HUP0003138A2 - Farnezil-protein-transzferáz gátlására alkalmas benzpirido-cikloheptán-származékok - Google Patents

Farnezil-protein-transzferáz gátlására alkalmas benzpirido-cikloheptán-származékok

Info

Publication number
HUP0003138A2
HUP0003138A2 HU0003138A HUP0003138A HUP0003138A2 HU P0003138 A2 HUP0003138 A2 HU P0003138A2 HU 0003138 A HU0003138 A HU 0003138A HU P0003138 A HUP0003138 A HU P0003138A HU P0003138 A2 HUP0003138 A2 HU P0003138A2
Authority
HU
Hungary
Prior art keywords
protein transferase
farnesyl protein
benzpyrido
inhibition
compounds useful
Prior art date
Application number
HU0003138A
Other languages
English (en)
Inventor
John J. Baldwin
Alan B. Cooper
Ronald J. Doll
Ashit Ganguly
Viyyoor M. Girijavallabhan
Chia-Yu Huang
John C. Reader
Original Assignee
Pharmacopeia, Inc.
Schering Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacopeia, Inc., Schering Corp. filed Critical Pharmacopeia, Inc.
Publication of HUP0003138A2 publication Critical patent/HUP0003138A2/hu
Publication of HUP0003138A3 publication Critical patent/HUP0003138A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgyát az (1.0) általános képletű, farnezil-protein-transzferáz inhibitor hatású, új vegyületek - ahol a szaggatott vonaladott esetben jelen levő kettős kötést jelent, és előnyösen anitrogénatom vagy N-oxiddá oxidált nitrogénatom; Rb és Re hidrogénatom, Ra, Rc és Rd halogénatom; Rf -(CH2)n-R15általános képletű csoport, amelyben n = 0-8, és R15 adott esetbenszubsztituált karbamoil-, szulfamoil-, aril-, heteroaril-, cikloalkil-vagy heterocikloalkil-csoport; R hidrogénatom, valeril-, metil-szulfonil-, (2-metoxi-etoxi)-acetil- vagy metoxi-acetil-csoport, N-butil-, N-ciklohexil- vagy N-(ciklohexil-metil)-karbamoil-csoport, (N-oxido-piridil-3-il)-acetil- vagy 3-ciklohexil-propionil-csoport; és Rhhidrogénatom vagy oxocsoport - és sóik, ezeket tartalmazógyógyszerkészítmények képezik. Ó
HU0003138A 1997-06-17 1998-06-15 Benzpyrido cycloheptane compounds useful for inhibition of farnesyl protein transferase HUP0003138A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87774197A 1997-06-17 1997-06-17
PCT/US1998/011495 WO1998057960A1 (en) 1997-06-17 1998-06-15 Benzpyrido cycloheptane compounds useful for inhibition of farnesyl protein transferase

Publications (2)

Publication Number Publication Date
HUP0003138A2 true HUP0003138A2 (hu) 2001-06-28
HUP0003138A3 HUP0003138A3 (en) 2002-11-28

Family

ID=25370618

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003138A HUP0003138A3 (en) 1997-06-17 1998-06-15 Benzpyrido cycloheptane compounds useful for inhibition of farnesyl protein transferase

Country Status (18)

Country Link
EP (1) EP0989983B1 (hu)
JP (1) JP2002504144A (hu)
KR (1) KR100640672B1 (hu)
CN (1) CN1266433A (hu)
AR (1) AR012991A1 (hu)
AT (1) ATE273299T1 (hu)
AU (1) AU753658B2 (hu)
CA (1) CA2293714C (hu)
DE (1) DE69825589T2 (hu)
ES (1) ES2224408T3 (hu)
HU (1) HUP0003138A3 (hu)
IL (2) IL133386A0 (hu)
MY (1) MY143570A (hu)
NZ (1) NZ501376A (hu)
PE (1) PE104798A1 (hu)
TW (1) TW587935B (hu)
WO (1) WO1998057960A1 (hu)
ZA (1) ZA985203B (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU776558B2 (en) 1998-12-18 2004-09-16 Schering Corporation Tricyclic farnesyl protein transferase inhibitors
US6800636B2 (en) 1998-12-18 2004-10-05 Schering Corporation Farnesyl protein transferase inhibitors
US6362188B1 (en) 1998-12-18 2002-03-26 Schering Corporation Farnesyl protein transferase inhibitors
US6372747B1 (en) 1998-12-18 2002-04-16 Schering Corporation Farnesyl protein transferase inhibitors
BR9916328A (pt) * 1998-12-18 2001-10-02 Schering Corp Inibidores de transferase de farnesila
US6432959B1 (en) * 1998-12-23 2002-08-13 Schering Corporation Inhibitors of farnesyl-protein transferase
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
AU2002236813A1 (en) 2001-01-22 2002-07-30 Schering Corporation Treatment of malaria with farnesyl protein transferase inhibitors
WO2002080895A2 (en) * 2001-04-06 2002-10-17 Schering Corporation Treatment of malaria with farsenyl protein transferase inhibitors
JP4713152B2 (ja) * 2002-09-20 2011-06-29 メルク セローノ ソシエテ アノニム ピペラジン誘導体及び使用方法
JP2008523104A (ja) 2004-12-13 2008-07-03 シェーリング コーポレイション 癌を治療するための新規なファルネシルタンパク質トランスフェラーゼ阻害剤およびその使用
CA2591123A1 (en) * 2004-12-14 2006-06-22 Schering Corporation Farnesyl protein transferase inhibitors and methods for treating proliferative diseases
PT2807153T (pt) * 2012-01-25 2020-06-18 Novartis Ag Compostos heterocíclicos e métodos para seu uso
EP3541375B1 (en) * 2016-11-18 2023-08-23 Merck Sharp & Dohme LLC Factor xiia inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT76066A (en) * 1993-10-15 1997-06-30 Schering Corp Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases, pharmaceutical compositions containing them and process for producing them
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
IL117797A0 (en) * 1995-04-07 1996-08-04 Pharmacopeia Inc Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
TW587935B (en) 2004-05-21
CN1266433A (zh) 2000-09-13
MY143570A (en) 2011-05-31
DE69825589T2 (de) 2005-09-08
HUP0003138A3 (en) 2002-11-28
AU8058098A (en) 1999-01-04
WO1998057960A1 (en) 1998-12-23
IL133386A0 (en) 2001-04-30
EP0989983A1 (en) 2000-04-05
EP0989983B1 (en) 2004-08-11
PE104798A1 (es) 1999-11-06
ES2224408T3 (es) 2005-03-01
ATE273299T1 (de) 2004-08-15
CA2293714C (en) 2009-09-08
JP2002504144A (ja) 2002-02-05
KR20010013822A (ko) 2001-02-26
CA2293714A1 (en) 1998-12-23
ZA985203B (en) 1999-01-05
DE69825589D1 (de) 2004-09-16
AU753658B2 (en) 2002-10-24
NZ501376A (en) 2002-03-28
IL133386A (en) 2006-12-10
AR012991A1 (es) 2000-11-22
KR100640672B1 (ko) 2006-11-02

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees