FI952011L - Farnesyyliproteiinitransferaasin estäjät - Google Patents
Farnesyyliproteiinitransferaasin estäjät Download PDFInfo
- Publication number
- FI952011L FI952011L FI952011A FI952011A FI952011L FI 952011 L FI952011 L FI 952011L FI 952011 A FI952011 A FI 952011A FI 952011 A FI952011 A FI 952011A FI 952011 L FI952011 L FI 952011L
- Authority
- FI
- Finland
- Prior art keywords
- protein transferase
- transferase inhibitors
- farnesyl protein
- farnesyl
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96802592A | 1992-10-29 | 1992-10-29 | |
| PCT/US1993/010353 WO1994010138A1 (en) | 1992-10-29 | 1993-10-28 | Inhibitors of farnesyl-protein transferase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI952011A0 FI952011A0 (fi) | 1995-04-27 |
| FI952011A7 FI952011A7 (fi) | 1995-04-27 |
| FI952011L true FI952011L (fi) | 1995-04-27 |
Family
ID=25513608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI952011A FI952011L (fi) | 1992-10-29 | 1993-10-28 | Farnesyyliproteiinitransferaasin estäjät |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5686472A (fi) |
| EP (1) | EP0666844B1 (fi) |
| JP (1) | JPH08502972A (fi) |
| KR (1) | KR100305989B1 (fi) |
| AT (1) | ATE195727T1 (fi) |
| AU (1) | AU680850B2 (fi) |
| CA (1) | CA2147241A1 (fi) |
| CZ (1) | CZ110395A3 (fi) |
| DE (1) | DE69329291T2 (fi) |
| ES (1) | ES2149859T3 (fi) |
| FI (1) | FI952011L (fi) |
| HU (1) | HUT72966A (fi) |
| NO (1) | NO304593B1 (fi) |
| NZ (1) | NZ258303A (fi) |
| PL (1) | PL177310B1 (fi) |
| RU (1) | RU95109935A (fi) |
| SK (1) | SK53895A3 (fi) |
| WO (1) | WO1994010138A1 (fi) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5504212A (en) * | 1992-10-29 | 1996-04-02 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5326773A (en) * | 1992-10-29 | 1994-07-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US6936447B1 (en) | 2000-04-03 | 2005-08-30 | University Of Iowa Research Foundation | Autoinducer molecule |
| US5510510A (en) * | 1994-05-10 | 1996-04-23 | Bristol-Meyers Squibb Company | Inhibitors of farnesyl protein transferase |
| IT1273986B (it) * | 1994-09-28 | 1997-07-14 | Merck & Co Inc | Inibitori peptidici di farnesil proteina transferasi |
| US5661161A (en) * | 1994-09-29 | 1997-08-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5523456A (en) * | 1994-09-29 | 1996-06-04 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5585359A (en) * | 1994-09-29 | 1996-12-17 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| FR2729390A1 (fr) * | 1995-01-18 | 1996-07-19 | Rhone Poulenc Rorer Sa | Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5972984A (en) * | 1995-06-06 | 1999-10-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5703241A (en) * | 1995-10-16 | 1997-12-30 | Merck & Co., Inc. | Inhibitor of farnesyl-protein transferase |
| US6127366A (en) * | 1995-11-22 | 2000-10-03 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US6028201A (en) * | 1996-01-30 | 2000-02-22 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU704087B2 (en) * | 1996-01-30 | 1999-04-15 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5968965A (en) * | 1996-01-30 | 1999-10-19 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5981562A (en) * | 1996-01-30 | 1999-11-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US6455031B1 (en) * | 1997-06-18 | 2002-09-24 | David G Davies | Methods and compositions for controlling biofilm development |
| US6756404B2 (en) * | 1998-06-18 | 2004-06-29 | The Research & Development Institute, Inc. | Autoinducer compounds |
| US6838467B2 (en) | 2000-02-24 | 2005-01-04 | Janssen Pharmaceutica N. V. | Dosing regimen |
| AU2001286976A1 (en) * | 2000-08-31 | 2002-03-13 | East Carolina University | Novel autoinducer molecules and uses therefor |
| EP1815247B1 (en) | 2004-11-05 | 2013-02-20 | Janssen Pharmaceutica NV | Therapeutic use of farnesyltransferase inhibitors and methods of monitoring the efficacy thereof |
| EP1656931A1 (en) * | 2004-11-15 | 2006-05-17 | Exonhit Therapeutics SA | Compounds which inhibits protein prenylation ( e.g. geranylgeranyltransferase or farnesyltransferase inhibitors) for treating Parkinson's disease |
| US20060281788A1 (en) | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor |
| EP2016070B1 (en) | 2006-04-20 | 2016-01-13 | Janssen Pharmaceutica N.V. | Inhibitors of c-fms kinase |
| MX2008013533A (es) | 2006-04-20 | 2009-01-15 | Janssen Pharmaceutica Nv | Compuestos heterociclicos como inhibidores de c-fms cinasa. |
| US8697716B2 (en) | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
| JO3240B1 (ar) | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
| CN107266405A (zh) | 2012-08-07 | 2017-10-20 | 詹森药业有限公司 | 用于制备c‑fms激酶抑制剂的方法 |
| CN104870454B (zh) | 2012-08-07 | 2020-03-03 | 詹森药业有限公司 | 用于制备杂环酯衍生物的方法 |
| EA201890512A1 (ru) | 2015-08-17 | 2018-09-28 | Кура Онколоджи, Инк. | Способы лечения пациентов со злокачественными опухолями с использованием ингибиторов фарнезилтрансферазы |
| WO2017184968A1 (en) | 2016-04-22 | 2017-10-26 | Kura Oncology, Inc. | Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors |
| RS61745B1 (sr) | 2016-11-03 | 2021-05-31 | Kura Oncology Inc | Inhibitori farneziltransferaze za upotrebu u tretiranju kancera |
| US10137121B2 (en) | 2017-02-21 | 2018-11-27 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| KR102003179B1 (ko) | 2017-02-21 | 2019-07-23 | 쿠라 온콜로지, 인크. | 파르네실트랜스퍼라제 억제제를 사용하는 암 환자의 치료 방법 |
| US10806730B2 (en) | 2017-08-07 | 2020-10-20 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| MX2020001207A (es) | 2017-08-07 | 2020-03-20 | Kura Oncology Inc | Metodos de tratamiento del cancer con inhibidores de farnesiltransferasa. |
| WO2019113269A1 (en) | 2017-12-08 | 2019-06-13 | Kura Oncology, Inc. | Methods of treating cancer patients with farnesyltransferase inhibitors |
| EP3873469A2 (en) | 2018-11-01 | 2021-09-08 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| US20220071941A1 (en) | 2018-12-21 | 2022-03-10 | Kura Oncology, Inc. | Therapies for squamous cell carcinomas |
| WO2020180663A1 (en) | 2019-03-01 | 2020-09-10 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| US20220143006A1 (en) | 2019-03-15 | 2022-05-12 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| SG11202110472WA (en) | 2019-03-29 | 2021-10-28 | Kura Oncology Inc | Methods of treating squamous cell carcinomas with farnesyltransferase inhibitors |
| US20220168296A1 (en) | 2019-04-01 | 2022-06-02 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| US20220305001A1 (en) | 2019-05-02 | 2022-09-29 | Kura Oncology, Inc. | Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT66467B (de) * | 1912-08-27 | 1914-08-25 | Theodor Johann Cavier | Schuhsohlenschoner. |
| US4720585A (en) * | 1985-09-18 | 1988-01-19 | E. R. Squibb & Sons, Inc. | Aminopeptidase inhibitors |
| US5141851A (en) * | 1990-04-18 | 1992-08-25 | Board Of Regents, The University Of Texas System | Isolated farnesyl protein transferase enzyme |
| US5043268A (en) * | 1990-05-04 | 1991-08-27 | The Trustees Of Princeton University | Substrates and inhibitors for prenyl cysteine methyltransferase enzymes |
| US5185248A (en) * | 1990-05-08 | 1993-02-09 | E. R. Squibb & Sons, Inc. | Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation |
| US5238922A (en) * | 1991-09-30 | 1993-08-24 | Merck & Co., Inc. | Inhibitors of farnesyl protein transferase |
| US5340828A (en) * | 1991-09-30 | 1994-08-23 | Merck & Co., Inc. | Inhibitors of farnesyl protein transferase |
| US5352705A (en) * | 1992-06-26 | 1994-10-04 | Merck & Co., Inc. | Inhibitors of farnesyl protein transferase |
| US5326773A (en) * | 1992-10-29 | 1994-07-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5504212A (en) * | 1992-10-29 | 1996-04-02 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
-
1993
- 1993-10-27 US US08/143,943 patent/US5686472A/en not_active Expired - Fee Related
- 1993-10-28 AU AU55882/94A patent/AU680850B2/en not_active Ceased
- 1993-10-28 WO PCT/US1993/010353 patent/WO1994010138A1/en not_active Ceased
- 1993-10-28 SK SK538-95A patent/SK53895A3/sk unknown
- 1993-10-28 JP JP6511318A patent/JPH08502972A/ja active Pending
- 1993-10-28 DE DE69329291T patent/DE69329291T2/de not_active Expired - Fee Related
- 1993-10-28 EP EP94901218A patent/EP0666844B1/en not_active Expired - Lifetime
- 1993-10-28 RU RU95109935/04A patent/RU95109935A/ru unknown
- 1993-10-28 AT AT94901218T patent/ATE195727T1/de not_active IP Right Cessation
- 1993-10-28 PL PL93308554A patent/PL177310B1/pl unknown
- 1993-10-28 ES ES94901218T patent/ES2149859T3/es not_active Expired - Lifetime
- 1993-10-28 KR KR1019950701641A patent/KR100305989B1/ko not_active Expired - Fee Related
- 1993-10-28 CA CA002147241A patent/CA2147241A1/en not_active Abandoned
- 1993-10-28 FI FI952011A patent/FI952011L/fi unknown
- 1993-10-28 CZ CZ951103A patent/CZ110395A3/cs unknown
- 1993-10-28 NZ NZ258303A patent/NZ258303A/en unknown
- 1993-10-28 HU HU9501238A patent/HUT72966A/hu unknown
-
1995
- 1995-04-28 NO NO951649A patent/NO304593B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2149859T3 (es) | 2000-11-16 |
| FI952011A0 (fi) | 1995-04-27 |
| DE69329291T2 (de) | 2001-04-05 |
| EP0666844B1 (en) | 2000-08-23 |
| KR950704248A (ko) | 1995-11-17 |
| HU9501238D0 (en) | 1995-06-28 |
| SK53895A3 (en) | 1995-09-13 |
| NZ258303A (en) | 1996-05-28 |
| RU95109935A (ru) | 1997-01-10 |
| KR100305989B1 (ko) | 2001-11-30 |
| PL177310B1 (pl) | 1999-10-29 |
| AU680850B2 (en) | 1997-08-14 |
| CA2147241A1 (en) | 1994-05-11 |
| NO304593B1 (no) | 1999-01-18 |
| CZ110395A3 (en) | 1996-04-17 |
| NO951649D0 (no) | 1995-04-28 |
| US5686472A (en) | 1997-11-11 |
| NO951649L (no) | 1995-06-28 |
| FI952011A7 (fi) | 1995-04-27 |
| JPH08502972A (ja) | 1996-04-02 |
| EP0666844A1 (en) | 1995-08-16 |
| HUT72966A (en) | 1996-06-28 |
| ATE195727T1 (de) | 2000-09-15 |
| AU5588294A (en) | 1994-05-24 |
| PL308554A1 (en) | 1995-08-21 |
| WO1994010138A1 (en) | 1994-05-11 |
| DE69329291D1 (de) | 2000-09-28 |
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