HRP20000189A2 - Halogen substituted tetracyclic tetrahydrofuran derivatives - Google Patents
Halogen substituted tetracyclic tetrahydrofuran derivatives Download PDFInfo
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- HRP20000189A2 HRP20000189A2 HR20000189A HRP20000189A HRP20000189A2 HR P20000189 A2 HRP20000189 A2 HR P20000189A2 HR 20000189 A HR20000189 A HR 20000189A HR P20000189 A HRP20000189 A HR P20000189A HR P20000189 A2 HRP20000189 A2 HR P20000189A2
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- hydrogen
- halogen
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- 229910052736 halogen Inorganic materials 0.000 title claims description 18
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical class C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 title description 15
- 125000005843 halogen group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 110
- 239000000543 intermediate Substances 0.000 claims description 38
- 150000003839 salts Chemical class 0.000 claims description 29
- 239000002253 acid Substances 0.000 claims description 20
- 125000004432 carbon atom Chemical group C* 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 18
- 150000002367 halogens Chemical class 0.000 claims description 17
- 229910052739 hydrogen Inorganic materials 0.000 claims description 17
- 239000001257 hydrogen Substances 0.000 claims description 17
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 17
- -1 C1-6alkyloxy Chemical group 0.000 claims description 14
- 239000002585 base Substances 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 12
- 125000003118 aryl group Chemical group 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 10
- 125000001424 substituent group Chemical group 0.000 claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 9
- 125000004122 cyclic group Chemical group 0.000 claims description 9
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 6
- 125000004970 halomethyl group Chemical group 0.000 claims description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 5
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims description 4
- 208000019901 Anxiety disease Diseases 0.000 claims description 4
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- 230000036506 anxiety Effects 0.000 claims description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
- 239000012458 free base Substances 0.000 claims description 4
- 125000002757 morpholinyl group Chemical group 0.000 claims description 4
- 231100000252 nontoxic Toxicity 0.000 claims description 4
- 230000003000 nontoxic effect Effects 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
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- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 2
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims description 2
- 125000005129 aryl carbonyl group Chemical group 0.000 claims description 2
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- FMTKCZODXQWUGC-UHFFFAOYSA-N 11-fluoro-3,3a,8,12b-tetrahydro-n,n-dimethyl-2h-dibenzo-[3,4:6,7]cyclohepta[1,2-b]furan-2-methanamine Chemical compound C1C2=CC=CC=C2C2CC(CN(C)C)OC2C2=CC(F)=CC=C21 FMTKCZODXQWUGC-UHFFFAOYSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 description 29
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- 238000000034 method Methods 0.000 description 19
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
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- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
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- NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
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Classifications
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97203154 | 1997-10-10 | ||
PCT/EP1998/006352 WO1999019317A1 (en) | 1997-10-10 | 1998-10-06 | Halogen substituted tetracyclic tetrahydrofuran derivatives |
Publications (1)
Publication Number | Publication Date |
