DE68918878T2 - Pt(IV) Komplexe. - Google Patents

Pt(IV) Komplexe.

Info

Publication number
DE68918878T2
DE68918878T2 DE68918878T DE68918878T DE68918878T2 DE 68918878 T2 DE68918878 T2 DE 68918878T2 DE 68918878 T DE68918878 T DE 68918878T DE 68918878 T DE68918878 T DE 68918878T DE 68918878 T2 DE68918878 T2 DE 68918878T2
Authority
DE
Germany
Prior art keywords
complexes
alkyl
dicarboxylate
alkylamino
aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68918878T
Other languages
English (en)
Other versions
DE68918878D1 (de
Inventor
Michael J Abrams
Christen M Gaindomenico
Barry A Murrer
Jean F Vollano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johnson Matthey Inc
Original Assignee
Johnson Matthey Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson Matthey Inc filed Critical Johnson Matthey Inc
Publication of DE68918878D1 publication Critical patent/DE68918878D1/de
Application granted granted Critical
Publication of DE68918878T2 publication Critical patent/DE68918878T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic System
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE68918878T 1988-02-02 1989-01-27 Pt(IV) Komplexe. Expired - Lifetime DE68918878T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15167488A 1988-02-02 1988-02-02
US29677689A 1989-01-13 1989-01-13

Publications (2)

Publication Number Publication Date
DE68918878D1 DE68918878D1 (de) 1994-11-24
DE68918878T2 true DE68918878T2 (de) 1995-02-23

Family

ID=26848859

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68918878T Expired - Lifetime DE68918878T2 (de) 1988-02-02 1989-01-27 Pt(IV) Komplexe.

Country Status (16)

Country Link
EP (1) EP0328274B1 (de)
JP (1) JP2781403B2 (de)
KR (1) KR0147270B1 (de)
AT (1) ATE113054T1 (de)
AU (1) AU618310B2 (de)
CA (1) CA1340286C (de)
DE (1) DE68918878T2 (de)
DK (1) DK175050B1 (de)
ES (1) ES2063119T3 (de)
FI (1) FI91260C (de)
HU (1) HU205767B (de)
IE (1) IE65503B1 (de)
IL (1) IL89119A (de)
NO (1) NO177569C (de)
NZ (1) NZ227839A (de)
PT (1) PT89608B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI905018A0 (fi) * 1989-10-17 1990-10-12 Bristol Myers Squibb Co I vatten och loesningsmedel loesliga axiala hydroxi-och mono- och dikarboxylsyraderivat med stor tumoeraktivitet.
US5196555A (en) * 1989-10-17 1993-03-23 Bristol-Myers Squibb Company Water and solvent soluble axial hydroxy and mono- and di- carboxylic acid derivatives having high tumor activity
GB9105037D0 (en) * 1991-03-09 1991-04-24 Johnson Matthey Plc Improvements in chemical compounds
IT1251115B (it) * 1991-07-26 1995-05-04 Mauro Esposito Complessi molecolari del platino ad attivita' antitumorale
US5624919A (en) * 1993-09-14 1997-04-29 The University Of Vermont And State Agricultural College Trans platinum (IV) complexes
EP0646589A3 (de) * 1993-10-04 1995-06-28 Tanaka Precious Metal Ind Anti-tumor Platin (IV) Komplexe.
GB9408218D0 (en) * 1994-04-26 1994-06-15 Johnson Matthey Plc Improvements in platinum complexes
GB9502799D0 (en) * 1995-02-14 1995-04-05 Johnson Matthey Plc Improvements in platinum complexes
JP3715650B2 (ja) * 1995-02-28 2005-11-09 喜徳 喜谷 新規白金（ｉｖ）錯体、その製造方法及びそれを含む制癌剤
KR100246722B1 (ko) * 1997-12-30 2000-04-01 박호군 경구용 백금 착화합물 항암제 및 그 제조방법
CZ288912B6 (cs) * 1998-05-27 2001-09-12 Lachema, A. S. Komplex platiny v oxidačním čísle IV, způsob přípravy tohoto komplexu, tento komplex jako léčivo a farmaceutická kompozice tento komplex obsahující
EP1490090A4 (de) 2002-02-22 2006-09-20 New River Pharmaceuticals Inc Wirkstoff-abgabesystem und verfahren zum schutz und zur verabreichung von wirkstoffen
CN1296377C (zh) * 2003-06-11 2007-01-24 南京大学 含醚键羧酸根为配体的铂（ⅱ）配合物的制备
CA2535762A1 (en) * 2003-08-13 2005-03-17 University Of South Florida Methods for inhibiting tumor cell proliferation
ATE346076T1 (de) * 2003-10-13 2006-12-15 Salama Zoser B Nat Rer Dr Verfahren zur herstellung von trans- oder cis- diammoniumdichlorodihydroxoplatin (iv)-salzen und derivaten und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen
US20050288365A1 (en) 2004-01-06 2005-12-29 Heidi Kay Platinum complexes and methods for inhibiting tumor cell proliferation
US20060205810A1 (en) * 2004-11-24 2006-09-14 Schering Corporation Platinum therapeutic combinations
CZ300424B6 (cs) * 2006-06-20 2009-05-13 Pliva - Lachema A. S. Farmaceutická kompozice pro perorální podání
CZ300590B6 (cs) * 2006-06-20 2009-06-24 Pliva - Lachema A. S. Farmaceutická kompozice pro injekcní podání
US9771387B2 (en) 2013-07-16 2017-09-26 Placon Therapeutics Platinum compounds having a heterocycle ligand, nanoparticles, and uses thereof
US10017532B2 (en) 2014-09-03 2018-07-10 Vuab Pharma A.S. Platinum (IV) complex with increased anti-tumor efficacy
CA2990369A1 (en) 2015-06-24 2016-12-29 Nippon Kayaku Kabushiki Kaisha Novel platinum (iv) complex
RU2715048C2 (ru) 2015-09-14 2020-02-25 Ниппон Каяку Кабусики Каися Полимерный конъюгат гексакоординированного комплекса платины
CN105713046B (zh) * 2016-02-01 2018-10-26 复旦大学 一种铂类抗肿瘤前体药物，其纳米水凝胶药物及其制备方法
CN107955042B (zh) * 2017-11-23 2020-01-21 青岛大学附属医院 具有抗癌活性的铂类配合物、制备方法及应用
AU2019464913A1 (en) 2019-09-05 2022-03-03 Vuab Pharma A.S. New platinum IV complexes with substantially increased antitumor efficacy
CN112961190A (zh) * 2021-02-07 2021-06-15 山东省第二人民医院(山东省耳鼻喉医院、山东省耳鼻喉研究所) 一种藜芦酸四价铂及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8101026A (nl) * 1981-03-03 1982-10-01 Tno Platinadiamine-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiamine-complex voor de behandeling van kanker alsmede aldus verkregen gevormd geneesmiddel.
JPS6087295A (ja) * 1983-10-19 1985-05-16 Nippon Kayaku Co Ltd 新規白金錯体
JPS62207283A (ja) * 1986-03-07 1987-09-11 Yoshinori Kitani 新規な白金錯体

Also Published As

Publication number Publication date
FI91260C (fi) 1994-06-10
FI890512A0 (fi) 1989-02-02
AU2897189A (en) 1989-08-03
JP2781403B2 (ja) 1998-07-30
ATE113054T1 (de) 1994-11-15
DK175050B1 (da) 2004-05-10
JPH01294684A (ja) 1989-11-28
NO890426L (no) 1989-08-03
PT89608A (pt) 1989-10-04
EP0328274A1 (de) 1989-08-16
DE68918878D1 (de) 1994-11-24
PT89608B (pt) 1994-05-31
KR890013044A (ko) 1989-09-21
IL89119A (en) 1994-04-12
EP0328274B1 (de) 1994-10-19
FI890512A (fi) 1989-08-03
IL89119A0 (en) 1989-08-15
NO177569B (no) 1995-07-03
DK49189A (da) 1989-08-03
ES2063119T3 (es) 1995-01-01
IE890319L (en) 1989-08-02
CA1340286C (en) 1998-12-22
AU618310B2 (en) 1991-12-19
NZ227839A (en) 1991-06-25
HU205767B (en) 1992-06-29
IE65503B1 (en) 1995-11-01
DK49189D0 (da) 1989-02-02
KR0147270B1 (ko) 1998-08-17
HUT49890A (en) 1989-11-28
FI91260B (fi) 1994-02-28
NO177569C (no) 1995-10-11
NO890426D0 (no) 1989-02-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition