ATE255579T1 - Pyrrolidin-derivate die eine phospholipase-a2- hemmende wirkung haben - Google Patents
Pyrrolidin-derivate die eine phospholipase-a2- hemmende wirkung habenInfo
- Publication number
- ATE255579T1 ATE255579T1 AT98900741T AT98900741T ATE255579T1 AT E255579 T1 ATE255579 T1 AT E255579T1 AT 98900741 T AT98900741 T AT 98900741T AT 98900741 T AT98900741 T AT 98900741T AT E255579 T1 ATE255579 T1 AT E255579T1
- Authority
- AT
- Austria
- Prior art keywords
- phospholipase
- inhibiting effect
- optionally substituted
- pyrrolidine derivatives
- ch2nhco
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1796297 | 1997-01-31 | ||
| PCT/JP1998/000307 WO1998033797A1 (fr) | 1997-01-31 | 1998-01-27 | Derives de pyrrolidine ayant une activite inhibant la phospholipase a2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE255579T1 true ATE255579T1 (de) | 2003-12-15 |
Family
ID=11958379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98900741T ATE255579T1 (de) | 1997-01-31 | 1998-01-27 | Pyrrolidin-derivate die eine phospholipase-a2- hemmende wirkung haben |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6147100A (de) |
| EP (1) | EP0976748B1 (de) |
| JP (1) | JP3850450B2 (de) |
| KR (1) | KR100354358B1 (de) |
| CN (1) | CN1217942C (de) |
| AT (1) | ATE255579T1 (de) |
| AU (1) | AU719210B2 (de) |
| BR (1) | BR9807132A (de) |
| CA (1) | CA2277947C (de) |
| DE (1) | DE69820248T2 (de) |
| DK (1) | DK0976748T3 (de) |
| ES (1) | ES2210710T3 (de) |
| HU (1) | HUP0000965A3 (de) |
| NO (1) | NO313881B1 (de) |
| PL (1) | PL334915A1 (de) |
| PT (1) | PT976748E (de) |
| RU (1) | RU2198174C2 (de) |
| TR (1) | TR199901847T2 (de) |
| TW (1) | TW577875B (de) |
| WO (1) | WO1998033797A1 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| US7098196B1 (en) | 1999-10-13 | 2006-08-29 | Johns Hopkins University School Of Medicine | Regulators of the hedgehog pathway, compositions and uses related thereto |
| CA2380206A1 (en) * | 1999-07-26 | 2001-02-01 | Shionogi & Co., Ltd. | Pharmaceutical compositions exhibiting thrombopoietin receptor agonism |
| JP4898044B2 (ja) * | 1999-10-14 | 2012-03-14 | キュリス，インコーポレイテッド | ヘッジホッグシグナル伝達経路のメディエーター、それらと関連する組成物及び利用 |
| US6552016B1 (en) | 1999-10-14 | 2003-04-22 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| WO2001030387A1 (fr) * | 1999-10-22 | 2001-05-03 | Shionogi & Co., Ltd. | Produits prophylactiques ou de traitement contre l'arythmie |
| AU2155001A (en) * | 1999-11-10 | 2001-06-06 | Aventis Pharma Deutschland Gmbh | N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor xa |
| US7361663B2 (en) | 1999-11-10 | 2008-04-22 | Aventis Pharmaceuticals Inc. | N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa |
| NZ523956A (en) * | 2000-08-07 | 2004-02-27 | Akzo Nobel Nv | A process for the production of paper |
| EP1354880A4 (de) * | 2001-01-26 | 2004-08-25 | Shionogi & Co | Halogenverbindungen, die als agonisten am thrombopoietinrezeptor wirken |
| US20030073945A1 (en) * | 2001-10-17 | 2003-04-17 | Liang-Kuang Diang | Ozone hemodiafiltration device |
| US6867320B2 (en) * | 2002-02-21 | 2005-03-15 | Asahi Kasei Pharma Corporation | Substituted phenylalkanoic acid derivatives and use thereof |
| US20040018533A1 (en) * | 2002-06-04 | 2004-01-29 | Adam Gail Isabel Reid | Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions |
| AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
| AU2003248793A1 (en) * | 2002-06-27 | 2004-01-19 | Sequenom, Inc | Diagnosing predisposition to fat deposition and associated condition |
| EP1581095A4 (de) * | 2002-06-27 | 2006-10-18 | Harkness Pharmaceuticals Inc | Therapeutische methoden zur reduzierung der fettablagerung und zur behandlung von damit einhergehenden erkrankungen |
| EP1597255A1 (de) * | 2002-11-13 | 2005-11-23 | Rigel Pharmaceuticals, Inc. | Rhodanin-derivate und sie enthaltende pharmazeutische zusammensetzungen |
| WO2004050654A1 (ja) * | 2002-11-29 | 2004-06-17 | Shionogi & Co., Ltd. | ピロリジン化合物の合成とその塩 |
| US7521465B2 (en) * | 2003-01-17 | 2009-04-21 | Bexel Pharmaceuticals, Inc. | Diphenyl ether derivatives |
| US6794401B2 (en) * | 2003-01-17 | 2004-09-21 | Bexel Pharmaceuticals, Inc. | Amino acid phenoxy ethers |
| US7781464B2 (en) * | 2003-01-17 | 2010-08-24 | Bexel Pharmaceuticals, Inc. | Heterocyclic diphenyl ethers |
| DE10305089A1 (de) * | 2003-02-07 | 2004-08-26 | Merckle Gmbh | Neue heteroarylsubstituierte Acetonderivate als Hemmstoffe der Phospholiphase A2 |
| TW200503698A (en) * | 2003-04-08 | 2005-02-01 | Shionogi & Co | Composition for treating or preventing dermatitis |
| CA2535665A1 (en) * | 2003-08-14 | 2005-02-24 | Asahi Kasei Pharma Corporation | Substituted arylalkanoic acid derivative and use thereof |
| US7087576B2 (en) * | 2003-10-07 | 2006-08-08 | Bexel Pharmaceuticals, Inc. | Dipeptide phenyl ethers |
| US7207652B2 (en) * | 2003-10-17 | 2007-04-24 | Lexmark International, Inc. | Balanced satellite distributions |
| US20090215857A1 (en) * | 2005-09-13 | 2009-08-27 | Pfizer Products Inc. | Therapeutic Pyrrolidines |
| UY31952A (es) * | 2008-07-02 | 2010-01-29 | Astrazeneca Ab | 5-metilideno-1,3-tiazolidina-2,4-dionas sustituidas como inhibidores de quinasa pim |
| JP2012506377A (ja) * | 2008-10-21 | 2012-03-15 | メルク・シャープ・エンド・ドーム・コーポレイション | ２，４−二置換フェニルカルボキサミド・オレキシン受容体アンタゴニスト |
| JP6053675B2 (ja) | 2010-06-18 | 2016-12-27 | ホワイトヘッド・インスティチュート・フォア・バイオメディカル・リサーチ | 抗ウイルス化合物のためのターゲットとしてのｐｌａ２ｇ１６ |
| TW201311679A (zh) | 2011-08-04 | 2013-03-16 | Takeda Pharmaceutical | 含氮雜環化合物 |
| USD804651S1 (en) | 2017-01-10 | 2017-12-05 | Howard Loonan | Syringe |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2826379B2 (ja) * | 1990-01-22 | 1998-11-18 | 三共株式会社 | チアゾリジン誘導体を有効成分とする肥満性高血圧症治療剤 |
| FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5317016A (en) * | 1991-08-20 | 1994-05-31 | Shionogi Seiyaku Kabushiki Kaisha | Pyrrolidylthiocarbapenem derivative |
| JPH05306224A (ja) * | 1992-04-24 | 1993-11-19 | Wakamoto Pharmaceut Co Ltd | ドーパミン β−ヒドロキシラーゼ阻害剤 |
| EP0586229A1 (de) * | 1992-09-01 | 1994-03-09 | Zeneca Limited | 3-Hydroxy-3-(Subst.-Alkyl)-Pyrrolidine als 5-Lipoxygenase-Inhibitoren |
| TW245716B (de) * | 1992-12-28 | 1995-04-21 | Takeda Pharm Industry Co | |
| AU684316B2 (en) * | 1993-10-15 | 1997-12-11 | Shionogi & Co., Ltd. | Oxazolinone derivative having intracellular phospholipase A2 inhibitor activity |
| JPH07138258A (ja) * | 1993-11-16 | 1995-05-30 | Taiho Yakuhin Kogyo Kk | チアゾリジンジオン誘導体又はその塩 |
| CA2145257A1 (en) * | 1994-03-23 | 1995-09-24 | Takashi Fujita | Thiazolidine and oxazolidine derivatives, their preparation and their medical use |
| JP3923079B2 (ja) * | 1995-07-31 | 2007-05-30 | 塩野義製薬株式会社 | ホスホリパーゼａ２阻害活性を有するピロリジン誘導体 |
| JPH09176162A (ja) * | 1995-12-22 | 1997-07-08 | Toubishi Yakuhin Kogyo Kk | チアゾリジンジオン誘導体及びその製造法並びにそれを含む医薬組成物 |
| AU2995497A (en) * | 1996-07-26 | 1997-11-19 | Dr. Reddy's Research Foundation | Thiazolidinedione compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions thereof |
| DE69727837T2 (de) * | 1997-05-02 | 2004-12-30 | Dr. Reddy's Research Foundation, Hyderabad | Neue antidiabetische verbindungen mit hypolipidimischen und antihypertensiven eigenschaften, verfahren zu ihrer herstellung und ihre enthaltenden arzneimittel |
| EP0894089B9 (de) * | 1997-05-02 | 2003-04-02 | Dr. Reddy's Laboratories Ltd. | Neue heterozyklische verbindungen mit antidiabetischen, hypolipiddaemischen und blutdrucksenkenden eigenschaften, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die diese enthalten |
-
1998
- 1998-01-26 TW TW087101064A patent/TW577875B/zh not_active IP Right Cessation
- 1998-01-27 AU AU55775/98A patent/AU719210B2/en not_active Ceased
- 1998-01-27 US US09/355,008 patent/US6147100A/en not_active Expired - Fee Related
- 1998-01-27 PT PT98900741T patent/PT976748E/pt unknown
- 1998-01-27 KR KR1019997006741A patent/KR100354358B1/ko not_active IP Right Cessation
- 1998-01-27 ES ES98900741T patent/ES2210710T3/es not_active Expired - Lifetime
- 1998-01-27 JP JP53270898A patent/JP3850450B2/ja not_active Expired - Fee Related
- 1998-01-27 EP EP98900741A patent/EP0976748B1/de not_active Expired - Lifetime
- 1998-01-27 DK DK98900741T patent/DK0976748T3/da active
- 1998-01-27 WO PCT/JP1998/000307 patent/WO1998033797A1/ja active IP Right Grant
- 1998-01-27 HU HU0000965A patent/HUP0000965A3/hu unknown
- 1998-01-27 PL PL98334915A patent/PL334915A1/xx not_active Application Discontinuation
- 1998-01-27 RU RU99119481/04A patent/RU2198174C2/ru not_active IP Right Cessation
- 1998-01-27 CN CN988038021A patent/CN1217942C/zh not_active Expired - Fee Related
- 1998-01-27 CA CA002277947A patent/CA2277947C/en not_active Expired - Fee Related
- 1998-01-27 TR TR1999/01847T patent/TR199901847T2/xx unknown
- 1998-01-27 DE DE69820248T patent/DE69820248T2/de not_active Expired - Lifetime
- 1998-01-27 AT AT98900741T patent/ATE255579T1/de not_active IP Right Cessation
- 1998-01-27 BR BR9807132-7A patent/BR9807132A/pt not_active Application Discontinuation
-
1999
- 1999-07-29 NO NO19993706A patent/NO313881B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU5577598A (en) | 1998-08-25 |
| EP0976748A4 (de) | 2001-08-08 |
| CA2277947C (en) | 2004-09-21 |
| TW577875B (en) | 2004-03-01 |
| BR9807132A (pt) | 2000-01-25 |
| US6147100A (en) | 2000-11-14 |
| ES2210710T3 (es) | 2004-07-01 |
| TR199901847T2 (xx) | 2000-06-21 |
| EP0976748B1 (de) | 2003-12-03 |
| KR20000070497A (ko) | 2000-11-25 |
| HUP0000965A3 (en) | 2001-11-28 |
| WO1998033797A1 (fr) | 1998-08-06 |
| CN1251587A (zh) | 2000-04-26 |
| JP3850450B2 (ja) | 2006-11-29 |
| EP0976748A1 (de) | 2000-02-02 |
| PL334915A1 (en) | 2000-03-27 |
| CA2277947A1 (en) | 1998-08-06 |
| CN1217942C (zh) | 2005-09-07 |
| DK0976748T3 (da) | 2004-03-22 |
| PT976748E (pt) | 2004-03-31 |
| HUP0000965A2 (hu) | 2001-04-28 |
| NO313881B1 (no) | 2002-12-16 |
| DE69820248T2 (de) | 2004-09-23 |
| AU719210B2 (en) | 2000-05-04 |
| NO993706D0 (no) | 1999-07-29 |
| NO993706L (no) | 1999-09-30 |
| RU2198174C2 (ru) | 2003-02-10 |
| KR100354358B1 (ko) | 2002-09-28 |
| DE69820248D1 (de) | 2004-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0976748 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |