NO993706L - Pyrrolidinderivater med fosfolipase A2 inhiberende aktivitet - Google Patents

Pyrrolidinderivater med fosfolipase A2 inhiberende aktivitet

Info

Publication number
NO993706L
NO993706L NO993706A NO993706A NO993706L NO 993706 L NO993706 L NO 993706L NO 993706 A NO993706 A NO 993706A NO 993706 A NO993706 A NO 993706A NO 993706 L NO993706 L NO 993706L
Authority
NO
Norway
Prior art keywords
phospholipase
inhibitory activity
optionally substituted
pyrrolidine derivatives
ch2nhco
Prior art date
Application number
NO993706A
Other languages
English (en)
Other versions
NO313881B1 (no
NO993706D0 (no
Inventor
Kaoru Seno
Mitsuaki Ohtani
Fumihiko Watanabe
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of NO993706D0 publication Critical patent/NO993706D0/no
Publication of NO993706L publication Critical patent/NO993706L/no
Publication of NO313881B1 publication Critical patent/NO313881B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cosmetics (AREA)
NO19993706A 1997-01-31 1999-07-29 Pyrrolidinderivater med fosfolipase A2 inhiberende aktivitet, og preparater inneholdende slike forbindelser NO313881B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1796297 1997-01-31
PCT/JP1998/000307 WO1998033797A1 (fr) 1997-01-31 1998-01-27 Derives de pyrrolidine ayant une activite inhibant la phospholipase a2

Publications (3)

Publication Number Publication Date
NO993706D0 NO993706D0 (no) 1999-07-29
NO993706L true NO993706L (no) 1999-09-30
NO313881B1 NO313881B1 (no) 2002-12-16

Family

ID=11958379

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19993706A NO313881B1 (no) 1997-01-31 1999-07-29 Pyrrolidinderivater med fosfolipase A2 inhiberende aktivitet, og preparater inneholdende slike forbindelser

Country Status (20)

Country Link
US (1) US6147100A (no)
EP (1) EP0976748B1 (no)
JP (1) JP3850450B2 (no)
KR (1) KR100354358B1 (no)
CN (1) CN1217942C (no)
AT (1) ATE255579T1 (no)
AU (1) AU719210B2 (no)
BR (1) BR9807132A (no)
CA (1) CA2277947C (no)
DE (1) DE69820248T2 (no)
DK (1) DK0976748T3 (no)
ES (1) ES2210710T3 (no)
HU (1) HUP0000965A3 (no)
NO (1) NO313881B1 (no)
PL (1) PL334915A1 (no)
PT (1) PT976748E (no)
RU (1) RU2198174C2 (no)
TR (1) TR199901847T2 (no)
TW (1) TW577875B (no)
WO (1) WO1998033797A1 (no)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7291626B1 (en) 1998-04-09 2007-11-06 John Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
CA2380206A1 (en) 1999-07-26 2001-02-01 Shionogi & Co., Ltd. Pharmaceutical compositions exhibiting thrombopoietin receptor agonism
WO2001027135A2 (en) 1999-10-13 2001-04-19 Johns Hopkins University School Of Medicine Regulators of the hedgehog pathway, compositions and uses related thereto
WO2001026644A2 (en) * 1999-10-14 2001-04-19 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
US6552016B1 (en) 1999-10-14 2003-04-22 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
US6924301B1 (en) * 1999-10-22 2005-08-02 Shionogi & Co., Ltd. Composition for treating or preventing arrhythmia
WO2001034567A1 (en) * 1999-11-10 2001-05-17 Aventis Pharma Deutschland Gmbh N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor xa
US7361663B2 (en) 1999-11-10 2008-04-22 Aventis Pharmaceuticals Inc. N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa
KR20030074587A (ko) * 2000-08-07 2003-09-19 악조 노벨 엔.브이. 사이징 분산물
US20040063764A1 (en) * 2001-01-26 2004-04-01 Hiroshi Takemoto Halogen compounds having thrombopoietin receptor agonism
US20030073945A1 (en) * 2001-10-17 2003-04-17 Liang-Kuang Diang Ozone hemodiafiltration device
US6867320B2 (en) * 2002-02-21 2005-03-15 Asahi Kasei Pharma Corporation Substituted phenylalkanoic acid derivatives and use thereof
WO2003101177A2 (en) * 2002-06-04 2003-12-11 Sequenom, Inc. Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions
AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
EP1581095A4 (en) * 2002-06-27 2006-10-18 Harkness Pharmaceuticals Inc THERAPEUTIC METHODS FOR REDUCING FAT DEPOSIT AND TREATING THE DISEASES THEREOF
WO2004002295A2 (en) * 2002-06-27 2004-01-08 Sequenom, Inc. Diagnosing predisposition to fat deposition and associated condition
EP1597255A1 (en) * 2002-11-13 2005-11-23 Rigel Pharmaceuticals, Inc. Rhodanine derivatives and pharmaceutical compositions containing them
JPWO2004050654A1 (ja) * 2002-11-29 2006-03-30 塩野義製薬株式会社 ピロリジン化合物の合成とその塩
US6794401B2 (en) * 2003-01-17 2004-09-21 Bexel Pharmaceuticals, Inc. Amino acid phenoxy ethers
US7781464B2 (en) * 2003-01-17 2010-08-24 Bexel Pharmaceuticals, Inc. Heterocyclic diphenyl ethers
US7521465B2 (en) * 2003-01-17 2009-04-21 Bexel Pharmaceuticals, Inc. Diphenyl ether derivatives
DE10305089A1 (de) * 2003-02-07 2004-08-26 Merckle Gmbh Neue heteroarylsubstituierte Acetonderivate als Hemmstoffe der Phospholiphase A2
WO2004089368A1 (ja) * 2003-04-08 2004-10-21 Shionogi & Co. Ltd. 皮膚炎の治療または予防剤
CA2535665A1 (en) * 2003-08-14 2005-02-24 Asahi Kasei Pharma Corporation Substituted arylalkanoic acid derivative and use thereof
US7087576B2 (en) * 2003-10-07 2006-08-08 Bexel Pharmaceuticals, Inc. Dipeptide phenyl ethers
US7207652B2 (en) * 2003-10-17 2007-04-24 Lexmark International, Inc. Balanced satellite distributions
US20090215857A1 (en) * 2005-09-13 2009-08-27 Pfizer Products Inc. Therapeutic Pyrrolidines
TWI461423B (zh) * 2008-07-02 2014-11-21 Astrazeneca Ab 用於治療Pim激酶相關病狀及疾病之噻唑啶二酮化合物
AU2009307918A1 (en) * 2008-10-21 2010-04-29 Merck Sharp & Dohme Corp. 2,4-disubstituted pyrrolidine orexin receptor antagonists
KR101931628B1 (ko) 2010-06-18 2019-03-13 화이트헤드 인스티튜트 포 바이오메디칼 리서치 항바이러스 화합물에 대한 타켓인 pla2g16
TW201311679A (zh) 2011-08-04 2013-03-16 Takeda Pharmaceutical 含氮雜環化合物
USD804651S1 (en) 2017-01-10 2017-12-05 Howard Loonan Syringe

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2826379B2 (ja) * 1990-01-22 1998-11-18 三共株式会社 チアゾリジン誘導体を有効成分とする肥満性高血圧症治療剤
US5317016A (en) * 1991-08-20 1994-05-31 Shionogi Seiyaku Kabushiki Kaisha Pyrrolidylthiocarbapenem derivative
FR2680512B1 (fr) * 1991-08-20 1995-01-20 Adir Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
JPH05306224A (ja) * 1992-04-24 1993-11-19 Wakamoto Pharmaceut Co Ltd ドーパミン β−ヒドロキシラーゼ阻害剤
EP0586229A1 (en) * 1992-09-01 1994-03-09 Zeneca Limited 3-Hydroxy-3-(subst-akyl)-pyrrolidines as 5-lipoxygenase inhibitors
WO1995010508A1 (fr) * 1993-10-15 1995-04-20 Shionogi & Co., Ltd. Derive d'oxazolinone presentant une activite inhibitrice de la phospholipase a2 intracellulaire
TW245716B (no) * 1992-12-28 1995-04-21 Takeda Pharm Industry Co
JPH07138258A (ja) * 1993-11-16 1995-05-30 Taiho Yakuhin Kogyo Kk チアゾリジンジオン誘導体又はその塩
CA2145257A1 (en) * 1994-03-23 1995-09-24 Takashi Fujita Thiazolidine and oxazolidine derivatives, their preparation and their medical use
CN1064682C (zh) * 1995-07-31 2001-04-18 盐野义制药株式会社 具有磷脂酶a2抑制活性的吡咯烷衍生物
JPH09176162A (ja) * 1995-12-22 1997-07-08 Toubishi Yakuhin Kogyo Kk チアゾリジンジオン誘導体及びその製造法並びにそれを含む医薬組成物
WO1997041120A1 (en) * 1996-07-26 1997-11-06 Dr. Reddy's Research Foundation Thiazolidinedione compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions thereof
EP0981526B1 (en) * 1997-05-02 2004-02-25 Dr. Reddy's Laboratories Ltd. Novel antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
WO1997041121A1 (en) * 1997-05-02 1997-11-06 Dr. Reddy's Research Foundation Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
PL334915A1 (en) 2000-03-27
EP0976748A4 (en) 2001-08-08
BR9807132A (pt) 2000-01-25
CA2277947C (en) 2004-09-21
KR100354358B1 (ko) 2002-09-28
HUP0000965A2 (hu) 2001-04-28
HUP0000965A3 (en) 2001-11-28
DE69820248T2 (de) 2004-09-23
US6147100A (en) 2000-11-14
PT976748E (pt) 2004-03-31
AU5577598A (en) 1998-08-25
JP3850450B2 (ja) 2006-11-29
ATE255579T1 (de) 2003-12-15
TW577875B (en) 2004-03-01
CN1251587A (zh) 2000-04-26
TR199901847T2 (xx) 2000-06-21
DK0976748T3 (da) 2004-03-22
CA2277947A1 (en) 1998-08-06
EP0976748A1 (en) 2000-02-02
RU2198174C2 (ru) 2003-02-10
CN1217942C (zh) 2005-09-07
EP0976748B1 (en) 2003-12-03
AU719210B2 (en) 2000-05-04
NO313881B1 (no) 2002-12-16
NO993706D0 (no) 1999-07-29
ES2210710T3 (es) 2004-07-01
KR20000070497A (ko) 2000-11-25
DE69820248D1 (de) 2004-01-15
WO1998033797A1 (fr) 1998-08-06

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