ES2134939T3 - Derivados de peptidilo como inhibidores de metaloproteinas. - Google Patents

Derivados de peptidilo como inhibidores de metaloproteinas.

Info

Publication number
ES2134939T3
ES2134939T3 ES94913709T ES94913709T ES2134939T3 ES 2134939 T3 ES2134939 T3 ES 2134939T3 ES 94913709 T ES94913709 T ES 94913709T ES 94913709 T ES94913709 T ES 94913709T ES 2134939 T3 ES2134939 T3 ES 2134939T3
Authority
ES
Spain
Prior art keywords
group
hydrogen
optionally substituted
atom
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94913709T
Other languages
English (en)
Inventor
Richard John Morphy
Andrew Thomas Millican
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Celltech Ltd
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939308696A external-priority patent/GB9308696D0/en
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Application granted granted Critical
Publication of ES2134939T3 publication Critical patent/ES2134939T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/38—Eight-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/61—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SE DESCRIBEN COMPUESTOS DE LA FORMULA (1) DONDE R REPRESENTA UN GRUPO CONHOR6 [DONDE R6 ES UN ATOMO DE HIDROGENO O UN GRUPO ACILO], CARBOXIL (-CO2H), CARBOXILO ESTERIFICADO, -SR6 O -P(O)(X1R7ERENTES, SON CADA UNO UN ATOMO DE OXIGENO O DE AZUFRE Y R7 Y R8, QUE PUEDEN SER IGUALES O DIFERENTES, REPRESENTA CADA UNO UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO, ARILO O ALRALQUILO OPCIONALMENTE SUSTITUIDO; R1 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO, ALQUENILO, ARILO, ARALQUILO, HETEROARALQUILO O HETEROARILTIOALQUILO, R2 REPRESENTA UN GRUPO -Z2(CH2)MZ1-AR EN DONDE AR ES UN GRUPO ARILO A HETEROARILO, Z1 Y Z2, QUE PUEDEN SER IGUALES O DIFERENTES, ES CADA UNO UN ENLACE O UN HETEROATOMO Y M ES CERO O UN ENTERO DE 1 A 6 SIEMPRE Y CUANDO SI M ES CERO, Z2 SEA UN ENLACE Y Z1 SEA UN HETEROATOMO; R3 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO; R4 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO; R5 REPRESENTA UN GRUPO -C(R9)(R10)HETR11, EN DONDE R9 Y R10, QUE PUEDEN SER IGUALES O DIFERENTES, ES CADA UNO UN GRUPO ALQUILO O ALQUENILO OPCIONALMENTE SUSTITUIDO INTERRUMPIDO POR UNO O MAS ATOMOS DE -OGRUPOS -N(R12)(DONDE R12 ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO OPCIONALMENTE SUSTITUIDO) O UN GRUPO CICLOALQUILO, CICLOALQUENILO, ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDO, O R9 Y R10 JUNTO CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS SE ENLAZAN ENTRE SI PARA FORMAR UN GRUPO CICLOALQUILO O CICLOALQUENILO OPCIONALMENTE SUSTITUIDO, HET ES -O-, -S(O)P ERO O UN ENTERO 1 O 2] O -N(R12)NO O UN GRUPO ALIFATICO, CICLOALIFATICO, HETEROCICLOALIFATICO, AROMATICO O HETEROAROMATICO; X ES UN GRUPO AMINO (-NH2), AMINO SUSTITUIDO, HIDROXILO O HIDROXILO SUSTITUIDO O SE ENCUENTRA ENLAZADO AL ATOMO DEL GRUPO HET EN R5 PARA FORMAR UNA CADENA -X-ALK-R5 CIONALMENTE SUSTITUIDA Y R5 ES -HET-C(R9)(R10)-; Y LAS SALES, SOLVATOS, HIDRATOS Y PROFARMACOS DE LOS MISMOS. LOS COMPUESTOS SON INHIBIDORES DE LA METALOPROTEINASA, ORALMENTE ACTIVOS Y EN PARTICULAR TIENEN UNA ACCION A LA GELATINASA SELECTIVA, TIENE UNA LARGA DURACION DE ACCION Y SE PUEDEN UTILIZAR EN LA PROFILAXIS O TRATAMIENTO DE ENFERMEDADES O TRASTORNOS EN LOS QUE JUEGAN UN PAPEL LA ESTROMELISINA, LA COLAGENASA O LA GELATINASA PARA, POR EJEMPLO, EL TRATAMIENTO DEL CANCER PARA CONTROLAR EL DESARROLLO DE METASTASIS DE TUMORES.
ES94913709T 1993-04-27 1994-04-27 Derivados de peptidilo como inhibidores de metaloproteinas. Expired - Lifetime ES2134939T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939308696A GB9308696D0 (en) 1993-04-27 1993-04-27 Peptidyl derivatives
ZA948169A ZA948169B (en) 1993-04-27 1994-10-18 Peptidyl derivatives and processes for their preparation

Publications (1)

Publication Number Publication Date
ES2134939T3 true ES2134939T3 (es) 1999-10-16

Family

ID=26302820

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94913709T Expired - Lifetime ES2134939T3 (es) 1993-04-27 1994-04-27 Derivados de peptidilo como inhibidores de metaloproteinas.

Country Status (10)

Country Link
US (1) US5714491A (es)
EP (1) EP0648205B1 (es)
JP (1) JPH08500124A (es)
AT (1) ATE182137T1 (es)
AU (1) AU6575394A (es)
CA (1) CA2139128A1 (es)
DE (1) DE69419473T2 (es)
ES (1) ES2134939T3 (es)
WO (1) WO1994025434A1 (es)
ZA (1) ZA948169B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
GB2315750B (en) * 1994-01-22 1998-07-01 British Biotech Pharm Metalloproteinase inhibitors
HUT74511A (en) * 1994-01-22 1997-01-28 British Biotech Pharm Metalloproteinase inhibitors, pharmaceutical compns. contg. them and process to prepare the said compds.
GB9423914D0 (en) * 1994-11-26 1995-01-11 British Biotech Pharm Polyether derivatives as metalloproteinase inhibitors
US5917090A (en) * 1995-06-30 1999-06-29 British Biotech Pharmaceuticals Ltd. Matrix metalloproteinase inhibitors
EP0873304B1 (en) 1995-11-23 2001-09-05 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
ES2183905T3 (es) * 1995-12-20 2003-04-01 Hoffmann La Roche Inhibidores de metaloproteasa de matriz.
WO1997031892A1 (fr) * 1996-03-01 1997-09-04 Sankyo Company, Limited Derives d'acide hydroxamique
EP0900381A1 (en) * 1996-04-26 1999-03-10 Children's Medical Center Corporation Non-invasive enzyme screen for tissue remodelling-associated conditions
US6811995B1 (en) 1996-04-26 2004-11-02 Children's Medical Center Corporation Non-invasive enzyme screen for cancer
US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
CZ298048B6 (cs) 1996-09-10 2007-06-06 British Biotech Pharmaceuticals Limited Farmaceutický prostredek a deriváty kyseliny hydroxamové
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US20020099004A1 (en) * 1996-12-06 2002-07-25 Lund Leif Roge Inhibition of invasive remodelling
US5952320A (en) * 1997-01-07 1999-09-14 Abbott Laboratories Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
ATE258063T1 (de) * 1997-03-03 2004-02-15 Darwin Discovery Ltd Selektive mmp inhibitoren mit verringerten nebenwirkungen
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
GB9707333D0 (en) * 1997-04-11 1997-05-28 British Biotech Pharm Metalloproteinase inhibitors
AU1110799A (en) * 1997-10-29 1999-05-17 Warner-Lambert Company Method of inhibiting metastases of cancer cells
WO1999035124A1 (en) 1998-01-09 1999-07-15 Pfizer Limited Matrix metalloprotease inhibitors
GB9803005D0 (en) 1998-02-12 1998-04-08 British Biotech Pharm Anti-inflammatory agents
US6329418B1 (en) 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
US6696456B1 (en) * 1999-10-14 2004-02-24 The Procter & Gamble Company Beta disubstituted metalloprotease inhibitors
PL357275A1 (en) * 2000-03-21 2004-07-26 The Procter & Gamble Company Carbocyclic side chain containing metalloprotease inhibitors
IL151125A0 (en) 2000-03-21 2003-04-10 Procter & Gamble Heterocyclic side chain containing, n-substituted metalloprotease inhibitors
CA2401728A1 (en) * 2000-03-21 2001-09-27 The Procter & Gamble Company Difluorobutyric acid metalloprotease inhibitors
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
EP1406893B1 (en) 2001-06-15 2007-04-18 Vicuron Pharmaceuticals, Inc. Pyrrolidine bicyclic compounds
CN1732023A (zh) * 2002-12-27 2006-02-08 血管技术国际股份公司 组合物和使用collajolie的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8919251D0 (en) * 1989-08-24 1989-10-04 British Bio Technology Compounds
CA2073510A1 (en) * 1990-12-03 1992-06-04 Celltech Therapeutics Limited Peptidyl derivatives

Also Published As

Publication number Publication date
ZA948169B (en) 1996-04-18
DE69419473D1 (de) 1999-08-19
EP0648205A1 (en) 1995-04-19
US5714491A (en) 1998-02-03
WO1994025434A1 (en) 1994-11-10
EP0648205B1 (en) 1999-07-14
ATE182137T1 (de) 1999-07-15
DE69419473T2 (de) 2000-03-16
CA2139128A1 (en) 1994-11-10
AU6575394A (en) 1994-11-21
JPH08500124A (ja) 1996-01-09

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