ATE214381T1 - Thiazole derivate als protein kinase c inhibitoren - Google Patents
Thiazole derivate als protein kinase c inhibitorenInfo
- Publication number
- ATE214381T1 ATE214381T1 AT97933046T AT97933046T ATE214381T1 AT E214381 T1 ATE214381 T1 AT E214381T1 AT 97933046 T AT97933046 T AT 97933046T AT 97933046 T AT97933046 T AT 97933046T AT E214381 T1 ATE214381 T1 AT E214381T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- protein kinase
- thiazole derivatives
- thiazole
- derivatives
- Prior art date
Links
- 229940123924 Protein kinase C inhibitor Drugs 0.000 title 1
- 239000003881 protein kinase C inhibitor Substances 0.000 title 1
- 150000007979 thiazole derivatives Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20089896 | 1996-07-31 | ||
| PCT/JP1997/002609 WO1998004536A1 (en) | 1996-07-31 | 1997-07-29 | Thiazole derivative as protein kinase c inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE214381T1 true ATE214381T1 (de) | 2002-03-15 |
Family
ID=16432095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97933046T ATE214381T1 (de) | 1996-07-31 | 1997-07-29 | Thiazole derivate als protein kinase c inhibitoren |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6140330A (de) |
| EP (1) | EP0858452B1 (de) |
| KR (1) | KR19990063910A (de) |
| CN (1) | CN1070856C (de) |
| AR (1) | AR008111A1 (de) |
| AT (1) | ATE214381T1 (de) |
| AU (1) | AU695817B2 (de) |
| BR (1) | BR9706792A (de) |
| CA (1) | CA2233611A1 (de) |
| DE (1) | DE69711020T2 (de) |
| DK (1) | DK0858452T3 (de) |
| ES (1) | ES2179355T3 (de) |
| ID (1) | ID19474A (de) |
| PT (1) | PT858452E (de) |
| TW (1) | TW513418B (de) |
| WO (1) | WO1998004536A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849769A (en) * | 1994-08-24 | 1998-12-15 | Medivir Ab | N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection |
| US6569878B1 (en) | 1997-10-27 | 2003-05-27 | Agouron Pharmaceuticals Inc. | Substituted 4-amino-thiazol-2-yl compounds as cyclin-dependent kinase inhibitors |
| IL135176A0 (en) | 1997-11-10 | 2001-05-20 | Bristol Myers Squibb Co | Benzothiazole derivatives and pharmaceutical compositions containing the same |
| WO1999058514A1 (en) * | 1998-05-12 | 1999-11-18 | American Home Products Corporation | (2-acylaminothiazole-4-yl)acetic acid derivatives |
| US6407124B1 (en) | 1998-06-18 | 2002-06-18 | Bristol-Myers Squibb Company | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases |
| CA2332325A1 (en) * | 1998-06-18 | 1999-12-23 | Bristol-Myers Squibb Company | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases |
| GB9823871D0 (en) | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
| US6114365A (en) * | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
| TWI284639B (en) * | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
| WO2001056567A1 (en) * | 2000-02-04 | 2001-08-09 | Novo Nordisk A/S | 2,4-diaminothiazole derivatives and their use as glycogen synthase kinase-3 (gsk-3) inhibitors |
| JP2003521543A (ja) | 2000-02-07 | 2003-07-15 | アボット ゲーエムベーハー ウント カンパニー カーゲー | ２−ベンゾチアゾリル尿素誘導体およびそのプロテインキナーゼ阻害剤としての使用 |
| DE60212836T2 (de) * | 2001-05-16 | 2007-01-25 | Gpc Biotech Ag | Pyridylpyrimidin-derivate als wirksame verbindungen gegen prionen-krankheiten |
| HN2002000156A (es) | 2001-07-06 | 2003-11-27 | Inc Agouron Pharmaceuticals | Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización. |
| EP1724270A3 (de) | 2001-07-19 | 2007-01-03 | Pfizer Italia S.r.l. | Phenylacetamido-thiazole Verbindungen, Verfahren zu ihren Herstellung und ihre Anwendung als antitumor Mittel |
| EP1505983A2 (de) * | 2002-01-25 | 2005-02-16 | Pharmacia Corporation | Prävention und behandlung von durch entzündung bedingten krankheiten mit aldosteronhemmern |
| US7101898B2 (en) * | 2002-02-01 | 2006-09-05 | Novo Nordisk A/S | Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes |
| CN103130739B (zh) * | 2003-08-12 | 2015-09-16 | 盐野义制药株式会社 | 具有血小板生成素受体激动作用的化合物 |
| AU2005287729A1 (en) * | 2004-09-22 | 2006-03-30 | H. Lundbeck A/S | 2-acylaminothiazole derivatives |
| US7674912B2 (en) * | 2005-04-25 | 2010-03-09 | H. Lundbeck A/S | Pro-drugs of N-thiazol-2-yl-benzamide derivatives |
| TW200821316A (en) * | 2006-07-19 | 2008-05-16 | Astrazeneca Ab | Novel compounds 243 |
| WO2009011653A1 (en) * | 2007-07-17 | 2009-01-22 | Astrazeneca Ab | A process for the preparation of intermediates and their us in the synthesis of spiropiperidine compounds |
| WO2009120826A1 (en) * | 2008-03-27 | 2009-10-01 | Wyeth | 2-aryl- and 2-heteroarylthiazolyl compounds, methods for their preparation and use thereof |
| WO2011025951A1 (en) * | 2009-08-28 | 2011-03-03 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
| MX2012015105A (es) * | 2010-07-02 | 2013-05-28 | Gilead Sciences Inc | Inhibidores de cinasa de regulacion mediante señal de apoptosis. |
| WO2012104857A1 (en) * | 2011-02-04 | 2012-08-09 | Council Of Scientific & Industrial Research | Amidobenzothiazoles and process for the preparation thereof |
| ES2489297B1 (es) * | 2013-01-22 | 2015-06-10 | Consejo Superior De Investigaciones Científicas (Csic) | Benzotiazoles sustituidos y sus aplicaciones terapeuticas para el tratamiento de enfermedades humanas |
| GB201401886D0 (en) | 2014-02-04 | 2014-03-19 | Lytix Biopharma As | Neurodegenerative therapies |
| CN110317230B (zh) * | 2018-03-30 | 2023-11-07 | 上海昇悦医药科技有限公司 | 磷酸盐类衍生物及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1982001517A1 (en) * | 1980-11-04 | 1982-05-13 | Martin C Anderson | Basic color media set for providing tonally matched palettes |
| US4957932A (en) * | 1987-11-25 | 1990-09-18 | Merck Frosst Canada, Inc. | Benzoheterazoles |
| IL90337A0 (en) * | 1988-05-24 | 1989-12-15 | Pfizer | Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents |
| JP2869561B2 (ja) * | 1989-05-22 | 1999-03-10 | 大塚製薬株式会社 | 血小板粘着抑制剤 |
| TW205041B (de) * | 1989-08-07 | 1993-05-01 | Fujisawa Pharmaceutical Co | |
| AU3884993A (en) * | 1992-04-10 | 1993-11-18 | Merck Frosst Canada Inc. | Benzothiazole-substituted benzyl alcohols as leukotriene antagonists |
| AU3884893A (en) * | 1992-04-10 | 1993-11-18 | Merck Frosst Canada Inc. | Thiazole-substituted benzyl alcohols as leukotriene antagonists |
| EP0638564B1 (de) * | 1993-02-19 | 1999-09-01 | Asahi Kasei Kogyo Kabushiki Kaisha | Benzothiazolsulfonamid-derivate, verfahren zu deren herstellung und anwendungen |
-
1997
- 1997-07-28 TW TW086110703A patent/TW513418B/zh not_active IP Right Cessation
- 1997-07-29 PT PT97933046T patent/PT858452E/pt unknown
- 1997-07-29 CN CN97190997A patent/CN1070856C/zh not_active Expired - Fee Related
- 1997-07-29 DE DE69711020T patent/DE69711020T2/de not_active Expired - Fee Related
- 1997-07-29 CA CA002233611A patent/CA2233611A1/en not_active Abandoned
- 1997-07-29 WO PCT/JP1997/002609 patent/WO1998004536A1/en not_active Ceased
- 1997-07-29 EP EP97933046A patent/EP0858452B1/de not_active Expired - Lifetime
- 1997-07-29 KR KR1019980702383A patent/KR19990063910A/ko not_active Ceased
- 1997-07-29 US US09/043,642 patent/US6140330A/en not_active Expired - Fee Related
- 1997-07-29 DK DK97933046T patent/DK0858452T3/da active
- 1997-07-29 ES ES97933046T patent/ES2179355T3/es not_active Expired - Lifetime
- 1997-07-29 AT AT97933046T patent/ATE214381T1/de not_active IP Right Cessation
- 1997-07-29 BR BR9706792-0A patent/BR9706792A/pt not_active Application Discontinuation
- 1997-07-29 AU AU36354/97A patent/AU695817B2/en not_active Ceased
- 1997-07-30 AR ARP970103439A patent/AR008111A1/es not_active Application Discontinuation
- 1997-07-31 ID IDP972653A patent/ID19474A/id unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69711020D1 (de) | 2002-04-18 |
| ES2179355T3 (es) | 2003-01-16 |
| BR9706792A (pt) | 2001-11-27 |
| EP0858452A1 (de) | 1998-08-19 |
| WO1998004536A1 (en) | 1998-02-05 |
| AU3635497A (en) | 1998-02-20 |
| CN1198160A (zh) | 1998-11-04 |
| ID19474A (id) | 1998-07-16 |
| AU695817B2 (en) | 1998-08-20 |
| HK1016586A1 (en) | 1999-11-05 |
| KR19990063910A (ko) | 1999-07-26 |
| DK0858452T3 (da) | 2002-05-21 |
| DE69711020T2 (de) | 2002-11-21 |
| AR008111A1 (es) | 1999-12-09 |
| US6140330A (en) | 2000-10-31 |
| TW513418B (en) | 2002-12-11 |
| CA2233611A1 (en) | 1998-02-05 |
| CN1070856C (zh) | 2001-09-12 |
| EP0858452B1 (de) | 2002-03-13 |
| PT858452E (pt) | 2002-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |