DE69825608D1 - Benzo[5,6]cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren - Google Patents

Benzo[5,6]cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren

Info

Publication number
DE69825608D1
DE69825608D1 DE69825608T DE69825608T DE69825608D1 DE 69825608 D1 DE69825608 D1 DE 69825608D1 DE 69825608 T DE69825608 T DE 69825608T DE 69825608 T DE69825608 T DE 69825608T DE 69825608 D1 DE69825608 D1 DE 69825608D1
Authority
DE
Germany
Prior art keywords
cycloheptapyridine
benzo
protein transferase
transferase inhibitors
farnesyl protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69825608T
Other languages
English (en)
Other versions
DE69825608T2 (de
Inventor
F Rane
W Remiszewski
J Doll
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE69825608D1 publication Critical patent/DE69825608D1/de
Publication of DE69825608T2 publication Critical patent/DE69825608T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69825608T 1997-06-17 1998-06-15 Benzo[5,6]cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren Expired - Lifetime DE69825608T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/877,366 US5939416A (en) 1997-06-17 1997-06-17 Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors
US877366 1997-06-17
PCT/US1998/011505 WO1998057970A1 (en) 1997-06-17 1998-06-15 Benzo(5,6)cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors

Publications (2)

Publication Number Publication Date
DE69825608D1 true DE69825608D1 (de) 2004-09-16
DE69825608T2 DE69825608T2 (de) 2005-08-04

Family

ID=25369837

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69825608T Expired - Lifetime DE69825608T2 (de) 1997-06-17 1998-06-15 Benzo[5,6]cycloheptapyridin derivate anwendbar als farnesyl protein transferase inhibitoren

Country Status (12)

Country Link
US (1) US5939416A (de)
EP (1) EP1019400B1 (de)
JP (1) JP3258342B2 (de)
CN (1) CN1119345C (de)
AR (1) AR012990A1 (de)
AT (1) ATE273307T1 (de)
AU (1) AU8253398A (de)
CA (1) CA2293711C (de)
DE (1) DE69825608T2 (de)
ES (1) ES2221989T3 (de)
WO (1) WO1998057970A1 (de)
ZA (1) ZA985211B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524832B1 (en) * 1994-02-04 2003-02-25 Arch Development Corporation DNA damaging agents in combination with tyrosine kinase inhibitors
US6632455B2 (en) 1997-12-22 2003-10-14 Schering Corporation Molecular dispersion composition with enhanced bioavailability
US6271378B1 (en) 1998-12-18 2001-08-07 Schering Corporation Process for preparing tricyclic compounds having antihistaminic activity
US6316462B1 (en) 1999-04-09 2001-11-13 Schering Corporation Methods of inducing cancer cell death and tumor regression
EP1337522B1 (de) 2000-11-29 2007-08-29 Schering Corporation Farnesyl-protein-transferaseinhibitoren
WO2005089518A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Uch-l1 expression and cancer therapy
EP1732549A4 (de) * 2004-03-18 2009-11-11 Brigham & Womens Hospital Verfahren zur behandlung von synucleinopathien
US20060194821A1 (en) * 2005-02-18 2006-08-31 The Brigham And Women's Hospital, Inc. Compounds inhibiting the aggregation of superoxide dismutase-1
US20070148660A1 (en) * 2005-06-16 2007-06-28 The Regents Of The University Of California Treatment of maladaptive substance use with H-ras antagonists
US8232402B2 (en) 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
WO2010057006A1 (en) 2008-11-13 2010-05-20 Link Medicine Corporation Azaquinolinone derivatives and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5721236A (en) * 1993-10-15 1998-02-24 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
JP2001500515A (ja) * 1996-09-13 2001-01-16 シェーリング コーポレイション ファルネシルタンパク質トランスフェラーゼの阻害に有用な化合物
IL128928A0 (en) * 1996-09-13 2000-02-17 Schering Corp Tricyclic inhibitors of farnesyl protein transferase

Also Published As

Publication number Publication date
CN1119345C (zh) 2003-08-27
DE69825608T2 (de) 2005-08-04
US5939416A (en) 1999-08-17
JP3258342B2 (ja) 2002-02-18
AU8253398A (en) 1999-01-04
CN1267302A (zh) 2000-09-20
CA2293711C (en) 2004-08-24
CA2293711A1 (en) 1998-12-23
EP1019400B1 (de) 2004-08-11
AR012990A1 (es) 2000-11-22
ATE273307T1 (de) 2004-08-15
ES2221989T3 (es) 2005-01-16
JP2000513034A (ja) 2000-10-03
ZA985211B (en) 1998-12-15
EP1019400A1 (de) 2000-07-19
WO1998057970A1 (en) 1998-12-23

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Legal Events

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