.

Info

Publication number
AR008111A1
AR008111A1 ARP970103439A ARP970103439A AR008111A1 AR 008111 A1 AR008111 A1 AR 008111A1 AR P970103439 A ARP970103439 A AR P970103439A AR P970103439 A ARP970103439 A AR P970103439A AR 008111 A1 AR008111 A1 AR 008111A1
Authority
AR
Argentina
Prior art keywords
compound
protein kinase
inhibitor
preparing
tiazole
Prior art date
Application number
ARP970103439A
Other languages
English (en)
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of AR008111A1 publication Critical patent/AR008111A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de tiazol de la formula I, en donde T es alquileno inferior; u es 0 o 1; R1 y R2 son iguales o diferentes y cada uno de los mismos es un H,o un alquilo inferior, etc; R3 es II o III; R4 es H o alcanoiloxi-alquilo inferior, quepr esenta actividad inhibidora sobre la proteina quinasa C(PKC, Ca2+/serina dependiente de fosfolípido/fosfatasa proteína treonina), y son útiles como un inhibidor de proteína quinasa C. Inhibidor de proteínaquinasa C que lo comprende yprocedimiento para preparar dicho compuesto.
ARP970103439A 1996-07-31 1997-07-30 Compuesto de tiazol, inhibidor de proteina quinasa c que lo comprende y procedimiento para preparar dicho compuesto. AR008111A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20089896 1996-07-31

Publications (1)

Publication Number Publication Date
AR008111A1 true AR008111A1 (es) 1999-12-09

Family

ID=16432095

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970103439A AR008111A1 (es) 1996-07-31 1997-07-30 Compuesto de tiazol, inhibidor de proteina quinasa c que lo comprende y procedimiento para preparar dicho compuesto.

Country Status (17)

Country Link
US (1) US6140330A (es)
EP (1) EP0858452B1 (es)
KR (1) KR19990063910A (es)
CN (1) CN1070856C (es)
AR (1) AR008111A1 (es)
AT (1) ATE214381T1 (es)
AU (1) AU695817B2 (es)
BR (1) BR9706792A (es)
CA (1) CA2233611A1 (es)
DE (1) DE69711020T2 (es)
DK (1) DK0858452T3 (es)
ES (1) ES2179355T3 (es)
HK (1) HK1016586A1 (es)
ID (1) ID19474A (es)
PT (1) PT858452E (es)
TW (1) TW513418B (es)
WO (1) WO1998004536A1 (es)

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US5849769A (en) * 1994-08-24 1998-12-15 Medivir Ab N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection
GEP20032896B (en) 1997-10-27 2003-02-25 Agouron Pharma 4-Aminothiazole Derivatives, Containing Them Pharmaceutical Compositions Inhibiting Cyclin-Dependent Kinases and Methods for Treatment
BR9814956A (pt) 1997-11-10 2000-10-03 Bristol Myers Squibb Co Inibidores de benzotiazol da tirosina cinase de proteìna
JP2002514633A (ja) * 1998-05-12 2002-05-21 アメリカン・ホーム・プロダクツ・コーポレイション （２−アシルアミノチアゾール−４−イル）酢酸誘導体
US6407124B1 (en) 1998-06-18 2002-06-18 Bristol-Myers Squibb Company Carbon substituted aminothiazole inhibitors of cyclin dependent kinases
ES2237919T4 (es) * 1998-06-18 2007-05-01 Bristol-Myers Squibb Company Inhibidores aminotiazol sustituidos con carbono de quinasas dependientes de ciclina.
GB9823871D0 (en) 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
US6114365A (en) 1999-08-12 2000-09-05 Pharmacia & Upjohn S.P.A. Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
TWI284639B (en) * 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
WO2001056567A1 (en) * 2000-02-04 2001-08-09 Novo Nordisk A/S 2,4-diaminothiazole derivatives and their use as glycogen synthase kinase-3 (gsk-3) inhibitors
AU2001236698A1 (en) * 2000-02-07 2001-08-14 Abbott Gesellschaft Mit Beschrankter Haftung & Company Kommanditgesellschaft 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors
US20030176443A1 (en) * 2001-05-16 2003-09-18 Matthias Stein-Gerlach Pyridylpyrimidine derivatives as effective compounds against prion diseases
HN2002000156A (es) 2001-07-06 2003-11-27 Inc Agouron Pharmaceuticals Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización.
EP1724270A3 (en) 2001-07-19 2007-01-03 Pfizer Italia S.r.l. Phenylacetamido-thiazole derivatives, process for their preparation and their use as antitumor agents
AU2002368473A1 (en) * 2002-01-25 2004-09-09 Pharmacia Corporation Aldosterone blocker therapy to prevent or treat inflammation-related disorders
US7101898B2 (en) * 2002-02-01 2006-09-05 Novo Nordisk A/S Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
CN102796058B (zh) * 2003-08-12 2015-05-13 盐野义制药株式会社 具有血小板生成素受体激动作用的化合物
US7910613B2 (en) * 2004-09-22 2011-03-22 H. Lundbeck A/S 2-acylaminothiazole derivatives
US7674912B2 (en) * 2005-04-25 2010-03-09 H. Lundbeck A/S Pro-drugs of N-thiazol-2-yl-benzamide derivatives
CN101553493B (zh) * 2006-07-19 2012-07-04 阿斯利康(瑞典)有限公司 三环螺哌啶化合物、它们的合成和它们作为趋化因子受体活性调节剂的用途
WO2009011654A1 (en) * 2007-07-17 2009-01-22 Astrazeneca Ab Process for the preparation of cyclic spiropiperidines
WO2009120826A1 (en) * 2008-03-27 2009-10-01 Wyeth 2-aryl- and 2-heteroarylthiazolyl compounds, methods for their preparation and use thereof
EP2470539A1 (en) * 2009-08-28 2012-07-04 Array Biopharma, Inc. Raf inhibitor compounds and methods of use thereof
EA023040B1 (ru) * 2010-07-02 2016-04-29 Джилид Сайэнс, Инк. Ингибиторы киназ, регулирующих апоптозный сигнал
EP2670740B1 (en) * 2011-02-04 2015-12-30 Council of Scientific and Industrial Research Amidobenzothiazoles and process for the preparation thereof
ES2489297B1 (es) * 2013-01-22 2015-06-10 Consejo Superior De Investigaciones Científicas (Csic) Benzotiazoles sustituidos y sus aplicaciones terapeuticas para el tratamiento de enfermedades humanas
GB201401886D0 (en) 2014-02-04 2014-03-19 Lytix Biopharma As Neurodegenerative therapies
CN110317230B (zh) * 2018-03-30 2023-11-07 上海昇悦医药科技有限公司 磷酸盐类衍生物及其用途

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EP0063564A1 (en) * 1980-11-04 1982-11-03 ANDERSON, Martin C. Basic color media set for providing tonally matched palettes
US4957932A (en) * 1987-11-25 1990-09-18 Merck Frosst Canada, Inc. Benzoheterazoles
IL90337A0 (en) * 1988-05-24 1989-12-15 Pfizer Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents
JP2869561B2 (ja) * 1989-05-22 1999-03-10 大塚製薬株式会社 血小板粘着抑制剤
TW205041B (es) * 1989-08-07 1993-05-01 Fujisawa Pharmaceutical Co
AU3884993A (en) * 1992-04-10 1993-11-18 Merck Frosst Canada Inc. Benzothiazole-substituted benzyl alcohols as leukotriene antagonists
WO1993021168A1 (en) * 1992-04-10 1993-10-28 Merck Frosst Canada Inc. Thiazole-substituted benzyl alcohols as leukotriene antagonists
KR0134069B1 (ko) * 1993-02-19 1998-04-22 유미꾸라 레이이찌 벤조티아졸 술폰아미드 유도체, 그의 제조법 및 그의 용도

Also Published As

Publication number Publication date
ID19474A (id) 1998-07-16
HK1016586A1 (en) 1999-11-05
DE69711020D1 (de) 2002-04-18
PT858452E (pt) 2002-07-31
BR9706792A (pt) 2001-11-27
CN1198160A (zh) 1998-11-04
KR19990063910A (ko) 1999-07-26
CN1070856C (zh) 2001-09-12
WO1998004536A1 (en) 1998-02-05
TW513418B (en) 2002-12-11
EP0858452B1 (en) 2002-03-13
ES2179355T3 (es) 2003-01-16
US6140330A (en) 2000-10-31
DE69711020T2 (de) 2002-11-21
AU3635497A (en) 1998-02-20
CA2233611A1 (en) 1998-02-05
ATE214381T1 (de) 2002-03-15
EP0858452A1 (en) 1998-08-19
AU695817B2 (en) 1998-08-20
DK0858452T3 (da) 2002-05-21

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