KR927003520A - 펩티딜(peptidyl) 유도체 - Google Patents

펩티딜(peptidyl) 유도체 Download PDF

Info

Publication number
KR927003520A
KR927003520A KR1019920701787A KR920701787A KR927003520A KR 927003520 A KR927003520 A KR 927003520A KR 1019920701787 A KR1019920701787 A KR 1019920701787A KR 920701787 A KR920701787 A KR 920701787A KR 927003520 A KR927003520 A KR 927003520A
Authority
KR
South Korea
Prior art keywords
group
alkyl
amino
compound
optionally substituted
Prior art date
Application number
KR1019920701787A
Other languages
English (en)
Inventor
죤 로버트 포터
죤 리차드 멀피
토마스 앤드류 밀리칸
니겔 로버트 아놀드 빌레이
Original Assignee
죤 에드워드 베리만
쎌텍크 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909026251A external-priority patent/GB9026251D0/en
Priority claimed from GB919110338A external-priority patent/GB9110338D0/en
Priority claimed from GB919110339A external-priority patent/GB9110339D0/en
Priority claimed from GB919112901A external-priority patent/GB9112901D0/en
Priority claimed from GB919112888A external-priority patent/GB9112888D0/en
Priority claimed from GB919115039A external-priority patent/GB9115039D0/en
Priority claimed from GB919115038A external-priority patent/GB9115038D0/en
Priority claimed from GB919115916A external-priority patent/GB9115916D0/en
Application filed by 죤 에드워드 베리만, 쎌텍크 리미티드 filed Critical 죤 에드워드 베리만
Publication of KR927003520A publication Critical patent/KR927003520A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

펩티딜(peptidyl) 유도체
[도면의 간단한 설명]
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 식(I)의 화합물과 이의 염, 용매화합물 및 수화물,
    여기서 R은 -CONHOH, 카르복실(-CO2H) 또는 에스테르화 된 카르복실 그룹이고, R1은 선택적으로 치환되는 알킬, 알케닐, 알릴, 알알킬, 헤테로 알알킬 그룹이며, R2는 선택적으로 치환되는 페닐 에틸, 페닐프로필, 또는 페닐 부틸 그룹이고, R3는 수소원자 또는 알킬 그룹이며, R4는 수소원자 또는 알킬 그룹이고, R5는 하나 또는 그 이상의 -O- 또는 -S- 원자 또는 -N(R7)- 그룹들[여기서 R7은 수소원자 또는 C1-6알킬그룹]에 의해 선택적으로 치환되는 알킬 또는 알케닐 그룹이며, X는 아미노(-NH2), 또는 치환된 아미노, 히드록실 또는 치환된 히드록실 그룹이다.
  2. 제1항에 있어서, R은 -CONHOH 또는 카르복실 (-CO2H) 그룹임을 특징으로 하는 화합물.
  3. 제1항 또는 제2항에 있어서, R1, R3와 R4가 각각 수소원자 임을 특징으로 하는 화합물.
  4. 제1-3항 중의 어느 한 항에 있어서, R2는 선택적으로 치환된는 페닐프로필 그룹임을 특징으로 하는 화합물.
  5. 상술된 항 중의 어느 한 항에 있어서, X는 아미노 또는 치환된 아미노 그룹임을 특징으로 하는 화합물.
  6. 식(Ia)의 화합물과 이의 염, 용매화합물 및 수화물.
    여기서 R은 -CONHOH, 카르복실(-CO2H) 또는 에스테르화 된 카르복실 그룹이고, R2는 선택적으로 치환되는 페닐프로필 그룹이며, R5는 하나 또는 그 이상의 -O- 또는 -S- 원자들 또는 -N(R7)-그룹 [여기서 R7은 수소원자 또는 C1-6알킬그룹]에 의해 선택적으로 억제되는, 선택적으로 치환되는 알킬 또는 알케닐 그룹이고, X는 아미노(-NH2) 또는 치환된 아미노, 히드록실 또는 치환된 히드록실 그룹이다.
  7. 제1 내지 6항 중의 어느 한 항에 따르는 화합물과 약학적으로 받아들여질 수 있는 희석제, 담체나 또는 부형제를 포함하는 약학적 조성물.
  8. 하기 (a), (b), (c)를 포함하는, 1항에 설명된 식(I)의 화합물의 제조방법, (a)식(II) 산 또는 이의 활성인 그리고/또는 보호된 유도체들은 식(III) 아민 또는 이의 보호된 유도체와 결합시키고 보호그룹을 제거하거나,
    또는 (b)식(IX)의 화합물을 탈카르복실화시켜 R이 -CO2H기인 식(I)의 화합물을 만들고/또는 (c)식(I)의 화합물을 상호전이(interconverting)시킨다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920701787A 1990-12-03 1991-12-03 펩티딜(peptidyl) 유도체 KR927003520A (ko)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
GB9026251.0 1990-12-03
GB909026251A GB9026251D0 (en) 1990-12-03 1990-12-03 Netalloproteinase inhibitors
GB919110338A GB9110338D0 (en) 1991-05-13 1991-05-13 Metalloproteinase inhibitors
GB9110338.2 1991-05-13
GB9110339.0 1991-05-13
GB919110339A GB9110339D0 (en) 1991-05-13 1991-05-13 Metalloproteinase inhibitors
GB9112901.5 1991-06-14
GB919112901A GB9112901D0 (en) 1991-06-14 1991-06-14 Metalloproteinase inhibitors
GB919112888A GB9112888D0 (en) 1991-06-14 1991-06-14 Metalloproteinase inhibitors
GB9112888.4 1991-06-14
GB919115039A GB9115039D0 (en) 1991-07-11 1991-07-11 Metalloproteinase inhibitors
GB9115039.1 1991-07-11
GB919115038A GB9115038D0 (en) 1991-07-11 1991-07-11 Metalloproteinase inhibitors
GB9115038.3 1991-07-11
GB919115916A GB9115916D0 (en) 1991-07-23 1991-07-23 Metalloproteinase inhibitors
GB9115916.0 1991-07-23
PCT/GB1991/002142 WO1992009564A1 (en) 1990-12-03 1991-12-03 Peptidyl derivatives

Publications (1)

Publication Number Publication Date
KR927003520A true KR927003520A (ko) 1992-12-18

Family

ID=27571285

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019920701787A KR927003520A (ko) 1990-12-03 1991-12-03 펩티딜(peptidyl) 유도체
KR1019920701788A KR927003521A (ko) 1990-12-03 1991-12-03 펩티딜(peptidyl) 유도체

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019920701788A KR927003521A (ko) 1990-12-03 1991-12-03 펩티딜(peptidyl) 유도체

Country Status (16)

Country Link
US (1) US5300501A (ko)
EP (2) EP0489577B1 (ko)
JP (2) JPH05503720A (ko)
KR (2) KR927003520A (ko)
AT (2) ATE120451T1 (ko)
AU (2) AU652793B2 (ko)
CA (2) CA2073513A1 (ko)
DE (2) DE69108529T2 (ko)
DK (1) DK0489579T3 (ko)
ES (1) ES2069833T3 (ko)
FI (2) FI923494A (ko)
GB (2) GB2255339B (ko)
GR (1) GR3015567T3 (ko)
HU (3) HUT62263A (ko)
NO (2) NO922967L (ko)
WO (2) WO1992009565A1 (ko)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268384A (en) * 1990-11-21 1993-12-07 Galardy Richard E Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
US5892112A (en) * 1990-11-21 1999-04-06 Glycomed Incorporated Process for preparing synthetic matrix metalloprotease inhibitors
US5189178A (en) * 1990-11-21 1993-02-23 Galardy Richard E Matrix metalloprotease inhibitors
EP0520573A1 (en) * 1991-06-27 1992-12-30 Glaxo Inc. Cyclic imide derivatives
DE69309047T2 (de) * 1992-04-07 1997-09-11 British Biotech Pharm Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren
GB9211706D0 (en) * 1992-06-03 1992-07-15 Celltech Ltd Peptidyl derivatives
GB9211707D0 (en) * 1992-06-03 1992-07-15 Celltech Ltd Peptidyl derivatives
AU666727B2 (en) * 1992-06-25 1996-02-22 F. Hoffmann-La Roche Ag Hydroxamic acid derivatives
US5326760A (en) * 1992-06-29 1994-07-05 Glaxo, Inc. Aminobutanoic acid compounds having metalloprotease inhibiting properties
US5629343A (en) * 1992-10-02 1997-05-13 Merck & Co., Inc. N-(mercaptoacyl) peptidyl derivatives as antidegenerative agents
US6090785A (en) * 1992-10-15 2000-07-18 Merck & Co., Inc. Substituted N-carboxyalkylpeptidyl derivatives as antidegenerative agents
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
JPH08503475A (ja) * 1992-11-25 1996-04-16 メルク エンド カンパニー インコーポレーテッド 抗変性活性剤としてのカルボキシ−ペプチジル誘導体
US5646167A (en) * 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
US5552419A (en) * 1993-01-06 1996-09-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5506242A (en) * 1993-01-06 1996-04-09 Ciba-Geigy Corporation Arylsufonamido-substituted hydroxamic acids
US5455258A (en) * 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
GB2290543B (en) * 1993-03-16 1996-05-22 British Biotech Pharm Hydroxamic acid derivatives as metalloproteinase inhibitors
WO1994022309A1 (en) * 1993-04-07 1994-10-13 Glycomed Incorporated Synthetic matrix metalloprotease inhibitors and uses thereof
GB9307956D0 (en) * 1993-04-17 1993-06-02 Walls Alan J Hydroxamic acid derivatives
GB9308695D0 (en) * 1993-04-27 1993-06-09 Celltech Ltd Peptidyl derivatives
AU6575394A (en) * 1993-04-27 1994-11-21 Celltech Therapeutics Limited Peptidyl derivatives as metalloproteinase inhibitors
AU7270794A (en) * 1993-08-02 1995-02-28 Celltech Limited Succinamide derivatives, processes for their preparation and their use as gelatinase and collagenase inhibitors
US5594106A (en) * 1993-08-23 1997-01-14 Immunex Corporation Inhibitors of TNF-α secretion
GB9320660D0 (en) * 1993-10-07 1993-11-24 British Bio Technology Inhibition of cytokine production
US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
DE69515702T2 (de) * 1994-01-20 2000-08-10 British Biotech Pharmaceuticals Ltd., Cowley L-Tertiär-leucin-2-pyridylamid
US5514716A (en) * 1994-02-25 1996-05-07 Sterling Winthrop, Inc. Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof
GB9501737D0 (en) * 1994-04-25 1995-03-22 Hoffmann La Roche Hydroxamic acid derivatives
WO1995032944A1 (en) * 1994-05-28 1995-12-07 British Biotech Pharmaceuticals Limited Succinyl hydroxamic acid, n-formyl-n-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors
GB9411088D0 (en) * 1994-06-03 1994-07-27 Hoffmann La Roche Hydroxylamine derivatives
JPH10507158A (ja) * 1994-06-22 1998-07-14 ブリティッシュ バイオテック ファーマシューティカルズ リミテッド 金属タンパク質分解酵素阻害剤
US5831004A (en) 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
GB9423914D0 (en) * 1994-11-26 1995-01-11 British Biotech Pharm Polyether derivatives as metalloproteinase inhibitors
US5919940A (en) * 1995-01-20 1999-07-06 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
US5857961A (en) * 1995-06-07 1999-01-12 Clarus Medical Systems, Inc. Surgical instrument for use with a viewing system
US5917090A (en) * 1995-06-30 1999-06-29 British Biotech Pharmaceuticals Ltd. Matrix metalloproteinase inhibitors
IT1277904B1 (it) * 1995-08-07 1997-11-12 Polifarma Spa Metodo per determinare l'attivita' terapeutica di composti inibitori di metalloproteinasi, nuovi composti inibitori, e loro impiego
US5665777A (en) * 1995-11-14 1997-09-09 Abbott Laboratories Biphenyl hydroxamate inhibitors of matrix metalloproteinases
NZ322553A (en) 1995-11-23 1998-12-23 British Biotech Pharm Metalloproteinase inhibitors
ATE283264T1 (de) * 1995-12-08 2004-12-15 Agouron Pharma Zwischenprodukte zur herstellung von metallproteinasehemmern
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
GB9613547D0 (en) * 1996-06-27 1996-08-28 Pharmacia Spa Matrix metalloproteinase inhibitors
US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
EP0925278B1 (en) 1996-09-10 2002-07-17 British Biotech Pharmaceuticals Limited Cytostatic hydroxamic acid derivatives
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
JPH10130217A (ja) * 1996-11-01 1998-05-19 Kotobuki Seiyaku Kk カルボン酸及びその誘導体及びその製造法並びにこれを含有する医薬組成物
US5952320A (en) * 1997-01-07 1999-09-14 Abbott Laboratories Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
US5985911A (en) * 1997-01-07 1999-11-16 Abbott Laboratories C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion
ZA9818B (en) * 1997-01-07 1998-07-02 Abbott Lab C-terminal ketone inhibitors of matrix metalloproteinases and tnf alpha secretion
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
EP0887077A1 (de) * 1997-06-27 1998-12-30 Roche Diagnostics GmbH Verwendung von Azulenderivaten als Metalloproteaseinhibitoren
GB9803005D0 (en) 1998-02-12 1998-04-08 British Biotech Pharm Anti-inflammatory agents
GB9804504D0 (en) * 1998-03-03 1998-04-29 Leo Pharm Prod Ltd Matrix metalloproteinase inhibitors
US6288261B1 (en) 1998-12-18 2001-09-11 Abbott Laboratories Inhibitors of matrix metalloproteinases
JP2001031637A (ja) * 1999-05-17 2001-02-06 Fuji Chemical Industries Ltd 新規なヒドロキサム酸誘導体
CN1353689A (zh) * 1999-05-17 2002-06-12 第一精密化学株式会社 新的异羟肟酸衍生物
CO5210860A1 (es) 1999-10-01 2002-10-30 Hoffmann La Roche Nuevos derivados de pirimidina-2,4,6-triona
US6797820B2 (en) 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
WO2002006227A1 (fr) * 2000-07-18 2002-01-24 Chugai Seiyaku Kabushiki Kaisha Inhibiteurs de la metalloprotease matricielle
US6716845B2 (en) 2001-03-30 2004-04-06 Hoffmann-La Roche Inc. Barbituric acid derivatives
DE60219630T2 (de) 2001-06-15 2007-12-27 Vicuron Pharmaceuticals, Inc., Fremont Bicyclische pyrrolidinverbindungen
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
WO2005090387A2 (en) * 2004-03-23 2005-09-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Histone h2a peptide derivatives and analogs and methods of use thereof
US7605132B2 (en) * 2001-08-29 2009-10-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Protective factors against inflammation, burns and noxious stimuli
US7528227B2 (en) 2004-03-23 2009-05-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Histone H2A peptide derivatives and uses thereof
CN1732023A (zh) * 2002-12-27 2006-02-08 血管技术国际股份公司 组合物和使用collajolie的方法
GB0818907D0 (en) * 2008-10-15 2008-11-19 Isis Innovation Histone lysine demethylase inhibitors
EP3061460A1 (en) 2009-04-10 2016-08-31 Tufts Medical Center, Inc. Par-1 activation by metalloproteinase-1 (mmp-1)
DE102014206916A1 (de) 2014-04-10 2015-10-15 Wacker Chemie Ag Verfahren zur Ruthenium-katalysierten Umvinylierung von Carbonsäuren

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743587A (en) * 1985-09-10 1988-05-10 G. D. Searle & Co. Hydroxamic acid based collagenase inhibitors
FR2609289B1 (fr) * 1987-01-06 1991-03-29 Bellon Labor Sa Roger Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes
GB8827308D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds
GB8827305D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds
CA2058797A1 (en) * 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
US5196412A (en) * 1991-03-06 1993-03-23 Johnson Matthey, Inc. Gallium compounds

Also Published As

Publication number Publication date
AU9023391A (en) 1992-06-25
NO922968L (no) 1992-09-24
GB2255340B (en) 1994-09-28
AU652596B2 (en) 1994-09-01
FI923494A0 (fi) 1992-08-03
GB2255339B (en) 1994-10-05
DE69108529D1 (de) 1995-05-04
JPH05503720A (ja) 1993-06-17
FI923495A0 (fi) 1992-08-03
DE69108529T2 (de) 1995-11-30
EP0489579A1 (en) 1992-06-10
HU9202497D0 (en) 1992-10-28
EP0489579B1 (en) 1995-03-29
HUT62263A (en) 1993-04-28
NO922967L (no) 1992-09-24
GB2255340A (en) 1992-11-04
DE69108363T2 (de) 1995-08-31
CA2073513A1 (en) 1992-06-04
ES2069833T3 (es) 1995-05-16
FI923495A (fi) 1992-08-03
NO922968D0 (no) 1992-07-28
HU9202498D0 (en) 1992-10-28
US5300501A (en) 1994-04-05
ATE120451T1 (de) 1995-04-15
GB2255339A (en) 1992-11-04
NO922967D0 (no) 1992-07-28
WO1992009565A1 (en) 1992-06-11
ATE120182T1 (de) 1995-04-15
FI923494A (fi) 1992-08-03
EP0489577A1 (en) 1992-06-10
AU9017391A (en) 1992-06-25
EP0489577B1 (en) 1995-03-22
DK0489579T3 (da) 1995-06-12
JPH05503719A (ja) 1993-06-17
GB9211714D0 (en) 1992-08-26
DE69108363D1 (de) 1995-04-27
WO1992009564A1 (en) 1992-06-11
AU652793B2 (en) 1994-09-08
GR3015567T3 (en) 1995-06-30
GB9211715D0 (en) 1992-08-26
CA2073510A1 (en) 1992-06-04
KR927003521A (ko) 1992-12-18
HUT61973A (en) 1993-03-29

Similar Documents

Publication Publication Date Title
KR927003520A (ko) 펩티딜(peptidyl) 유도체
DE68916071D1 (de) 3-Pyrrolidinylthio-1-azabicyclo (3.2.0)hept-2-en-2-carbonsäure-Verbindungen.
EA200300792A1 (ru) Хиназолины в качестве ингибиторов ммр-13
ATE255579T1 (de) Pyrrolidin-derivate die eine phospholipase-a2- hemmende wirkung haben
DE68917023D1 (de) 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-en-2-carbonsäureverbindungen.
DE3372707D1 (en) Spiro-(4,(3+n))-2-aza-alkan-3-carboxylic-acid derivatives, process for their preparation,agents containing them and their use
ATE129241T1 (de) Derivate von 1-naphthylpiperazin, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
KR890013044A (ko) Pt(IV)착화합물
DE69011569D1 (de) Verbindungen der 1-Azabicyclo(3.2.0)hept-2-en-2-carbonsäure.
ES488656A1 (es) Procedimiento para la preparacion de derivados de acidos aziridin-2-carboxilicos substituidos en n
KR900014388A (ko) 에세롤린의 카보네이트 유도체, 이의 제조방법 및 약제로서의 용도
GB1212460A (en) Naphthacene derivatives
KR900001715A (ko) Bu-3608 유도체
KR910000133A (ko) 아민
EA200001107A1 (ru) ПРОИЗВОДНЫЕ ОКТАГИДРО-6,10-ДИОКСО-6H-ПИРИДАЗИНО [1,2-a] [1,2] ДИАЗЕПИН-1-КАРБОНОВОЙ КИСЛОТЫ, СПОСОБ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ ДЛЯ ПОЛУЧЕНИЯ ТЕРАПЕВТИЧЕСКИ АКТИВНЫХ СОЕДИНЕНИЙ
EA200000374A2 (ru) Новые соединения 2,3-метаноаминокислоты, способ их получения и содержащие их фармацевтические композиции
CA2280395A1 (fr) Nouveaux derives d'acide hydroxamique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
RU2004130283A (ru) Комбинации, включающие производные эпотилона и алкилирующие агенты
DK0452809T3 (da) Terapautisk middel til pollakisuri, urgeinkontinens eller urininkontinens omfattende alfa-phenyl-alfa-pyridylalkansyrederivater
KR960031439A (ko) 치환 인돌 유도체
RU94026088A (ru) Способ лечения шока и способ ингибирования продуцирования альфа фактора некроза опухоли
SE8303718L (sv) E-homo-enurnanderivat, forfarande for framstellning derav samt farmaceutiska kompositioner innehallande dessa foreningar
RU94043799A (ru) Производные эпи-эпибатиденов

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid