BR9706792A - Derivado de tiazol - Google Patents

Derivado de tiazol

Info

Publication number
BR9706792A
BR9706792A BR9706792-0A BR9706792A BR9706792A BR 9706792 A BR9706792 A BR 9706792A BR 9706792 A BR9706792 A BR 9706792A BR 9706792 A BR9706792 A BR 9706792A
Authority
BR
Brazil
Prior art keywords
threonine
thiazole derivative
protein kinase
lower alkyl
protein
Prior art date
Application number
BR9706792-0A
Other languages
English (en)
Inventor
Toyoki Mori
Michiaki Tominaga
Fujio Tabusa
Kazuyoshi Nagami
Aoru Abe
Kenji Nakaya
Isao Takemura
Tomoichi Shinohara
Oshihisa Tanada
Takahito Yamauchi
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of BR9706792A publication Critical patent/BR9706792A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: "DERIVADO DE TIAZOL". Um composto detiazol da fórmula: em que T é alquileno inferior; u é 0 ou 1; R^ 1^ eR^ 2^ são os mesmos ou diferentes e são cada um H, ou alquilainferior, etc.; R^ 3^ é R^ 4^ é H ou alcanoilóxi inferior-alquilainferior, que mostra atividade inibitória sobre quinase C de proteína(PKC, fosfatase de proteína de treonina/serina dependentefosfolípidio/Ca^ 2+^) e é útil como um inibidor de quinase C deproteína.
BR9706792-0A 1996-07-31 1997-07-29 Derivado de tiazol BR9706792A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20089896 1996-07-31
PCT/JP1997/002609 WO1998004536A1 (en) 1996-07-31 1997-07-29 Thiazole derivative as protein kinase c inhibitors

Publications (1)

Publication Number Publication Date
BR9706792A true BR9706792A (pt) 2001-11-27

Family

ID=16432095

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9706792-0A BR9706792A (pt) 1996-07-31 1997-07-29 Derivado de tiazol

Country Status (17)

Country Link
US (1) US6140330A (pt)
EP (1) EP0858452B1 (pt)
KR (1) KR19990063910A (pt)
CN (1) CN1070856C (pt)
AR (1) AR008111A1 (pt)
AT (1) ATE214381T1 (pt)
AU (1) AU695817B2 (pt)
BR (1) BR9706792A (pt)
CA (1) CA2233611A1 (pt)
DE (1) DE69711020T2 (pt)
DK (1) DK0858452T3 (pt)
ES (1) ES2179355T3 (pt)
HK (1) HK1016586A1 (pt)
ID (1) ID19474A (pt)
PT (1) PT858452E (pt)
TW (1) TW513418B (pt)
WO (1) WO1998004536A1 (pt)

Families Citing this family (28)

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US5849769A (en) * 1994-08-24 1998-12-15 Medivir Ab N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection
IL135574A0 (en) 1997-10-27 2001-05-20 Agouron Pharma Substituted 4-amino-thiazol-2-yl compounds as cdk inhibitors
IL135176A0 (en) 1997-11-10 2001-05-20 Bristol Myers Squibb Co Benzothiazole derivatives and pharmaceutical compositions containing the same
CA2330558A1 (en) * 1998-05-12 1999-11-18 Wyeth (2-acylaminothiazole-4-yl)acetic acid derivatives
JP2002518380A (ja) * 1998-06-18 2002-06-25 ブリストル−マイヤーズ スクイブ カンパニー サイクリン依存キナーゼの炭素置換アミノチアゾール抑制剤
US6407124B1 (en) 1998-06-18 2002-06-18 Bristol-Myers Squibb Company Carbon substituted aminothiazole inhibitors of cyclin dependent kinases
GB9823871D0 (en) 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
US6114365A (en) * 1999-08-12 2000-09-05 Pharmacia & Upjohn S.P.A. Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
TWI284639B (en) * 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
AU2001230026A1 (en) * 2000-02-04 2001-08-14 Novo-Nordisk A/S 2,4-diaminothiazole derivatives
MXPA02007632A (es) * 2000-02-07 2004-08-23 Abbott Gmbh & Co Kg Derivados de 2-benzotiazolil urea y su uso como inhibidores de proteina cinasa.
EP1721609A3 (en) * 2001-05-16 2007-01-31 GPC Biotech AG Pyridylpyrimidine derivatives as effective compounds against prion diseases
HN2002000156A (es) 2001-07-06 2003-11-27 Inc Agouron Pharmaceuticals Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización.
EP1724270A3 (en) 2001-07-19 2007-01-03 Pfizer Italia S.r.l. Phenylacetamido-thiazole derivatives, process for their preparation and their use as antitumor agents
MXPA04007213A (es) * 2002-01-25 2005-02-25 Pharmacia Corp Terapia de bloqueo de la aldosterona para prevenir o tratar trastornos relacionados con la inflamacion.
US7101898B2 (en) * 2002-02-01 2006-09-05 Novo Nordisk A/S Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
CN103130739B (zh) * 2003-08-12 2015-09-16 盐野义制药株式会社 具有血小板生成素受体激动作用的化合物
WO2006032273A1 (en) * 2004-09-22 2006-03-30 H. Lundbeck A/S 2-acylaminothiazole derivatives
US7674912B2 (en) * 2005-04-25 2010-03-09 H. Lundbeck A/S Pro-drugs of N-thiazol-2-yl-benzamide derivatives
BRPI0714463A2 (pt) * 2006-07-19 2013-04-02 Astrazeneca Ab compostos de espiropiperidina tricÍclicos, sua sÍntese e seus usos como moduladores de atividade receptora de quimiocina
WO2009011653A1 (en) * 2007-07-17 2009-01-22 Astrazeneca Ab A process for the preparation of intermediates and their us in the synthesis of spiropiperidine compounds
WO2009120826A1 (en) * 2008-03-27 2009-10-01 Wyeth 2-aryl- and 2-heteroarylthiazolyl compounds, methods for their preparation and use thereof
EP2470539A1 (en) * 2009-08-28 2012-07-04 Array Biopharma, Inc. Raf inhibitor compounds and methods of use thereof
PL2588475T3 (pl) * 2010-07-02 2015-10-30 Gilead Sciences Inc Inhibitory kinazy regulującej sygnał apoptozy
WO2012104857A1 (en) * 2011-02-04 2012-08-09 Council Of Scientific & Industrial Research Amidobenzothiazoles and process for the preparation thereof
ES2489297B1 (es) * 2013-01-22 2015-06-10 Consejo Superior De Investigaciones Científicas (Csic) Benzotiazoles sustituidos y sus aplicaciones terapeuticas para el tratamiento de enfermedades humanas
GB201401886D0 (en) 2014-02-04 2014-03-19 Lytix Biopharma As Neurodegenerative therapies
CN110317230B (zh) * 2018-03-30 2023-11-07 上海昇悦医药科技有限公司 磷酸盐类衍生物及其用途

Family Cites Families (8)

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WO1982001517A1 (en) * 1980-11-04 1982-05-13 Martin C Anderson Basic color media set for providing tonally matched palettes
US4957932A (en) * 1987-11-25 1990-09-18 Merck Frosst Canada, Inc. Benzoheterazoles
IL90337A0 (en) * 1988-05-24 1989-12-15 Pfizer Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents
JP2869561B2 (ja) * 1989-05-22 1999-03-10 大塚製薬株式会社 血小板粘着抑制剤
TW205041B (pt) * 1989-08-07 1993-05-01 Fujisawa Pharmaceutical Co
CA2132724A1 (en) * 1992-04-10 1993-10-28 Robert Zamboni Thiazole-substituted benzyl alcohols as leukotriene antagonists
WO1993021169A1 (en) * 1992-04-10 1993-10-28 Merck Frosst Canada Inc. Benzothiazole-substituted benzyl alcohols as leukotriene antagonists
WO1994019336A1 (en) * 1993-02-19 1994-09-01 Asahi Kasei Kogyo Kabushiki Kaisha Benzothiazolesulfonamide derivative, process for producing the same, and use thereof

Also Published As

Publication number Publication date
CN1070856C (zh) 2001-09-12
ATE214381T1 (de) 2002-03-15
AU3635497A (en) 1998-02-20
DE69711020T2 (de) 2002-11-21
ID19474A (id) 1998-07-16
KR19990063910A (ko) 1999-07-26
US6140330A (en) 2000-10-31
DE69711020D1 (de) 2002-04-18
EP0858452B1 (en) 2002-03-13
CN1198160A (zh) 1998-11-04
PT858452E (pt) 2002-07-31
ES2179355T3 (es) 2003-01-16
EP0858452A1 (en) 1998-08-19
CA2233611A1 (en) 1998-02-05
HK1016586A1 (en) 1999-11-05
DK0858452T3 (da) 2002-05-21
TW513418B (en) 2002-12-11
AU695817B2 (en) 1998-08-20
AR008111A1 (es) 1999-12-09
WO1998004536A1 (en) 1998-02-05

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements