ES2129679T3 - Derivados que contienen el grupo amidino, utiles como inhibidores de la sintasa de oxido nitrico. - Google Patents

Derivados que contienen el grupo amidino, utiles como inhibidores de la sintasa de oxido nitrico.

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Publication number
ES2129679T3
ES2129679T3 ES94931893T ES94931893T ES2129679T3 ES 2129679 T3 ES2129679 T3 ES 2129679T3 ES 94931893 T ES94931893 T ES 94931893T ES 94931893 T ES94931893 T ES 94931893T ES 2129679 T3 ES2129679 T3 ES 2129679T3
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Spain
Prior art keywords
nitric oxide
inhibitors
useful
amidino group
derivatives containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94931893T
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English (en)
Inventor
Donald W Hansen Jr
Mark G Currie
E Ann Hallinan
Kam F Fok
Timothy J Hagen
Arija A Bergmanis
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GD Searle LLC
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GD Searle LLC
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Publication of ES2129679T3 publication Critical patent/ES2129679T3/es
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/5545—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having eight-membered rings not containing additional condensed or non-condensed nitrogen-containing 3-7 membered rings
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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Abstract

LA INVENCION ACTUAL DESCRIBE COMPOSICIONES FARMACEUTICAS UTILES QUE CONTIENEN DERIVADOS DE AMIDINO DE FORMULA (I) COMO INHIBIDORES DE SINTASA DE OXIDO NITRICO.
ES94931893T 1993-10-21 1994-10-20 Derivados que contienen el grupo amidino, utiles como inhibidores de la sintasa de oxido nitrico. Expired - Lifetime ES2129679T3 (es)

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US6046211A (en) 2000-04-04
US5854234A (en) 1998-12-29
NO309303B1 (no) 2001-01-15
US6071906A (en) 2000-06-06
EP0724570B1 (en) 1999-03-03
EP0897912A1 (en) 1999-02-24
AU8081194A (en) 1995-05-08
CN1137268A (zh) 1996-12-04
WO1995011231A1 (en) 1995-04-27
JPH09504028A (ja) 1997-04-22
NO961403L (no) 1996-04-09
KR100342275B1 (ko) 2002-12-05
US6448286B1 (en) 2002-09-10
CN1077886C (zh) 2002-01-16
DK0724570T3 (da) 1999-09-27
DE69416848T2 (de) 1999-07-08
EP0724570A1 (en) 1996-08-07
AU688811B2 (en) 1998-03-19
ATE177078T1 (de) 1999-03-15
NO961403D0 (no) 1996-04-09
RU2136661C1 (ru) 1999-09-10
GR3030167T3 (en) 1999-08-31
KR960705777A (ko) 1996-11-08
DE69416848D1 (en) 1999-04-08

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