BR9909666A - Derivados de amida e antagonistas de nociceptina - Google Patents
Derivados de amida e antagonistas de nociceptinaInfo
- Publication number
- BR9909666A BR9909666A BR9909666-8A BR9909666A BR9909666A BR 9909666 A BR9909666 A BR 9909666A BR 9909666 A BR9909666 A BR 9909666A BR 9909666 A BR9909666 A BR 9909666A
- Authority
- BR
- Brazil
- Prior art keywords
- similar
- nociceptin
- integer
- compound
- amide derivatives
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
- A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
- C07D219/12—Amino-alkylamino radicals attached in position 9
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: <B>"DERIVADOS DE AMIDA E ANTAGONISTAS DE NOCICEPTINA"<D>. A presente invenção refere-se a um composto da fórmula [1'] onde R² é alquila inferior opcionalmente substituída por hidróxi, amino e similar, onde o anel B é fenila, tienila e similar, E é uma ligação simples, -O-, -S-, e similar, o anel G é arila, grupo heterocíclico e similar, R^ 5^ é átomo de halogênio, hidróxi, alquila inferior opcionalmente substituída por átomo de halogênio etc, e similar, t é 0 ou um número inteiro de 1 a 5, quanto t é um número inteiro de 2 a 5, cada R^ 5^ pode ser igual ou diferente, m é 0 ou um número inteiro de 1 a 8, e n é 0 ou um número inteiro de 1 a 4, e um composto [1'] contendo o antagonista de nociceptina como um ingrediente ativo. O composto [1'] mostra, devido à ação antagonística da nociceptina, efeito analgésico contra dor aguda tal como dor do pós-operatório e similar. A presente invenção também refere-se ao uso de certos derivados de amida que incluem o composto [1'] como um antagonista de nociceptina ou analgésico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10002998 | 1998-03-26 | ||
PCT/JP1999/001462 WO1999048492A1 (fr) | 1998-03-26 | 1999-03-23 | Derives d'amide et antagonistes de nociceptine |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9909666A true BR9909666A (pt) | 2001-09-11 |
Family
ID=14263120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9909666-8A BR9909666A (pt) | 1998-03-26 | 1999-03-23 | Derivados de amida e antagonistas de nociceptina |
Country Status (21)
Country | Link |
---|---|
US (3) | US6410561B1 (pt) |
EP (1) | EP1072263A4 (pt) |
KR (1) | KR20010042161A (pt) |
CN (1) | CN1301154A (pt) |
AR (1) | AR018168A1 (pt) |
AU (1) | AU754716B2 (pt) |
BR (1) | BR9909666A (pt) |
CA (1) | CA2325638A1 (pt) |
CO (1) | CO5080780A1 (pt) |
FI (1) | FI20002103A (pt) |
HU (1) | HUP0101275A3 (pt) |
ID (1) | ID26099A (pt) |
IL (1) | IL138573A0 (pt) |
NO (1) | NO20004778L (pt) |
NZ (1) | NZ507760A (pt) |
RU (1) | RU2202344C2 (pt) |
SK (1) | SK14272000A3 (pt) |
TR (1) | TR200003598T2 (pt) |
TW (1) | TW487571B (pt) |
WO (1) | WO1999048492A1 (pt) |
ZA (1) | ZA200005881B (pt) |
Families Citing this family (110)
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AU3676100A (en) | 1999-04-09 | 2000-11-14 | Mochida Pharmaceutical Co., Ltd. | Remedies for neuropathic pain |
WO2001039723A2 (en) | 1999-12-06 | 2001-06-07 | Euro-Celtique, S.A. | Triazospiro compounds having nociceptin receptor affinity |
EP1244437A4 (en) | 1999-12-06 | 2005-02-09 | Euro Celtique Sa | TERTIARY AMINO COMPOUNDS HAVING AFFINITY FOR OPIOID RECEPTOR |
DE60022226D1 (de) | 1999-12-06 | 2005-09-29 | Euro Celtique Sa | Benzimidazolverbindungen die nociceptinrezeptoraffinität haben |
DE19963175A1 (de) * | 1999-12-27 | 2001-07-12 | Gruenenthal Gmbh | Verwendung von substituierten 4-Amino-1-phenylbutan-2-ol-Verbindungen als Arzneimittel |
CA2403605A1 (en) | 2000-03-31 | 2002-09-18 | Kazuya Mori | Heterocycle derivatives and drugs |
US20040229781A1 (en) * | 2000-05-10 | 2004-11-18 | Marks Andrew Robert | Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias |
US6489125B1 (en) * | 2000-05-10 | 2002-12-03 | The Trustees Of Columbia University In The City Of New York | Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor |
US7393652B2 (en) | 2000-05-10 | 2008-07-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2) |
US20060293266A1 (en) * | 2000-05-10 | 2006-12-28 | The Trustees Of Columbia | Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure |
US20040048780A1 (en) * | 2000-05-10 | 2004-03-11 | The Trustees Of Columbia University In The City Of New York | Method for treating and preventing cardiac arrhythmia |
US7718644B2 (en) | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
US7879840B2 (en) | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
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SE0004053D0 (sv) | 2000-11-06 | 2000-11-06 | Astrazeneca Ab | N-type calcium channel antagonists for the treatment of pain |
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KR101939710B1 (ko) | 2011-12-21 | 2019-01-17 | 노비라 테라퓨틱스, 인코포레이티드 | B형 간염의 항바이러스성 제제 |
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1999
- 1999-03-23 RU RU2000126841/04A patent/RU2202344C2/ru not_active IP Right Cessation
- 1999-03-23 SK SK1427-2000A patent/SK14272000A3/sk unknown
- 1999-03-23 NZ NZ507760A patent/NZ507760A/xx unknown
- 1999-03-23 CA CA002325638A patent/CA2325638A1/en not_active Abandoned
- 1999-03-23 TR TR2000/03598T patent/TR200003598T2/xx unknown
- 1999-03-23 BR BR9909666-8A patent/BR9909666A/pt not_active IP Right Cessation
- 1999-03-23 WO PCT/JP1999/001462 patent/WO1999048492A1/ja not_active Application Discontinuation
- 1999-03-23 AU AU28558/99A patent/AU754716B2/en not_active Ceased
- 1999-03-23 US US09/646,781 patent/US6410561B1/en not_active Expired - Fee Related
- 1999-03-23 EP EP99909320A patent/EP1072263A4/en not_active Withdrawn
- 1999-03-23 IL IL13857399A patent/IL138573A0/xx unknown
- 1999-03-23 KR KR1020007010601A patent/KR20010042161A/ko not_active Application Discontinuation
- 1999-03-23 HU HU0101275A patent/HUP0101275A3/hu unknown
- 1999-03-23 CN CN99806429A patent/CN1301154A/zh active Pending
- 1999-03-23 ID IDW20002152A patent/ID26099A/id unknown
- 1999-03-24 TW TW088104619A patent/TW487571B/zh not_active IP Right Cessation
- 1999-03-26 AR ARP990101349A patent/AR018168A1/es not_active Application Discontinuation
- 1999-03-26 CO CO99018458A patent/CO5080780A1/es unknown
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2000
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- 2000-10-20 ZA ZA200005881A patent/ZA200005881B/en unknown
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2002
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2005
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US20030055087A1 (en) | 2003-03-20 |
ZA200005881B (en) | 2001-08-23 |
CO5080780A1 (es) | 2001-09-25 |
EP1072263A1 (en) | 2001-01-31 |
EP1072263A4 (en) | 2004-03-31 |
TR200003598T2 (tr) | 2001-06-21 |
US20060030565A1 (en) | 2006-02-09 |
FI20002103A (fi) | 2000-11-17 |
HUP0101275A3 (en) | 2002-12-28 |
NZ507760A (en) | 2002-10-25 |
NO20004778L (no) | 2000-11-27 |
AU754716B2 (en) | 2002-11-21 |
US6410561B1 (en) | 2002-06-25 |
AR018168A1 (es) | 2001-10-31 |
CN1301154A (zh) | 2001-06-27 |
HUP0101275A2 (hu) | 2001-09-28 |
KR20010042161A (ko) | 2001-05-25 |
CA2325638A1 (en) | 1999-09-30 |
ID26099A (id) | 2000-11-23 |
RU2202344C2 (ru) | 2003-04-20 |
US6903094B2 (en) | 2005-06-07 |
WO1999048492A1 (fr) | 1999-09-30 |
AU2855899A (en) | 1999-10-18 |
NO20004778D0 (no) | 2000-09-25 |
TW487571B (en) | 2002-05-21 |
IL138573A0 (en) | 2001-10-31 |
SK14272000A3 (sk) | 2001-05-10 |
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