KR890013044A - Pt(IV)착화합물 - Google Patents

Pt(IV)착화합물 Download PDF

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Publication number
KR890013044A
KR890013044A KR1019890001069A KR890001069A KR890013044A KR 890013044 A KR890013044 A KR 890013044A KR 1019890001069 A KR1019890001069 A KR 1019890001069A KR 890001069 A KR890001069 A KR 890001069A KR 890013044 A KR890013044 A KR 890013044A
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KR
South Korea
Prior art keywords
complex
alkyl
dicarboxylate
alkylamino
alkoxy
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KR1019890001069A
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English (en)
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KR0147270B1 (ko
Inventor
제이. 아브람스 마이클
엠.게인도메니코 크리스틴
에이. 뮤어러 베리
에프. 볼란코 제인
Original Assignee
원본미기재
죤슨 마테이 인코포레이티드
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Publication of KR890013044A publication Critical patent/KR890013044A/ko
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Publication of KR0147270B1 publication Critical patent/KR0147270B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic System
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음.

Description

Pt(IV)착화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 다음 일반식의 Pt(IV)착 화합물
    상기식에서 A 및 A1는 NH3또는 아미노그룹에서 선택되고, R 및 R1는 수소, C1-C10알킬, 아케닐, 아릴, 아르알킬, 아킬아미노 또는 알콕시이고, X는 할로겐 또는 알킬 모노카복실레이트 또는 디카복실레이트이다.
  2. 제1항에 있어서, X는 Cl이고, A는 NH3이고, A1는 시클로알킬아민이고, R 및 R1는 C1-C7알킬인 Pt(IV) 착화합물.
  3. 제2항에 있어서, A1는 시클로펜틸아민 또는 시클로헥실아민이고, R 및 R1는 둘다 프로필인 Pt(IV) 착 화합물.
  4. 제1항에 있어서, X는 Cl이고, A는 NH3이고, A1는 알킬아민이고, R 및 R1는 저급알킬, 저급 알킬아미노 또는 저급 알콕시인 Pt(IV) 착 화합물.
  5. 제1항에 있어서, X는 Cl이고, A 및 A1는 둘다 저급 알킬아민이고, R 및 R1는 저급알킬인 Pt(IV)착 화합물.
  6. 제1항에 있어서, X는 모노카복실레이트 또는 킬레이트 디카복실레이트이고, R 및 R1는 둘다 저급 알킬이고, A는 NH3이고, A1는 알킬 아미노인 Pt(IV) 착화합물.
  7. 활성성분으로서 제1항에 따른 착화합물 유효량을 포함하는 경구 또는 비경구투여에 적합한 약제학적 조성물.
  8. 제1항에 따른 착화합물의 종양을 가진 숙주에 투여하는 것으로 이루어진 종양의 처치방법.
  9. 제8항에 있어서, 착화합물을 경구투여하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890001069A 1988-02-02 1989-01-31 Pt(iv) 착화합물 KR0147270B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15167488A 1988-02-02 1988-02-02
US151674 1988-02-02
US29677689A 1989-01-13 1989-01-13
US296776 1989-01-13

Publications (2)

Publication Number Publication Date
KR890013044A true KR890013044A (ko) 1989-09-21
KR0147270B1 KR0147270B1 (ko) 1998-08-17

Family

ID=26848859

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890001069A KR0147270B1 (ko) 1988-02-02 1989-01-31 Pt(iv) 착화합물

Country Status (16)

Country Link
EP (1) EP0328274B1 (ko)
JP (1) JP2781403B2 (ko)
KR (1) KR0147270B1 (ko)
AT (1) ATE113054T1 (ko)
AU (1) AU618310B2 (ko)
CA (1) CA1340286C (ko)
DE (1) DE68918878T2 (ko)
DK (1) DK175050B1 (ko)
ES (1) ES2063119T3 (ko)
FI (1) FI91260C (ko)
HU (1) HU205767B (ko)
IE (1) IE65503B1 (ko)
IL (1) IL89119A (ko)
NO (1) NO177569C (ko)
NZ (1) NZ227839A (ko)
PT (1) PT89608B (ko)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI905018A0 (fi) * 1989-10-17 1990-10-12 Bristol Myers Squibb Co I vatten och loesningsmedel loesliga axiala hydroxi-och mono- och dikarboxylsyraderivat med stor tumoeraktivitet.
US5196555A (en) * 1989-10-17 1993-03-23 Bristol-Myers Squibb Company Water and solvent soluble axial hydroxy and mono- and di- carboxylic acid derivatives having high tumor activity
GB9105037D0 (en) * 1991-03-09 1991-04-24 Johnson Matthey Plc Improvements in chemical compounds
IT1251115B (it) * 1991-07-26 1995-05-04 Mauro Esposito Complessi molecolari del platino ad attivita' antitumorale
US5624919A (en) * 1993-09-14 1997-04-29 The University Of Vermont And State Agricultural College Trans platinum (IV) complexes
EP0646589A3 (en) * 1993-10-04 1995-06-28 Tanaka Precious Metal Ind Anti-tumor platinum (IV) complexes.
GB9408218D0 (en) * 1994-04-26 1994-06-15 Johnson Matthey Plc Improvements in platinum complexes
GB9502799D0 (en) * 1995-02-14 1995-04-05 Johnson Matthey Plc Improvements in platinum complexes
AU4842996A (en) * 1995-02-28 1996-09-18 Yoshinori Kidani Novel platinum (iv) complexes, process for producing the same, and carcinostatic agents containing the same
KR100246722B1 (ko) * 1997-12-30 2000-04-01 박호군 경구용 백금 착화합물 항암제 및 그 제조방법
CZ288912B6 (cs) * 1998-05-27 2001-09-12 Lachema, A. S. Komplex platiny v oxidačním čísle IV, způsob přípravy tohoto komplexu, tento komplex jako léčivo a farmaceutická kompozice tento komplex obsahující
EP2266590A3 (en) 2002-02-22 2011-04-20 Shire LLC Active agent delivery sytems and methods for protecting and administering active agents
CN1296377C (zh) * 2003-06-11 2007-01-24 南京大学 含醚键羧酸根为配体的铂（ⅱ）配合物的制备
DE602004024909D1 (de) 2003-08-13 2010-02-11 Univ South Florida Platinkomplexe zur behandlung von tumoren
DE50305768D1 (de) * 2003-10-13 2007-01-04 Salama Zoser B Verfahren zur Herstellung von trans- oder cis-Diammoniumdichlorodihydroxoplatin (IV)-Salzen und -Derivaten und ihre Verwendung zur Herstellung von pharmazeutischen Wirkstoffen
US20050288365A1 (en) 2004-01-06 2005-12-29 Heidi Kay Platinum complexes and methods for inhibiting tumor cell proliferation
US20060205810A1 (en) * 2004-11-24 2006-09-14 Schering Corporation Platinum therapeutic combinations
CZ300590B6 (cs) * 2006-06-20 2009-06-24 Pliva - Lachema A. S. Farmaceutická kompozice pro injekcní podání
CZ300424B6 (cs) * 2006-06-20 2009-05-13 Pliva - Lachema A. S. Farmaceutická kompozice pro perorální podání
US9771387B2 (en) 2013-07-16 2017-09-26 Placon Therapeutics Platinum compounds having a heterocycle ligand, nanoparticles, and uses thereof
DK3189064T3 (en) 2014-09-03 2018-11-12 Vuab Pharma A S PLATIN (IV) complex with increased antitumor effect
US10988496B2 (en) 2015-06-24 2021-04-27 Nippon Kayaku Kabushiki Kaisha Platinum (IV) complex
US10596191B2 (en) 2015-09-14 2020-03-24 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of hexa-coordinated platinum complex
CN105713046B (zh) * 2016-02-01 2018-10-26 复旦大学 一种铂类抗肿瘤前体药物，其纳米水凝胶药物及其制备方法
CN107955042B (zh) * 2017-11-23 2020-01-21 青岛大学附属医院 具有抗癌活性的铂类配合物、制备方法及应用
IL291110A (en) 2019-09-05 2022-07-01 Vuab Pharma A S New iv platinum complexes with significantly increased antitumor activity
CN112961190A (zh) * 2021-02-07 2021-06-15 山东省第二人民医院(山东省耳鼻喉医院、山东省耳鼻喉研究所) 一种藜芦酸四价铂及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8101026A (nl) * 1981-03-03 1982-10-01 Tno Platinadiamine-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiamine-complex voor de behandeling van kanker alsmede aldus verkregen gevormd geneesmiddel.
JPS6087295A (ja) * 1983-10-19 1985-05-16 Nippon Kayaku Co Ltd 新規白金錯体
JPS62207283A (ja) * 1986-03-07 1987-09-11 Yoshinori Kitani 新規な白金錯体

Also Published As

Publication number Publication date
JPH01294684A (ja) 1989-11-28
EP0328274B1 (en) 1994-10-19
DK49189A (da) 1989-08-03
DE68918878D1 (de) 1994-11-24
DK49189D0 (da) 1989-02-02
HU205767B (en) 1992-06-29
KR0147270B1 (ko) 1998-08-17
NO177569C (no) 1995-10-11
HUT49890A (en) 1989-11-28
FI91260C (fi) 1994-06-10
PT89608B (pt) 1994-05-31
JP2781403B2 (ja) 1998-07-30
PT89608A (pt) 1989-10-04
NO890426D0 (no) 1989-02-02
IE890319L (en) 1989-08-02
DE68918878T2 (de) 1995-02-23
FI91260B (fi) 1994-02-28
ATE113054T1 (de) 1994-11-15
NO177569B (no) 1995-07-03
NZ227839A (en) 1991-06-25
DK175050B1 (da) 2004-05-10
ES2063119T3 (es) 1995-01-01
FI890512A0 (fi) 1989-02-02
CA1340286C (en) 1998-12-22
IL89119A (en) 1994-04-12
IE65503B1 (en) 1995-11-01
NO890426L (no) 1989-08-03
AU2897189A (en) 1989-08-03
EP0328274A1 (en) 1989-08-16
FI890512A (fi) 1989-08-03
IL89119A0 (en) 1989-08-15
AU618310B2 (en) 1991-12-19

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