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HRP20000189A2 true HRP20000189A2 (en) | 2001-02-28 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HR20000189A HRP20000189A2 (en) | 1997-10-10 | 2000-04-05 | Halogen substituted tetracyclic tetrahydrofuran derivatives |
Country Status (36)
Country | Link |
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US (2) | US6511976B1 (et) |
EP (1) | EP1021432B1 (et) |
JP (1) | JP3248902B2 (et) |
KR (1) | KR100366014B1 (et) |
CN (1) | CN100340554C (et) |
AP (1) | AP1239A (et) |
AR (1) | AR017325A1 (et) |
AT (1) | ATE235479T1 (et) |
AU (1) | AU737334B2 (et) |
BG (1) | BG64387B1 (et) |
BR (1) | BR9812871A (et) |
CA (1) | CA2305612C (et) |
CZ (1) | CZ296928B6 (et) |
DE (1) | DE69812668T2 (et) |
DK (1) | DK1021432T3 (et) |
EA (1) | EA003698B1 (et) |
EE (1) | EE04526B1 (et) |
ES (1) | ES2195403T3 (et) |
HK (1) | HK1029106A1 (et) |
HR (1) | HRP20000189A2 (et) |
HU (1) | HU225161B1 (et) |
ID (1) | ID23903A (et) |
IL (1) | IL135538A (et) |
MY (1) | MY117783A (et) |
NO (1) | NO317159B1 (et) |
NZ (1) | NZ503294A (et) |
OA (1) | OA11898A (et) |
PL (1) | PL339833A1 (et) |
PT (1) | PT1021432E (et) |
SI (1) | SI1021432T1 (et) |
SK (1) | SK284028B6 (et) |
TR (1) | TR200000918T2 (et) |
TW (1) | TW567186B (et) |
UA (1) | UA52778C2 (et) |
WO (1) | WO1999019317A1 (et) |
ZA (1) | ZA989204B (et) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
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UA79248C2 (en) * | 2001-11-09 | 2007-06-11 | Janssen Pharmaceutica Nv | Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives |
BR0214775A (pt) | 2001-12-07 | 2004-11-09 | Janssen Pharmaceutica Nv | Preparação de derivados de 3,3a,8,12b-tetraidro-2h-dibenzo[3,4:6,7]ciclohepta[1,2- b]furano cis-fundidos |
NZ532806A (en) * | 2001-12-07 | 2006-01-27 | Janssen Pharmaceutica Nv | Preparation of trans-fused 3,3a,8,12b-tetrahydro-2H-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives |
HRP20020305A8 (en) * | 2002-04-10 | 2009-03-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
HRP20020441A2 (en) * | 2002-05-21 | 2003-12-31 | Pliva D D | 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof |
HRP20030160A2 (en) * | 2003-03-06 | 2005-04-30 | Pliva-Istra�iva�ki institut d.o.o. | 1-thiadibenzoazulene derivatives and biological action thereof |
HRP20030885A2 (en) * | 2003-11-03 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS |
HRP20030958A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
HRP20030959A2 (et) * | 2003-11-21 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | |
HRP20030954A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva D.D. | USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
HRP20030956A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU |
HRP20030955A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
HRP20030957A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
HRP20030953A2 (en) * | 2003-11-21 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
HRP20040104A2 (en) * | 2004-01-30 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders |
AR049512A1 (es) * | 2004-06-14 | 2006-08-09 | Janssen Pharmaceutica Nv | Derivados de tetrahidrofurano tetraciclicos. composiciones farmaceuticas |
JP4823221B2 (ja) * | 2004-06-23 | 2011-11-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 新規な不飽和四環式テトラヒドロフラン誘導体 |
AU2011202995B2 (en) * | 2004-12-07 | 2012-02-02 | Janssen Pharmaceutica N.V. | Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives |
US7799785B2 (en) | 2004-12-07 | 2010-09-21 | Janssen Pharmaceutica Nv | Substituted tetracyclic tetahydrofuran, pyrrolidine and tetrahydrothiophene derivatives |
WO2006079637A1 (en) | 2005-01-27 | 2006-08-03 | Janssen Pharmaceutica N.V. | Heterocyclic tetracyclic tetrahydrofuran derivatives as 5ht2 inhibitors in the treatment of cns disorders |
CN101175749B (zh) * | 2005-05-19 | 2011-05-18 | 詹森药业有限公司 | 选择的含环胺侧链的四环四氢呋喃衍生物 |
BRPI0611408A2 (pt) * | 2005-05-26 | 2010-09-08 | Janssen Pharmaceutica Nv | derivados de tetra-hidrofurano tetracìclico substituìdo, pirrolidina e tetrahidrotiofeno, seus usos como um medicamento, composição farmacêutica e processo para o preparo da mesma |
CA2611443C (en) * | 2005-06-17 | 2014-08-26 | Janssen Pharmaceutica N.V. | Novel tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain |
US9125866B1 (en) | 2015-01-28 | 2015-09-08 | King Saud University | Antidepressant compounds |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL183618B1 (pl) | 1994-11-02 | 2002-06-28 | Janssen Pharmaceutica Nv | Nowy związek, pochodna podstawionej tetracyklicznej oksazepiny lub tiazepiny, kompozycja farmaceutyczna i sposób wytwarzania pochodnej podstawionej tetracyklicznej oksazepiny lub tiazepiny |
US5552399A (en) * | 1994-11-02 | 1996-09-03 | Janssen Pharmaceutica N.V. | Substituted tetracyclic azepine derivatives |
IL123655A (en) | 1996-04-12 | 2001-03-19 | Janssen Pharmaceutica Nv | Substituted tetracyclic tetrahydrofuran derivatives and pharmaceutical compositions containing them |
YU10499A (sh) | 1996-08-28 | 2001-03-07 | Eli Lilly And Company | Supstituisani 1,2,3,4-tetrahidro-2-dibenzofuranamini i 2-aminociklohepta /b/benzofurani |
-
1998
- 1998-06-10 UA UA2000041945A patent/UA52778C2/uk unknown
- 1998-10-06 DE DE69812668T patent/DE69812668T2/de not_active Expired - Lifetime
- 1998-10-06 DK DK98950107T patent/DK1021432T3/da active
- 1998-10-06 CN CNB98809956XA patent/CN100340554C/zh not_active Expired - Fee Related
- 1998-10-06 US US09/529,252 patent/US6511976B1/en not_active Expired - Fee Related
- 1998-10-06 BR BR9812871-0A patent/BR9812871A/pt not_active Application Discontinuation
- 1998-10-06 MY MYPI98004563A patent/MY117783A/en unknown
- 1998-10-06 IL IL13553898A patent/IL135538A/xx not_active IP Right Cessation
- 1998-10-06 SK SK471-2000A patent/SK284028B6/sk unknown
- 1998-10-06 EE EEP200000161A patent/EE04526B1/et not_active IP Right Cessation
- 1998-10-06 WO PCT/EP1998/006352 patent/WO1999019317A1/en active IP Right Grant
- 1998-10-06 EA EA200000400A patent/EA003698B1/ru not_active IP Right Cessation
- 1998-10-06 PT PT98950107T patent/PT1021432E/pt unknown
- 1998-10-06 ID IDW20000646A patent/ID23903A/id unknown
- 1998-10-06 TR TR2000/00918T patent/TR200000918T2/xx unknown
- 1998-10-06 EP EP98950107A patent/EP1021432B1/en not_active Expired - Lifetime
- 1998-10-06 KR KR1020007001926A patent/KR100366014B1/ko not_active IP Right Cessation
- 1998-10-06 CZ CZ20001136A patent/CZ296928B6/cs not_active IP Right Cessation
- 1998-10-06 OA OA00000105A patent/OA11898A/en unknown
- 1998-10-06 HU HU0003748A patent/HU225161B1/hu not_active IP Right Cessation
- 1998-10-06 ES ES98950107T patent/ES2195403T3/es not_active Expired - Lifetime
- 1998-10-06 AU AU96296/98A patent/AU737334B2/en not_active Ceased
- 1998-10-06 CA CA002305612A patent/CA2305612C/en not_active Expired - Fee Related
- 1998-10-06 AP APAP/P/2000/001784A patent/AP1239A/en active
- 1998-10-06 AT AT98950107T patent/ATE235479T1/de active
- 1998-10-06 NZ NZ503294A patent/NZ503294A/en not_active IP Right Cessation
- 1998-10-06 JP JP2000515890A patent/JP3248902B2/ja not_active Expired - Fee Related
- 1998-10-06 PL PL98339833A patent/PL339833A1/xx not_active IP Right Cessation
- 1998-10-06 SI SI9830430T patent/SI1021432T1/xx unknown
- 1998-10-08 ZA ZA9809204A patent/ZA989204B/xx unknown
- 1998-10-09 TW TW087116681A patent/TW567186B/zh not_active IP Right Cessation
- 1998-10-09 AR ARP980105055A patent/AR017325A1/es unknown
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2000
- 2000-03-30 BG BG104287A patent/BG64387B1/bg unknown
- 2000-04-05 HR HR20000189A patent/HRP20000189A2/hr not_active Application Discontinuation
- 2000-04-06 NO NO20001792A patent/NO317159B1/no not_active IP Right Cessation
- 2000-11-10 HK HK00107164A patent/HK1029106A1/xx not_active IP Right Cessation
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2002
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