ATE273307T1 - Benzo(5,6)cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren - Google Patents

Benzo(5,6)cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren

Info

Publication number
ATE273307T1
ATE273307T1 AT98932715T AT98932715T ATE273307T1 AT E273307 T1 ATE273307 T1 AT E273307T1 AT 98932715 T AT98932715 T AT 98932715T AT 98932715 T AT98932715 T AT 98932715T AT E273307 T1 ATE273307 T1 AT E273307T1
Authority
AT
Austria
Prior art keywords
cycloheptapyridine
benzo
protein transferase
transferase inhibitors
farnesyl protein
Prior art date
Application number
AT98932715T
Other languages
English (en)
Inventor
Dinanath F Rane
Stacy W Remiszewski
Ronald J Doll
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE273307T1 publication Critical patent/ATE273307T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98932715T 1997-06-17 1998-06-15 Benzo(5,6)cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren ATE273307T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/877,366 US5939416A (en) 1997-06-17 1997-06-17 Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors
PCT/US1998/011505 WO1998057970A1 (en) 1997-06-17 1998-06-15 Benzo(5,6)cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors

Publications (1)

Publication Number Publication Date
ATE273307T1 true ATE273307T1 (de) 2004-08-15

Family

ID=25369837

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98932715T ATE273307T1 (de) 1997-06-17 1998-06-15 Benzo(5,6)cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren

Country Status (12)

Country Link
US (1) US5939416A (de)
EP (1) EP1019400B1 (de)
JP (1) JP3258342B2 (de)
CN (1) CN1119345C (de)
AR (1) AR012990A1 (de)
AT (1) ATE273307T1 (de)
AU (1) AU8253398A (de)
CA (1) CA2293711C (de)
DE (1) DE69825608T2 (de)
ES (1) ES2221989T3 (de)
WO (1) WO1998057970A1 (de)
ZA (1) ZA985211B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524832B1 (en) * 1994-02-04 2003-02-25 Arch Development Corporation DNA damaging agents in combination with tyrosine kinase inhibitors
US6632455B2 (en) 1997-12-22 2003-10-14 Schering Corporation Molecular dispersion composition with enhanced bioavailability
US6271378B1 (en) 1998-12-18 2001-08-07 Schering Corporation Process for preparing tricyclic compounds having antihistaminic activity
US6316462B1 (en) 1999-04-09 2001-11-13 Schering Corporation Methods of inducing cancer cell death and tumor regression
PE20020635A1 (es) 2000-11-29 2002-07-11 Schering Corp Compuestos triciclicos como inhibidores de la farnesil transferasa
WO2005089518A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Uch-l1 expression and cancer therapy
WO2005089496A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
US20060194821A1 (en) * 2005-02-18 2006-08-31 The Brigham And Women's Hospital, Inc. Compounds inhibiting the aggregation of superoxide dismutase-1
US20070148660A1 (en) * 2005-06-16 2007-06-28 The Regents Of The University Of California Treatment of maladaptive substance use with H-ras antagonists
US8232402B2 (en) 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
EP2370436A1 (de) 2008-11-13 2011-10-05 Link Medicine Corporation Azachinolinonderivate und deren verwendungen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5721236A (en) * 1993-10-15 1998-02-24 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
KR20000036120A (ko) * 1996-09-13 2000-06-26 둘락 노먼 씨. 파르네실 단백질 트랜스퍼라제에 대한 트리사이클릭 저해제
CA2266014A1 (en) * 1996-09-13 1998-03-19 Schering Corporation Tricyclic compounds useful for inhibition of farnesyl protein transferase

Also Published As

Publication number Publication date
AU8253398A (en) 1999-01-04
EP1019400A1 (de) 2000-07-19
DE69825608T2 (de) 2005-08-04
ES2221989T3 (es) 2005-01-16
WO1998057970A1 (en) 1998-12-23
CA2293711C (en) 2004-08-24
DE69825608D1 (de) 2004-09-16
AR012990A1 (es) 2000-11-22
CA2293711A1 (en) 1998-12-23
JP2000513034A (ja) 2000-10-03
US5939416A (en) 1999-08-17
CN1119345C (zh) 2003-08-27
JP3258342B2 (ja) 2002-02-18
ZA985211B (en) 1998-12-15
CN1267302A (zh) 2000-09-20
EP1019400B1 (de) 2004-08-11

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Legal Events

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