ATE44280T1 - Trizyklische verbindungen, verfahren zur herstellung derselben, pharmazeutische praeparate und behandlungsmethode. - Google Patents
Trizyklische verbindungen, verfahren zur herstellung derselben, pharmazeutische praeparate und behandlungsmethode.Info
- Publication number
- ATE44280T1 ATE44280T1 AT86100324T AT86100324T ATE44280T1 AT E44280 T1 ATE44280 T1 AT E44280T1 AT 86100324 T AT86100324 T AT 86100324T AT 86100324 T AT86100324 T AT 86100324T AT E44280 T1 ATE44280 T1 AT E44280T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- hydrogen
- compounds
- lower alkyl
- same
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- -1 nitro, hydroxy, cyano, carbamyl Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- ATYBXHSAIOKLMG-UHFFFAOYSA-N oxepin Chemical compound O1C=CC=CC=C1 ATYBXHSAIOKLMG-UHFFFAOYSA-N 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/12—[b,e]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/12—[b,e]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8500273A SE8500273D0 (sv) | 1985-01-22 | 1985-01-22 | Nya tricykliska foreningar, kompositioner innehallande sadana foreningar, framstellningsforfaranden och behandlingsmetoder |
| EP86100324A EP0189078B1 (de) | 1985-01-22 | 1986-01-11 | Trizyklische Verbindungen, Verfahren zur Herstellung derselben, pharmazeutische Präparate und Behandlungsmethode |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE44280T1 true ATE44280T1 (de) | 1989-07-15 |
Family
ID=20358842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86100324T ATE44280T1 (de) | 1985-01-22 | 1986-01-11 | Trizyklische verbindungen, verfahren zur herstellung derselben, pharmazeutische praeparate und behandlungsmethode. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4645758A (de) |
| EP (1) | EP0189078B1 (de) |
| JP (1) | JPH0798817B2 (de) |
| AT (1) | ATE44280T1 (de) |
| AU (1) | AU587597B2 (de) |
| CA (1) | CA1309409C (de) |
| DE (1) | DE3664136D1 (de) |
| DK (1) | DK31486A (de) |
| FI (1) | FI860199A7 (de) |
| IE (1) | IE59600B1 (de) |
| NO (1) | NO855373L (de) |
| SE (1) | SE8500273D0 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0560831B1 (de) * | 1986-06-17 | 1993-09-03 | Dainippon Pharmaceutical Co | |
| GB9318935D0 (en) * | 1992-10-20 | 1993-10-27 | Zeneca Ltd | Heterocyclic derivatives |
| US5340826A (en) * | 1993-02-04 | 1994-08-23 | Pfizer Inc. | Pharmaceutical agents for treatment of urinary incontinence |
| US5574173A (en) * | 1993-12-06 | 1996-11-12 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
| JP3348230B2 (ja) | 1995-03-03 | 2002-11-20 | アルゴス ファーマシューティカル コーポレーション | 尿失禁の治療用のデキシトルメトルファン又はデキシトルオルファンの使用 |
| ES2259795T3 (es) * | 1995-06-07 | 2006-10-16 | Nippon Shinyaku Company, Limited | Derivados de pirrol y composicion medicinal. |
| US6323206B1 (en) | 1996-07-12 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| BR9808552A (pt) * | 1997-04-15 | 2000-05-23 | Kyowa Hakko Kogyo Kk | Composto tricìclico ou um sal farmaceuticamente aceitável do mesmo, e, composição farmacêutica |
| US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| DK1049700T3 (da) | 1998-01-21 | 2006-02-20 | Millennium Pharm Inc | Kemokinreceptorantagonister og fremgangsmåder til anvendelse deraf |
| US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7271176B2 (en) * | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7378408B2 (en) * | 2001-11-30 | 2008-05-27 | Pfizer Inc. | Methods of treatment and formulations of cephalosporin |
| TWI291467B (en) * | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL279409A (de) * | 1961-06-08 | |||
| NL300844A (de) * | 1962-11-24 | |||
| NL130988C (de) * | 1966-07-21 | Boehringer Mannheim Gmbh | ||
| US3876659A (en) * | 1970-09-18 | 1975-04-08 | Sandoz Ag | Spiro tricyclic isoindolines |
| FR2512024A1 (fr) * | 1981-08-27 | 1983-03-04 | Adir | Ethers tricycliques, leur preparation et les compositions pharmaceutiques les contenant |
| JPS6147466A (ja) * | 1984-08-10 | 1986-03-07 | Dainippon Pharmaceut Co Ltd | アミン誘導体 |
-
1985
- 1985-01-22 SE SE8500273A patent/SE8500273D0/xx unknown
- 1985-12-30 IE IE332585A patent/IE59600B1/en not_active IP Right Cessation
- 1985-12-30 NO NO855373A patent/NO855373L/no unknown
-
1986
- 1986-01-10 AU AU52171/86A patent/AU587597B2/en not_active Ceased
- 1986-01-11 DE DE8686100324T patent/DE3664136D1/de not_active Expired
- 1986-01-11 AT AT86100324T patent/ATE44280T1/de not_active IP Right Cessation
- 1986-01-11 EP EP86100324A patent/EP0189078B1/de not_active Expired
- 1986-01-16 FI FI860199A patent/FI860199A7/fi not_active Application Discontinuation
- 1986-01-17 US US06/820,428 patent/US4645758A/en not_active Expired - Fee Related
- 1986-01-21 CA CA000500044A patent/CA1309409C/en not_active Expired - Fee Related
- 1986-01-21 JP JP61010959A patent/JPH0798817B2/ja not_active Expired - Lifetime
- 1986-01-21 DK DK31486A patent/DK31486A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK31486D0 (da) | 1986-01-21 |
| JPH0798817B2 (ja) | 1995-10-25 |
| US4645758A (en) | 1987-02-24 |
| FI860199A7 (fi) | 1986-07-23 |
| JPS61172871A (ja) | 1986-08-04 |
| IE853325L (en) | 1986-07-22 |
| SE8500273D0 (sv) | 1985-01-22 |
| AU5217186A (en) | 1986-07-31 |
| AU587597B2 (en) | 1989-08-24 |
| DK31486A (da) | 1986-07-23 |
| NO855373L (no) | 1986-07-23 |
| CA1309409C (en) | 1992-10-27 |
| EP0189078A1 (de) | 1986-07-30 |
| EP0189078B1 (de) | 1989-06-28 |
| IE59600B1 (en) | 1994-03-09 |
| DE3664136D1 (en) | 1989-08-03 |
| FI860199A0 (fi) | 1986-01-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |