ATE273299T1 - Benzpyrido cycloheptan derivate mit farnesyl protein transferase inhibierender wirkung - Google Patents
Benzpyrido cycloheptan derivate mit farnesyl protein transferase inhibierender wirkungInfo
- Publication number
- ATE273299T1 ATE273299T1 AT98928886T AT98928886T ATE273299T1 AT E273299 T1 ATE273299 T1 AT E273299T1 AT 98928886 T AT98928886 T AT 98928886T AT 98928886 T AT98928886 T AT 98928886T AT E273299 T1 ATE273299 T1 AT E273299T1
- Authority
- AT
- Austria
- Prior art keywords
- benzpyrido
- cycloheptan
- derivatives
- inhibiting effect
- protein transferase
- Prior art date
Links
- JXBSHSBNOVLGHF-BUJBXKITSA-N (6E,10E)-2,6,10-trimethyldodeca-2,6,10-triene Chemical compound C\C=C(/C)CC\C=C(/C)CCC=C(C)C JXBSHSBNOVLGHF-BUJBXKITSA-N 0.000 title 1
- QPDYCRJIHVDOAD-UHFFFAOYSA-N 7,8,9,10-tetrahydro-6h-cyclohepta[b]quinoline Chemical class C1CCCCC2=CC3=CC=CC=C3N=C21 QPDYCRJIHVDOAD-UHFFFAOYSA-N 0.000 title 1
- 102000004357 Transferases Human genes 0.000 title 1
- 108090000992 Transferases Proteins 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87774197A | 1997-06-17 | 1997-06-17 | |
| PCT/US1998/011495 WO1998057960A1 (en) | 1997-06-17 | 1998-06-15 | Benzpyrido cycloheptane compounds useful for inhibition of farnesyl protein transferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE273299T1 true ATE273299T1 (de) | 2004-08-15 |
Family
ID=25370618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98928886T ATE273299T1 (de) | 1997-06-17 | 1998-06-15 | Benzpyrido cycloheptan derivate mit farnesyl protein transferase inhibierender wirkung |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0989983B1 (de) |
| JP (1) | JP2002504144A (de) |
| KR (1) | KR100640672B1 (de) |
| CN (1) | CN1266433A (de) |
| AR (1) | AR012991A1 (de) |
| AT (1) | ATE273299T1 (de) |
| AU (1) | AU753658B2 (de) |
| CA (1) | CA2293714C (de) |
| DE (1) | DE69825589T2 (de) |
| ES (1) | ES2224408T3 (de) |
| HU (1) | HUP0003138A3 (de) |
| IL (2) | IL133386A0 (de) |
| MY (1) | MY143570A (de) |
| NZ (1) | NZ501376A (de) |
| PE (1) | PE104798A1 (de) |
| TW (1) | TW587935B (de) |
| WO (1) | WO1998057960A1 (de) |
| ZA (1) | ZA985203B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6800636B2 (en) | 1998-12-18 | 2004-10-05 | Schering Corporation | Farnesyl protein transferase inhibitors |
| JP2002533336A (ja) | 1998-12-18 | 2002-10-08 | シェーリング コーポレイション | 三環式ファルネシルタンパク質トランスフェラーゼインヒビター |
| SK7582001A3 (en) * | 1998-12-18 | 2002-03-05 | Schering Corp | Compound, method of therapy and pharmaceutical composition comprising the same, and its use for farnesyl protein transferase inhibition |
| US6362188B1 (en) | 1998-12-18 | 2002-03-26 | Schering Corporation | Farnesyl protein transferase inhibitors |
| US6372747B1 (en) | 1998-12-18 | 2002-04-16 | Schering Corporation | Farnesyl protein transferase inhibitors |
| US6432959B1 (en) * | 1998-12-23 | 2002-08-13 | Schering Corporation | Inhibitors of farnesyl-protein transferase |
| US7342016B2 (en) | 2000-08-30 | 2008-03-11 | Schering Corporation | Farnesyl protein transferase inhibitors as antitumor agents |
| AU2002236813A1 (en) | 2001-01-22 | 2002-07-30 | Schering Corporation | Treatment of malaria with farnesyl protein transferase inhibitors |
| WO2002080895A2 (en) * | 2001-04-06 | 2002-10-17 | Schering Corporation | Treatment of malaria with farsenyl protein transferase inhibitors |
| CA2499732A1 (en) * | 2002-09-20 | 2004-04-15 | Applied Research Systems Ars Holding N.V. | Piperazine derivatives and methods of use |
| CN101115486A (zh) | 2004-12-13 | 2008-01-30 | 先灵公司 | 新的法呢基蛋白转移酶抑制剂及其治疗癌症的用途 |
| CN101128202A (zh) | 2004-12-14 | 2008-02-20 | 先灵公司 | 法呢基蛋白质转移酶抑制剂和用于治疗增殖性疾病的方法 |
| JP6258867B2 (ja) * | 2012-01-25 | 2018-01-10 | ノバルティス アーゲー | 複素環式化合物およびその使用方法 |
| US10875851B2 (en) | 2016-11-18 | 2020-12-29 | Merck Sharp & Dohme Corp. | Factor XIIa inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2875393B2 (ja) * | 1993-10-15 | 1999-03-31 | シェーリング コーポレイション | Ｇ−タンパク質機能の阻害および増殖性疾患の治療に有用な三環式カルバメート化合物 |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| IL117797A0 (en) * | 1995-04-07 | 1996-08-04 | Pharmacopeia Inc | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| US5712280A (en) * | 1995-04-07 | 1998-01-27 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
-
1998
- 1998-06-15 AT AT98928886T patent/ATE273299T1/de not_active IP Right Cessation
- 1998-06-15 ES ES98928886T patent/ES2224408T3/es not_active Expired - Lifetime
- 1998-06-15 KR KR1019997011842A patent/KR100640672B1/ko not_active Expired - Fee Related
- 1998-06-15 AU AU80580/98A patent/AU753658B2/en not_active Ceased
- 1998-06-15 ZA ZA985203A patent/ZA985203B/xx unknown
- 1998-06-15 CN CN98808124A patent/CN1266433A/zh active Pending
- 1998-06-15 HU HU0003138A patent/HUP0003138A3/hu unknown
- 1998-06-15 TW TW087109501A patent/TW587935B/zh not_active IP Right Cessation
- 1998-06-15 EP EP98928886A patent/EP0989983B1/de not_active Expired - Lifetime
- 1998-06-15 CA CA002293714A patent/CA2293714C/en not_active Expired - Fee Related
- 1998-06-15 JP JP50449099A patent/JP2002504144A/ja not_active Ceased
- 1998-06-15 NZ NZ501376A patent/NZ501376A/en not_active IP Right Cessation
- 1998-06-15 PE PE1998000505A patent/PE104798A1/es not_active Application Discontinuation
- 1998-06-15 DE DE69825589T patent/DE69825589T2/de not_active Expired - Lifetime
- 1998-06-15 WO PCT/US1998/011495 patent/WO1998057960A1/en not_active Ceased
- 1998-06-15 IL IL13338698A patent/IL133386A0/xx active IP Right Grant
- 1998-06-16 MY MYPI98002697A patent/MY143570A/en unknown
- 1998-06-16 AR ARP980102862A patent/AR012991A1/es unknown
-
1999
- 1999-12-08 IL IL133386A patent/IL133386A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ501376A (en) | 2002-03-28 |
| CN1266433A (zh) | 2000-09-13 |
| AU753658B2 (en) | 2002-10-24 |
| TW587935B (en) | 2004-05-21 |
| PE104798A1 (es) | 1999-11-06 |
| CA2293714A1 (en) | 1998-12-23 |
| HUP0003138A3 (en) | 2002-11-28 |
| AU8058098A (en) | 1999-01-04 |
| DE69825589T2 (de) | 2005-09-08 |
| CA2293714C (en) | 2009-09-08 |
| JP2002504144A (ja) | 2002-02-05 |
| KR100640672B1 (ko) | 2006-11-02 |
| MY143570A (en) | 2011-05-31 |
| IL133386A (en) | 2006-12-10 |
| HUP0003138A2 (hu) | 2001-06-28 |
| DE69825589D1 (de) | 2004-09-16 |
| ZA985203B (en) | 1999-01-05 |
| KR20010013822A (ko) | 2001-02-26 |
| EP0989983A1 (de) | 2000-04-05 |
| EP0989983B1 (de) | 2004-08-11 |
| WO1998057960A1 (en) | 1998-12-23 |
| AR012991A1 (es) | 2000-11-22 |
| IL133386A0 (en) | 2001-04-30 |
| ES2224408T3 (es) | 2005-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |