KR900004714A - 신규의 3,4-디아미노 퀴놀린 및 피리딘계 화합물 - Google Patents

신규의 3,4-디아미노 퀴놀린 및 피리딘계 화합물 Download PDF

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Publication number
KR900004714A
KR900004714A KR1019890014031A KR890014031A KR900004714A KR 900004714 A KR900004714 A KR 900004714A KR 1019890014031 A KR1019890014031 A KR 1019890014031A KR 890014031 A KR890014031 A KR 890014031A KR 900004714 A KR900004714 A KR 900004714A
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South Korea
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group
hydrogen atom
lower alkyl
compound according
cycloalkyl
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KR1019890014031A
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유따까 미우라
미쓰따까 요시다
야스오 후지무라
사까에 다까꾸
유끼후미 노다
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사노 하지메
쥬우가이세이야꾸 가부시끼가이샤
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Publication of KR900004714A publication Critical patent/KR900004714A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Abstract

내용 없음

Description

신규의 3,4-디아미노퀴놀린 및 피리딘계 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 방사상 미로과제 수행시험에서의 본 발명 화합물의 투여량과 정반응 수와의 관계를 나타낸 것이다.

Claims (12)

  1. 하기 일반식(I)로 표시되는 4-아미노피리딘 유도체, 또는 그의 산부가염.
    (식중 R1은 수소원자; 수산기; 수산기로 치환되어 있어도 무방한 직쇄상 또는 분지쇄상의 저급알킬기 혹은 시클로알킬기; 저급알코시기; 카르보닐기를 함유한 저급알킬기 혹은 시클로알킬기; 모르폴리노기 또는 -N,H-B를 나타내며, B는 저급알킬기, 시클로알킬기 및 페닐기를 나타낸다. R2및 R3은 가각 동일 혹은 상이하며, 수소원자, 저급알킬기 또는 저급알킬카르보닐기를 나타내거나, 함께되어 질소원자를 함유하고, 아자시클로알킬기, 모르폴리노기, N-메틸피페라질기를 나타내며, R4및 R5는 각각 수소원자를 나타내거나, 또는 함께되어 환 A가 함께 퀴놀린환 혹은 5,6,7,8-테트라히드로퀴놀린 환을 구성한다. 단, R1,R4및 R5가 모두 소소원자일 경우에는, R2및 R3이 함께 수소원자이거나 R2및 R3이 함께 메틸기인 경우는 없고; 또한 R1이 수소원자이고, R4및 R5가 함께되어 환 A와 함께 퀴놀린 환을 구성하는 경우에는, R2및 R3이 함께 수소원자이건, R2및 R3이 함께 에틸기인 경우는 없다.)
  2. 제1항에 있어서, 저급알킬기의 탄소수가 1∼6이고, 저급알콕시기의 탄소수가 1∼6이며, 시클로알킬기의 탄소수가 3∼7인 화합물.
  3. 제2항에 있어서, 저급알킬기가 메틸기, 에틸기, n-프로필기, n-부틸기 또는 2-펜틸기이고, 저급 알콕시기가 메톡시기 또는 에톡시기이며, 시클로알킬기가 시클로헥실기인 화합물.
  4. 제1항에 있어서, 저급알킬카르보닐기의 탄소수가 2∼7인 화합물.
  5. 제4항에 있어서, 저급알킬카르보닐기가 아세틸기 또는 프로피오닐기인 화합물.
  6. 제1항에 있어서, 아자시클로알킬기의 탄소수가 3∼6인 화합물.
  7. 제6항에 있어서, 아자시클로알킬기가 피롤리딜기 또는 피페리딜기인 화합물.
  8. 제1항에 있어서, R2및 R3이 함께되어 질소원자를 함유하며 아자시클로알킬기, 모르폴리노기 또는 N-메틸피페라질기를 구성하는 화합물.
  9. 약학적으로 허용될 수 있는 담체 및 하기 일반식으로 표시되는 4-아미노피리딘 유도체, 또는 그의 산부가염을 유효성분으로서 함유하는 정신신경기능 개선제.
    (식중 R1은 수소원자; 수산기; 수산기로 치환되어 있어도 무방한 직쇄상 또는 분지쇄상의 저급알킬기 혹은 시클로알킬기; 저급알코시기; 카르보닐기를 함유한 저급알킬기 혹은 시클로알킬기; 모르폴리노기 또는 -N,H-B를 나타내며, B는 저급알킬기, 시클로알킬기 및 페닐기를 나타낸다. R2및 R3은 각각 동일 혹은 상이하며, 수소원자, 저급알킬기 또는 저급알킬카르보닐기를 나타내거나, 함께되어 질소원자를 함유하고, 아자시클로알킬기, 모르폴리노기, N-메틸피페라질기를 나타내며, R4및 R5는 각각 수소원자를 나타내거나, 또는 함께되어 환 A가 함께 퀴놀린 환 혹은 5,6,7,8-테트라히드로 퀴놀린 환을 구성한다. 단, R1,R4및 R5가 모두 소소원자일 경우에는, R2및 R3이 함께 수소원자이거나 R2및 R3이 함께 메틸기인 경우는 없다.)
  10. 알쯔하이머형 치매중 치료용의 제9항에 기재된 의약 조성물.
  11. 카테콜아민계의 장해에 의한 정신기능장해 치료용의 제9항에 기재된 의약 조성물.
  12. 기억학습기능 촉진용의 제9항에 기재된 의약 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890014031A 1988-09-30 1989-09-29 신규의 3,4-디아미노 퀴놀린 및 피리딘계 화합물 KR900004714A (ko)

Applications Claiming Priority (2)

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JP24623788 1988-09-30
JP63-246237 1988-09-30

Publications (1)

Publication Number Publication Date
KR900004714A true KR900004714A (ko) 1990-04-12

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KR1019890014031A KR900004714A (ko) 1988-09-30 1989-09-29 신규의 3,4-디아미노 퀴놀린 및 피리딘계 화합물

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Country Link
US (1) US5019574A (ko)
EP (1) EP0361489A3 (ko)
KR (1) KR900004714A (ko)
FI (1) FI894629A (ko)
NO (1) NO893886L (ko)

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TW200462B (ko) * 1990-09-27 1993-02-21 Hoechst Roussel Pharma
US5110815A (en) * 1990-12-03 1992-05-05 Hoechst-Roussel Pharmaceuticals Inc. 5-amino-5,6,7,8-tetrahydroquinolines and related compounds and pharmaceutical use
SK285198B6 (sk) * 1997-10-27 2006-08-03 Neurosearch A/S Homopiperazínový derivát, farmaceutická kompozícia obsahujúca tento derivát a jeho použitie
HUP0101275A3 (en) 1998-03-26 2002-12-28 Japan Tobacco Inc Amide derivatives and pharmaceutical compositions containing them as nociceptin antagonists
ATE245153T1 (de) 1999-04-26 2003-08-15 Neurosearch As Heteroaryl-diazacycloalkane, ihre herstellung und verwendung
US6458326B1 (en) 1999-11-24 2002-10-01 Home Diagnostics, Inc. Protective test strip platform
US6525330B2 (en) 2001-02-28 2003-02-25 Home Diagnostics, Inc. Method of strip insertion detection
US6541266B2 (en) 2001-02-28 2003-04-01 Home Diagnostics, Inc. Method for determining concentration of an analyte in a test strip
US6562625B2 (en) 2001-02-28 2003-05-13 Home Diagnostics, Inc. Distinguishing test types through spectral analysis
NZ560917A (en) 2005-03-31 2011-01-28 Pfizer Prod Inc Cyclopentapyridine and tetrahydroquinoline derivatives
FR2885616B1 (fr) 2005-05-12 2007-06-22 Servier Lab Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2885615B1 (fr) * 2005-05-12 2007-06-22 Servier Lab Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2008010073A1 (en) * 2006-07-14 2008-01-24 Pfizer Products Inc. Tartrate salt of (7s)-7-[(5-fluoro-2-methyl-benzyl)oxy]-2-[(2r)-2-methylpiperazin-1-yl]-6,7-dihydro-5h-cyclopenta[b]pyridine
AU2010232923A1 (en) * 2009-04-03 2011-11-03 Medisyn Technologies, Inc. Compositions for treatment of Alzheimer's disease
CN109467538A (zh) 2017-09-07 2019-03-15 和记黄埔医药（上海）有限公司 环烯烃取代的杂芳环类化合物及其用途

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US4734275A (en) * 1983-08-19 1988-03-29 Research Corporation Anti-curare agents
CA1271477A (en) * 1983-11-18 1990-07-10 John F. Gerster 1h-imidazo[4,5-c]quinolin-4-amines
CA1306260C (en) * 1985-10-18 1992-08-11 Shionogi & Co., Ltd. Condensed imidazopyridine derivatives
US4789678A (en) * 1986-08-25 1988-12-06 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds
CA1335996C (en) * 1988-02-16 1995-06-20 Susumu Takada 2-substituted carbonylimidazo¬4,5-c|quinolines

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Publication number Publication date
NO893886L (no) 1990-04-02
EP0361489A3 (en) 1991-06-12
NO893886D0 (no) 1989-09-29
EP0361489A2 (en) 1990-04-04
FI894629A (fi) 1990-03-31
US5019574A (en) 1991-05-28
FI894629A0 (fi) 1989-09-29

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