ATE113054T1 - Pt(iv) komplexe. - Google Patents

Pt(iv) komplexe.

Info

Publication number
ATE113054T1
ATE113054T1 AT89300787T AT89300787T ATE113054T1 AT E113054 T1 ATE113054 T1 AT E113054T1 AT 89300787 T AT89300787 T AT 89300787T AT 89300787 T AT89300787 T AT 89300787T AT E113054 T1 ATE113054 T1 AT E113054T1
Authority
AT
Austria
Prior art keywords
complexes
alkyl
dicarboxylate
alkylamino
aralkyl
Prior art date
Application number
AT89300787T
Other languages
English (en)
Inventor
Michael J Abrams
Christen M Gaindomenico
Barry A Murrer
Jean F Vollano
Original Assignee
Johnson Matthey Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson Matthey Inc filed Critical Johnson Matthey Inc
Application granted granted Critical
Publication of ATE113054T1 publication Critical patent/ATE113054T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT89300787T 1988-02-02 1989-01-27 Pt(iv) komplexe. ATE113054T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15167488A 1988-02-02 1988-02-02
US29677689A 1989-01-13 1989-01-13

Publications (1)

Publication Number Publication Date
ATE113054T1 true ATE113054T1 (de) 1994-11-15

Family

ID=26848859

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89300787T ATE113054T1 (de) 1988-02-02 1989-01-27 Pt(iv) komplexe.

Country Status (16)

Country Link
EP (1) EP0328274B1 (de)
JP (1) JP2781403B2 (de)
KR (1) KR0147270B1 (de)
AT (1) ATE113054T1 (de)
AU (1) AU618310B2 (de)
CA (1) CA1340286C (de)
DE (1) DE68918878T2 (de)
DK (1) DK175050B1 (de)
ES (1) ES2063119T3 (de)
FI (1) FI91260C (de)
HU (1) HU205767B (de)
IE (1) IE65503B1 (de)
IL (1) IL89119A (de)
NO (1) NO177569C (de)
NZ (1) NZ227839A (de)
PT (1) PT89608B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI905018A0 (fi) * 1989-10-17 1990-10-12 Bristol Myers Squibb Co I vatten och loesningsmedel loesliga axiala hydroxi-och mono- och dikarboxylsyraderivat med stor tumoeraktivitet.
US5196555A (en) * 1989-10-17 1993-03-23 Bristol-Myers Squibb Company Water and solvent soluble axial hydroxy and mono- and di- carboxylic acid derivatives having high tumor activity
GB9105037D0 (en) * 1991-03-09 1991-04-24 Johnson Matthey Plc Improvements in chemical compounds
IT1251115B (it) * 1991-07-26 1995-05-04 Mauro Esposito Complessi molecolari del platino ad attivita' antitumorale
US5624919A (en) * 1993-09-14 1997-04-29 The University Of Vermont And State Agricultural College Trans platinum (IV) complexes
EP0646589A3 (de) * 1993-10-04 1995-06-28 Tanaka Precious Metal Ind Anti-tumor Platin (IV) Komplexe.
GB9408218D0 (en) * 1994-04-26 1994-06-15 Johnson Matthey Plc Improvements in platinum complexes
GB9502799D0 (en) * 1995-02-14 1995-04-05 Johnson Matthey Plc Improvements in platinum complexes
EP0812852B1 (de) * 1995-02-28 2003-04-23 Yoshinori Kidani Platin(iv)-komplexe, verfahren zu ihrer herstellung und sie enthaltende carcinostatische mittel
KR100246722B1 (ko) * 1997-12-30 2000-04-01 박호군 경구용 백금 착화합물 항암제 및 그 제조방법
CZ288912B6 (cs) * 1998-05-27 2001-09-12 Lachema, A. S. Komplex platiny v oxidačním čísle IV, způsob přípravy tohoto komplexu, tento komplex jako léčivo a farmaceutická kompozice tento komplex obsahující
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
CN1296377C (zh) * 2003-06-11 2007-01-24 南京大学 含醚键羧酸根为配体的铂（ⅱ）配合物的制备
DE602004015811D1 (de) * 2003-08-13 2008-09-25 Univ South Florida Verfahren zur inhibierung der proliferation von tumorzellen, bei dem platinkomplexe eingesetzt werden
DE50305768D1 (de) * 2003-10-13 2007-01-04 Salama Zoser B Verfahren zur Herstellung von trans- oder cis-Diammoniumdichlorodihydroxoplatin (IV)-Salzen und -Derivaten und ihre Verwendung zur Herstellung von pharmazeutischen Wirkstoffen
US20050288365A1 (en) 2004-01-06 2005-12-29 Heidi Kay Platinum complexes and methods for inhibiting tumor cell proliferation
US20060205810A1 (en) * 2004-11-24 2006-09-14 Schering Corporation Platinum therapeutic combinations
CZ300424B6 (cs) * 2006-06-20 2009-05-13 Pliva - Lachema A. S. Farmaceutická kompozice pro perorální podání
CZ300590B6 (cs) * 2006-06-20 2009-06-24 Pliva - Lachema A. S. Farmaceutická kompozice pro injekcní podání
WO2015009841A2 (en) * 2013-07-16 2015-01-22 Blend Therapeutics Platinum compounds having a heterocycle ligand, nanoparticles, and uses thereof
EP3189064B1 (de) * 2014-09-03 2018-08-08 Vuab Pharma A. S. Platin-(iv)-komplexe mit erhöhter antitumorwirksamkeit
RU2695357C1 (ru) * 2015-06-24 2019-07-23 Ниппон Каяку Кабусики Каися Новый комплекс платины (iv)
JP6725520B2 (ja) 2015-09-14 2020-07-22 日本化薬株式会社 ６配位白金錯体の高分子結合体
CN105713046B (zh) * 2016-02-01 2018-10-26 复旦大学 一种铂类抗肿瘤前体药物，其纳米水凝胶药物及其制备方法
CN107955042B (zh) * 2017-11-23 2020-01-21 青岛大学附属医院 具有抗癌活性的铂类配合物、制备方法及应用
JP7386972B2 (ja) 2019-09-05 2023-11-27 ブイユーエービー ファーマ エー．エス． 実質的に増加した抗腫瘍効果を有する新規白金ｉｖ錯体
CN112961190A (zh) * 2021-02-07 2021-06-15 山东省第二人民医院(山东省耳鼻喉医院、山东省耳鼻喉研究所) 一种藜芦酸四价铂及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8101026A (nl) * 1981-03-03 1982-10-01 Tno Platinadiamine-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiamine-complex voor de behandeling van kanker alsmede aldus verkregen gevormd geneesmiddel.
JPS6087295A (ja) * 1983-10-19 1985-05-16 Nippon Kayaku Co Ltd 新規白金錯体
JPS62207283A (ja) * 1986-03-07 1987-09-11 Yoshinori Kitani 新規な白金錯体

Also Published As

Publication number Publication date
NZ227839A (en) 1991-06-25
AU2897189A (en) 1989-08-03
AU618310B2 (en) 1991-12-19
HU205767B (en) 1992-06-29
JPH01294684A (ja) 1989-11-28
DE68918878D1 (de) 1994-11-24
DK49189D0 (da) 1989-02-02
CA1340286C (en) 1998-12-22
EP0328274B1 (de) 1994-10-19
IE890319L (en) 1989-08-02
PT89608B (pt) 1994-05-31
IE65503B1 (en) 1995-11-01
NO177569C (no) 1995-10-11
DK49189A (da) 1989-08-03
IL89119A0 (en) 1989-08-15
IL89119A (en) 1994-04-12
KR0147270B1 (ko) 1998-08-17
ES2063119T3 (es) 1995-01-01
KR890013044A (ko) 1989-09-21
DK175050B1 (da) 2004-05-10
EP0328274A1 (de) 1989-08-16
JP2781403B2 (ja) 1998-07-30
HUT49890A (en) 1989-11-28
NO177569B (no) 1995-07-03
FI890512A (fi) 1989-08-03
NO890426L (no) 1989-08-03
NO890426D0 (no) 1989-02-02
FI890512A0 (fi) 1989-02-02
PT89608A (pt) 1989-10-04
DE68918878T2 (de) 1995-02-23
FI91260C (fi) 1994-06-10
FI91260B (fi) 1994-02-28

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time