ES472384A1 - Un procedimiento para la preparacion de derivados de amino- piridina - Google Patents
Un procedimiento para la preparacion de derivados de amino- piridinaInfo
- Publication number
- ES472384A1 ES472384A1 ES472384A ES472384A ES472384A1 ES 472384 A1 ES472384 A1 ES 472384A1 ES 472384 A ES472384 A ES 472384A ES 472384 A ES472384 A ES 472384A ES 472384 A1 ES472384 A1 ES 472384A1
- Authority
- ES
- Spain
- Prior art keywords
- substituted amino
- pyridine derivatives
- alkyl
- hydrogen
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un procedimiento para la preparación de derivados de aminopiridina de fórmula **(Fórmula)** donde R3 es hidrógeno o un grupo ácido carboxílico o una sal o éster farmacéuticamente aceptable de un grupo ácido carboxílico; un grupo alquilo opcionalmente sustituido con uno o más grupos hidroxilo; o un grupo nitrilo, formilo, tetrazolilo o alquil (C1-6)carbonilo; R2 es hidrógeno o alquilo C1-6; R4 y R5 son hidrógeno, alquilo C1-6 ó halógeno; Z representa hidrógeno, fenilo o alquilo C1-6, opcionalmente sustituido con fenilo; Alq representa un grupo alquileno de cadena lineal o ramificada conteniendo hasta 12 átomos de carbono; x es 0 ó 1 y R1 representa fenilo o naftilo, opcionalmente sustituido con hasta tres grupos seleccionados entre alquilo C1-6, fenilo, halógeno, alcoxi C1-6, amino, nitro, hidroxi, alquilamido C1-6, alquil(C1-6)carboniloxi, carboxi, alcoxi(C1-6)carbonilo, halolaquilo C1-6 y oxoalquilo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3305577 | 1977-08-06 | ||
GB1940678 | 1978-05-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES472384A1 true ES472384A1 (es) | 1979-10-01 |
Family
ID=26254035
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES472384A Expired ES472384A1 (es) | 1977-08-06 | 1978-08-04 | Un procedimiento para la preparacion de derivados de amino- piridina |
ES479931A Expired ES479931A1 (es) | 1977-08-06 | 1979-04-25 | Un procedimiento para la preparacion de derivados de amino- piridina. |
ES479933A Expired ES479933A1 (es) | 1977-08-06 | 1979-04-25 | Un procedimiento para la preparacion de derivados de amino- piridina. |
ES479932A Expired ES479932A1 (es) | 1977-08-06 | 1979-04-25 | Un procedimiento para la preparacion de derivados de amino- piridina. |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES479931A Expired ES479931A1 (es) | 1977-08-06 | 1979-04-25 | Un procedimiento para la preparacion de derivados de amino- piridina. |
ES479933A Expired ES479933A1 (es) | 1977-08-06 | 1979-04-25 | Un procedimiento para la preparacion de derivados de amino- piridina. |
ES479932A Expired ES479932A1 (es) | 1977-08-06 | 1979-04-25 | Un procedimiento para la preparacion de derivados de amino- piridina. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0000816A1 (es) |
JP (1) | JPS5441881A (es) |
AU (1) | AU3862078A (es) |
DK (1) | DK346278A (es) |
ES (4) | ES472384A1 (es) |
IL (1) | IL55242A0 (es) |
IT (1) | IT1106623B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1160229A (en) * | 1979-03-13 | 1984-01-10 | Pieter T. Haken | Pyridyliminomethylbenzene derivatives |
DE3066911D1 (en) * | 1979-04-21 | 1984-04-19 | Beecham Group Plc | Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions containing them |
JPS5938653B2 (ja) * | 1980-05-30 | 1984-09-18 | 日本ビクター株式会社 | 電極付き針の製作法 |
JPS5798143A (en) * | 1980-12-05 | 1982-06-18 | Victor Co Of Japan Ltd | Base body of detection type for variation in electrostatic capacity value |
DE3124673A1 (de) * | 1981-06-24 | 1983-01-13 | Bayer Ag, 5090 Leverkusen | Subsituierte 2-amino-pyridinderivate, verfahren zu ihrer herstellung, ihre verwendung in arzneimitteln, sowie deren herstellung |
US4552960A (en) * | 1983-06-20 | 1985-11-12 | Eli Lilly And Company | Fungicidal amines |
US4774251A (en) * | 1984-06-18 | 1988-09-27 | Eli Lilly And Company | Method of inhibiting aromatase |
US4855308A (en) * | 1987-12-04 | 1989-08-08 | Warner-Lambert Company | Method of treating senile cognitive decline with N'-substituted aminopyridine adrenergic agents |
US4931457B1 (en) * | 1989-06-28 | 1993-11-16 | Hoechst-Roussel Pharmaceuticals Incorporated | Naphthylamino-and naphthyloxy-pyridineamin compounds useful as topical antiinflammatory agents for the treatment of skin disorders |
AU630877B2 (en) * | 1989-07-28 | 1992-11-12 | Ah N. Fah | Improved automatic plant watering and feeding system |
FR2668770A1 (fr) * | 1990-11-07 | 1992-05-07 | Nyco Sa | Esters d'acides amines heterocycliques et leurs derives, et leur application comme additifs anti-oxydants pour les huiles de graissage a temperature elevee. |
GB9514160D0 (en) * | 1994-07-25 | 1995-09-13 | Zeneca Ltd | Aromatic compounds |
GB9420557D0 (en) * | 1994-10-12 | 1994-11-30 | Zeneca Ltd | Aromatic compounds |
TW434240B (en) * | 1995-06-20 | 2001-05-16 | Zeneca Ltd | Aromatic compounds, preparation thereof and pharmaceutical composition comprising same |
TW502026B (en) * | 1995-06-20 | 2002-09-11 | Zeneca Ltd | Aromatic compounds useful as antagonists of e-type prostaglandins, processes for the preparation thereof, pharmaceutical compositions comprising the compounds, and intermediates |
EP0752421B1 (en) * | 1995-07-07 | 2005-10-12 | AstraZeneca AB | Ortho-substituted aromatic compounds, containing three (het)aryl moieties, their preparation and their use as prostaglandin E2-(PGE2)-antagonists |
DE19845406C2 (de) * | 1998-10-02 | 2001-10-18 | Aventis Pharma Gmbh | Substituierte 1,3-Diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)- propanolderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
HUP0201033A3 (en) * | 1999-05-17 | 2003-03-28 | Novo Nordisk As | Glucagon antagonists/inverse agonists, process for their preparation and their use |
US6503949B1 (en) | 1999-05-17 | 2003-01-07 | Noro Nordisk A/S | Glucagon antagonists/inverse agonists |
US20020198219A1 (en) * | 2000-08-08 | 2002-12-26 | Grant Elfrida R. | 2-pyridinamine compositions and related methods |
JP2008534597A (ja) * | 2005-03-28 | 2008-08-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | PKC−θのインヒビターとして有用なピリジン誘導体 |
CA2691662A1 (en) | 2007-07-02 | 2009-01-08 | F. Hoffmann-La Roche Ag | Imidazole derivatives as ccr2 receptor antagonists |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2784138A (en) * | 1953-03-07 | 1957-03-05 | Bayer Ag | Fungicidal compositions of nu-arylhydroxyarylmethylamines |
DE1119274B (de) * | 1954-03-19 | 1961-12-14 | Raschig Gmbh Dr F | Verfahren zur Herstellung von 2-Amino-4-alkyl-pyridinen |
NL132603C (es) * | 1964-08-29 | |||
DE1670522C3 (de) * | 1966-05-12 | 1978-08-31 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | Neue Benzylaminopyridine |
NL6707290A (es) * | 1966-05-28 | 1967-11-29 | ||
US3450707A (en) * | 1966-12-13 | 1969-06-17 | Sterling Drug Inc | Certain 2-anilino-pyridine derivatives |
US3535328A (en) * | 1967-09-01 | 1970-10-20 | Exxon Research Engineering Co | Certain substituted aminothioethoxy pyridines |
FR2050940A5 (es) * | 1969-06-30 | 1971-04-02 | Rhone Poulenc Sa | |
DE2141418A1 (de) * | 1970-08-18 | 1972-03-09 | Roemmers S.A. Industrial Comercial Y Financiera, Buenos Aires | Anilinderivate der Nikotinsäure und ihre Salze |
FR2155922A2 (en) * | 1971-10-15 | 1973-05-25 | Aries Robert | Organophosphorus pesticides - stabilized by amino- or aminoalkyl-pyridines |
DE2230392A1 (de) * | 1972-06-22 | 1974-01-31 | Cassella Farbwerke Mainkur Ag | Substituierte pyridinverbindungen und verfahren zu ihrer herstellung |
GB1405308A (en) * | 1972-12-13 | 1975-09-10 | Basf Ag | Amino-pytidines as coupling components for azo dyes |
FR2288798A1 (fr) * | 1974-10-24 | 1976-05-21 | Popescu Francine | Bain et procede de zingage electrolytique brillant |
DE2605467A1 (de) * | 1976-02-12 | 1977-08-18 | Basf Ag | Pyridinverbindungen |
-
1978
- 1978-07-25 EP EP78300190A patent/EP0000816A1/en not_active Withdrawn
- 1978-07-28 IL IL55242A patent/IL55242A0/xx unknown
- 1978-08-03 AU AU38620/78A patent/AU3862078A/en active Pending
- 1978-08-04 DK DK346278A patent/DK346278A/da unknown
- 1978-08-04 ES ES472384A patent/ES472384A1/es not_active Expired
- 1978-08-04 IT IT50601/78A patent/IT1106623B/it active
- 1978-08-07 JP JP9604778A patent/JPS5441881A/ja active Pending
-
1979
- 1979-04-25 ES ES479931A patent/ES479931A1/es not_active Expired
- 1979-04-25 ES ES479933A patent/ES479933A1/es not_active Expired
- 1979-04-25 ES ES479932A patent/ES479932A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IT1106623B (it) | 1985-11-11 |
AU3862078A (en) | 1980-02-07 |
JPS5441881A (en) | 1979-04-03 |
ES479932A1 (es) | 1979-12-01 |
DK346278A (da) | 1979-02-07 |
EP0000816A1 (en) | 1979-02-21 |
IT7850601A0 (it) | 1978-08-04 |
ES479933A1 (es) | 1979-12-01 |
ES479931A1 (es) | 1979-12-01 |
IL55242A0 (en) | 1978-09-29 |
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