ZA200308379B - N-formyl hydroxylamine compounds as inhibitors of PDF. - Google Patents

N-formyl hydroxylamine compounds as inhibitors of PDF. Download PDF

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Publication number
ZA200308379B
ZA200308379B ZA200308379A ZA200308379A ZA200308379B ZA 200308379 B ZA200308379 B ZA 200308379B ZA 200308379 A ZA200308379 A ZA 200308379A ZA 200308379 A ZA200308379 A ZA 200308379A ZA 200308379 B ZA200308379 B ZA 200308379B
Authority
ZA
South Africa
Prior art keywords
pyrrolidine
methyl
carboxylic acid
amide
pyridin
Prior art date
Application number
ZA200308379A
Other languages
English (en)
Inventor
Dinesh V Patel
Zhengyu Yuan
Rakesh K Jain
Salvador Garcia Alvarez
Jeffrey Jacobs
Original Assignee
Vicuron Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vicuron Pharm Inc filed Critical Vicuron Pharm Inc
Publication of ZA200308379B publication Critical patent/ZA200308379B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA200308379A 2001-06-15 2003-10-28 N-formyl hydroxylamine compounds as inhibitors of PDF. ZA200308379B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29841901P 2001-06-15 2001-06-15
US36031302P 2002-02-27 2002-02-27
PCT/EP2002/006604 WO2002102790A1 (en) 2001-06-15 2002-06-14 N-formyl hydroxylamine compounds as inhibitors of pdf

Publications (1)

Publication Number Publication Date
ZA200308379B true ZA200308379B (en) 2004-05-21

Family

ID=26970649

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200308379A ZA200308379B (en) 2001-06-15 2003-10-28 N-formyl hydroxylamine compounds as inhibitors of PDF.

Country Status (31)

Country Link
US (1) US7148242B2 (de)
EP (1) EP1401828B1 (de)
JP (1) JP4361365B2 (de)
KR (2) KR100589544B1 (de)
CN (1) CN1511152A (de)
AR (1) AR036053A1 (de)
AT (1) ATE323081T1 (de)
AU (1) AU2002321062B2 (de)
BR (1) BR0210377A (de)
CA (1) CA2448526A1 (de)
CO (1) CO5640131A2 (de)
CY (1) CY1105085T1 (de)
CZ (1) CZ20033388A3 (de)
DE (1) DE60210612T2 (de)
DK (1) DK1401828T3 (de)
ES (1) ES2262824T3 (de)
HK (1) HK1064370A1 (de)
HU (1) HUP0400208A3 (de)
IL (1) IL158770A0 (de)
MX (1) MXPA03011628A (de)
MY (1) MY138619A (de)
NO (1) NO327420B1 (de)
NZ (1) NZ529489A (de)
PE (1) PE20030100A1 (de)
PL (1) PL364476A1 (de)
PT (1) PT1401828E (de)
RU (1) RU2325386C2 (de)
SI (1) SI1401828T1 (de)
SK (1) SK15242003A3 (de)
WO (1) WO2002102790A1 (de)
ZA (1) ZA200308379B (de)

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EP1406893B1 (de) * 2001-06-15 2007-04-18 Vicuron Pharmaceuticals, Inc. Bicyclische pyrrolidinverbindungen
GB0208579D0 (en) * 2002-04-13 2002-05-22 British Biotech Pharm Antibacterial agents
NZ538833A (en) * 2002-09-19 2008-05-30 Novartis Ag Process for preparing intermediates
CN101092342A (zh) * 2003-02-21 2007-12-26 诺瓦提斯公司 制备用以获得n－甲酰基羟胺的中间体的化学方法
TW200427458A (en) * 2003-04-02 2004-12-16 Novartis Ag Crystalline N-formyl hydroxylamine compounds
JP2009513485A (ja) * 2003-06-26 2009-04-02 ノバルティス アクチエンゲゼルシャフト ある種の抗菌性ｎ−ホルミルヒドロキシルアミン化合物の製造に有用な中間体の製造法
KR100527624B1 (ko) * 2003-08-21 2005-11-22 한기종 질소에 포밀기를 갖는 아민유도체의 새로운 제조방법
WO2006002896A1 (en) * 2004-06-30 2006-01-12 Novartis Ag Method for increasing the susceptibility of peptide deformylase inhibitors by using efflux pump inhibitors
US20080161249A1 (en) 2004-11-17 2008-07-03 Smithkline Beecham Corporation Use of Novel Antibacterial Compounds
GT200600196A (es) * 2005-05-23 2007-01-15 Compuestos n-formil de hidroxilamina
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DE102005026231A1 (de) * 2005-06-07 2006-12-14 Origenis Ag Peptid-Deformylase (PDF) Inhibitoren 3
SG133452A1 (en) * 2005-12-30 2007-07-30 Novartis Ag Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases
KR20080095895A (ko) * 2006-03-03 2008-10-29 노파르티스 아게 Ｎ―포르밀 히드록실아민 화합물
CN101328155B (zh) * 2007-06-20 2010-11-03 上海医药工业研究院 噁唑烷衍生物及其制备方法和应用
CN101434570B (zh) * 2007-11-16 2011-02-02 上海医药工业研究院 吡咯烷衍生物及其制备方法和应用
CN101584694B (zh) * 2009-06-15 2011-01-12 华东师范大学 含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法
AU2010291212A1 (en) * 2009-09-04 2012-02-23 Novartis Ag Heteroaryl compounds as kinase inhibitors
NZ601924A (en) * 2010-03-10 2014-10-31 Astrazeneca Ab 4-phenyl pyridine analogues as protein kinase inhibitors
JP5825086B2 (ja) 2011-12-19 2015-12-02 住友化学株式会社 α−置換−β−アミノ酸エステル誘導体不斉加水分解酵素
US9512084B2 (en) 2013-11-29 2016-12-06 Novartis Ag Amino pyrimidine derivatives
US20180140602A1 (en) 2015-04-07 2018-05-24 Novartis Ag Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives
US10738028B2 (en) * 2016-05-11 2020-08-11 Rudong Ruien Pharmaceutical Technology Co. Ltd Spiro three-membered ring, spiro five-membered ring peptide deformylase inhibitor and use thereof in antibacteria and anti-tumor

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Also Published As

Publication number Publication date
CA2448526A1 (en) 2002-12-27
WO2002102790A1 (en) 2002-12-27
ATE323081T1 (de) 2006-04-15
KR100589544B1 (ko) 2006-06-15
PL364476A1 (en) 2004-12-13
DE60210612D1 (de) 2006-05-24
RU2003137565A (ru) 2005-05-27
IL158770A0 (en) 2004-05-12
SK15242003A3 (sk) 2004-07-07
HUP0400208A2 (hu) 2004-06-28
US7148242B2 (en) 2006-12-12
PE20030100A1 (es) 2003-03-28
SI1401828T1 (sl) 2006-10-31
PT1401828E (pt) 2006-08-31
AU2002321062B2 (en) 2006-02-02
NO20035571D0 (no) 2003-12-12
NO327420B1 (no) 2009-06-29
HUP0400208A3 (en) 2008-10-28
JP2005502606A (ja) 2005-01-27
BR0210377A (pt) 2004-08-10
EP1401828A1 (de) 2004-03-31
KR20040010721A (ko) 2004-01-31
CO5640131A2 (es) 2006-05-31
CY1105085T1 (el) 2009-11-04
MY138619A (en) 2009-07-31
US20030045479A1 (en) 2003-03-06
RU2325386C2 (ru) 2008-05-27
ES2262824T3 (es) 2006-12-01
AR036053A1 (es) 2004-08-04
DE60210612T2 (de) 2006-09-21
JP4361365B2 (ja) 2009-11-11
KR20060014083A (ko) 2006-02-14
CN1511152A (zh) 2004-07-07
MXPA03011628A (es) 2005-03-07
EP1401828B1 (de) 2006-04-12
HK1064370A1 (en) 2005-01-28
CZ20033388A3 (en) 2004-03-17
NO20035571L (no) 2004-02-16
NZ529489A (en) 2005-10-28
DK1401828T3 (da) 2006-07-31

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