ATE214381T1 - Thiazole derivate als protein kinase c inhibitoren - Google Patents
Thiazole derivate als protein kinase c inhibitorenInfo
- Publication number
- ATE214381T1 ATE214381T1 AT97933046T AT97933046T ATE214381T1 AT E214381 T1 ATE214381 T1 AT E214381T1 AT 97933046 T AT97933046 T AT 97933046T AT 97933046 T AT97933046 T AT 97933046T AT E214381 T1 ATE214381 T1 AT E214381T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- protein kinase
- thiazole derivatives
- thiazole
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20089896 | 1996-07-31 | ||
| PCT/JP1997/002609 WO1998004536A1 (en) | 1996-07-31 | 1997-07-29 | Thiazole derivative as protein kinase c inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE214381T1 true ATE214381T1 (de) | 2002-03-15 |
Family
ID=16432095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97933046T ATE214381T1 (de) | 1996-07-31 | 1997-07-29 | Thiazole derivate als protein kinase c inhibitoren |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6140330A (de) |
| EP (1) | EP0858452B1 (de) |
| KR (1) | KR19990063910A (de) |
| CN (1) | CN1070856C (de) |
| AR (1) | AR008111A1 (de) |
| AT (1) | ATE214381T1 (de) |
| AU (1) | AU695817B2 (de) |
| BR (1) | BR9706792A (de) |
| CA (1) | CA2233611A1 (de) |
| DE (1) | DE69711020T2 (de) |
| DK (1) | DK0858452T3 (de) |
| ES (1) | ES2179355T3 (de) |
| HK (1) | HK1016586A1 (de) |
| ID (1) | ID19474A (de) |
| PT (1) | PT858452E (de) |
| TW (1) | TW513418B (de) |
| WO (1) | WO1998004536A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849769A (en) * | 1994-08-24 | 1998-12-15 | Medivir Ab | N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection |
| SK5212000A3 (en) | 1997-10-27 | 2001-04-09 | Agouron Pharmaceuticals Inc Ag | 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases |
| HUP0102101A3 (en) | 1997-11-10 | 2002-11-28 | Bristol Myers Squibb Co | Protein tyrosine kinase inhibitor benzothiazole derivatives and pharmaceutical compositions containing them |
| CN1308619A (zh) * | 1998-05-12 | 2001-08-15 | 美国家用产品公司 | (2－酰氨基噻唑－4－基)乙酸衍生物 |
| EP1087951B9 (de) * | 1998-06-18 | 2006-09-13 | Bristol-Myers Squibb Company | Durch kohlenstoff substituierte aminothiazole als inhibitoren von zyclin-abhägigen kinasen |
| US6407124B1 (en) | 1998-06-18 | 2002-06-18 | Bristol-Myers Squibb Company | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases |
| GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
| US6114365A (en) | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
| TWI284639B (en) * | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
| AU2001230026A1 (en) * | 2000-02-04 | 2001-08-14 | Novo-Nordisk A/S | 2,4-diaminothiazole derivatives |
| CN1422262A (zh) | 2000-02-07 | 2003-06-04 | 艾博特股份有限两合公司 | 2－苯并噻唑基脲衍生物及其作为蛋白激酶抑制剂的应用 |
| DE60212836T2 (de) * | 2001-05-16 | 2007-01-25 | Gpc Biotech Ag | Pyridylpyrimidin-derivate als wirksame verbindungen gegen prionen-krankheiten |
| HN2002000156A (es) | 2001-07-06 | 2003-11-27 | Inc Agouron Pharmaceuticals | Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización. |
| EP1724270A3 (de) | 2001-07-19 | 2007-01-03 | Pfizer Italia S.r.l. | Phenylacetamido-thiazole Verbindungen, Verfahren zu ihren Herstellung und ihre Anwendung als antitumor Mittel |
| AU2002368473A1 (en) * | 2002-01-25 | 2004-09-09 | Pharmacia Corporation | Aldosterone blocker therapy to prevent or treat inflammation-related disorders |
| US7101898B2 (en) * | 2002-02-01 | 2006-09-05 | Novo Nordisk A/S | Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes |
| US7601746B2 (en) * | 2003-08-12 | 2009-10-13 | Shionogi & Co., Ltd. | Compounds exhibiting thrombopoietin receptor agonism |
| WO2006032273A1 (en) * | 2004-09-22 | 2006-03-30 | H. Lundbeck A/S | 2-acylaminothiazole derivatives |
| US7674912B2 (en) * | 2005-04-25 | 2010-03-09 | H. Lundbeck A/S | Pro-drugs of N-thiazol-2-yl-benzamide derivatives |
| MX2009000475A (es) * | 2006-07-19 | 2009-07-10 | Astrazeneca Ab | Nuevos compuestos de espiropiperidina triciclicos, su sintesis y sus usos como moduladores de la actividad de los receptores de quimioquinas. |
| WO2009011653A1 (en) * | 2007-07-17 | 2009-01-22 | Astrazeneca Ab | A process for the preparation of intermediates and their us in the synthesis of spiropiperidine compounds |
| WO2009120826A1 (en) * | 2008-03-27 | 2009-10-01 | Wyeth | 2-aryl- and 2-heteroarylthiazolyl compounds, methods for their preparation and use thereof |
| US20120157451A1 (en) * | 2009-08-28 | 2012-06-21 | Genentech, Inc | Raf inhibitor compounds and methods of use thereof |
| CN102985418B (zh) * | 2010-07-02 | 2015-09-09 | 吉利德科学股份有限公司 | 凋亡信号调节激酶抑制剂 |
| WO2012104857A1 (en) * | 2011-02-04 | 2012-08-09 | Council Of Scientific & Industrial Research | Amidobenzothiazoles and process for the preparation thereof |
| ES2489297B1 (es) * | 2013-01-22 | 2015-06-10 | Consejo Superior De Investigaciones Científicas (Csic) | Benzotiazoles sustituidos y sus aplicaciones terapeuticas para el tratamiento de enfermedades humanas |
| GB201401886D0 (en) | 2014-02-04 | 2014-03-19 | Lytix Biopharma As | Neurodegenerative therapies |
| CN110317230B (zh) * | 2018-03-30 | 2023-11-07 | 上海昇悦医药科技有限公司 | 磷酸盐类衍生物及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0063564A1 (de) * | 1980-11-04 | 1982-11-03 | ANDERSON, Martin C. | Grundfarbenmediasatz zur schaffung von tonlich angepassten paletten |
| US4957932A (en) * | 1987-11-25 | 1990-09-18 | Merck Frosst Canada, Inc. | Benzoheterazoles |
| IL90337A0 (en) * | 1988-05-24 | 1989-12-15 | Pfizer | Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents |
| JP2869561B2 (ja) * | 1989-05-22 | 1999-03-10 | 大塚製薬株式会社 | 血小板粘着抑制剤 |
| TW205041B (de) * | 1989-08-07 | 1993-05-01 | Fujisawa Pharmaceutical Co | |
| WO1993021169A1 (en) * | 1992-04-10 | 1993-10-28 | Merck Frosst Canada Inc. | Benzothiazole-substituted benzyl alcohols as leukotriene antagonists |
| CA2132724A1 (en) * | 1992-04-10 | 1993-10-28 | Robert Zamboni | Thiazole-substituted benzyl alcohols as leukotriene antagonists |
| ES2134928T3 (es) * | 1993-02-19 | 1999-10-16 | Asahi Chemical Ind | Derivado de benzotiazolsulfonamida, procedimiento de produccion y aplicacion del mismo. |
-
1997
- 1997-07-28 TW TW086110703A patent/TW513418B/zh not_active IP Right Cessation
- 1997-07-29 KR KR1019980702383A patent/KR19990063910A/ko not_active Application Discontinuation
- 1997-07-29 DK DK97933046T patent/DK0858452T3/da active
- 1997-07-29 WO PCT/JP1997/002609 patent/WO1998004536A1/en not_active Application Discontinuation
- 1997-07-29 DE DE69711020T patent/DE69711020T2/de not_active Expired - Fee Related
- 1997-07-29 AU AU36354/97A patent/AU695817B2/en not_active Ceased
- 1997-07-29 EP EP97933046A patent/EP0858452B1/de not_active Expired - Lifetime
- 1997-07-29 US US09/043,642 patent/US6140330A/en not_active Expired - Fee Related
- 1997-07-29 BR BR9706792-0A patent/BR9706792A/pt not_active Application Discontinuation
- 1997-07-29 AT AT97933046T patent/ATE214381T1/de not_active IP Right Cessation
- 1997-07-29 PT PT97933046T patent/PT858452E/pt unknown
- 1997-07-29 ES ES97933046T patent/ES2179355T3/es not_active Expired - Lifetime
- 1997-07-29 CN CN97190997A patent/CN1070856C/zh not_active Expired - Fee Related
- 1997-07-29 CA CA002233611A patent/CA2233611A1/en not_active Abandoned
- 1997-07-30 AR ARP970103439A patent/AR008111A1/es not_active Application Discontinuation
- 1997-07-31 ID IDP972653A patent/ID19474A/id unknown
-
1999
- 1999-04-12 HK HK99101470A patent/HK1016586A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0858452A1 (de) | 1998-08-19 |
| KR19990063910A (ko) | 1999-07-26 |
| DE69711020T2 (de) | 2002-11-21 |
| DE69711020D1 (de) | 2002-04-18 |
| ID19474A (id) | 1998-07-16 |
| CN1070856C (zh) | 2001-09-12 |
| EP0858452B1 (de) | 2002-03-13 |
| CN1198160A (zh) | 1998-11-04 |
| CA2233611A1 (en) | 1998-02-05 |
| PT858452E (pt) | 2002-07-31 |
| TW513418B (en) | 2002-12-11 |
| DK0858452T3 (da) | 2002-05-21 |
| AU695817B2 (en) | 1998-08-20 |
| AR008111A1 (es) | 1999-12-09 |
| AU3635497A (en) | 1998-02-20 |
| HK1016586A1 (en) | 1999-11-05 |
| ES2179355T3 (es) | 2003-01-16 |
| US6140330A (en) | 2000-10-31 |
| WO1998004536A1 (en) | 1998-02-05 |
| BR9706792A (pt) | 2001-11-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |