BRPI0507604A - medicamentos com atividade de receptor hm74a - Google Patents

medicamentos com atividade de receptor hm74a

Info

Publication number
BRPI0507604A
BRPI0507604A BRPI0507604-8A BRPI0507604A BRPI0507604A BR PI0507604 A BRPI0507604 A BR PI0507604A BR PI0507604 A BRPI0507604 A BR PI0507604A BR PI0507604 A BRPI0507604 A BR PI0507604A
Authority
BR
Brazil
Prior art keywords
alkyl
hm74a
medicines
hydrogen
receptor activity
Prior art date
Application number
BRPI0507604-8A
Other languages
English (en)
Inventor
Ivan Leo Pinto
Shahzad Sharooq Rahman
Neville Hubert Nicholson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0403282A external-priority patent/GB0403282D0/en
Priority claimed from GB0423562A external-priority patent/GB0423562D0/en
Priority claimed from GB0428375A external-priority patent/GB0428375D0/en
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BRPI0507604A publication Critical patent/BRPI0507604A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

MEDICAMENTOS COM ATIVIDADE DE RECPTOR HM74A A presente invenção fornece compostos ativos terapeuticamente que são derivados de xantina, processos para a produção dos ditos derivados, formulações farmacêuticas contendo os compostos ativos e o uso dos compostos na terapia, particularmente no tratamento de doenças onde subativação do recptor HM74A contribui para a doença ou onde ativação do recptor será benéfica, tendo a fórmula (II): em que R¬ 1¬ é selecionado de: hidrogênio e alquila C~ 1~-~ 4~ que pode ser opcionalmente substituído com um ou mais grupos slecionados de CN e CF~ 3~, R¬ 1¬ é selecionado de: hidrogênio e alquila C~ 1~-~ 10~ não subistítuido com um grupo selecioandos de fluór e CN, alquenila C¬ 5¬ , aquila C¬ 4¬ não ramificado e alquila C~ 1~-~ 4~ substituído com cicloaquila e R~ 3~ é selecionados de halogênio e CN.
BRPI0507604-8A 2004-02-14 2005-02-10 medicamentos com atividade de receptor hm74a BRPI0507604A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0403282A GB0403282D0 (en) 2004-02-14 2004-02-14 Chemical compounds
GB0423562A GB0423562D0 (en) 2004-10-22 2004-10-22 Novel compounds
GB0428375A GB0428375D0 (en) 2004-12-24 2004-12-24 Novel compounds
PCT/EP2005/001449 WO2005077950A2 (en) 2004-02-14 2005-02-10 Medicaments with hm74a receptor activity

Publications (1)

Publication Number Publication Date
BRPI0507604A true BRPI0507604A (pt) 2007-07-03

Family

ID=34864831

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507604-8A BRPI0507604A (pt) 2004-02-14 2005-02-10 medicamentos com atividade de receptor hm74a

Country Status (26)

Country Link
US (5) US7713982B2 (pt)
EP (1) EP1781657B1 (pt)
JP (2) JP5001012B2 (pt)
KR (1) KR101100601B1 (pt)
CN (2) CN101863888B (pt)
AR (1) AR047669A1 (pt)
AU (1) AU2005212816C1 (pt)
BR (1) BRPI0507604A (pt)
CA (1) CA2556073C (pt)
CY (1) CY1114022T1 (pt)
DK (1) DK1781657T3 (pt)
ES (1) ES2406732T3 (pt)
HK (1) HK1104530A1 (pt)
HR (1) HRP20130406T1 (pt)
IL (1) IL177051A (pt)
MA (1) MA28357A1 (pt)
MY (1) MY148937A (pt)
NO (1) NO337281B1 (pt)
NZ (1) NZ548496A (pt)
PE (1) PE20060317A1 (pt)
PL (1) PL1781657T3 (pt)
PT (1) PT1781657E (pt)
SG (1) SG157242A1 (pt)
SI (1) SI1781657T1 (pt)
TW (1) TWI350289B (pt)
WO (1) WO2005077950A2 (pt)

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CN105622610A (zh) * 2016-03-28 2016-06-01 浙江诚意药业股份有限公司 一种黄嘌呤化合物的制备方法
CN109661238B (zh) 2016-07-27 2023-07-25 哈里斯制药公司 治疗红细胞疾病的治疗组合
CN106632061B (zh) * 2016-11-23 2020-07-24 上海皓元医药股份有限公司 一种1-(4-苯基-1-烷基-1h-咪唑-2-基)乙酮及其衍生物的合成方法
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Also Published As

Publication number Publication date
PL1781657T3 (pl) 2013-08-30
TWI350289B (en) 2011-10-11
NO20064151L (no) 2006-11-06
CN101103030B (zh) 2010-10-13
PE20060317A1 (es) 2006-06-22
EP1781657B1 (en) 2013-03-27
AU2005212816B2 (en) 2009-07-23
MA28357A1 (fr) 2006-12-01
JP2008120831A (ja) 2008-05-29
PT1781657E (pt) 2013-05-23
TW200536537A (en) 2005-11-16
ES2406732T3 (es) 2013-06-07
CN101863888B (zh) 2012-07-18
SG157242A1 (en) 2009-12-29
IL177051A (en) 2013-01-31
NO337281B1 (no) 2016-02-29
IL177051A0 (en) 2006-12-10
US20130150383A1 (en) 2013-06-13
US7713982B2 (en) 2010-05-11
US20100010021A1 (en) 2010-01-14
CY1114022T1 (el) 2016-07-27
MY148937A (en) 2013-06-14
US20070135456A1 (en) 2007-06-14
US20150080418A1 (en) 2015-03-19
CN101103030A (zh) 2008-01-09
JP5001012B2 (ja) 2012-08-15
CA2556073A1 (en) 2005-08-25
AU2005212816C1 (en) 2010-03-04
HK1104530A1 (en) 2008-01-18
DK1781657T3 (da) 2013-06-10
WO2005077950A3 (en) 2007-04-19
KR101100601B1 (ko) 2011-12-29
AU2005212816A1 (en) 2005-08-25
CA2556073C (en) 2012-01-10
JP5020848B2 (ja) 2012-09-05
SI1781657T1 (sl) 2013-07-31
NZ548496A (en) 2010-02-26
AR047669A1 (es) 2006-02-01
KR20060126772A (ko) 2006-12-08
WO2005077950A2 (en) 2005-08-25
EP1781657A2 (en) 2007-05-09
JP2007522176A (ja) 2007-08-09
HRP20130406T1 (hr) 2013-06-30
CN101863888A (zh) 2010-10-20
US20100160354A1 (en) 2010-06-24
US8268839B2 (en) 2012-09-18
US8394808B2 (en) 2013-03-12

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