BR0214775A - Preparação de derivados de 3,3a,8,12b-tetraidro-2h-dibenzo[3,4:6,7]ciclohepta[1,2- b]furano cis-fundidos - Google Patents
Preparação de derivados de 3,3a,8,12b-tetraidro-2h-dibenzo[3,4:6,7]ciclohepta[1,2- b]furano cis-fundidosInfo
- Publication number
- BR0214775A BR0214775A BR0214775-0A BR0214775A BR0214775A BR 0214775 A BR0214775 A BR 0214775A BR 0214775 A BR0214775 A BR 0214775A BR 0214775 A BR0214775 A BR 0214775A
- Authority
- BR
- Brazil
- Prior art keywords
- cis
- fused
- dibenzo
- tetrahydro
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
Abstract
"PREPARAçãO DE DERIVADOS DE 3,3a,8,12b-TETRAIDRO-2H-DIBENZO[3,4:6,7]CICLOHEPTA[1,2- b]FURANO CIS-FUNDIDOS". A presente invenção refere-se a um processo para preparação de cada dos 4 diastereómeros individuais de fórmula (I) em forma estereoquimicamente pura de um precursor enantiomericamente puro simples. O sistema de anel tetracíclico tendo anéis de sete membros e cinco cis-fundidos é formado em uma reação de ciclização de base catalisada. A invenção ainda refere-se aos intermediários de álcool tetracíclicos cis-fundidos desse modo obtidos e produtos finais de metanamina, e os produtos finais de metanamina para uso como um medicamento, em particular como medicamentos ativos de CNS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01204962 | 2001-12-07 | ||
PCT/EP2002/013561 WO2003048147A2 (en) | 2001-12-07 | 2002-12-02 | PREPARATION OF CIS-FUSED 3,3a,8,12b-TETRAHYDRO-2H-DIBENZO[3,4:6,7]CYCLOHEPTA[1,2-b]FURAN DERIVATIVES |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0214775A true BR0214775A (pt) | 2004-11-09 |
Family
ID=8181461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0214775-0A BR0214775A (pt) | 2001-12-07 | 2002-12-02 | Preparação de derivados de 3,3a,8,12b-tetraidro-2h-dibenzo[3,4:6,7]ciclohepta[1,2- b]furano cis-fundidos |
Country Status (16)
Country | Link |
---|---|
US (1) | US7205335B2 (pt) |
EP (1) | EP1463722A2 (pt) |
JP (1) | JP2005511692A (pt) |
KR (1) | KR20050044334A (pt) |
CN (1) | CN1697833A (pt) |
AU (1) | AU2002352205A1 (pt) |
BR (1) | BR0214775A (pt) |
CA (1) | CA2468040A1 (pt) |
HR (1) | HRP20040489A2 (pt) |
HU (1) | HUP0402325A2 (pt) |
IL (1) | IL162350A0 (pt) |
MX (1) | MXPA04005399A (pt) |
NO (1) | NO20042883L (pt) |
PL (1) | PL370440A1 (pt) |
WO (1) | WO2003048147A2 (pt) |
ZA (1) | ZA200404392B (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0402152A3 (en) * | 2001-12-07 | 2007-03-28 | Janssen Pharmaceutica Nv | Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives |
CN100591652C (zh) * | 2004-08-31 | 2010-02-24 | 詹森药业有限公司 | 生产2-(4-氟-苄基)-苯基-乙酸的方法 |
CA2588760C (en) | 2004-12-07 | 2014-05-13 | Janssen Pharmaceutica N.V. | Substituted tetracyclic tetrahydropyran, pyrrolidine and tetrahydrothiophene derivatives |
AU2006259020C1 (en) | 2005-06-17 | 2012-01-19 | Janssen Pharmaceutica N.V. | Novel tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain |
PT2874607T (pt) | 2012-07-17 | 2017-08-14 | Dow Global Technologies Llc | Resumo |
WO2014014753A1 (en) * | 2012-07-17 | 2014-01-23 | Dow Global Technologies Llc | Composition comprising an organic liquid diluent and a cellulose ether of very low viscosity |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI0892793T1 (en) * | 1996-04-12 | 2003-10-31 | Janssen Pharmaceutica N.V. | Substituted tetracyclic tetrahydrofuran derivatives |
UA52778C2 (uk) | 1997-10-10 | 2003-01-15 | Янссен Фармацевтика Н.В. | Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі |
-
2002
- 2002-12-02 WO PCT/EP2002/013561 patent/WO2003048147A2/en not_active Application Discontinuation
- 2002-12-02 EP EP02787892A patent/EP1463722A2/en not_active Withdrawn
- 2002-12-02 BR BR0214775-0A patent/BR0214775A/pt not_active IP Right Cessation
- 2002-12-02 CA CA002468040A patent/CA2468040A1/en not_active Abandoned
- 2002-12-02 KR KR1020047006350A patent/KR20050044334A/ko not_active Application Discontinuation
- 2002-12-02 JP JP2003549338A patent/JP2005511692A/ja not_active Withdrawn
- 2002-12-02 CN CNA028242912A patent/CN1697833A/zh active Pending
- 2002-12-02 PL PL02370440A patent/PL370440A1/xx not_active Application Discontinuation
- 2002-12-02 AU AU2002352205A patent/AU2002352205A1/en not_active Abandoned
- 2002-12-02 IL IL16235002A patent/IL162350A0/xx unknown
- 2002-12-02 US US10/496,277 patent/US7205335B2/en not_active Expired - Fee Related
- 2002-12-02 HU HU0402325A patent/HUP0402325A2/hu unknown
-
2004
- 2004-05-31 HR HR20040489A patent/HRP20040489A2/hr not_active Application Discontinuation
- 2004-06-03 ZA ZA200404392A patent/ZA200404392B/en unknown
- 2004-06-04 MX MXPA04005399A patent/MXPA04005399A/es unknown
- 2004-07-07 NO NO20042883A patent/NO20042883L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US7205335B2 (en) | 2007-04-17 |
EP1463722A2 (en) | 2004-10-06 |
MXPA04005399A (es) | 2004-10-11 |
HUP0402325A2 (hu) | 2005-02-28 |
WO2003048147A2 (en) | 2003-06-12 |
IL162350A0 (en) | 2005-11-20 |
CA2468040A1 (en) | 2003-06-12 |
HRP20040489A2 (en) | 2005-04-30 |
CN1697833A (zh) | 2005-11-16 |
PL370440A1 (en) | 2005-05-30 |
WO2003048147A3 (en) | 2004-04-01 |
JP2005511692A (ja) | 2005-04-28 |
KR20050044334A (ko) | 2005-05-12 |
AU2002352205A1 (en) | 2003-06-17 |
US20050033067A1 (en) | 2005-02-10 |
NO20042883L (no) | 2004-07-07 |
ZA200404392B (en) | 2005-09-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A,7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2064 DE 27/07/2010. |