ATE182137T1 - Peptidylderivate als inhibitoren von metalloproteinase - Google Patents

Peptidylderivate als inhibitoren von metalloproteinase

Info

Publication number
ATE182137T1
ATE182137T1 AT94913709T AT94913709T ATE182137T1 AT E182137 T1 ATE182137 T1 AT E182137T1 AT 94913709 T AT94913709 T AT 94913709T AT 94913709 T AT94913709 T AT 94913709T AT E182137 T1 ATE182137 T1 AT E182137T1
Authority
AT
Austria
Prior art keywords
pct
inhibitors
derivatives
metalloproteinase
sec
Prior art date
Application number
AT94913709T
Other languages
English (en)
Inventor
Richard John Morphy
Andrew Thomas Millican
Original Assignee
Celltech Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939308696A external-priority patent/GB9308696D0/en
Application filed by Celltech Therapeutics Ltd filed Critical Celltech Therapeutics Ltd
Application granted granted Critical
Publication of ATE182137T1 publication Critical patent/ATE182137T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/38—Eight-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/61—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT94913709T 1993-04-27 1994-04-27 Peptidylderivate als inhibitoren von metalloproteinase ATE182137T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939308696A GB9308696D0 (en) 1993-04-27 1993-04-27 Peptidyl derivatives
ZA948169A ZA948169B (en) 1993-04-27 1994-10-18 Peptidyl derivatives and processes for their preparation

Publications (1)

Publication Number Publication Date
ATE182137T1 true ATE182137T1 (de) 1999-07-15

Family

ID=26302820

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94913709T ATE182137T1 (de) 1993-04-27 1994-04-27 Peptidylderivate als inhibitoren von metalloproteinase

Country Status (10)

Country Link
US (1) US5714491A (de)
EP (1) EP0648205B1 (de)
JP (1) JPH08500124A (de)
AT (1) ATE182137T1 (de)
AU (1) AU6575394A (de)
CA (1) CA2139128A1 (de)
DE (1) DE69419473T2 (de)
ES (1) ES2134939T3 (de)
WO (1) WO1994025434A1 (de)
ZA (1) ZA948169B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
GB2315750B (en) * 1994-01-22 1998-07-01 British Biotech Pharm Metalloproteinase inhibitors
HUT74511A (en) * 1994-01-22 1997-01-28 British Biotech Pharm Metalloproteinase inhibitors, pharmaceutical compns. contg. them and process to prepare the said compds.
GB9423914D0 (en) * 1994-11-26 1995-01-11 British Biotech Pharm Polyether derivatives as metalloproteinase inhibitors
US5917090A (en) * 1995-06-30 1999-06-29 British Biotech Pharmaceuticals Ltd. Matrix metalloproteinase inhibitors
EP0873304B1 (de) 1995-11-23 2001-09-05 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitoren
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
ES2183905T3 (es) * 1995-12-20 2003-04-01 Hoffmann La Roche Inhibidores de metaloproteasa de matriz.
WO1997031892A1 (fr) * 1996-03-01 1997-09-04 Sankyo Company, Limited Derives d'acide hydroxamique
EP0900381A1 (de) * 1996-04-26 1999-03-10 Children's Medical Center Corporation Nicht-invasiver enzym-siebtest für gewebe-remodelling-assozierte zustände
US6811995B1 (en) 1996-04-26 2004-11-02 Children's Medical Center Corporation Non-invasive enzyme screen for cancer
US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
CZ298048B6 (cs) 1996-09-10 2007-06-06 British Biotech Pharmaceuticals Limited Farmaceutický prostredek a deriváty kyseliny hydroxamové
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US20020099004A1 (en) * 1996-12-06 2002-07-25 Lund Leif Roge Inhibition of invasive remodelling
US5952320A (en) * 1997-01-07 1999-09-14 Abbott Laboratories Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
ATE258063T1 (de) * 1997-03-03 2004-02-15 Darwin Discovery Ltd Selektive mmp inhibitoren mit verringerten nebenwirkungen
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
GB9707333D0 (en) * 1997-04-11 1997-05-28 British Biotech Pharm Metalloproteinase inhibitors
AU1110799A (en) * 1997-10-29 1999-05-17 Warner-Lambert Company Method of inhibiting metastases of cancer cells
WO1999035124A1 (en) 1998-01-09 1999-07-15 Pfizer Limited Matrix metalloprotease inhibitors
GB9803005D0 (en) 1998-02-12 1998-04-08 British Biotech Pharm Anti-inflammatory agents
US6329418B1 (en) 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
US6696456B1 (en) * 1999-10-14 2004-02-24 The Procter & Gamble Company Beta disubstituted metalloprotease inhibitors
PL357275A1 (en) * 2000-03-21 2004-07-26 The Procter & Gamble Company Carbocyclic side chain containing metalloprotease inhibitors
IL151125A0 (en) 2000-03-21 2003-04-10 Procter & Gamble Heterocyclic side chain containing, n-substituted metalloprotease inhibitors
CA2401728A1 (en) * 2000-03-21 2001-09-27 The Procter & Gamble Company Difluorobutyric acid metalloprotease inhibitors
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
EP1406893B1 (de) 2001-06-15 2007-04-18 Vicuron Pharmaceuticals, Inc. Bicyclische pyrrolidinverbindungen
CN1732023A (zh) * 2002-12-27 2006-02-08 血管技术国际股份公司 组合物和使用collajolie的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8919251D0 (en) * 1989-08-24 1989-10-04 British Bio Technology Compounds
CA2073510A1 (en) * 1990-12-03 1992-06-04 Celltech Therapeutics Limited Peptidyl derivatives

Also Published As

Publication number Publication date
ZA948169B (en) 1996-04-18
ES2134939T3 (es) 1999-10-16
DE69419473D1 (de) 1999-08-19
EP0648205A1 (de) 1995-04-19
US5714491A (en) 1998-02-03
WO1994025434A1 (en) 1994-11-10
EP0648205B1 (de) 1999-07-14
DE69419473T2 (de) 2000-03-16
CA2139128A1 (en) 1994-11-10
AU6575394A (en) 1994-11-21
JPH08500124A (ja) 1996-01-09

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Legal Events

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