ATE475640T1 - Antagonisten des opioidrezeptors - Google Patents

Antagonisten des opioidrezeptors

Info

Publication number
ATE475640T1
ATE475640T1 AT05724567T AT05724567T ATE475640T1 AT E475640 T1 ATE475640 T1 AT E475640T1 AT 05724567 T AT05724567 T AT 05724567T AT 05724567 T AT05724567 T AT 05724567T AT E475640 T1 ATE475640 T1 AT E475640T1
Authority
AT
Austria
Prior art keywords
sup
antagonists
opioid receptor
racemate
diastereomer
Prior art date
Application number
AT05724567T
Other languages
English (en)
Inventor
La Torre Marta Garcia De
Charles Mitch
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE475640T1 publication Critical patent/ATE475640T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Child & Adolescent Psychology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
AT05724567T 2004-03-12 2005-03-08 Antagonisten des opioidrezeptors ATE475640T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04380058 2004-03-12
US55318404P 2004-03-15 2004-03-15
PCT/US2005/007051 WO2005090286A1 (en) 2004-03-12 2005-03-08 Opioid receptor antagonists

Publications (1)

Publication Number Publication Date
ATE475640T1 true ATE475640T1 (de) 2010-08-15

Family

ID=34961741

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05724567T ATE475640T1 (de) 2004-03-12 2005-03-08 Antagonisten des opioidrezeptors

Country Status (7)

Country Link
US (1) US7381750B2 (de)
EP (1) EP1727788B1 (de)
AT (1) ATE475640T1 (de)
CA (1) CA2558568A1 (de)
DE (1) DE602005022572D1 (de)
ES (1) ES2347577T3 (de)
WO (1) WO2005090286A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA80437C2 (en) * 2002-09-19 2007-09-25 Lilly Co Eli Diaryl ethers as opioid receptor antagonist
ES2318472T3 (es) 2004-03-15 2009-05-01 Eli Lilly And Company Derivados de 5-(5-(aminoetil)-indol-1-ilmetil)-benzamida y compuestos relacionados como antagonistas del receptor opioide para el tratamiento de la obesidad.
KR20090051778A (ko) 2006-09-08 2009-05-22 화이자 프로덕츠 인코포레이티드 다이아릴 에터 유도체 및 이의 용도
US8278442B2 (en) 2007-05-22 2012-10-02 Prosidion Limited Bicyclic aryl and heteroaryl compounds for the treatment of metabolic disorders
WO2009030962A1 (en) 2007-09-07 2009-03-12 Prosidion Limited Bicyclic aryl and heteroaryl receptor modulators
NZ586225A (en) * 2008-01-22 2012-05-25 Lilly Co Eli Kappa selective opioid receptor antagonist
PE20120991A1 (es) * 2009-09-18 2012-08-01 Adolor Corp Antagonista del receptor opiaceo para los trastornos del tracto gastrointestinal
US8425885B2 (en) * 2009-11-09 2013-04-23 Conopco, Inc. Substituted 3-(phenoxymethyl) benzyl amines and personal care compositions
US8309064B2 (en) 2009-11-09 2012-11-13 Conopco, Inc. Skin care compositions comprising phenoxyalkyl amines
EP3037408A4 (de) * 2013-08-23 2017-03-08 Ishihara Sangyo Kaisha, Ltd. Mittel zur bekämpfung schädlicher organismen
EP3265456B1 (de) 2015-03-06 2020-11-18 Pharmakea, Inc. Fluorierte lysyloxidase-like-2-inhibitoren und verwendungen davon
EP3265445B1 (de) 2015-03-06 2021-05-05 Pharmakea, Inc. Lysyloxidase-like-2-inhibitoren und verwendungen davon
US10774069B2 (en) 2016-09-07 2020-09-15 Pharmakea, Inc. Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making
WO2018048942A1 (en) 2016-09-07 2018-03-15 Pharmakea, Inc. Uses of a lysyl oxidase-like 2 inhibitor
US12161622B2 (en) 2021-05-04 2024-12-10 Janssen Pharmaceuticals, Inc. Compositions and methods for the treatment of depression
IL315415A (en) 2022-03-07 2024-11-01 Janssen Pharmaceuticals Inc The compositions containing eticarpant
CA3254365A1 (en) 2022-03-07 2023-09-14 Janssen Pharmaceuticals, Inc. POLYMORPHIC FORMS OF ATICAPRANT INTENDED FOR USE IN THE TREATMENT OF MAJOR DEPRESSION

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA754192B (en) 1974-08-05 1976-06-30 Ciba Geigy Ag 2-(aralkoxyphenyl)-1-(bis-arylalkylamino)-alkanes
GB9104656D0 (en) 1991-03-05 1991-04-17 Zambeletti Spa L Pharmaceuticals
GB9417532D0 (en) 1994-08-31 1994-10-19 Zeneca Ltd Aromatic compounds
BR9909666A (pt) * 1998-03-26 2001-09-11 Japan Tobacco Inc Derivados de amida e antagonistas de nociceptina
DK1859798T3 (en) 2001-03-29 2016-03-21 Lilly Co Eli N- (2-arylethyl) -BENZYLAMINER as antagonists of 5-HT6 receptor
UA80437C2 (en) 2002-09-19 2007-09-25 Lilly Co Eli Diaryl ethers as opioid receptor antagonist
ATE406360T1 (de) 2003-03-07 2008-09-15 Lilly Co Eli Antagonisten der opioidrezeptoren
DE10317098A1 (de) 2003-04-14 2004-07-22 Infineon Technologies Ag Verfahren zur Herstellung eines Bipolartransistors
US7196100B2 (en) 2003-12-12 2007-03-27 Eli Lilly And Company Opioid receptor antagonists
EP1699783B1 (de) 2003-12-22 2012-07-25 Eli Lilly And Company Antagonisten des opioidrezeptors

Also Published As

Publication number Publication date
US20070287751A1 (en) 2007-12-13
CA2558568A1 (en) 2005-09-29
ES2347577T3 (es) 2010-11-02
US7381750B2 (en) 2008-06-03
WO2005090286A1 (en) 2005-09-29
EP1727788A1 (de) 2006-12-06
DE602005022572D1 (de) 2010-09-09
EP1727788B1 (de) 2010-07-28
WO2005090286B1 (en) 2005-12-22

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties